| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Jiang, Feng Li, Kejian Shi, Pa Wu, Jiajia An, Yang Yang, Caimin X. ATF4 activation by the p38MAPK-eIF4E axis mediates apoptosis and autophagy induced by selenite in Jurkat cells. FEBS letters. vol 587. issue 15. 2013-10-22. PMID:23792164. |
upregulated atf4 results in the transcriptional initiation of the apoptosis-related chop gene and autophagy-related map1lc3b gene, through which selenite links er stress to apoptosis and autophagy during leukemia treatment. |
2013-10-22 |
2023-08-12 |
Not clear |
| Ji Hoon Jang, Taha Iqbal, Kyoung-Jin Min, Shin Kim, Jong-Wook Park, Eun-Ik Son, Tae-Jin Lee, Taeg Kyu Kwo. Helenalin-induced apoptosis is dependent on production of reactive oxygen species and independent of induction of endoplasmic reticulum stress in renal cell carcinoma. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 2. 2013-08-20. PMID:23123298. |
however, down-regulation of atf4 and/or chop expression by sirna had no effect on helenalin-induced apoptosis in caki and hct116 cells. |
2013-08-20 |
2023-08-12 |
human |
| Justin T Babcock, Hoa B Nguyen, Yujun He, Jeremiah W Hendricks, Ronald C Wek, Lawrence A Quillia. Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. The Journal of biological chemistry. vol 288. issue 22. 2013-08-06. PMID:23612979. |
consistent with this notion, exogenously expressed c-myc reversed the ability of rapamycin to prevent bortezomib-induced chop and atf4 expression as well as apoptosis. |
2013-08-06 |
2023-08-12 |
rat |
| Daniela Beck, Heike Niessner, Keiran S M Smalley, Keith Flaherty, Kim H T Paraiso, Christian Busch, Tobias Sinnberg, Sophie Vasseur, Juan Lucio Iovanna, Stefan Drießen, Björn Stork, Sebastian Wesselborg, Martin Schaller, Tilo Biedermann, Jürgen Bauer, Konstantinos Lasithiotakis, Benjamin Weide, Jürgen Eberle, Birgit Schittek, Dirk Schadendorf, Claus Garbe, Dagmar Kulms, Friedegund Meie. Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells. Science signaling. vol 6. issue 260. 2013-07-12. PMID:23362240. |
knockdown of the er stress response protein activating transcription factor 4 (atf4) significantly reduced vemurafenib-induced apoptosis. |
2013-07-12 |
2023-08-12 |
Not clear |
| Linyan Xu, Ling Su, Xiangguo Li. PKCδ regulates death receptor 5 expression induced by PS-341 through ATF4-ATF3/CHOP axis in human lung cancer cells. Molecular cancer therapeutics. vol 11. issue 10. 2013-07-08. PMID:22848091. |
silencing either one of the atf4, atf3, and chop expression decreased dr5 upregulation and subsequent apoptosis. |
2013-07-08 |
2023-08-12 |
human |
| Jaeseok Han, Sung Hoon Back, Junguk Hur, Yu-Hsuan Lin, Robert Gildersleeve, Jixiu Shan, Celvie L Yuan, Dawid Krokowski, Shiyu Wang, Maria Hatzoglou, Michael S Kilberg, Maureen A Sartor, Randal J Kaufma. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature cell biology. vol 15. issue 5. 2013-06-25. PMID:23624402. |
chip-seq and mrna-seq of activating transcription factor 4 (atf4) and c/ebp homologous protein (chop), key transcription factors downstream of p-eif2α, demonstrated that they interact to directly induce genes encoding protein synthesis and the unfolded protein response, but not apoptosis. |
2013-06-25 |
2023-08-12 |
Not clear |
| Guoliang Qing, Bo Li, Annette Vu, Nicolas Skuli, Zandra E Walton, Xueyuan Liu, Patrick A Mayes, David R Wise, Craig B Thompson, John M Maris, Michael D Hogarty, M Celeste Simo. ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer cell. vol 22. issue 5. 2013-01-21. PMID:23153536. |
consequently, either atf4 agonists or glutaminolysis inhibitors potently induce apoptosis in vitro and inhibit tumor growth in vivo. |
2013-01-21 |
2023-08-12 |
Not clear |
| Guoliang Qing, Bo Li, Annette Vu, Nicolas Skuli, Zandra E Walton, Xueyuan Liu, Patrick A Mayes, David R Wise, Craig B Thompson, John M Maris, Michael D Hogarty, M Celeste Simo. ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer cell. vol 22. issue 5. 2013-01-21. PMID:23153536. |
these results reveal mechanisms whereby myc sensitizes cells to apoptosis, and validate atf4 agonists and inhibitors of gln metabolism as potential myc-selective cancer therapeutics. |
2013-01-21 |
2023-08-12 |
Not clear |
| Guangbo Liu, Ling Su, Xuexi Hao, Ning Zhong, Diansheng Zhong, Sunil Singhal, Xiangguo Li. Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells. Journal of cellular and molecular medicine. vol 16. issue 7. 2012-11-30. PMID:21801305. |
we discovered that ire-1α, bip, activating transcription factor 3 (atf4), activating transcription factor 3 (atf3) and c/ebp homologous protein (chop) are induced by salermide, which suggests that dr5-dependent apoptosis is induced by endoplasmic reticulum stress. |
2012-11-30 |
2023-08-12 |
human |
| Pengfei Lin, YanZhou Yang, Xiao Li, Fenglei Chen, ChenChen Cui, Linyong Hu, Qian Li, Wei Liu, YaPing Ji. Endoplasmic reticulum stress is involved in granulosa cell apoptosis during follicular atresia in goat ovaries. Molecular reproduction and development. vol 79. issue 6. 2012-11-08. PMID:22532439. |
activating transcription factor-6 (atf6) and atf4 mrnas were significantly increased during granulosa cell apoptosis in vivo; in contrast to atf6, atf4 mrna was attenuated after 16 hr of culture despite the persistence of er stress. |
2012-11-08 |
2023-08-12 |
Not clear |
| Elena Vladykovskaya, Srinivas D Sithu, Petra Haberzettl, Nalinie S Wickramasinghe, Michael L Merchant, Bradford G Hill, James McCracken, Abhinav Agarwal, Susan Dougherty, Sharon A Gordon, Dale A Schuschke, Oleg A Barski, Timothy O'Toole, Stanley E D'Souza, Aruni Bhatnagar, Sanjay Srivastav. Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress. The Journal of biological chemistry. vol 287. issue 14. 2012-09-20. PMID:22228760. |
we also found that at concentrations that did not induce apoptosis or necrosis, hne activated the unfolded protein response, leading to an increase in xbp-1 splicing, phosphorylation of protein kinase-like er kinase and eukaryotic translation initiation factor 2α, and the induction of atf3 and atf4. |
2012-09-20 |
2023-08-12 |
human |
| Souvik Dey, Sudha Savant, Brian F Teske, Maria Hatzoglou, Cornelis F Calkhoven, Ronald C We. Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response. The Journal of biological chemistry. vol 287. issue 26. 2012-09-20. PMID:22556424. |
atf4 is a transcriptional activator of genes involved in metabolism and nutrient uptake, antioxidation, and regulation of apoptosis. |
2012-09-20 |
2023-08-12 |
Not clear |
| Jeffrey G Dickhout, Rachel E Carlisle, Danielle E Jerome, Zahraa Mohammed-Ali, Hua Jiang, Guangdong Yang, Sarathi Mani, Sanjay K Garg, Ruma Banerjee, Randal J Kaufman, Kenneth N Maclean, Rui Wang, Richard C Austi. Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. The Journal of biological chemistry. vol 287. issue 10. 2012-04-24. PMID:22215680. |
further, atf4(-/-) mefs were more sensitive to hcy-induced cytotoxicity and showed significantly reduced intracellular gsh levels associated with apoptosis. |
2012-04-24 |
2023-08-12 |
mouse |
| Jeffrey G Dickhout, Rachel E Carlisle, Danielle E Jerome, Zahraa Mohammed-Ali, Hua Jiang, Guangdong Yang, Sarathi Mani, Sanjay K Garg, Ruma Banerjee, Randal J Kaufman, Kenneth N Maclean, Rui Wang, Richard C Austi. Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. The Journal of biological chemistry. vol 287. issue 10. 2012-04-24. PMID:22215680. |
atf4(-/-) mefs could be rescued from l-hcy-induced apoptosis by β-mercaptoethanol medium supplementation that increases cysteine levels and restores gsh synthesis. |
2012-04-24 |
2023-08-12 |
mouse |
| Jeffrey G Dickhout, Rachel E Carlisle, Danielle E Jerome, Zahraa Mohammed-Ali, Hua Jiang, Guangdong Yang, Sarathi Mani, Sanjay K Garg, Ruma Banerjee, Randal J Kaufman, Kenneth N Maclean, Rui Wang, Richard C Austi. Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. The Journal of biological chemistry. vol 287. issue 10. 2012-04-24. PMID:22215680. |
consistent with atf4(-/-) mefs, cse(-/-) mefs showed significantly greater apoptosis when treated with tunicamycin, thapsigargin, and l-hcy, compared with cse(+/+) mefs. |
2012-04-24 |
2023-08-12 |
mouse |
| Jian-Tao Liu, Yong Yang, Xiao-Gang Guo, Miao Chen, Huan-Zhong Ding, Yong-Long Chen, Min-Ru Wan. Over-expression of atf4 in Xenopus embryos interferes with neurogenesis and eye formation. Dong wu xue yan jiu = Zoological research. vol 32. issue 5. 2012-03-27. PMID:22006799. |
ectopic expression of atf4 in the animal hemisphere of xenopus embryos had no obvious effects on the induction of neural progenitors, but suppressed neurogenesis and eye formation without promoting apoptosis. |
2012-03-27 |
2023-08-12 |
xenopus_laevis |
| Jinsong Hu, Nana Dang, Eline Menu, Elke De Bruyne, Elke De Bryune, Dehui Xu, Ben Van Camp, Els Van Valckenborgh, Karin Vanderkerke. Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition. Blood. vol 119. issue 3. 2012-03-13. PMID:22128141. |
knocking down atf4 was paralleled by down-regulation of mcl-1 induction by bortezomib and significantly increased bortezomib-induced apoptosis. |
2012-03-13 |
2023-08-12 |
Not clear |
| Gordon P Meares, Marjelo A Mines, Eléonore Beurel, Tae-Yeon Eom, Ling Song, Anna A Zmijewska, Richard S Jop. Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells. Experimental cell research. vol 317. issue 11. 2011-08-09. PMID:21356208. |
apoptosis following upr activation can be mediated by activation of two transcription factors, atf4 and atf6, that activate expression of the death-inducing transcription factor c/ebp homologous protein (chop/gadd153) following er stress. |
2011-08-09 |
2023-08-12 |
Not clear |
| S M Kim, S Y Yoon, J E Choi, J S Park, J M Choi, T Nguyen, D H Ki. Activation of eukaryotic initiation factor-2 α-kinases in okadaic acid-treated neurons. Neuroscience. vol 169. issue 4. 2011-04-18. PMID:20600673. |
activating transcription factor (atf4) which induces apoptosis in response to eif2 alpha phosphorylation was increased and translocated to nuclei in oa-treated neurons. |
2011-04-18 |
2023-08-12 |
rat |
| Zohreh Galehdar, Patrick Swan, Benjamin Fuerth, Steven M Callaghan, David S Park, Sean P Crega. Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 50. 2011-02-09. PMID:21159964. |
specifically, we demonstrate that ectopic expression of atf4 sensitizes mouse cortical neurons to er-stress-induced apoptosis and that atf4-deficient neurons exhibit markedly reduced levels of puma expression and cell death. |
2011-02-09 |
2023-08-12 |
mouse |