| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giulio Donati, Micol Ravà, Marco Filipuzzi, Paola Nicoli, Laura Cassina, Alessandro Verrecchia, Mirko Doni, Simona Rodighiero, Federica Parodi, Alessandra Boletta, Christopher P Vellano, Joseph R Marszalek, Giulio F Draetta, Bruno Amat. Targeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma. Molecular oncology. 2021-11-11. PMID:34632715. |
mechanistically, iacs-010759 triggered the integrated stress response (isr) pathway, driven by the transcription factors atf4 and chop, which engaged the intrinsic apoptosis pathway and lowered the apoptotic threshold in myc-overexpressing cells. |
2021-11-11 |
2023-08-13 |
Not clear |
| Kalishwaralal Kalimuthu, Jin Hong Kim, Yong Seok Park, Xu Luo, Lin Zhang, Ja-Lok Ku, M Haroon A Choudry, Yong J Le. Glucose deprivation-induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity. Journal of cellular physiology. vol 236. issue 9. 2021-11-10. PMID:33586156. |
studies with activating transcription factor 4 (atf4), c/ebp-homologous protein (chop), p53 upregulated modulator of apoptosis (puma), or death receptor 5 (dr5)-deficient mouse embryonic fibroblasts or hct116 cells suggest that the atf4-chop-puma axis and the atf4-chop-dr5 axis are involved in the combined treatment-induced apoptosis. |
2021-11-10 |
2023-08-13 |
mouse |
| Lifeng Feng, Muchun Li, Xinyang Hu, Yiling Li, Liyuan Zhu, Miaoqin Chen, Qi Wei, Wenxia Xu, Qiyin Zhou, Weikai Wang, Dingwei Chen, Xian Wang, Hongchuan Ji. CK1δ stimulates ubiquitination-dependent proteasomal degradation of ATF4 to promote chemoresistance in gastric Cancer. Clinical and translational medicine. vol 11. issue 10. 2021-11-04. PMID:34709767. |
the over-expression of atf4 reversed chemoresistance by activating chop transcription to enhance drug-induced apoptosis, and vice versa. |
2021-11-04 |
2023-08-13 |
Not clear |
| Yingchao Gong, Qingfeng Li, Zetao Ma, Tingting Jin, Jun Lin, Qingbo Lv, Meihui Wang, Guosheng Fu, Shengjie X. Downregulation of activating transcription factor 4 attenuates lysophosphatidycholine-induced inflammation via the NF-κB pathway. European journal of pharmacology. vol 911. 2021-11-01. PMID:34582847. |
activation of the nf-κb pathway and expression of its upstream factors, including toll like receptor 4 and cellular inhibitor of apoptosis, were also inhibited by atf4 silencing. |
2021-11-01 |
2023-08-13 |
human |
| Zhanxia Zhang, Junqian Zhang, Jianhui Tian, Hegen L. A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1). Journal of nanobiotechnology. vol 19. issue 1. 2021-10-24. PMID:34654435. |
more importantly, the genetic nanomedicine not only inhibited liver cancer cell proliferation but also promoted liver cell apoptosis by slowing roc1 activity, suppressing the neddylation pathway, enabling the accumulation of apototic factor atf4 and dna damage factor p-h2ax. |
2021-10-24 |
2023-08-13 |
Not clear |
| Yiqun Zhang, Lanlan Zhou, Howard Safran, Robyn Borsuk, Rishi Lulla, Nikos Tapinos, Attila A Seyhan, Wafik S El-Deir. EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG. Neoplasia (New York, N.Y.). vol 23. issue 8. 2021-09-23. PMID:34246076. |
knockdown of atf4 reduced dr5 induction and apoptosis following ezh2i and onc201 treatment of u251 glioma cells. |
2021-09-23 |
2023-08-13 |
human |
| Yihu Zheng, Qingqing Zhou, Chang Zhao, Junjian Li, Zhengping Yu, Qiandong Zh. ATP citrate lyase inhibitor triggers endoplasmic reticulum stress to induce hepatocellular carcinoma cell apoptosis via p-eIF2α/ATF4/CHOP axis. Journal of cellular and molecular medicine. vol 25. issue 3. 2021-09-22. PMID:33393219. |
in cells where er stress was induced, atf4 was involved in bms-303141-mediated cell death procession, and atf4 knockdown reduced hcc cell apoptosis stimulated by bms-303141. |
2021-09-22 |
2023-08-13 |
mouse |
| Xiaofeng Deng, Yu He, Xiongying Miao, Bo Y. ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis. Cell death & disease. vol 12. issue 1. 2021-09-13. PMID:33414424. |
firstly, we validated the effect of atf4 on pancreatic acinar cell proliferation, apoptosis, and inflammation through in vitro experiments on cellular models of caerulein-induced ap. |
2021-09-13 |
2023-08-13 |
mouse |
| Xiaofeng Deng, Yu He, Xiongying Miao, Bo Y. ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis. Cell death & disease. vol 12. issue 1. 2021-09-13. PMID:33414424. |
after ap induction, highly expressed atf4 was observed, and silencing atf4 could promote pancreatic acinar cell proliferation and inhibit apoptosis. |
2021-09-13 |
2023-08-13 |
mouse |
| Man-Lin Guo, Xiang-Yu Ma, Yu-Qing Gong, Meng-Lin Feng, Yu-Wan Zhao, Leng-Xin Dua. [Protective effect of ethyl acetate extract from Bidens bipinnata on hepatocyte damage induced by endoplasmic reticulum stress]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 15. 2021-09-03. PMID:34472265. |
methyl thiazolyl tetrazolium(mtt) colorimetric assay was used to investigate the survival rate of ethyl acetate extract from b. bipinnata in l02 cells injury induced by endoplasmic reticulum stress; the protein expressions of endoplasmic reticulum stress-related molecule glucose regulated protein 78(grp78), pkr-like er kinase(perk), eukaryotic initiation factor-2(eif2α), activating transcription factor 4(atf4), c/ebp homologous protein(chop), b-cell cll/lymphoma 2(bcl-2), bal-2 associated x apoptosis regulator(bax) were examined by wes-tern blot. |
2021-09-03 |
2023-08-13 |
Not clear |
| Li Tan, Lindsey R Harper, Alexandra Armstrong, Cathy S Carlson, Raghunatha R Yamman. Dietary saturated fatty acid palmitate promotes cartilage lesions and activates the unfolded protein response pathway in mouse knee joints. PloS one. vol 16. issue 2. 2021-08-23. PMID:33617553. |
mice fed on a diet rich in saturated or unsaturated fatty acid gained an equal amount of weight; however, mice fed a palmitate diet, but not a control or oleate diet, exhibited more cartilage lesions and increased expression of 1) unfolded protein response (upr)/endoplasmic reticulum (er) stress markers including bip, p-ire1α, xbp1, atf4, and chop; 2) apoptosis markers cc3 and c-parp; and 3) negative cell survival regulators nupr1 and trb3, in knee articular cartilage. |
2021-08-23 |
2023-08-13 |
mouse |
| Nami Kurozumi, Takayuki Tsujioka, Mamoru Ouchida, Kanae Sakakibara, Takako Nakahara, Shin-Ichiro Suemori, Masaki Takeuchi, Akira Kitanaka, Misako Shibakura, Kaoru Tohyam. VLX1570 induces apoptosis through the generation of ROS and induction of ER stress on leukemia cell lines. Cancer science. vol 112. issue 8. 2021-08-19. PMID:34032336. |
vlx1570 increased the amount of high molecular weight polyubiquitinated proteins and the expression of hsp70 as the result of the suppression of ubiquitin proteasome system, the expression of heme oxygenase-1, and the amount of phosphorylation in jnk and p38 associated with the generation of reactive oxygen species (ros) induced apoptosis and the amount of phosphorylation in eif2α, inducing the expression of atf4 and endoplasmic reticulum (er) stress dependent apoptosis protein, chop, and the amount of phosphorylation slightly in ire1α, leading to increased expression of xbp-1s in leukemia cell lines. |
2021-08-19 |
2023-08-13 |
Not clear |
| Yupei Liang, Yanyu Jiang, Xing Jin, Ping Chen, Yongqing Heng, Lili Cai, Wenjuan Zhang, Lihui Li, Lijun Ji. Neddylation inhibition activates the protective autophagy through NF-κB-catalase-ATF3 Axis in human esophageal cancer cells. Cell communication and signaling : CCS. vol 18. issue 1. 2021-08-10. PMID:32398095. |
our previous study demonstrated that neddylation inhibition induced the accumulation of atf4 to promote apoptosis in esophageal cancer cells. |
2021-08-10 |
2023-08-13 |
human |
| Ying Ying, Ran Xue, Yangfan Yang, Sarah X Zhang, Hui Xiao, Huazhang Zhu, Jingming Li, Guo Chen, Yiming Ye, Minbin Yu, Xing Liu, Yimin Zhon. Activation of ATF4 triggers trabecular meshwork cell dysfunction and apoptosis in POAG. Aging. vol 13. issue 6. 2021-07-19. PMID:33714955. |
activation of atf4 triggers trabecular meshwork cell dysfunction and apoptosis in poag. |
2021-07-19 |
2023-08-13 |
human |
| Ying Ying, Ran Xue, Yangfan Yang, Sarah X Zhang, Hui Xiao, Huazhang Zhu, Jingming Li, Guo Chen, Yiming Ye, Minbin Yu, Xing Liu, Yimin Zhon. Activation of ATF4 triggers trabecular meshwork cell dysfunction and apoptosis in POAG. Aging. vol 13. issue 6. 2021-07-19. PMID:33714955. |
inhibition of atf4 ameliorated tbhp-induced apoptosis and inflammatory cytokine production, while ectopic expression of atf4 increased the expression of endothelial leukocyte adhesion molecule (elam)-1 and il-8 in htmcs. |
2021-07-19 |
2023-08-13 |
human |
| Mengting Ren, Xinxin Zhou, Mengli Gu, Wenrui Jiao, Mosang Yu, Yamei Wang, Sha Liu, Jinpu Yang, Feng J. Resveratrol synergizes with cisplatin in antineoplastic effects against AGS gastric cancer cells by inducing endoplasmic reticulum stress‑mediated apoptosis and G2/M phase arrest. Oncology reports. vol 44. issue 4. 2021-07-06. PMID:32945472. |
in conclusion, res and ddp synergistically inhibited the growth of the gastric adenocarcinoma cell line ags by inducing endoplasmic reticulum stress‑mediated apoptosis and g2/m phase arrest via activation of the perk/eif2α/activating transcription factor 4 (atf4)/chop signaling pathway and caspase‑12 and by inactivating the cdk1‑cyclin b1 complex. |
2021-07-06 |
2023-08-13 |
Not clear |
| Yunjing Zhang, Shiwen Wang, Yukun Chen, Junqian Zhang, Jing Yang, Jingrong Xian, Lihui Li, Hu Zhao, Robert M Hoffman, Yanmei Zhang, Lijun Ji. Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis. Frontiers in oncology. vol 11. 2021-07-02. PMID:34195076. |
fangchinoline inhibits human esophageal cancer by transactivating atf4 to trigger both noxa-dependent intrinsic and dr5-dependent extrinsic apoptosis. |
2021-07-02 |
2023-08-13 |
human |
| Jing Chen, Dawei Zhou, Jian Kang, Chenxi Liu, Roujie Huang, Zhengqian Jiang, Yuxuan Liao, An Liu, Lihua Gao, Xiangzhi Song, Shuang Zhao, Yihui Chen, Hongyi Wang, Zehao Lan, Weidong Wang, Haoyu Guan, Xiang Chen, Jinhua Huan. ER stress modulates apoptosis in A431 cell subjected to EtNBSe-PDT via the PERK pathway. Photodiagnosis and photodynamic therapy. vol 34. 2021-06-30. PMID:33901688. |
furthermore, we demonstrate that atf4, whose expression is er-stress-inducible and elevated in response to the perk/eif2α signaling pathway activation, contributes to cytoprotection against etnbse-pdt induced apoptosis. |
2021-06-30 |
2023-08-13 |
mouse |
| Xiaobo Hu, Cong Hu, Jun Liu, Zhuan Wu, Tingting Duan, Zhaohui Ca. 1,25-(OH)2D3 protects pancreatic beta cells against H2O2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway. Acta biochimica et biophysica Sinica. vol 53. issue 1. 2021-06-17. PMID:33242093. |
h2o2 activated the phosphorylation of perk, upregulated the activating transcription factor 4 (atf4) and c/ebp homologous protein (chop) expression, and subsequently initiated cell apoptosis, which were significantly reversed by 1,25-(oh)2d3 pretreatment. |
2021-06-17 |
2023-08-13 |
mouse |
| Xiaobo Hu, Cong Hu, Jun Liu, Zhuan Wu, Tingting Duan, Zhaohui Ca. 1,25-(OH)2D3 protects pancreatic beta cells against H2O2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway. Acta biochimica et biophysica Sinica. vol 53. issue 1. 2021-06-17. PMID:33242093. |
in addition, gsk2606414, a specific inhibitor of perk, suppressed perk phosphorylation and reduced the expressions of atf4 and chop, leading to a significant decrease in β cell apoptosis induced by h2o2. |
2021-06-17 |
2023-08-13 |
mouse |