| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wanzhen Wang, Jiafu Guan, Yueying Feng, Shanji Liu, Yu Zhao, Yuanyuan Xu, Hengyi Xu, Fen F. Polystyrene Microplastics Induced Ovarian Toxicity in Juvenile Rats Associated with Oxidative Stress and Activation of the PERK-eIF2α-ATF4-CHOP Signaling Pathway. Toxics. vol 11. issue 3. 2023-03-28. PMID:36976990. |
furthermore, the expressions of genes related to er stress (perk, eif2α, atf4, and chop) and apoptosis were remarkably elevated in the 2.0 mg/kg ps-mps group compared with those in the control group. |
2023-03-28 |
2023-08-14 |
rat |
| Xiaomeng Yu, Xiaoyi Wang, Yinyin Xie, Tingting Peng, Yajun Lian, Cui Wang, Nanchang Xi. Activating Transcription Factor 4-mediated Mitochondrial Unfolded Protein Response Alleviates Hippocampal Neuronal Damage in an In Vitro Model of Epileptiform Discharges. Neurochemical research. 2023-03-17. PMID:36928813. |
in addition, atf4 overexpression increased neuronal viability and reduced seizure-induced apoptosis. |
2023-03-17 |
2023-08-14 |
Not clear |
| Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wan. Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes. Environment international. vol 173. 2023-02-25. PMID:36841186. |
data illustrated that exposure to bpa enhanced autophagy (ulk1, beclin-1, lc3, parkin, and pink1), ers (grp78, chop10, atf4, and atf6) and apoptosis (caspase 3, bcl-2, bax, p53) but decreased the antioxidant (cat, nrf2, ho-1, and nqo1)-related mrna and protein expressions as well as impaired the mitochondrial function. |
2023-02-25 |
2023-08-14 |
cat |
| Francesca R Di Cristofano, Mara W Fong, Kelsey E Huntington, Benedito A Carneiro, Lanlan Zhou, Wafik S El-Deir. Synergistic activity of ABT-263 and ONC201/TIC10 against solid tumor cell lines is associated with suppression of anti-apoptotic Mcl-1, BAG3, pAkt, and upregulation of pro-apoptotic Noxa and Bax cleavage during apoptosis. American journal of cancer research. vol 13. issue 1. 2023-02-13. PMID:36777502. |
combination therapy-induced cell death correlated with decreased levels of mcl-1, bag3, pakt, and upregulation of noxa along with bax cleavage during apoptosis at 48 hours, and atf4, trail, and dr5 induction at 24 hours. |
2023-02-13 |
2023-08-14 |
human |
| Youwen Zhang, Kim-Tuyen Huynh-Dam, Xiaokai Ding, Vitali Sikirzhytski, Chang-Uk Lim, Eugenia Broude, Hippokratis Kiari. RASSF1 is identified by transcriptome coordination analysis as a target of ATF4. FEBS open bio. 2023-02-01. PMID:36723232. |
reporter assays revealed that the rassf1 promoter is responsive to atf4, while ablation of rassf1 mitigated expression of the atf4 effector bbc3 and abrogated tunicamycin-induced apoptosis. |
2023-02-01 |
2023-08-14 |
mouse |
| Youwen Zhang, Kim-Tuyen Huynh-Dam, Xiaokai Ding, Vitali Sikirzhytski, Chang-Uk Lim, Eugenia Broude, Hippokratis Kiari. RASSF1 is identified by transcriptome coordination analysis as a target of ATF4. FEBS open bio. 2023-02-01. PMID:36723232. |
collectively, these results implicate rassf1 in the regulation of er stress-associated apoptosis downstream of atf4. |
2023-02-01 |
2023-08-14 |
mouse |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Harpreet Kaur, Deepaneeta Sarmah, Aishika Datta, Anupom Borah, Dileep R Yavagal, Pallab Bhattachary. Stem cells alleviate OGD/R mediated stress response in PC12 cells following a co-culture: modulation of the apoptotic cascade through BDNF-TrkB signaling. Cell stress & chaperones. 2023-01-09. PMID:36622548. |
results from our study have shown that oxygen-glucose deprivation/reoxygenation (ogd/r) potentiated er stress and apoptosis in the pheochromocytoma 12 (pc12) cell line as evident by the increase of protein kinase r (pkr)-like er kinase (p-perk), p-eukaryotic initiation factor 2α subunit (eif2α), activation transcription factor 4 (atf4), chop, and caspase 12 expressions. |
2023-01-09 |
2023-08-14 |
Not clear |
| Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Don. Geraniol-Mediated Suppression of Endoplasmic Reticulum Stress Protects against Cerebral Ischemia-Reperfusion Injury via the PERK-ATF4-CHOP Pathway. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613992. |
geraniol effectively attenuated cerebral infarction and pathological injury after ciri, had a protective effect against ciri, significantly reduced the expression of the er-stress-related proteins p-perk, atf4, chop, and grp78 and the pro-apoptotic protein bax, increased the expression of the anti-apoptotic protein bcl-2, and reduced the occurrence of apoptosis. |
2023-01-08 |
2023-08-14 |
rat |
| Yu Han, Xin-Ya Shen, Zhen-Kun Gao, Ping Ping Han, Xia B. Pre-ischaemic treatment with enriched environment alleviates acute neuronal injury by inhibiting endoplasmic reticulum stress-dependent autophagy and apoptosis. Neuroscience. 2022-12-22. PMID:36549603. |
the decrease in activating transcription factor 4(atf4), c/ebp homologous protein (chop), and phospho-c-jun n-terminal kinases(p-jnk) expression suggested ee pretreatment might inhibit autophagy and apoptosis via modulating er stress-mediated perk-atf4-chop and ire1-jnk signal pathways, which provides a new idea for the prevention of the deleterious cerebral and functional consequences of ischemic stroke. |
2022-12-22 |
2023-08-14 |
rat |
| Ying Liu, Xinran Wang, Juhui Qiao, Jiawen Wang, Leilei Jiang, Chenxi Wang, Shiting Yu, Peiguang Zhang, Daqing Zhao, Meiling Fan, Meichen Li. Ginsenoside Rh2 Induces HeLa Apoptosis through Upregulating Endoplasmic Reticulum Stress-Related and Downstream Apoptotic Gene Expression. Molecules (Basel, Switzerland). vol 27. issue 22. 2022-11-26. PMID:36431966. |
combined protein-protein interaction network, hub gene screening, and qpcr validation data showed that ers-related genes (atf4 and ddit3) and the downstream apoptotic genes (jun, fos, bbc3, and pmaip1) were potential novel targets of 20(s)-grh2-inducing cervical cancer cell apoptosis. |
2022-11-26 |
2023-08-14 |
Not clear |
| Yuko Nagao, Kikuko Amo-Shiinoki, Hiroko Nakabayashi, Masayuki Hatanaka, Manabu Kondo, Kimie Matsunaga, Masahiro Emoto, Shigeru Okuya, Yukio Tanizawa, Katsuya Tanab. Gsk-3-Mediated Proteasomal Degradation of ATF4 Is a Proapoptotic Mechanism in Mouse Pancreatic β-Cells. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362372. |
gsk-3 inhibition prevented proteasomal degradation of activating transcriptional factor 4 (atf4) and alleviated apoptosis. |
2022-11-11 |
2023-08-14 |
mouse |
| Longhao Wang, Tao Hu, Zhibo Shen, Yuanyuan Zheng, Qishun Geng, Lifeng Li, Beibei Sha, Miaomiao Li, Yaxin Sun, Yongjun Guo, Wenhua Xue, Dan Xuan, Ping Chen, Jie Zha. Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC. Cell death & disease. vol 13. issue 11. 2022-11-10. PMID:36357365. |
ml-323 treatment resulted in the accumulation of ubiquitinated proteins, induced er stress, and triggered noxa-dependent apoptosis, which was regulated by the activating transcription factor 4(atf4). |
2022-11-10 |
2023-08-14 |
Not clear |
| Yaping Chen, Zheming Chen, Weineng Cheng, Yajun Cao, Wen Xu, Wenfang Lai, Yuqin Zhang, Mei Huang, Lihong Na. The Role of the GRP78/PERK/ATF4 Pathway in the Ability of Gua Lou Gui Zhi Decoction to Attenuate Apoptosis by Inhibiting Endoplasmic Reticulum Stress after Ischemia-Reperfusion Injury. Frontiers in bioscience (Landmark edition). vol 27. issue 10. 2022-11-07. PMID:36336865. |
in addition, the unfolded protein response (upr) plays an important role in ers because it activates downstream apoptotic signal transduction and induces apoptosis through the glucose-regulated protein 78 (grp78)/protein kinase r (pkr)-like er kinase (perk)/activating transcription factor 4 (atf4) pathway. |
2022-11-07 |
2023-08-14 |
Not clear |
| Yuankang Zou, Ziyan Yuan, Yafei Sun, Maodeng Zhai, Zhice Tan, Ruili Guan, Michael Aschner, Wenjing Luo, Jianbin Zhan. Resetting Proteostasis of CIRBP with ISRIB Suppresses Neural Stem Cell Apoptosis under Hypoxic Exposure. Oxidative medicine and cellular longevity. vol 2022. 2022-10-10. PMID:36211820. |
interestingly, isrib, a small-molecule modulator of the perk-atf4 signaling pathway, could prevent the reduction and apoptosis of nscs in two steps: enhancing the expression of cirbp through the protein kinase r- (pkr-) like endoplasmic reticulum kinase (perk) and activating transcription factor 4 (atf4) axis. |
2022-10-10 |
2023-08-14 |
Not clear |
| Shuying Yuan, Yongfu Pan, Tong Xu, Li Zhang, Xihui Chen, Fengying Wang, Qian Liu, Lijun Ji. Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2 Oxidative medicine and cellular longevity. vol 2022. 2022-08-15. PMID:35965681. |
the induction of apoptosis by das was largely dependent on the activation of the transcription factor atf4 and its downstream noxa-dependent intrinsic and chop-dr5-dependent extrinsic apoptotic pathway. |
2022-08-15 |
2023-08-14 |
human |
| Hossam El-Sheikh Ali, Kirsten Scoggin, Harutaka Murase, Jamie Norris, Bruno Menarim, Pouya Dini, Barry Bal. Transcriptomic and histochemical analysis reveal the complex regulatory networks in equine Chorioallantois during spontaneous term labor. Biology of reproduction. 2022-08-01. PMID:35913756. |
also, tl was associated with the upregulation of matrix metalloproteinase (mmp1, mmp2, mmp3, and mmp9) with subsequent extracellular matrix degradation and apoptosis, as reflected by upregulation of several apoptosis-related genes (atf3, atf4, fas, fos, and birc3). |
2022-08-01 |
2023-08-14 |
Not clear |
| Daniele Missio, Alexandro Fritzen, Camila Cupper Vieira, Juliana Germano Ferst, Mariani Farias Fiorenza, Leonardo Guedes de Andrade, Bento Martins de Menezes, Monique Tomazele Rovani, Bernardo Gazieira Gasperin, Paulo Bayard Dias Gonçalves, Rogério Ferreir. Increased β-hydroxybutyrate (BHBA) concentration affect follicular growth in cattle. Animal reproduction science. vol 243. 2022-07-11. PMID:35816934. |
in addition, the relative abundance of genes involved in the ovulatory cascade (adam 17, areg, ereg, ptgs2), steroidogenesis (cyp19a1, 3bhsd, star), cellular stress (sod1, cat, gpx1, hspa5, xbp1s, xbp1u, atf4, atf6), monocarboxylic acid transporters (slc16a1, slc16a7) and apoptosis (xiap) was similar between groups. |
2022-07-11 |
2023-08-14 |
cat |
| K Zhang, X Liu, Y Tang, Z Liu, Q Yi, L Wang, B Geng, Y Xi. Fluid Shear Stress Promotes Osteoblast Proliferation and Suppresses Mitochondrial-Mediated Osteoblast Apoptosis Through the miR-214-3p-ATF4 Signaling Axis. Physiological research. 2022-06-30. PMID:35770472. |
moreover, mir-214 3p regulated osteoblast proliferation and apoptosis through targeting atf4. |
2022-06-30 |
2023-08-14 |
Not clear |
| Guang-Chen Zhang, Yi-Hao Wang, Pan-Pan Ruan, Zu-Qi Zhang, Ning-Ning Shen, Yu-Fu Liu, Yu-Guang Wang, Yue Ga. [Protective effect of ophiopogonin D against isoproterenol-induced cardiomyocyte injury and targets]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 10. 2022-06-19. PMID:35718492. |
cell count kit-8(cck-8) assay was used to detect viability of cells treated with opd and iso, western blot to examine the effect of opd and iso on the expression of endoplasmic reticulum stress-related bip, bax, perk, atf4, caspase-12, and chop, flow cytometry to determine cell apoptosis rate, and hoechst 33258 and tunel staining to observe cell apoptosis and morphological changes. |
2022-06-19 |
2023-08-14 |
rat |