| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongchao He, Ran Zhuo, Jun Dai, Xiaojing Wang, Xin Huang, Haofei Wang, Danfeng X. Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31568643. |
we further found that both knockdown of atf4 protein and overexpression of stat3 protein could reduce che-induced apoptosis in caki cells. |
2021-05-10 |
2023-08-13 |
human |
| Xu De Wang, Tao Li, Yan Li, Wei Hui Yuan, Yu Qing Zha. 2-Pyrazine-PPD, a novel dammarane derivative, showed anticancer activity by reactive oxygen species-mediate apoptosis and endoplasmic reticulum stress in gastric cancer cells. European journal of pharmacology. vol 881. 2021-05-10. PMID:32464194. |
further study indicated that 2-pyrazine-ppd induced apoptosis by mitochondria pathway in bgc-803 cancer cells, and activated unfolded protein response and the protein kinase rna-activated (pkr)-like er kinase (perk)/eukaryotic translation initiation factor-2α (eif-2α)/activating transcription factor 4 (atf4) axis, the expression level of the protein c/ebp homologous protein (chop), the marker of endoplasmic reticulum stress, and the apoptosis inducing by 2-pyrazine-ppd can partly be inhibited by sirna-mediated knockdown of chop. |
2021-05-10 |
2023-08-13 |
human |
| Jiong Li, Jing Xie, Yan-Zhen Wang, Yi-Rong Gan, Ling Wei, Guan-Waner Ding, Yan-Hong Ding, Ding-Xiong Xi. Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324. Molecular medicine reports. vol 23. issue 2. 2021-05-04. PMID:33300079. |
tm induced apoptosis, ers and autophagy, as indicated by an increased ratio of apoptotic cells, increased expression levels of bax, cleaved (c)-caspase-3/9, glucose-regulated protein 78 kda (grp78), phosphorylated (p)-inositol-requiring enzyme-1α (ire1α), spliced x-box-binding protein 1 (xbp1s), ire1α, activating transcription factor (atf)6, atf4, beclin 1 and microtubule associated protein 1 light chain 3α (lc3)ii/i, and decreased expression levels of bcl-2, unspliced xbp1 (xbp1u) and p62 in the tm group compared with the control group. |
2021-05-04 |
2023-08-13 |
rat |
| Tian-Hao Liu, Wen-Cong Tao, Qiu-Er Liang, Wan-Qing Tu, Ya Xiao, Li-Guo Che. Gut Microbiota-Related Evidence Provides New Insights Into the Association Between Activating Transcription Factor 4 and Development of Salt-Induced Hypertension in Mice. Frontiers in cell and developmental biology. vol 8. 2021-04-26. PMID:33282868. |
activating transcription factor 4 (atf4), which regulates genes associated with endoplasmic reticulum stress, apoptosis, autophagy, the gut microbiome, and metabolism, has been implicated in many diseases. |
2021-04-26 |
2023-08-13 |
mouse |
| Qianqian Dong, Yanting Chen, Wantao Liu, Xiaoyu Liu, An Chen, Xiulin Yang, Yining Li, Siyi Wang, Mingwei Fu, Jing-Song Ou, Lihe Lu, Jianyun Ya. 25-Hydroxycholesterol promotes vascular calcification via activation of endoplasmic reticulum stress. European journal of pharmacology. vol 880. 2021-03-24. PMID:32423869. |
in addition, western blot analysis showed that 25-hc significantly up-regulated the expression of endoplasmic reticulum stress (ers) signaling molecules including atf4 and chop in vsmcs and flow cytometry analysis revealed that 25-hc increased apoptosis of vsmcs. |
2021-03-24 |
2023-08-13 |
human |
| Takayoshi Matsumura, Ayako Nakamura-Ishizu, Siva Sai Naga Anurag Muddineni, Darren Qiancheng Tan, Chelsia Qiuxia Wang, Kenji Tokunaga, Roberto Tirado-Magallanes, Stephanie Sian, Touati Benoukraf, Tsukasa Okuda, Norio Asou, Masao Matsuoka, Motomi Osato, Toshio Sud. Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia. Blood. vol 136. issue 17. 2021-03-24. PMID:32573733. |
furthermore, loss of runx1 r233/r237 methylation suppressed endoplasmic reticulum stress-induced unfolded protein response genes, including atf4, ddit3, and gadd34; the radiation-induced p53 downstream genes bbc3, pmaip1, and cdkn1a; and subsequent apoptosis in hscs. |
2021-03-24 |
2023-08-13 |
mouse |
| Linyan Xu, Jun Jiao, Xiaoshen Sun, Wei Sang, Xiang Gao, Pu Yang, Dongmei Yan, Xuguang Song, Cai Sun, Mengdi Liu, Yuanyuan Qin, Yu Tian, Feng Zhu, Lingyu Zeng, Zhenyu Li, Kailin X. Cladribine Induces ATF4 Mediated Apoptosis and Synergizes with SAHA in Diffuse Large B-Cell Lymphoma Cells. International journal of medical sciences. vol 17. issue 10. 2021-03-08. PMID:32624694. |
cladribine induces atf4 mediated apoptosis and synergizes with saha in diffuse large b-cell lymphoma cells. |
2021-03-08 |
2023-08-13 |
Not clear |
| Sangiliyandi Gurunathan, Muniyandi Jeyaraj, Min-Hee Kang, Jin-Hoi Ki. Anticancer Properties of Platinum Nanoparticles and Retinoic Acid: Combination Therapy for the Treatment of Human Neuroblastoma Cancer. International journal of molecular sciences. vol 21. issue 18. 2021-02-26. PMID:32947930. |
endoplasmic reticulum-mediated stress and apoptosis were confirmed by upregulation of protein kinase rna-like endoplasmic reticulum kinase (perk), inositol-requiring enzyme 1 (ire1), activating transcription factor 6 (atf6), activating transcription factor 4 (atf4), p53, bax, and caspase-3 and down regulation of b-cell lymphoma 2 (bcl-2). |
2021-02-26 |
2023-08-13 |
human |
| Danielle E Read, Ananya Gupta, Karen Cawley, Laura Fontana, Patrizia Agostinis, Afshin Samali, Sanjeev Gupt. Downregulation of miR-17-92 Cluster by PERK Fine-Tunes Unfolded Protein Response Mediated Apoptosis. Life (Basel, Switzerland). vol 11. issue 1. 2021-02-18. PMID:33418948. |
our results reveal a novel function for atf4 and nrf2, where repression of the mir-17-92 cluster plays an important role in er stress-mediated apoptosis. |
2021-02-18 |
2023-08-13 |
Not clear |
| Yeon Sook Kim, Dae Won Kim, Seong-Gon Kim, Suk Keun Le. 4-hexylresorcinol-induced protein expression changes in human umbilical cord vein endothelial cells as determined by immunoprecipitation high-performance liquid chromatography. PloS one. vol 15. issue 12. 2021-02-15. PMID:33320912. |
4hr-treated huvecs tended to increase the er stress mediators by upregulating eif2ak3, atf4, atf6, lysozyme, and lc3 and downregulating eif2α and gadd153 (chop), resulting in parp-1/aif-mediated apoptosis. |
2021-02-15 |
2023-08-13 |
human |
| Renyi Zhou, Yue Ma, Zhengbo Tao, Shui Qiu, Zunlei Gong, Lin Tao, Yue Zh. Melatonin Inhibits Glucose-Induced Apoptosis in Osteoblastic Cell Line Through PERK-eIF2α-ATF4 Pathway. Frontiers in pharmacology. vol 11. 2021-01-05. PMID:33390989. |
this subsequently leads to post-translational activation of the transcription factor 4 (atf4) and upregulation of c/ebp-homologous protein (chop) which is an er stress-induced regulator of apoptosis, as well as downstream effectors dnajc3, hyou1, and calr. |
2021-01-05 |
2023-08-13 |
Not clear |
| Jianhua Xiong, Yalong Gao, Xiaotian Li, Kai Li, Qifeng Li, Jun Shen, Zhenying Han, Jianning Zhan. Losartan Treatment Could Improve the Outcome of TBI Mice. Frontiers in neurology. vol 11. 2020-11-13. PMID:33178092. |
we found that losartan treatment decreased brain lesion volume, neuronal apoptosis and er stress protein atf4 and eif2α. |
2020-11-13 |
2023-08-13 |
mouse |
| Takashi Matsumoto, Takeshi Uchiumi, Keisuke Monji, Mikako Yagi, Daiki Setoyama, Rie Amamoto, Yuichi Matsushima, Masaki Shiota, Masatoshi Eto, Dongchon Kan. Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity. Oncogenesis. vol 6. issue 11. 2020-10-01. PMID:29184058. |
mitochondrial targeting doxycycline induced activating transcription factor 4 (atf4) mediated expression of er stress response and led to p53-upregulated modulator of apoptosis (puma)-dependent apoptosis only in the cancer stem-like cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jingmei Liu, Ping Han, Jin Gong, Yunwu Wang, Bingxin Chen, Jiazhi Liao, Dean Tia. Knockdown of KIAA1199 attenuates growth and metastasis of hepatocellular carcinoma. Cell death discovery. vol 4. 2020-10-01. PMID:30455988. |
moreover, kiaa1199 knockdown induced apoptosis by activating endoplasmic reticulum (er) stress, which was based on the upregulation of er stress markers, activating transcription factor 4 (atf4) and caat/enhancer-binding protein homologous protein (chop). |
2020-10-01 |
2023-08-13 |
human |
| Lei Yu, Rujia Xie, Tian Tian, Lu Zheng, Lei Tang, Shuang Cai, Zihua Ma, Ting Yang, Bing Han, Qin Yan. Suberoylanilide hydroxamic acid upregulates histone acetylation and activates endoplasmic reticulum stress to induce apoptosis in HepG2 liver cancer cells. Oncology letters. vol 18. issue 4. 2020-10-01. PMID:31516571. |
saha induced dose-dependent apoptosis and increased both protein and mrna expression levels of grp78, atf4 and chop in hepg2 cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lei Yu, Rujia Xie, Tian Tian, Lu Zheng, Lei Tang, Shuang Cai, Zihua Ma, Ting Yang, Bing Han, Qin Yan. Suberoylanilide hydroxamic acid upregulates histone acetylation and activates endoplasmic reticulum stress to induce apoptosis in HepG2 liver cancer cells. Oncology letters. vol 18. issue 4. 2020-10-01. PMID:31516571. |
furthermore, the acetylation levels of h4 in the promoter regions of grp78, atf4 and chop were significantly increased in hepg2 cells exposed to 6 µm saha for 36 h. thus, saha induces apoptosis in hepg2 cells by activating the er stress-mediated apoptotic signaling pathway, at least partially by enhancing the acetylation of histone h4 on the promoter regions of er-stress associated genes, including grp78, atf4 and chop. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zhihui Jiao, Xiaoning Liu, Yajun Ma, Yansong Ge, Qianzhen Zhang, Boyang Liu, Hongbin Wan. Adipose-Derived Stem Cells Protect Ischemia-Reperfusion and Partial Hepatectomy by Attenuating Endoplasmic Reticulum Stress. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32266259. |
mechanistically, the adscs significantly downregulated ers-related proteins, including grp78, p-eif2α, atf6 and xbp1s, as well as the proteins involved in ers-induced apoptosis like p-jnk, atf4 and chop. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ling Cheng, Zhizhou Yang, Zhaorui Sun, Wei Zhang, Yi Ren, Mengmeng Wang, Xiaoqin Han, Libo Fei, Yang Zhao, Hui Pan, Ji Xie, Shinan Ni. Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress. Biological & pharmaceutical bulletin. vol 43. issue 1. 2020-09-23. PMID:31666439. |
we found that rfp increased apoptosis of l02 cells, decreased cell survival, and increased the gene and protein expression levels of grp78, perk, atf4, chop, atf6, armet, p-ire1 and xbp-1, suggesting that rfp could induce hepatocyte injury, and the degree of injury was positively correlated with the dose and time of rfp. |
2020-09-23 |
2023-08-13 |
Not clear |
| Ling Cheng, Zhizhou Yang, Zhaorui Sun, Wei Zhang, Yi Ren, Mengmeng Wang, Xiaoqin Han, Libo Fei, Yang Zhao, Hui Pan, Ji Xie, Shinan Ni. Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress. Biological & pharmaceutical bulletin. vol 43. issue 1. 2020-09-23. PMID:31666439. |
we found that schizandrin b increased cell survival rate in dose-dependent and time-dependent manner, decreased cell apoptosis rate, and reduced protein and gene expression levels of grp78, perk, atf4, chop, atf6, armet and xbp-1. |
2020-09-23 |
2023-08-13 |
Not clear |
| Jie Liu, Ya-Bin Q. Activation of LXRβ inhibits proliferation, promotes apoptosis, and increases chemosensitivity of gastric cancer cells by upregulating the expression of ATF4. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-17. PMID:31210377. |
activation of lxrβ inhibits proliferation, promotes apoptosis, and increases chemosensitivity of gastric cancer cells by upregulating the expression of atf4. |
2020-08-17 |
2023-08-13 |
Not clear |