| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Er-Ying Hao, Xue-Lu Liu, Xiang-Yu Chen, Han Xue, Bo-Fei Su, Yi-Fan Chen, De-He Wang, Lei Shi, Kang Bai, Fei Hou, Jian-Ku Hou, Hui-Ling Bao, Hui Che. Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens. Poultry science. vol 103. issue 6. 2024-04-07. PMID:38583308. |
then we explored whether melatonin protects follicular granulosa cells from ers-induced apoptosis through the mammalian target of rapamycin (mtor) signaling pathway by regulating atf4, we found that atf4 knockdown inhibited ers by decreasing the expression of ers-related genes and proteins and activating mtor signaling pathway by increasing the protein expression of p4e-bp1 and pt389-s6k (p<0.001), while these changes were promoted by tm+si-atf4+mel treatment (p<0.01). |
2024-04-07 |
2024-04-10 |
Not clear |
| Emeline Boët, Jean-Emmanuel Sarr. Targeting Metabolic Dependencies Fueling the TCA Cycle to Circumvent Therapy Resistance in Acute Myeloid Leukemia. Cancer research. vol 84. issue 7. 2024-04-01. PMID:38558131. |
in addition, onc-213 affected αkgdh, a pivotal nadh-producing enzyme of the tca cycle, to induce a mitochondrial stress response through atf4 activation that diminished the expression of the antiapoptotic protein mcl1, consequently promoting apoptosis of aml cells. |
2024-04-01 |
2024-04-04 |
Not clear |
| Adrien Corne, Florine Adolphe, Jérôme Estaquier, Sébastien Gaumer, Jean-Marc Cors. ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor. Biology. vol 13. issue 3. 2024-03-27. PMID:38534416. |
activating transcription factor 4 (atf4) plays a pivotal role in these pathways and controls the expression of many genes involved in redox processes, amino acid metabolism, protein misfolding, autophagy, and apoptosis. |
2024-03-27 |
2024-03-29 |
human |
| Adrien Corne, Florine Adolphe, Jérôme Estaquier, Sébastien Gaumer, Jean-Marc Cors. ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor. Biology. vol 13. issue 3. 2024-03-27. PMID:38534416. |
the role of atf4 in autophagy and apoptosis is explored as in the context of hiv-1 infection programmed cell deaths contribute to the depletion of cd4 t cells. |
2024-03-27 |
2024-03-29 |
human |
| Sokhna Haissatou Diaw, Sylvie Delcambre, Christoph Much, Fabian Ott, Vladimir S Kostic, Agata Gajos, Alexander Münchau, Simone Zittel, Hauke Busch, Anne Grünewald, Christine Klein, Katja Lohman. DYT-THAP1: exploring gene expression in fibroblasts for potential biomarker discovery. Neurogenetics. 2024-03-18. PMID:38498291. |
this included transcription factors and targets (atf4, cln3, eif2a, rrm1, yy1), genes involved in g protein-coupled receptor signaling (bdkrb2, lpar1), and a gene linked to apoptosis and dna replication/repair (cradd), which all showed higher expression levels in mmcs and nmcs than in controls. |
2024-03-18 |
2024-03-21 |
Not clear |
| Jianhua Shan, Haoyue Guan, Zhuoqi Zhang, Wenxue Ma, Jingzeng Cai, Ge Gao, Ziwei Zhan. BDE-47-induced damage prevented by melatonin in grass carp hepatocytes (L8824). Environmental science and pollution research international. 2024-03-16. PMID:38492135. |
compared with the bde-47 group, the bde-47 + mt group showed reduced levels of er and apoptosis of hepatocytes, while the expression of the er stress-related genes ire1, atf4, grp78, perk, and chop and the apoptosis-related genes caspase3, bax, and caspase9 were down-regulated (p < 0.05), and the level of bcl-2 was up-regulated (p < 0.01). |
2024-03-16 |
2024-03-19 |
Not clear |
| Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhan. Forsythoside A protects against Zearalenone-induced cell damage in chicken embryonic fibroblasts via mitigation of endoplasmic reticulum stress. Veterinary research communications. 2024-03-12. PMID:38467911. |
we also demonstrated that fa help to prevent ers and attenuated zea-induced apoptosis in df-1 cells by reducing the level of ros, downregulating grp78, perk, atf4, atf6, jnk, ire1, ask1, chop, bax expression, and up-regulating bcl-2 expression. |
2024-03-12 |
2024-03-14 |
chicken |
| Yujun Luo, Yiming Lei, Haoxiong Zhou, Yan Chen, Huiling Liu, Jie Jiang, Chengfang Xu, Bin W. ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling. Cell biology and toxicology. vol 40. issue 1. 2024-01-22. PMID:38252352. |
moreover, arrb1-ko mice exhibited increased er stress (indicated by phosphorylated α subunit of eukaryotic initiation factor 2 (p-eif2α)-activating transcription factor 4 (atf4)-ccaat-enhancer-binding protein homologous protein (chop)) and apoptosis (indicated by cleaved caspase 3). |
2024-01-22 |
2024-01-24 |
mouse |
| Harpreet Kaur, Deepaneeta Sarmah, Aishika Datta, Anupom Borah, Dileep R Yavagal, Pallab Bhattachary. Stem cells alleviate OGD/R mediated stress response in PC12 cells following a co-culture: modulation of the apoptotic cascade through BDNF-TrkB signaling. Cell stress & chaperones. vol 28. issue 6. 2024-01-15. PMID:38225002. |
results from our study have shown that oxygen-glucose deprivation/reoxygenation (ogd/r) potentiated er stress and apoptosis in the pheochromocytoma 12 (pc12) cell line as evident by the increase of protein kinase r (pkr)-like er kinase (p-perk), p-eukaryotic initiation factor 2α subunit (eif2α), activation transcription factor 4 (atf4), chop, and caspase 12 expressions. |
2024-01-15 |
2024-01-18 |
Not clear |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
additionally, nissl staining assessed hippocampal ca1 area neuronal density, tunel staining evaluated hippocampal ca1 area neuronal apoptosis, and western blot determined hippocampal ca1 area protein levels, including bax, bcl-2, p-perk/perk, p-eif2/eif2, atf4, chop, grp78, bax, and bcl-2 protein levels. |
2024-01-09 |
2024-01-13 |
rat |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
following spc treatment, hibd rats exhibited improved spatial learning and memory abilities, reduced neuronal apoptosis, increased neuronal density in the hippocampal ca1 area, elevated bcl-2 protein level, decreased bax protein levels, and decreased levels of endoplasmic reticulum stress pathway related proteins (p-perk/perk, p-eif2/eif2, atf4, chop and grp78). |
2024-01-09 |
2024-01-13 |
rat |
| Wei Liu, Linzhang Zhang, Xia Wei, Yongbin Xu, Qinqin Fang, Shenglan Qi, Jiamei Chen, Changhong Wang, Shunchun Wang, Luping Qin, Ping Liu, Jianjun W. Structural characterization of an inulin neoseries-type fructan from Ophiopogonis Radix and the therapeutic effect on liver fibrosis in vivo. Carbohydrate polymers. vol 327. 2024-01-03. PMID:38171656. |
pharmacological studies revealed that ojp-w2 exerted a marked hepatoprotective effect against liver fibrosis, the mechanism of action was involved in regulating collagen deposition (α-sma, col1a1 and liver hyp contents) and tgf-β/smads signaling pathway, alleviating liver inflammation (il-1β, il-6, ccl5 and f4/80) and mapk signaling pathway, and inhibiting hepatic apoptosis (bax, bcl-2, atf4 and caspase 3). |
2024-01-03 |
2024-01-06 |
Not clear |
| Erin van Zyl, Claire Peneycad, Evan Perehiniak, Bruce C McKa. Cyclin-dependent kinase inhibitor 1 plays a more prominent role than activating transcription factor 4 or the p53 tumour suppressor in thapsigargin-induced G1 arrest. PeerJ. vol 11. 2023-12-22. PMID:38130926. |
the activating transcription factor 4 (atf4) plays a key role in regulating er stress-induced gene expression so we sought to determine if atf4 is required for tg-induced cell cycle arrest and apoptosis using atf4-deficient cells. |
2023-12-22 |
2023-12-24 |
Not clear |
| Yuh-Jin Liang, Yu-Wei Chiou, Abby Pei-Ting Chiu, Ming-Shi Shiao, Wei Teng, Chin-Wei Lin, Mei-Ling Cheng, Yen-Hua Huang, Kung-Hao Liang, Chien-Wei Su, Chi-Yu Lai, Chih-Li Chen, Jaw-Ching W. Antiviral therapy reduces hepatocellular carcinoma through suppressing hepatitis B virus replication may improve ER stress, mitochondrial and metabolic dysfunctions and decrease p62 in hybridized mice with single HBV transgene and miR-122. Journal of medical virology. vol 95. issue 12. 2023-12-19. PMID:38108211. |
this effect was linked to the activation of er stress-responsive transcription factor atf4, clearance of autophagosome cargo p62, and suppression of the chop-mediated apoptosis pathway. |
2023-12-19 |
2023-12-21 |
mouse |
| Yaosheng Xiao, Xunlu Xie, Zhixi Chen, Guoqiang Yin, Weihao Kong, Jianguo Zho. Advances in the roles of ATF4 in osteoporosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 169. 2023-11-10. PMID:37948991. |
activating transcription factor 4 (atf4) plays a role in cell differentiation, proliferation, apoptosis, redox balance, amino acid uptake, and glycolipid metabolism. |
2023-11-10 |
2023-11-20 |
Not clear |
| Meina Huang, Jinhui Wang, Meili Zhai, Jiqiang Liu, Yongjie Zhu, Yang Zhang, Jing Zhao, Huiquan Wang, Jinglai Sun, Hui Yu, Chong Li. Sigma-1 receptor regulates the endoplasmic reticulum stress pathway in the protective mechanism of dexmedetomidine against hyperoxia-induced lung injury. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-15. PMID:37714499. |
subsequently, according to the dynamic changes of apoptosis in lung specimens, and the expression changes in sig-1r-regulated er stress pathway proteins (sig-1r, grp78, p-perk, atf6, ire1, caspase-12, atf4, chop, caspase-3 and p-jnk), it was confirmed that the sig-1r-regulated er stress signaling pathway was involved in the occurrence of hali. |
2023-09-15 |
2023-10-07 |
Not clear |
| Cancan You, Zilong Zhang, Huiya Ying, Zijing Yang, Yixuan Ma, Jingyi Hong, Mingjie Xue, Xuan Li, Huimin Li, Chengrui Zhang, Wei Wang, Xiaohong Cai, Xiucui L. Blockage of calcium-sensing receptor improves chronic intermittent hypoxia-induced cognitive impairment by PERK-ATF4-CHOP pathway. Experimental neurology. 2023-08-08. PMID:37553048. |
cih upregulated the level of casr, p-perk, atf4 and chop, contributing to the cell apoptosis. |
2023-08-08 |
2023-08-16 |
mouse |
| Cancan You, Zilong Zhang, Huiya Ying, Zijing Yang, Yixuan Ma, Jingyi Hong, Mingjie Xue, Xuan Li, Huimin Li, Chengrui Zhang, Wei Wang, Xiaohong Cai, Xiucui L. Blockage of calcium-sensing receptor improves chronic intermittent hypoxia-induced cognitive impairment by PERK-ATF4-CHOP pathway. Experimental neurology. 2023-08-08. PMID:37553048. |
treated with casr inhibitor (nps-2143) or p-perk inhibitor (gsk2656157) before cih exposure, cih-induced pc12 cell apoptosis was alleviated via inhibition of casr by downregulating p-perk, atf4 and chop. |
2023-08-08 |
2023-08-16 |
mouse |
| Cancan You, Zilong Zhang, Huiya Ying, Zijing Yang, Yixuan Ma, Jingyi Hong, Mingjie Xue, Xuan Li, Huimin Li, Chengrui Zhang, Wei Wang, Xiaohong Cai, Xiucui L. Blockage of calcium-sensing receptor improves chronic intermittent hypoxia-induced cognitive impairment by PERK-ATF4-CHOP pathway. Experimental neurology. 2023-08-08. PMID:37553048. |
besides, treatment of casr inhibitor alleviated the hippocampal neuronal apoptosis following cih with downregulated p-perk, atf4 and chop, suggesting that casr contributed to cih-induced neuronal apoptosis in hippocampus via ers pathway. |
2023-08-08 |
2023-08-16 |
mouse |
| Elikanah Olusayo Adegoke, Md Saidur Rahman, Shehreen Amjad, Won-Ki Pang, Do-Yeal Ryu, Yoo-Jin Park, Mung-Geol Pan. Environmentally relevant doses of endocrine disrupting chemicals affect male fertility by interfering with sertoli cell glucose metabolism in mice. Chemosphere. 2023-06-26. PMID:37364641. |
the accompanying upregulation of activating transcription factor 4 (atf4), inositol requiring enzyme-1 (ire1), c/ebp homologous protein (chop), and mitogen-activated protein kinase (mapk) signaling promoted antioxidant depletion, testicular cell apoptosis, abnormal regulation of the blood-testis barrier, and decreased sperm count. |
2023-06-26 |
2023-08-14 |
mouse |