| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaogang Huang, Xiongzhi He, Rongxian Qiu, Xuemei Xie, Fengfeng Zheng, Feihua Chen, Zhenting H. Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-06-19. PMID:37333449. |
the expression levels of bmi1, kat2b, and proteins related to upr (p-eif2α, eif2α, atf4, and atf6), nf-κb (p65 and p-p65), apoptosis (cleaved caspase-3, bcl-2, and bax) and necroptosis (p-mlkl and mlkl) were determined by western blot. |
2023-06-19 |
2023-08-14 |
Not clear |
| Bing-Ying Wan, Dong-Wei Cao, Yi-Gang Wan, Dai Chen, Wei Wu, Qi-Jun Fang, Si-Yi Liu, Yue Tu, Yu Wang, Zi-Yue Wa. [Effects and mechanisms of total flavones of Abelmoschus manihot in attenuating diabetic tubulopathy by targeting endoplasmic reticulum stress-induced cell apoptosis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 10. 2023-06-07. PMID:37282927. |
the effects of tfa and ros on various indicators related to urine and blood biochemistry, renal tubular injury, renal tubular epithelial cell apoptosis and endoplasmic reticulum stress(ers), as well as the activation of the protein kinase r-like endoplasmic reticulum kinase(perk)-eukaryotic translation initiation factor 2α(eif2α)-activating transcription factor 4(atf4)-c/ebp homologous protein(chop) signaling pathway in the kidney of the dt model rats were investigated. |
2023-06-07 |
2023-08-14 |
rat |
| Michael P Ludwig, Matthew D Galbraith, Neetha Paul Eduthan, Amanda A Hill, Michael R Clay, Cristiam Moreno Tellez, Breelyn A Wilky, Anthony Elias, Joaquín Maximiliano Espinosa, Kelly D Sulliva. Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway. Cancer research. 2023-05-19. PMID:37205634. |
crispr/cas9 gene editing experiments confirmed that atf4, chop, and the bh3-only protein, noxa, are all required for nutlin-3 and carfilzomib-induced apoptosis. |
2023-05-19 |
2023-08-14 |
Not clear |
| Shiqi Tang, Xueqin Wu, Qing Dai, Zhi Li, Shikun Yang, Yan Liu, Bin Yi, Jianwen Wang, Qin Liao, Wei Zhang, Hao Zhan. Vitamin D receptor attenuate ischemia-reperfusion kidney injury via inhibiting ATF4. Cell death discovery. vol 9. issue 1. 2023-05-14. PMID:37173347. |
herein, we showed that vdr agonist paricalcitol and vdr overexpression alleviated i/r-induced renal injury and cells apoptosis with decreased atf4 and attenuated ers, while vdr deletion significantly resulted in further increased atf4, more drastic ers and renal injury in i/r mice models. |
2023-05-14 |
2023-08-14 |
mouse |
| Shiqi Tang, Xueqin Wu, Qing Dai, Zhi Li, Shikun Yang, Yan Liu, Bin Yi, Jianwen Wang, Qin Liao, Wei Zhang, Hao Zhan. Vitamin D receptor attenuate ischemia-reperfusion kidney injury via inhibiting ATF4. Cell death discovery. vol 9. issue 1. 2023-05-14. PMID:37173347. |
moreover, overexpression of atf4 partially abolished the effect of paricalcitol against tm-induced ers and apoptosis, while inhibition of atf4 enhanced the protective effect of paricalcitol. |
2023-05-14 |
2023-08-14 |
mouse |
| Wanzhen Wang, Jiafu Guan, Yueying Feng, Shanji Liu, Yu Zhao, Yuanyuan Xu, Hengyi Xu, Fen F. Polystyrene Microplastics Induced Ovarian Toxicity in Juvenile Rats Associated with Oxidative Stress and Activation of the PERK-eIF2α-ATF4-CHOP Signaling Pathway. Toxics. vol 11. issue 3. 2023-03-28. PMID:36976990. |
furthermore, the expressions of genes related to er stress (perk, eif2α, atf4, and chop) and apoptosis were remarkably elevated in the 2.0 mg/kg ps-mps group compared with those in the control group. |
2023-03-28 |
2023-08-14 |
rat |
| Xiaomeng Yu, Xiaoyi Wang, Yinyin Xie, Tingting Peng, Yajun Lian, Cui Wang, Nanchang Xi. Activating Transcription Factor 4-mediated Mitochondrial Unfolded Protein Response Alleviates Hippocampal Neuronal Damage in an In Vitro Model of Epileptiform Discharges. Neurochemical research. 2023-03-17. PMID:36928813. |
in addition, atf4 overexpression increased neuronal viability and reduced seizure-induced apoptosis. |
2023-03-17 |
2023-08-14 |
Not clear |
| Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wan. Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes. Environment international. vol 173. 2023-02-25. PMID:36841186. |
data illustrated that exposure to bpa enhanced autophagy (ulk1, beclin-1, lc3, parkin, and pink1), ers (grp78, chop10, atf4, and atf6) and apoptosis (caspase 3, bcl-2, bax, p53) but decreased the antioxidant (cat, nrf2, ho-1, and nqo1)-related mrna and protein expressions as well as impaired the mitochondrial function. |
2023-02-25 |
2023-08-14 |
cat |
| Francesca R Di Cristofano, Mara W Fong, Kelsey E Huntington, Benedito A Carneiro, Lanlan Zhou, Wafik S El-Deir. Synergistic activity of ABT-263 and ONC201/TIC10 against solid tumor cell lines is associated with suppression of anti-apoptotic Mcl-1, BAG3, pAkt, and upregulation of pro-apoptotic Noxa and Bax cleavage during apoptosis. American journal of cancer research. vol 13. issue 1. 2023-02-13. PMID:36777502. |
combination therapy-induced cell death correlated with decreased levels of mcl-1, bag3, pakt, and upregulation of noxa along with bax cleavage during apoptosis at 48 hours, and atf4, trail, and dr5 induction at 24 hours. |
2023-02-13 |
2023-08-14 |
human |
| Youwen Zhang, Kim-Tuyen Huynh-Dam, Xiaokai Ding, Vitali Sikirzhytski, Chang-Uk Lim, Eugenia Broude, Hippokratis Kiari. RASSF1 is identified by transcriptome coordination analysis as a target of ATF4. FEBS open bio. 2023-02-01. PMID:36723232. |
reporter assays revealed that the rassf1 promoter is responsive to atf4, while ablation of rassf1 mitigated expression of the atf4 effector bbc3 and abrogated tunicamycin-induced apoptosis. |
2023-02-01 |
2023-08-14 |
mouse |
| Youwen Zhang, Kim-Tuyen Huynh-Dam, Xiaokai Ding, Vitali Sikirzhytski, Chang-Uk Lim, Eugenia Broude, Hippokratis Kiari. RASSF1 is identified by transcriptome coordination analysis as a target of ATF4. FEBS open bio. 2023-02-01. PMID:36723232. |
collectively, these results implicate rassf1 in the regulation of er stress-associated apoptosis downstream of atf4. |
2023-02-01 |
2023-08-14 |
mouse |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Harpreet Kaur, Deepaneeta Sarmah, Aishika Datta, Anupom Borah, Dileep R Yavagal, Pallab Bhattachary. Stem cells alleviate OGD/R mediated stress response in PC12 cells following a co-culture: modulation of the apoptotic cascade through BDNF-TrkB signaling. Cell stress & chaperones. 2023-01-09. PMID:36622548. |
results from our study have shown that oxygen-glucose deprivation/reoxygenation (ogd/r) potentiated er stress and apoptosis in the pheochromocytoma 12 (pc12) cell line as evident by the increase of protein kinase r (pkr)-like er kinase (p-perk), p-eukaryotic initiation factor 2α subunit (eif2α), activation transcription factor 4 (atf4), chop, and caspase 12 expressions. |
2023-01-09 |
2023-08-14 |
Not clear |
| Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Don. Geraniol-Mediated Suppression of Endoplasmic Reticulum Stress Protects against Cerebral Ischemia-Reperfusion Injury via the PERK-ATF4-CHOP Pathway. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613992. |
geraniol effectively attenuated cerebral infarction and pathological injury after ciri, had a protective effect against ciri, significantly reduced the expression of the er-stress-related proteins p-perk, atf4, chop, and grp78 and the pro-apoptotic protein bax, increased the expression of the anti-apoptotic protein bcl-2, and reduced the occurrence of apoptosis. |
2023-01-08 |
2023-08-14 |
rat |
| Yu Han, Xin-Ya Shen, Zhen-Kun Gao, Ping Ping Han, Xia B. Pre-ischaemic treatment with enriched environment alleviates acute neuronal injury by inhibiting endoplasmic reticulum stress-dependent autophagy and apoptosis. Neuroscience. 2022-12-22. PMID:36549603. |
the decrease in activating transcription factor 4(atf4), c/ebp homologous protein (chop), and phospho-c-jun n-terminal kinases(p-jnk) expression suggested ee pretreatment might inhibit autophagy and apoptosis via modulating er stress-mediated perk-atf4-chop and ire1-jnk signal pathways, which provides a new idea for the prevention of the deleterious cerebral and functional consequences of ischemic stroke. |
2022-12-22 |
2023-08-14 |
rat |
| Ying Liu, Xinran Wang, Juhui Qiao, Jiawen Wang, Leilei Jiang, Chenxi Wang, Shiting Yu, Peiguang Zhang, Daqing Zhao, Meiling Fan, Meichen Li. Ginsenoside Rh2 Induces HeLa Apoptosis through Upregulating Endoplasmic Reticulum Stress-Related and Downstream Apoptotic Gene Expression. Molecules (Basel, Switzerland). vol 27. issue 22. 2022-11-26. PMID:36431966. |
combined protein-protein interaction network, hub gene screening, and qpcr validation data showed that ers-related genes (atf4 and ddit3) and the downstream apoptotic genes (jun, fos, bbc3, and pmaip1) were potential novel targets of 20(s)-grh2-inducing cervical cancer cell apoptosis. |
2022-11-26 |
2023-08-14 |
Not clear |
| Yuko Nagao, Kikuko Amo-Shiinoki, Hiroko Nakabayashi, Masayuki Hatanaka, Manabu Kondo, Kimie Matsunaga, Masahiro Emoto, Shigeru Okuya, Yukio Tanizawa, Katsuya Tanab. Gsk-3-Mediated Proteasomal Degradation of ATF4 Is a Proapoptotic Mechanism in Mouse Pancreatic β-Cells. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362372. |
gsk-3 inhibition prevented proteasomal degradation of activating transcriptional factor 4 (atf4) and alleviated apoptosis. |
2022-11-11 |
2023-08-14 |
mouse |
| Longhao Wang, Tao Hu, Zhibo Shen, Yuanyuan Zheng, Qishun Geng, Lifeng Li, Beibei Sha, Miaomiao Li, Yaxin Sun, Yongjun Guo, Wenhua Xue, Dan Xuan, Ping Chen, Jie Zha. Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC. Cell death & disease. vol 13. issue 11. 2022-11-10. PMID:36357365. |
ml-323 treatment resulted in the accumulation of ubiquitinated proteins, induced er stress, and triggered noxa-dependent apoptosis, which was regulated by the activating transcription factor 4(atf4). |
2022-11-10 |
2023-08-14 |
Not clear |
| Yaping Chen, Zheming Chen, Weineng Cheng, Yajun Cao, Wen Xu, Wenfang Lai, Yuqin Zhang, Mei Huang, Lihong Na. The Role of the GRP78/PERK/ATF4 Pathway in the Ability of Gua Lou Gui Zhi Decoction to Attenuate Apoptosis by Inhibiting Endoplasmic Reticulum Stress after Ischemia-Reperfusion Injury. Frontiers in bioscience (Landmark edition). vol 27. issue 10. 2022-11-07. PMID:36336865. |
in addition, the unfolded protein response (upr) plays an important role in ers because it activates downstream apoptotic signal transduction and induces apoptosis through the glucose-regulated protein 78 (grp78)/protein kinase r (pkr)-like er kinase (perk)/activating transcription factor 4 (atf4) pathway. |
2022-11-07 |
2023-08-14 |
Not clear |
| Yuankang Zou, Ziyan Yuan, Yafei Sun, Maodeng Zhai, Zhice Tan, Ruili Guan, Michael Aschner, Wenjing Luo, Jianbin Zhan. Resetting Proteostasis of CIRBP with ISRIB Suppresses Neural Stem Cell Apoptosis under Hypoxic Exposure. Oxidative medicine and cellular longevity. vol 2022. 2022-10-10. PMID:36211820. |
interestingly, isrib, a small-molecule modulator of the perk-atf4 signaling pathway, could prevent the reduction and apoptosis of nscs in two steps: enhancing the expression of cirbp through the protein kinase r- (pkr-) like endoplasmic reticulum kinase (perk) and activating transcription factor 4 (atf4) axis. |
2022-10-10 |
2023-08-14 |
Not clear |