| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z-L Yuan, Z-X Zhang, Y-Z Mo, D-L Li, L Xie, M-H Che. Inhibition of extracellular signal-regulated kinase downregulates endoplasmic reticulum stress-induced apoptosis and decreases brain injury in a cardiac arrest rat model. Physiological research. 2022-05-26. PMID:35616042. |
twenty-four hours after resuscitation, neural injury was assessed by survival rate, neurological deficit scores (nds) and nissl staining; apoptosis of brain cells was detected using terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) staining; mrna expression and protein levels of ers-related protein bip, perk, atf4 and chop were checked with rt-pcr and western blot. |
2022-05-26 |
2023-08-13 |
rat |
| Z-L Yuan, Z-X Zhang, Y-Z Mo, D-L Li, L Xie, M-H Che. Inhibition of extracellular signal-regulated kinase downregulates endoplasmic reticulum stress-induced apoptosis and decreases brain injury in a cardiac arrest rat model. Physiological research. 2022-05-26. PMID:35616042. |
pd98059 significantly improved survival rate and nds, increased the nissl bodies in neurons, reduced apoptosis, downregulated the mrna transcription and expression levels of bip, perk, atf4 and chop at 24 h after ca/cpr. |
2022-05-26 |
2023-08-13 |
rat |
| Ashlyn Parkhurst, Sabrina Z Wang, Tyler R Findlay, Kristen J Malebranche, Arman Odabas, Jesse Alt, Micah J Maxwell, Harpreet Kaur, Cody J Peer, William D Figg, Katherine E Warren, Barbara S Slusher, Charles G Eberhart, Eric H Raabe, Jeffrey A Ruben. Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors. Cell death & disease. vol 13. issue 4. 2022-04-28. PMID:35484114. |
combination therapy activates the integrative stress response as determined by increased expression of phosphorylated eif2α, atf4, and chop, and disrupts the protective noxa.mcl-1.bim axis, forcing stressed cells to undergo apoptosis. |
2022-04-28 |
2023-08-13 |
mouse |
| Gang Wu, Xi'an Zhang, Shijun Li, Lina Wang, Jie Bai, Hanxiang Wang, Qing Sh. Silencing ATF4 inhibits JMJD3-dependent JUNB/ETS1 axis and mitigates cerebral ischemic injury. Journal of biochemical and molecular toxicology. 2022-04-11. PMID:35403324. |
activating transcription factor 4 (atf4) is known to play an important role in cerebral ischemia through apoptosis and neuron regulation. |
2022-04-11 |
2023-08-13 |
mouse |
| Gang Wu, Xi'an Zhang, Shijun Li, Lina Wang, Jie Bai, Hanxiang Wang, Qing Sh. Silencing ATF4 inhibits JMJD3-dependent JUNB/ETS1 axis and mitigates cerebral ischemic injury. Journal of biochemical and molecular toxicology. 2022-04-11. PMID:35403324. |
specifically, the regulatory function of atf4 and demethylase jmjd3 on the ischemic injury was explored via using ectopic expression and depletion by determination of modified neurologic severity score, blood-brain barrier, brain water content, apoptosis, infarct size, oxidative stress, and inflammation. |
2022-04-11 |
2023-08-13 |
mouse |
| Yujin Jin, Diem Thi Ngoc Huynh, Kyung-Sun He. Ginsenoside Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via mitochondrial ROS and ER stress-mediated signaling pathway. Archives of pharmacal research. 2022-03-24. PMID:35325393. |
inhibition of atf4 by sirna transfection significantly inhibited rh1-mediated apoptosis and calcium production. |
2022-03-24 |
2023-08-13 |
Not clear |
| Nicholas R Liguori, Ashley Sanchez Sevilla Uruchurtu, Leiqing Zhang, Abbas E Abbas, Young S Lee, Lanlan Zhou, Christopher G Azzoli, Wafik S El-Deir. Preclinical studies with ONC201/TIC10 and lurbinectedin as a novel combination therapy in small cell lung cancer (SCLC). American journal of cancer research. vol 12. issue 2. 2022-03-09. PMID:35261798. |
induction of the integrated stress response mediator atf4 and chop was observed with onc201 and lurbinectedin along with induction of parp cleavage indicative of apoptosis in response to cellular stress. |
2022-03-09 |
2023-08-13 |
Not clear |
| Bereket Molla Tanga, Xun Fang, Seonggyu Bang, Gyeonghwan Seong, Mahanama De Zoysa, Islam M Saadeldin, Sanghoon Lee, Jongki Ch. MiRNA-155 inhibition enhances porcine embryo preimplantation developmental competence by upregulating ZEB2 and downregulating ATF4. Theriogenology. vol 183. 2022-03-01. PMID:35231827. |
the relative gene expression level analysis showed downregulation of mrnas related to stress and apoptosis, bax, and the stress-induced autophagy gene atf4, and tnf-ɑ in the mirna-155 inhibitor group. |
2022-03-01 |
2023-08-13 |
Not clear |
| V N Mal'tseva, M V Goltyaev, S V Novoselov, E G Varlamov. [Effects of Sodium Selenite and Dithiothreitol on Expression of Endoplasmic Reticulum Selenoproteins and Apoptosis Markers in MSF7 Breast Adenocarcinoma Cells]. Molekuliarnaia biologiia. vol 56. issue 1. 2022-01-27. PMID:35082262. |
when the ss concentration was increased to 0.1 μm, an increase in expression was observed for key er stress genes and apoptosis markers, including chop, gadd34, puma, bim, atf4, sxbp, uxbp, akt1, bax, and bak. |
2022-01-27 |
2023-08-13 |
Not clear |
| Xiaogang Zheng, Bingtao Liu, Xiongxiong Liu, Ping Li, Pengcheng Zhang, Fei Ye, Ting Zhao, Yanbei Kuang, Weiqiang Chen, Xiaodong Jin, Qiang L. PERK Regulates the Sensitivity of Hepatocellular Carcinoma Cells to High-LET Carbon Ions via either Apoptosis or Ferroptosis. Journal of Cancer. vol 13. issue 2. 2022-01-24. PMID:35069910. |
on the one hand, perk promoted autophagy via regulating atf4 expression; on the other hand, perk regulated p53 expression, and the latter either induced autophagy through up-regulating dram, or directly promoting apoptosis through the mitochondrial pathway or facilitating ferroptosis via down-regulating |
2022-01-24 |
2023-08-13 |
Not clear |
| Dandan Yan, Na Wang, Jianling Yao, Xu Wu, Jingping Yuan, Hong Ya. Curcumin Attenuates the PERK-eIF2α Signaling to Relieve Acrylamide-Induced Neurotoxicity in SH‑SY5Y Neuroblastoma Cells. Neurochemical research. 2022-01-17. PMID:35037165. |
moreover, curcumin pretreatment inhibited perk-dependent eif2α phosphorylation, further suppressed gsk-3β and atf4 function, and abolished abnormal tau phosphorylation, p-creb reduction, and chop-induced apoptosis in sh-sy5y cells. |
2022-01-17 |
2023-08-13 |
Not clear |
| Moon Yi Ko, Sung-Ae Hyun, Sumi Jang, Joung-Wook Seo, Jaerang Rho, Byung-Seok Lee, Minhan K. Butylparaben Induces the Neuronal Death Through the ER Stress-Mediated Apoptosis of Primary Cortical Neurons. Neurotoxicity research. 2022-01-04. PMID:34981454. |
interestingly, butylparaben-induced activation of apoptosis involved the upstream activation of er stress proteins such as grp78, chop, and atf4. |
2022-01-04 |
2023-08-13 |
Not clear |
| Chulei Deng, Renxin Yi, Maoxing Fei, Tao Li, Yanling Han, Handong Wan. Naringenin attenuates endoplasmic reticulum stress, reduces apoptosis, and improves functional recovery in experimental traumatic brain injury. Brain research. vol 1769. 2021-12-09. PMID:34324877. |
further, naringenin suppressed tbi-induced activation of the er stress pathway (p-eif2α, atf4, and chop), oxidative stress and apoptosis on day 3 after tbi. |
2021-12-09 |
2023-08-13 |
mouse |
| Yan Cao, Maiying Fan, Yanfang Pei, Lei Su, Weiwei Xiao, Fang Chen, Jie Huang, Xiehong Liu, Zhengtao Gu, Zhongwei Zhang, Fangfang Yuan, Yu Jiang, Xiaotong Ha. CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Deficiency Attenuates Heatstroke-Induced Intestinal Injury. Inflammation. 2021-11-29. PMID:34841454. |
we observed the role of chop in apoptosis-mediated intestinal epithelial cell injury secondary to hs by evaluating cell viability, lactate dehydrogenase release, apoptosis levels, and grp78, perk, atf4, chop, bcl-2, and bax mrna and protein expression. |
2021-11-29 |
2023-08-13 |
mouse |
| Debasmita Mukherjee, Lena S Bercz, Molly A Torok, Thomas A Mac. Regulation of cellular immunity by activating transcription factor 4. Immunology letters. vol 228. 2021-11-18. PMID:33002512. |
there are multiple downstream targets of atf4 that can coordinate the regulation between survival and apoptosis of a cell based on time and exposure to stress. |
2021-11-18 |
2023-08-13 |
Not clear |
| Giulio Donati, Micol Ravà, Marco Filipuzzi, Paola Nicoli, Laura Cassina, Alessandro Verrecchia, Mirko Doni, Simona Rodighiero, Federica Parodi, Alessandra Boletta, Christopher P Vellano, Joseph R Marszalek, Giulio F Draetta, Bruno Amat. Targeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma. Molecular oncology. 2021-11-11. PMID:34632715. |
mechanistically, iacs-010759 triggered the integrated stress response (isr) pathway, driven by the transcription factors atf4 and chop, which engaged the intrinsic apoptosis pathway and lowered the apoptotic threshold in myc-overexpressing cells. |
2021-11-11 |
2023-08-13 |
Not clear |
| Kalishwaralal Kalimuthu, Jin Hong Kim, Yong Seok Park, Xu Luo, Lin Zhang, Ja-Lok Ku, M Haroon A Choudry, Yong J Le. Glucose deprivation-induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity. Journal of cellular physiology. vol 236. issue 9. 2021-11-10. PMID:33586156. |
studies with activating transcription factor 4 (atf4), c/ebp-homologous protein (chop), p53 upregulated modulator of apoptosis (puma), or death receptor 5 (dr5)-deficient mouse embryonic fibroblasts or hct116 cells suggest that the atf4-chop-puma axis and the atf4-chop-dr5 axis are involved in the combined treatment-induced apoptosis. |
2021-11-10 |
2023-08-13 |
mouse |
| Lifeng Feng, Muchun Li, Xinyang Hu, Yiling Li, Liyuan Zhu, Miaoqin Chen, Qi Wei, Wenxia Xu, Qiyin Zhou, Weikai Wang, Dingwei Chen, Xian Wang, Hongchuan Ji. CK1δ stimulates ubiquitination-dependent proteasomal degradation of ATF4 to promote chemoresistance in gastric Cancer. Clinical and translational medicine. vol 11. issue 10. 2021-11-04. PMID:34709767. |
the over-expression of atf4 reversed chemoresistance by activating chop transcription to enhance drug-induced apoptosis, and vice versa. |
2021-11-04 |
2023-08-13 |
Not clear |
| Yingchao Gong, Qingfeng Li, Zetao Ma, Tingting Jin, Jun Lin, Qingbo Lv, Meihui Wang, Guosheng Fu, Shengjie X. Downregulation of activating transcription factor 4 attenuates lysophosphatidycholine-induced inflammation via the NF-κB pathway. European journal of pharmacology. vol 911. 2021-11-01. PMID:34582847. |
activation of the nf-κb pathway and expression of its upstream factors, including toll like receptor 4 and cellular inhibitor of apoptosis, were also inhibited by atf4 silencing. |
2021-11-01 |
2023-08-13 |
human |
| Zhanxia Zhang, Junqian Zhang, Jianhui Tian, Hegen L. A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1). Journal of nanobiotechnology. vol 19. issue 1. 2021-10-24. PMID:34654435. |
more importantly, the genetic nanomedicine not only inhibited liver cancer cell proliferation but also promoted liver cell apoptosis by slowing roc1 activity, suppressing the neddylation pathway, enabling the accumulation of apototic factor atf4 and dna damage factor p-h2ax. |
2021-10-24 |
2023-08-13 |
Not clear |