| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Liu, Ya-Bin Q. Activation of LXRβ inhibits proliferation, promotes apoptosis, and increases chemosensitivity of gastric cancer cells by upregulating the expression of ATF4. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-17. PMID:31210377. |
gastric cancer cell lines were cultured and screened to figure out the proliferation and apoptosis of gastric cancer sgc7901 cells with the treatment of lxrβ agonist (gw3965), atf4 short hairpin rna (shrna), and chemotherapy drug paclitaxel. |
2020-08-17 |
2023-08-13 |
Not clear |
| Jie Liu, Ya-Bin Q. Activation of LXRβ inhibits proliferation, promotes apoptosis, and increases chemosensitivity of gastric cancer cells by upregulating the expression of ATF4. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-17. PMID:31210377. |
in addition, activation of lxrβ may inhibit the proliferation of gastric cancer cells, promote apoptosis, and increase chemosensitivity by upregulating the expression of atf4. |
2020-08-17 |
2023-08-13 |
Not clear |
| Zeyun Gao, Mongameli B Dlamini, Hong Ge, Liping Jiang, Chengyan Geng, Qiujuan Li, Xiaoxia Shi, Yong Liu, Jun Ca. ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells. Toxicology letters. vol 331. 2020-07-23. PMID:32569804. |
furthermore, knockdown of atf4 by siatf4 significantly decreased cr (vi)-induced aerobic glycolysis and apoptosis, suggesting that atf4 was involved in cr (vi)-induced aerobic glycolysis and its effect of attenuating apoptosis in a549 cells. |
2020-07-23 |
2023-08-13 |
Not clear |
| Alejandro Losada, Juan José Berlanga, José Manuel Molina-Guijarro, Antonio Jiménez-Ruiz, Federico Gago, Pablo Avilés, César de Haro, Juan Fernando Martínez-Lea. Generation of endoplasmic reticulum stress and inhibition of autophagy by plitidepsin induces proteotoxic apoptosis in cancer cells. Biochemical pharmacology. vol 172. 2020-07-20. PMID:31812675. |
interestingly, though pld induced a strong phosphorylation of eif2α in all the analyzed cell lines, it did not elicit an increased expression of atf4 and chop, a transcription factor involved in launching upr-mediated apoptosis. |
2020-07-20 |
2023-08-13 |
Not clear |
| Xue Wang, Hua-Ying Xia, Hong-You Qin, Xiang-Ping Kang, Hai-Yan Hu, Jing Zheng, Jia-Ye Jiang, Ling-Ai Yao, Yan-Wu Xu, Tong Zhang, Xue-Li Zhan. 20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway. Journal of cellular biochemistry. vol 120. issue 4. 2020-07-08. PMID:30259568. |
furthermore, sirna-mediated knockdown of perk or atf4 inhibited the induction of chop expression and 20(s)-ppd-induced apoptosis. |
2020-07-08 |
2023-08-13 |
human |
| Xue Wang, Hua-Ying Xia, Hong-You Qin, Xiang-Ping Kang, Hai-Yan Hu, Jing Zheng, Jia-Ye Jiang, Ling-Ai Yao, Yan-Wu Xu, Tong Zhang, Xue-Li Zhan. 20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway. Journal of cellular biochemistry. vol 120. issue 4. 2020-07-08. PMID:30259568. |
collectively, our findings show that 20(s)-ppd inhibits huvec growth by inducing apoptosis and that atf4 expression activated by the perk-eif2α signaling pathway is essential for this process. |
2020-07-08 |
2023-08-13 |
human |
| Jun-Feng Huo, Xiao-Bing Che. P2X4R silence suppresses glioma cell growth through BDNF/TrkB/ATF4 signaling pathway. Journal of cellular biochemistry. vol 120. issue 4. 2020-06-24. PMID:30362154. |
the impact of p2x4r silence on t98 and u87 cell growth and apoptosis was reversed by atf4 overexpression. |
2020-06-24 |
2023-08-13 |
human |
| Yu Zhao, Yang Yu, Hengcun Li, Zheng Zhang, Shuilong Guo, Shengtao Zhu, Qingdong Guo, Peng Li, Li Min, Shutian Zhan. FAM175B promotes apoptosis by inhibiting ATF4 ubiquitination in esophageal squamous cell carcinoma. Molecular oncology. vol 13. issue 5. 2020-04-22. PMID:30854784. |
fam175b promotes apoptosis by inhibiting atf4 ubiquitination in esophageal squamous cell carcinoma. |
2020-04-22 |
2023-08-13 |
Not clear |
| Yu Zhao, Yang Yu, Hengcun Li, Zheng Zhang, Shuilong Guo, Shengtao Zhu, Qingdong Guo, Peng Li, Li Min, Shutian Zhan. FAM175B promotes apoptosis by inhibiting ATF4 ubiquitination in esophageal squamous cell carcinoma. Molecular oncology. vol 13. issue 5. 2020-04-22. PMID:30854784. |
in summary, fam175b inhibited atf4 ubiquitination and promoted escc cell apoptosis in a p53-independent manner. |
2020-04-22 |
2023-08-13 |
Not clear |
| M D Khurshidul Zahid, Michael Rogowski, Christopher Ponce, Mahua Choudhury, Naima Moustaid-Moussa, Shaikh M Rahma. CCAAT/enhancer-binding protein beta (C/EBPβ) knockdown reduces inflammation, ER stress, and apoptosis, and promotes autophagy in oxLDL-treated RAW264.7 macrophage cells. Molecular and cellular biochemistry. vol 463. issue 1-2. 2020-03-18. PMID:31686316. |
we found that short interfering rna (sirna)-mediated knockdown of c/ebpβ attenuated atherogenic lipid-mediated induction of proteins and genes implicated in inflammation (p-nfkb-p65, nfkb-p65, and tnfα), er stress (atf4 and atf6), and apoptosis (chop, caspase 1, 3, and 12). |
2020-03-18 |
2023-08-13 |
Not clear |
| Yongzhe Liu, Li Sun, Yaqun Ma, Biyu Wei, Minglong Gao, Lixin Shan. High glucose and bupivacaine‑induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK‑ATF4‑CHOP and IRE1‑TRAF2 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-02-04. PMID:31524237. |
the effects that 3‑ma (autophagy inhibitor) and rapamycin (rapa; autophagy inducer) exerted on cell apoptosis, autophagy and the expression of protein kinase r‑like endoplasmic reticulum kinase (perk)‑activating transcription factor 4 (atf4)‑c/ebp‑homologous protein (chop) and inositol‑requiring enzyme 1 (ire1)‑tumor necrosis factor receptor associated factor 2 (traf2) signaling proteins were measured in high glucose and bupivacaine‑treated cells. |
2020-02-04 |
2023-08-13 |
human |
| Yongzhe Liu, Li Sun, Yaqun Ma, Biyu Wei, Minglong Gao, Lixin Shan. High glucose and bupivacaine‑induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK‑ATF4‑CHOP and IRE1‑TRAF2 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-02-04. PMID:31524237. |
compared with the control group, high glucose and bupivacaine significantly increased atf4, chop and caspase‑12 expression, increased apoptosis, and decreased p‑ire1, traf2, lc3‑ii/lc3‑i and beclin1 expression. |
2020-02-04 |
2023-08-13 |
human |
| Yongzhe Liu, Li Sun, Yaqun Ma, Biyu Wei, Minglong Gao, Lixin Shan. High glucose and bupivacaine‑induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK‑ATF4‑CHOP and IRE1‑TRAF2 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-02-04. PMID:31524237. |
promoting autophagy with rapa partly reversed the high glucose and bupivacaine‑induced changes in p‑perk, chop, traf2, beclin1, caspase‑12 and apoptosis, while inhibiting autophagy with 3‑ma further enhanced the changes in atf4, chop, p‑ire1, traf2 and apoptosis. |
2020-02-04 |
2023-08-13 |
human |
| Li Tan, Raghunatha R Yamman. Nupr1 regulates palmitate-induced apoptosis in human articular chondrocytes. Bioscience reports. vol 39. issue 2. 2020-01-28. PMID:30674641. |
in the present study, we found that palmitate treatment of human primary articular chondrocytes increased the expression of er stress markers [activating transcription factor 4 (atf4), c/ebp homologous protein (chop)] and apoptosis markers [cytochrome |
2020-01-28 |
2023-08-13 |
human |
| Rozita Bagheri-Yarmand, Krishna M Sinha, Ling Li, Yue Lu, Gilbert J Cote, Steven I Sherman, Robert F Gage. Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress-Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer. Molecular cancer research : MCR. vol 17. issue 3. 2020-01-24. PMID:30552230. |
combinations of tyrosine kinase inhibitor and erad inhibitor promote oxidative stress-induced apoptosis through atf4 and klf9 in medullary thyroid cancer. |
2020-01-24 |
2023-08-13 |
Not clear |
| Ming-Tai Chen, Ruo-Lan Huang, Li-Jun Ou, Ying-Nan Chen, Ling Men, Xiao Chang, Ling Wang, Yu-Zhu Yang, Zhong Zhan. Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-Vascular Smooth Muscle Cells through Down-Regulating PERK-eIF2α-ATF4-CHOP Pathway. Chinese journal of integrative medicine. vol 25. issue 8. 2020-01-24. PMID:30707413. |
to test the hypothesis that the inhibition of endoplasmic reticulum (er) stress-induced apoptosis in oxidized low-density lipoproteins (ox-ldl)-induced human aortic-vascular smooth muscle cells (ha-vsmcs) was associated with suppression of the protein kinase rna-like er kinase (perk)-eukaryotic translation initiation factor 2α (eif2α)-activating transcription factor 4 (atf4)-ccaat/enhancer binding protein homologous protein (chop) signaling pathway by pollen typhae total flavone (ptf). |
2020-01-24 |
2023-08-13 |
human |
| Misato Moriguchi, Tadashi Watanabe, Masahiro Fujimur. Capsaicin Induces ATF4 Translation with Upregulation of CHOP, GADD34 and PUMA. Biological & pharmaceutical bulletin. vol 42. issue 8. 2020-01-14. PMID:31366879. |
in sum, capsaicin promotes atf4 translation and transcriptional induction of chop, which results in puma expression and apoptosis in pel cells. |
2020-01-14 |
2023-08-13 |
Not clear |
| Baimei He, Qiong Chen, Dongbo Zhou, Lijing Wang, Zhaoqian Li. Role of reciprocal interaction between autophagy and endoplasmic reticulum stress in apoptosis of human bronchial epithelial cells induced by cigarette smoke extract. IUBMB life. vol 71. issue 1. 2019-12-13. PMID:30332528. |
moreover, the cse-induced autophagy was diminished by knockdown of grp78, perk, or eif2α but enhanced by knockdown of atf4 or chop; however, the cse-induced hbe apoptosis was enhanced by knockdown of grp78, perk, or eif2α but was attenuated by knockdown of atf4 or chop. |
2019-12-13 |
2023-08-13 |
human |
| Baimei He, Qiong Chen, Dongbo Zhou, Lijing Wang, Zhaoqian Li. Role of reciprocal interaction between autophagy and endoplasmic reticulum stress in apoptosis of human bronchial epithelial cells induced by cigarette smoke extract. IUBMB life. vol 71. issue 1. 2019-12-13. PMID:30332528. |
additionally, both sodium hydrosulfide (nahs) and melatonin attenuated the cse-induced apoptosis, enhanced the cse-induced autophagy, increased grp78, p-perk, and p-eif2α, and decreased chop, atf4, and caspase-4, via sirt1/orp150 pathway. |
2019-12-13 |
2023-08-13 |
human |
| Po-Chiao Chang, Hung-Wen Tsai, Ming-Tsai Chiang, Pei-Ling Huang, Song-Kun Shyue, Lee-Young Cha. TRC8 downregulation contributes to the development of non-alcoholic steatohepatitis by exacerbating hepatic endoplasmic reticulum stress. Biochimica et biophysica acta. vol 1852. issue 11. 2019-11-20. PMID:26319415. |
the hepatic er stress response, as evidenced by increased eif2α phosphorylation and expression of atf4 and chop, and the level of activated caspase 3, an apoptosis indicator, were augmented by trc8 deficiency. |
2019-11-20 |
2023-08-13 |
mouse |