| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiqun Zhang, Lanlan Zhou, Howard Safran, Robyn Borsuk, Rishi Lulla, Nikos Tapinos, Attila A Seyhan, Wafik S El-Deir. EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG. Neoplasia (New York, N.Y.). vol 23. issue 8. 2021-09-23. PMID:34246076. |
knockdown of atf4 reduced dr5 induction and apoptosis following ezh2i and onc201 treatment of u251 glioma cells. |
2021-09-23 |
2023-08-13 |
human |
| Yihu Zheng, Qingqing Zhou, Chang Zhao, Junjian Li, Zhengping Yu, Qiandong Zh. ATP citrate lyase inhibitor triggers endoplasmic reticulum stress to induce hepatocellular carcinoma cell apoptosis via p-eIF2α/ATF4/CHOP axis. Journal of cellular and molecular medicine. vol 25. issue 3. 2021-09-22. PMID:33393219. |
in cells where er stress was induced, atf4 was involved in bms-303141-mediated cell death procession, and atf4 knockdown reduced hcc cell apoptosis stimulated by bms-303141. |
2021-09-22 |
2023-08-13 |
mouse |
| Xiaofeng Deng, Yu He, Xiongying Miao, Bo Y. ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis. Cell death & disease. vol 12. issue 1. 2021-09-13. PMID:33414424. |
firstly, we validated the effect of atf4 on pancreatic acinar cell proliferation, apoptosis, and inflammation through in vitro experiments on cellular models of caerulein-induced ap. |
2021-09-13 |
2023-08-13 |
mouse |
| Xiaofeng Deng, Yu He, Xiongying Miao, Bo Y. ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis. Cell death & disease. vol 12. issue 1. 2021-09-13. PMID:33414424. |
after ap induction, highly expressed atf4 was observed, and silencing atf4 could promote pancreatic acinar cell proliferation and inhibit apoptosis. |
2021-09-13 |
2023-08-13 |
mouse |
| Man-Lin Guo, Xiang-Yu Ma, Yu-Qing Gong, Meng-Lin Feng, Yu-Wan Zhao, Leng-Xin Dua. [Protective effect of ethyl acetate extract from Bidens bipinnata on hepatocyte damage induced by endoplasmic reticulum stress]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 15. 2021-09-03. PMID:34472265. |
methyl thiazolyl tetrazolium(mtt) colorimetric assay was used to investigate the survival rate of ethyl acetate extract from b. bipinnata in l02 cells injury induced by endoplasmic reticulum stress; the protein expressions of endoplasmic reticulum stress-related molecule glucose regulated protein 78(grp78), pkr-like er kinase(perk), eukaryotic initiation factor-2(eif2α), activating transcription factor 4(atf4), c/ebp homologous protein(chop), b-cell cll/lymphoma 2(bcl-2), bal-2 associated x apoptosis regulator(bax) were examined by wes-tern blot. |
2021-09-03 |
2023-08-13 |
Not clear |
| Li Tan, Lindsey R Harper, Alexandra Armstrong, Cathy S Carlson, Raghunatha R Yamman. Dietary saturated fatty acid palmitate promotes cartilage lesions and activates the unfolded protein response pathway in mouse knee joints. PloS one. vol 16. issue 2. 2021-08-23. PMID:33617553. |
mice fed on a diet rich in saturated or unsaturated fatty acid gained an equal amount of weight; however, mice fed a palmitate diet, but not a control or oleate diet, exhibited more cartilage lesions and increased expression of 1) unfolded protein response (upr)/endoplasmic reticulum (er) stress markers including bip, p-ire1α, xbp1, atf4, and chop; 2) apoptosis markers cc3 and c-parp; and 3) negative cell survival regulators nupr1 and trb3, in knee articular cartilage. |
2021-08-23 |
2023-08-13 |
mouse |
| Nami Kurozumi, Takayuki Tsujioka, Mamoru Ouchida, Kanae Sakakibara, Takako Nakahara, Shin-Ichiro Suemori, Masaki Takeuchi, Akira Kitanaka, Misako Shibakura, Kaoru Tohyam. VLX1570 induces apoptosis through the generation of ROS and induction of ER stress on leukemia cell lines. Cancer science. vol 112. issue 8. 2021-08-19. PMID:34032336. |
vlx1570 increased the amount of high molecular weight polyubiquitinated proteins and the expression of hsp70 as the result of the suppression of ubiquitin proteasome system, the expression of heme oxygenase-1, and the amount of phosphorylation in jnk and p38 associated with the generation of reactive oxygen species (ros) induced apoptosis and the amount of phosphorylation in eif2α, inducing the expression of atf4 and endoplasmic reticulum (er) stress dependent apoptosis protein, chop, and the amount of phosphorylation slightly in ire1α, leading to increased expression of xbp-1s in leukemia cell lines. |
2021-08-19 |
2023-08-13 |
Not clear |
| Yupei Liang, Yanyu Jiang, Xing Jin, Ping Chen, Yongqing Heng, Lili Cai, Wenjuan Zhang, Lihui Li, Lijun Ji. Neddylation inhibition activates the protective autophagy through NF-κB-catalase-ATF3 Axis in human esophageal cancer cells. Cell communication and signaling : CCS. vol 18. issue 1. 2021-08-10. PMID:32398095. |
our previous study demonstrated that neddylation inhibition induced the accumulation of atf4 to promote apoptosis in esophageal cancer cells. |
2021-08-10 |
2023-08-13 |
human |
| Ying Ying, Ran Xue, Yangfan Yang, Sarah X Zhang, Hui Xiao, Huazhang Zhu, Jingming Li, Guo Chen, Yiming Ye, Minbin Yu, Xing Liu, Yimin Zhon. Activation of ATF4 triggers trabecular meshwork cell dysfunction and apoptosis in POAG. Aging. vol 13. issue 6. 2021-07-19. PMID:33714955. |
activation of atf4 triggers trabecular meshwork cell dysfunction and apoptosis in poag. |
2021-07-19 |
2023-08-13 |
human |
| Ying Ying, Ran Xue, Yangfan Yang, Sarah X Zhang, Hui Xiao, Huazhang Zhu, Jingming Li, Guo Chen, Yiming Ye, Minbin Yu, Xing Liu, Yimin Zhon. Activation of ATF4 triggers trabecular meshwork cell dysfunction and apoptosis in POAG. Aging. vol 13. issue 6. 2021-07-19. PMID:33714955. |
inhibition of atf4 ameliorated tbhp-induced apoptosis and inflammatory cytokine production, while ectopic expression of atf4 increased the expression of endothelial leukocyte adhesion molecule (elam)-1 and il-8 in htmcs. |
2021-07-19 |
2023-08-13 |
human |
| Mengting Ren, Xinxin Zhou, Mengli Gu, Wenrui Jiao, Mosang Yu, Yamei Wang, Sha Liu, Jinpu Yang, Feng J. Resveratrol synergizes with cisplatin in antineoplastic effects against AGS gastric cancer cells by inducing endoplasmic reticulum stress‑mediated apoptosis and G2/M phase arrest. Oncology reports. vol 44. issue 4. 2021-07-06. PMID:32945472. |
in conclusion, res and ddp synergistically inhibited the growth of the gastric adenocarcinoma cell line ags by inducing endoplasmic reticulum stress‑mediated apoptosis and g2/m phase arrest via activation of the perk/eif2α/activating transcription factor 4 (atf4)/chop signaling pathway and caspase‑12 and by inactivating the cdk1‑cyclin b1 complex. |
2021-07-06 |
2023-08-13 |
Not clear |
| Yunjing Zhang, Shiwen Wang, Yukun Chen, Junqian Zhang, Jing Yang, Jingrong Xian, Lihui Li, Hu Zhao, Robert M Hoffman, Yanmei Zhang, Lijun Ji. Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis. Frontiers in oncology. vol 11. 2021-07-02. PMID:34195076. |
fangchinoline inhibits human esophageal cancer by transactivating atf4 to trigger both noxa-dependent intrinsic and dr5-dependent extrinsic apoptosis. |
2021-07-02 |
2023-08-13 |
human |
| Jing Chen, Dawei Zhou, Jian Kang, Chenxi Liu, Roujie Huang, Zhengqian Jiang, Yuxuan Liao, An Liu, Lihua Gao, Xiangzhi Song, Shuang Zhao, Yihui Chen, Hongyi Wang, Zehao Lan, Weidong Wang, Haoyu Guan, Xiang Chen, Jinhua Huan. ER stress modulates apoptosis in A431 cell subjected to EtNBSe-PDT via the PERK pathway. Photodiagnosis and photodynamic therapy. vol 34. 2021-06-30. PMID:33901688. |
furthermore, we demonstrate that atf4, whose expression is er-stress-inducible and elevated in response to the perk/eif2α signaling pathway activation, contributes to cytoprotection against etnbse-pdt induced apoptosis. |
2021-06-30 |
2023-08-13 |
mouse |
| Xiaobo Hu, Cong Hu, Jun Liu, Zhuan Wu, Tingting Duan, Zhaohui Ca. 1,25-(OH)2D3 protects pancreatic beta cells against H2O2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway. Acta biochimica et biophysica Sinica. vol 53. issue 1. 2021-06-17. PMID:33242093. |
h2o2 activated the phosphorylation of perk, upregulated the activating transcription factor 4 (atf4) and c/ebp homologous protein (chop) expression, and subsequently initiated cell apoptosis, which were significantly reversed by 1,25-(oh)2d3 pretreatment. |
2021-06-17 |
2023-08-13 |
mouse |
| Xiaobo Hu, Cong Hu, Jun Liu, Zhuan Wu, Tingting Duan, Zhaohui Ca. 1,25-(OH)2D3 protects pancreatic beta cells against H2O2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway. Acta biochimica et biophysica Sinica. vol 53. issue 1. 2021-06-17. PMID:33242093. |
in addition, gsk2606414, a specific inhibitor of perk, suppressed perk phosphorylation and reduced the expressions of atf4 and chop, leading to a significant decrease in β cell apoptosis induced by h2o2. |
2021-06-17 |
2023-08-13 |
mouse |
| Li Wu, Yuncheng Lv, Ying Lv, Sunmin Xiang, Zhibo Zhao, Ziqing Tang, Linling Ou, Bin Yan, Xinhua Xiao, Gebo Wen, Renxian Cao, Jing Yan. A novel secretagogin/ATF4 pathway is involved in oxidized LDL-induced endoplasmic reticulum stress and islet β-cell apoptosis. Acta biochimica et biophysica Sinica. vol 53. issue 1. 2021-06-17. PMID:33289795. |
we found that ox-ldl treatment increased the levels of er stress markers, such as phosphorylated protein kinase-like endoplasmic reticulum kinase, phosphorylated eukaryotic initiation factor 2 alpha, activating transcription factor 4 (atf4), and transcription factor ccaat-enhancer-binding protein homologous protein, and promoted min6 cell apoptosis; in addition, the expression of scgn was downregulated. |
2021-06-17 |
2023-08-13 |
Not clear |
| Ling Zhou, Xinlu Yang, Shuhua Shu, Sheng Wang, Fenglin Guo, Ying Yin, Weide Zhou, Han Han, Xiaoqing Cha. Sufentanil Protects the Liver from Ischemia/Reperfusion-Induced Inflammation and Apoptosis by Inhibiting ATF4-Induced TP53BP2 Expression. Inflammation. vol 44. issue 3. 2021-05-24. PMID:33751357. |
these findings demonstrated that sufentanil protects the liver from inflammation and apoptosis injury induced by i/r by inhibiting atf4 expression and further suppressing tp53bp2 expression, suggesting a promising therapeutic candidate for the treatment of liver i/r injury. |
2021-05-24 |
2023-08-13 |
rat |
| Junqian Zhang, Chunjie Li, Li Zhang, Yongqing Heng, Tong Xu, Yunjing Zhang, Xihui Chen, Robert M Hoffman, Lijun Ji. Andrographolide Induces Noxa-Dependent Apoptosis by Transactivating ATF4 in Human Lung Adenocarcinoma Cells. Frontiers in pharmacology. vol 12. 2021-05-18. PMID:33995110. |
andrographolide induces noxa-dependent apoptosis by transactivating atf4 in human lung adenocarcinoma cells. |
2021-05-18 |
2023-08-13 |
human |
| Hafiza Khatun, Yasuhiko Wada, Toshihiro Konno, Hideki Tatemoto, Ken-Ichi Yamanak. Endoplasmic reticulum stress attenuation promotes bovine oocyte maturation in vitro. Reproduction (Cambridge, England). vol 159. issue 4. 2021-05-12. PMID:31990669. |
subsequently, treatment of tudca (100 µm) decreased the localization and amount of grp78/bip protein level as well as er stress (grp78/bip, perk, ier1, atf4, and xbp1) and apoptosis (chop and bax)-related gene expression, while it increased the anti-apoptotic gene bcl2 level in matured cocs. |
2021-05-12 |
2023-08-13 |
cattle |
| Qipeng Zhang, Wenying Chen, Boyang Zhang, Chen Li, Xunyao Zhang, Qian Wang, Yan Wang, Qian Zhou, Xiaohong Li, Xiao Li She. Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A. Toxicology. vol 450. 2021-05-12. PMID:33465424. |
results indicated that a 24 h-treatment of 1-5 μm ota could notably induce mitochondrial-mediated and er stress (ers)-excitated apoptosis via inhibiting trap1, thereby activating cypd, bax, cyt-c, cleaved caspase-9, cleaved caspase-3, grp78, p-perk, p-eif2α, atf4, and chop and inhibiting bcl-2 (p < 0.05). |
2021-05-12 |
2023-08-13 |
human |