| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Yu, Rujia Xie, Tian Tian, Lu Zheng, Lei Tang, Shuang Cai, Zihua Ma, Ting Yang, Bing Han, Qin Yan. Suberoylanilide hydroxamic acid upregulates histone acetylation and activates endoplasmic reticulum stress to induce apoptosis in HepG2 liver cancer cells. Oncology letters. vol 18. issue 4. 2020-10-01. PMID:31516571. |
furthermore, the acetylation levels of h4 in the promoter regions of grp78, atf4 and chop were significantly increased in hepg2 cells exposed to 6 µm saha for 36 h. thus, saha induces apoptosis in hepg2 cells by activating the er stress-mediated apoptotic signaling pathway, at least partially by enhancing the acetylation of histone h4 on the promoter regions of er-stress associated genes, including grp78, atf4 and chop. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zhihui Jiao, Xiaoning Liu, Yajun Ma, Yansong Ge, Qianzhen Zhang, Boyang Liu, Hongbin Wan. Adipose-Derived Stem Cells Protect Ischemia-Reperfusion and Partial Hepatectomy by Attenuating Endoplasmic Reticulum Stress. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32266259. |
mechanistically, the adscs significantly downregulated ers-related proteins, including grp78, p-eif2α, atf6 and xbp1s, as well as the proteins involved in ers-induced apoptosis like p-jnk, atf4 and chop. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ling Cheng, Zhizhou Yang, Zhaorui Sun, Wei Zhang, Yi Ren, Mengmeng Wang, Xiaoqin Han, Libo Fei, Yang Zhao, Hui Pan, Ji Xie, Shinan Ni. Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress. Biological & pharmaceutical bulletin. vol 43. issue 1. 2020-09-23. PMID:31666439. |
we found that rfp increased apoptosis of l02 cells, decreased cell survival, and increased the gene and protein expression levels of grp78, perk, atf4, chop, atf6, armet, p-ire1 and xbp-1, suggesting that rfp could induce hepatocyte injury, and the degree of injury was positively correlated with the dose and time of rfp. |
2020-09-23 |
2023-08-13 |
Not clear |
| Ling Cheng, Zhizhou Yang, Zhaorui Sun, Wei Zhang, Yi Ren, Mengmeng Wang, Xiaoqin Han, Libo Fei, Yang Zhao, Hui Pan, Ji Xie, Shinan Ni. Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress. Biological & pharmaceutical bulletin. vol 43. issue 1. 2020-09-23. PMID:31666439. |
we found that schizandrin b increased cell survival rate in dose-dependent and time-dependent manner, decreased cell apoptosis rate, and reduced protein and gene expression levels of grp78, perk, atf4, chop, atf6, armet and xbp-1. |
2020-09-23 |
2023-08-13 |
Not clear |
| Jie Liu, Ya-Bin Q. Activation of LXRβ inhibits proliferation, promotes apoptosis, and increases chemosensitivity of gastric cancer cells by upregulating the expression of ATF4. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-17. PMID:31210377. |
activation of lxrβ inhibits proliferation, promotes apoptosis, and increases chemosensitivity of gastric cancer cells by upregulating the expression of atf4. |
2020-08-17 |
2023-08-13 |
Not clear |
| Jie Liu, Ya-Bin Q. Activation of LXRβ inhibits proliferation, promotes apoptosis, and increases chemosensitivity of gastric cancer cells by upregulating the expression of ATF4. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-17. PMID:31210377. |
gastric cancer cell lines were cultured and screened to figure out the proliferation and apoptosis of gastric cancer sgc7901 cells with the treatment of lxrβ agonist (gw3965), atf4 short hairpin rna (shrna), and chemotherapy drug paclitaxel. |
2020-08-17 |
2023-08-13 |
Not clear |
| Jie Liu, Ya-Bin Q. Activation of LXRβ inhibits proliferation, promotes apoptosis, and increases chemosensitivity of gastric cancer cells by upregulating the expression of ATF4. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-17. PMID:31210377. |
in addition, activation of lxrβ may inhibit the proliferation of gastric cancer cells, promote apoptosis, and increase chemosensitivity by upregulating the expression of atf4. |
2020-08-17 |
2023-08-13 |
Not clear |
| Zeyun Gao, Mongameli B Dlamini, Hong Ge, Liping Jiang, Chengyan Geng, Qiujuan Li, Xiaoxia Shi, Yong Liu, Jun Ca. ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells. Toxicology letters. vol 331. 2020-07-23. PMID:32569804. |
furthermore, knockdown of atf4 by siatf4 significantly decreased cr (vi)-induced aerobic glycolysis and apoptosis, suggesting that atf4 was involved in cr (vi)-induced aerobic glycolysis and its effect of attenuating apoptosis in a549 cells. |
2020-07-23 |
2023-08-13 |
Not clear |
| Alejandro Losada, Juan José Berlanga, José Manuel Molina-Guijarro, Antonio Jiménez-Ruiz, Federico Gago, Pablo Avilés, César de Haro, Juan Fernando Martínez-Lea. Generation of endoplasmic reticulum stress and inhibition of autophagy by plitidepsin induces proteotoxic apoptosis in cancer cells. Biochemical pharmacology. vol 172. 2020-07-20. PMID:31812675. |
interestingly, though pld induced a strong phosphorylation of eif2α in all the analyzed cell lines, it did not elicit an increased expression of atf4 and chop, a transcription factor involved in launching upr-mediated apoptosis. |
2020-07-20 |
2023-08-13 |
Not clear |
| Xue Wang, Hua-Ying Xia, Hong-You Qin, Xiang-Ping Kang, Hai-Yan Hu, Jing Zheng, Jia-Ye Jiang, Ling-Ai Yao, Yan-Wu Xu, Tong Zhang, Xue-Li Zhan. 20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway. Journal of cellular biochemistry. vol 120. issue 4. 2020-07-08. PMID:30259568. |
furthermore, sirna-mediated knockdown of perk or atf4 inhibited the induction of chop expression and 20(s)-ppd-induced apoptosis. |
2020-07-08 |
2023-08-13 |
human |
| Xue Wang, Hua-Ying Xia, Hong-You Qin, Xiang-Ping Kang, Hai-Yan Hu, Jing Zheng, Jia-Ye Jiang, Ling-Ai Yao, Yan-Wu Xu, Tong Zhang, Xue-Li Zhan. 20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway. Journal of cellular biochemistry. vol 120. issue 4. 2020-07-08. PMID:30259568. |
collectively, our findings show that 20(s)-ppd inhibits huvec growth by inducing apoptosis and that atf4 expression activated by the perk-eif2α signaling pathway is essential for this process. |
2020-07-08 |
2023-08-13 |
human |
| Jun-Feng Huo, Xiao-Bing Che. P2X4R silence suppresses glioma cell growth through BDNF/TrkB/ATF4 signaling pathway. Journal of cellular biochemistry. vol 120. issue 4. 2020-06-24. PMID:30362154. |
the impact of p2x4r silence on t98 and u87 cell growth and apoptosis was reversed by atf4 overexpression. |
2020-06-24 |
2023-08-13 |
human |
| Yu Zhao, Yang Yu, Hengcun Li, Zheng Zhang, Shuilong Guo, Shengtao Zhu, Qingdong Guo, Peng Li, Li Min, Shutian Zhan. FAM175B promotes apoptosis by inhibiting ATF4 ubiquitination in esophageal squamous cell carcinoma. Molecular oncology. vol 13. issue 5. 2020-04-22. PMID:30854784. |
fam175b promotes apoptosis by inhibiting atf4 ubiquitination in esophageal squamous cell carcinoma. |
2020-04-22 |
2023-08-13 |
Not clear |
| Yu Zhao, Yang Yu, Hengcun Li, Zheng Zhang, Shuilong Guo, Shengtao Zhu, Qingdong Guo, Peng Li, Li Min, Shutian Zhan. FAM175B promotes apoptosis by inhibiting ATF4 ubiquitination in esophageal squamous cell carcinoma. Molecular oncology. vol 13. issue 5. 2020-04-22. PMID:30854784. |
in summary, fam175b inhibited atf4 ubiquitination and promoted escc cell apoptosis in a p53-independent manner. |
2020-04-22 |
2023-08-13 |
Not clear |
| M D Khurshidul Zahid, Michael Rogowski, Christopher Ponce, Mahua Choudhury, Naima Moustaid-Moussa, Shaikh M Rahma. CCAAT/enhancer-binding protein beta (C/EBPβ) knockdown reduces inflammation, ER stress, and apoptosis, and promotes autophagy in oxLDL-treated RAW264.7 macrophage cells. Molecular and cellular biochemistry. vol 463. issue 1-2. 2020-03-18. PMID:31686316. |
we found that short interfering rna (sirna)-mediated knockdown of c/ebpβ attenuated atherogenic lipid-mediated induction of proteins and genes implicated in inflammation (p-nfkb-p65, nfkb-p65, and tnfα), er stress (atf4 and atf6), and apoptosis (chop, caspase 1, 3, and 12). |
2020-03-18 |
2023-08-13 |
Not clear |
| Yongzhe Liu, Li Sun, Yaqun Ma, Biyu Wei, Minglong Gao, Lixin Shan. High glucose and bupivacaine‑induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK‑ATF4‑CHOP and IRE1‑TRAF2 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-02-04. PMID:31524237. |
the effects that 3‑ma (autophagy inhibitor) and rapamycin (rapa; autophagy inducer) exerted on cell apoptosis, autophagy and the expression of protein kinase r‑like endoplasmic reticulum kinase (perk)‑activating transcription factor 4 (atf4)‑c/ebp‑homologous protein (chop) and inositol‑requiring enzyme 1 (ire1)‑tumor necrosis factor receptor associated factor 2 (traf2) signaling proteins were measured in high glucose and bupivacaine‑treated cells. |
2020-02-04 |
2023-08-13 |
human |
| Yongzhe Liu, Li Sun, Yaqun Ma, Biyu Wei, Minglong Gao, Lixin Shan. High glucose and bupivacaine‑induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK‑ATF4‑CHOP and IRE1‑TRAF2 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-02-04. PMID:31524237. |
compared with the control group, high glucose and bupivacaine significantly increased atf4, chop and caspase‑12 expression, increased apoptosis, and decreased p‑ire1, traf2, lc3‑ii/lc3‑i and beclin1 expression. |
2020-02-04 |
2023-08-13 |
human |
| Yongzhe Liu, Li Sun, Yaqun Ma, Biyu Wei, Minglong Gao, Lixin Shan. High glucose and bupivacaine‑induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK‑ATF4‑CHOP and IRE1‑TRAF2 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-02-04. PMID:31524237. |
promoting autophagy with rapa partly reversed the high glucose and bupivacaine‑induced changes in p‑perk, chop, traf2, beclin1, caspase‑12 and apoptosis, while inhibiting autophagy with 3‑ma further enhanced the changes in atf4, chop, p‑ire1, traf2 and apoptosis. |
2020-02-04 |
2023-08-13 |
human |
| Li Tan, Raghunatha R Yamman. Nupr1 regulates palmitate-induced apoptosis in human articular chondrocytes. Bioscience reports. vol 39. issue 2. 2020-01-28. PMID:30674641. |
in the present study, we found that palmitate treatment of human primary articular chondrocytes increased the expression of er stress markers [activating transcription factor 4 (atf4), c/ebp homologous protein (chop)] and apoptosis markers [cytochrome |
2020-01-28 |
2023-08-13 |
human |
| Rozita Bagheri-Yarmand, Krishna M Sinha, Ling Li, Yue Lu, Gilbert J Cote, Steven I Sherman, Robert F Gage. Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress-Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer. Molecular cancer research : MCR. vol 17. issue 3. 2020-01-24. PMID:30552230. |
combinations of tyrosine kinase inhibitor and erad inhibitor promote oxidative stress-induced apoptosis through atf4 and klf9 in medullary thyroid cancer. |
2020-01-24 |
2023-08-13 |
Not clear |