| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jaeseok Han, Sung Hoon Back, Junguk Hur, Yu-Hsuan Lin, Robert Gildersleeve, Jixiu Shan, Celvie L Yuan, Dawid Krokowski, Shiyu Wang, Maria Hatzoglou, Michael S Kilberg, Maureen A Sartor, Randal J Kaufma. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature cell biology. vol 15. issue 5. 2013-06-25. PMID:23624402. |
chip-seq and mrna-seq of activating transcription factor 4 (atf4) and c/ebp homologous protein (chop), key transcription factors downstream of p-eif2α, demonstrated that they interact to directly induce genes encoding protein synthesis and the unfolded protein response, but not apoptosis. |
2013-06-25 |
2023-08-12 |
Not clear |
| Guoliang Qing, Bo Li, Annette Vu, Nicolas Skuli, Zandra E Walton, Xueyuan Liu, Patrick A Mayes, David R Wise, Craig B Thompson, John M Maris, Michael D Hogarty, M Celeste Simo. ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer cell. vol 22. issue 5. 2013-01-21. PMID:23153536. |
consequently, either atf4 agonists or glutaminolysis inhibitors potently induce apoptosis in vitro and inhibit tumor growth in vivo. |
2013-01-21 |
2023-08-12 |
Not clear |
| Guoliang Qing, Bo Li, Annette Vu, Nicolas Skuli, Zandra E Walton, Xueyuan Liu, Patrick A Mayes, David R Wise, Craig B Thompson, John M Maris, Michael D Hogarty, M Celeste Simo. ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer cell. vol 22. issue 5. 2013-01-21. PMID:23153536. |
these results reveal mechanisms whereby myc sensitizes cells to apoptosis, and validate atf4 agonists and inhibitors of gln metabolism as potential myc-selective cancer therapeutics. |
2013-01-21 |
2023-08-12 |
Not clear |
| Guangbo Liu, Ling Su, Xuexi Hao, Ning Zhong, Diansheng Zhong, Sunil Singhal, Xiangguo Li. Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells. Journal of cellular and molecular medicine. vol 16. issue 7. 2012-11-30. PMID:21801305. |
we discovered that ire-1α, bip, activating transcription factor 3 (atf4), activating transcription factor 3 (atf3) and c/ebp homologous protein (chop) are induced by salermide, which suggests that dr5-dependent apoptosis is induced by endoplasmic reticulum stress. |
2012-11-30 |
2023-08-12 |
human |
| Pengfei Lin, YanZhou Yang, Xiao Li, Fenglei Chen, ChenChen Cui, Linyong Hu, Qian Li, Wei Liu, YaPing Ji. Endoplasmic reticulum stress is involved in granulosa cell apoptosis during follicular atresia in goat ovaries. Molecular reproduction and development. vol 79. issue 6. 2012-11-08. PMID:22532439. |
activating transcription factor-6 (atf6) and atf4 mrnas were significantly increased during granulosa cell apoptosis in vivo; in contrast to atf6, atf4 mrna was attenuated after 16 hr of culture despite the persistence of er stress. |
2012-11-08 |
2023-08-12 |
Not clear |
| Elena Vladykovskaya, Srinivas D Sithu, Petra Haberzettl, Nalinie S Wickramasinghe, Michael L Merchant, Bradford G Hill, James McCracken, Abhinav Agarwal, Susan Dougherty, Sharon A Gordon, Dale A Schuschke, Oleg A Barski, Timothy O'Toole, Stanley E D'Souza, Aruni Bhatnagar, Sanjay Srivastav. Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress. The Journal of biological chemistry. vol 287. issue 14. 2012-09-20. PMID:22228760. |
we also found that at concentrations that did not induce apoptosis or necrosis, hne activated the unfolded protein response, leading to an increase in xbp-1 splicing, phosphorylation of protein kinase-like er kinase and eukaryotic translation initiation factor 2α, and the induction of atf3 and atf4. |
2012-09-20 |
2023-08-12 |
human |
| Souvik Dey, Sudha Savant, Brian F Teske, Maria Hatzoglou, Cornelis F Calkhoven, Ronald C We. Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response. The Journal of biological chemistry. vol 287. issue 26. 2012-09-20. PMID:22556424. |
atf4 is a transcriptional activator of genes involved in metabolism and nutrient uptake, antioxidation, and regulation of apoptosis. |
2012-09-20 |
2023-08-12 |
Not clear |
| Jeffrey G Dickhout, Rachel E Carlisle, Danielle E Jerome, Zahraa Mohammed-Ali, Hua Jiang, Guangdong Yang, Sarathi Mani, Sanjay K Garg, Ruma Banerjee, Randal J Kaufman, Kenneth N Maclean, Rui Wang, Richard C Austi. Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. The Journal of biological chemistry. vol 287. issue 10. 2012-04-24. PMID:22215680. |
further, atf4(-/-) mefs were more sensitive to hcy-induced cytotoxicity and showed significantly reduced intracellular gsh levels associated with apoptosis. |
2012-04-24 |
2023-08-12 |
mouse |
| Jeffrey G Dickhout, Rachel E Carlisle, Danielle E Jerome, Zahraa Mohammed-Ali, Hua Jiang, Guangdong Yang, Sarathi Mani, Sanjay K Garg, Ruma Banerjee, Randal J Kaufman, Kenneth N Maclean, Rui Wang, Richard C Austi. Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. The Journal of biological chemistry. vol 287. issue 10. 2012-04-24. PMID:22215680. |
atf4(-/-) mefs could be rescued from l-hcy-induced apoptosis by β-mercaptoethanol medium supplementation that increases cysteine levels and restores gsh synthesis. |
2012-04-24 |
2023-08-12 |
mouse |
| Jeffrey G Dickhout, Rachel E Carlisle, Danielle E Jerome, Zahraa Mohammed-Ali, Hua Jiang, Guangdong Yang, Sarathi Mani, Sanjay K Garg, Ruma Banerjee, Randal J Kaufman, Kenneth N Maclean, Rui Wang, Richard C Austi. Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. The Journal of biological chemistry. vol 287. issue 10. 2012-04-24. PMID:22215680. |
consistent with atf4(-/-) mefs, cse(-/-) mefs showed significantly greater apoptosis when treated with tunicamycin, thapsigargin, and l-hcy, compared with cse(+/+) mefs. |
2012-04-24 |
2023-08-12 |
mouse |
| Jian-Tao Liu, Yong Yang, Xiao-Gang Guo, Miao Chen, Huan-Zhong Ding, Yong-Long Chen, Min-Ru Wan. Over-expression of atf4 in Xenopus embryos interferes with neurogenesis and eye formation. Dong wu xue yan jiu = Zoological research. vol 32. issue 5. 2012-03-27. PMID:22006799. |
ectopic expression of atf4 in the animal hemisphere of xenopus embryos had no obvious effects on the induction of neural progenitors, but suppressed neurogenesis and eye formation without promoting apoptosis. |
2012-03-27 |
2023-08-12 |
xenopus_laevis |
| Jinsong Hu, Nana Dang, Eline Menu, Elke De Bruyne, Elke De Bryune, Dehui Xu, Ben Van Camp, Els Van Valckenborgh, Karin Vanderkerke. Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition. Blood. vol 119. issue 3. 2012-03-13. PMID:22128141. |
knocking down atf4 was paralleled by down-regulation of mcl-1 induction by bortezomib and significantly increased bortezomib-induced apoptosis. |
2012-03-13 |
2023-08-12 |
Not clear |
| Gordon P Meares, Marjelo A Mines, Eléonore Beurel, Tae-Yeon Eom, Ling Song, Anna A Zmijewska, Richard S Jop. Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells. Experimental cell research. vol 317. issue 11. 2011-08-09. PMID:21356208. |
apoptosis following upr activation can be mediated by activation of two transcription factors, atf4 and atf6, that activate expression of the death-inducing transcription factor c/ebp homologous protein (chop/gadd153) following er stress. |
2011-08-09 |
2023-08-12 |
Not clear |
| S M Kim, S Y Yoon, J E Choi, J S Park, J M Choi, T Nguyen, D H Ki. Activation of eukaryotic initiation factor-2 α-kinases in okadaic acid-treated neurons. Neuroscience. vol 169. issue 4. 2011-04-18. PMID:20600673. |
activating transcription factor (atf4) which induces apoptosis in response to eif2 alpha phosphorylation was increased and translocated to nuclei in oa-treated neurons. |
2011-04-18 |
2023-08-12 |
rat |
| Zohreh Galehdar, Patrick Swan, Benjamin Fuerth, Steven M Callaghan, David S Park, Sean P Crega. Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 50. 2011-02-09. PMID:21159964. |
specifically, we demonstrate that ectopic expression of atf4 sensitizes mouse cortical neurons to er-stress-induced apoptosis and that atf4-deficient neurons exhibit markedly reduced levels of puma expression and cell death. |
2011-02-09 |
2023-08-12 |
mouse |
| Souvik Dey, Thomas D Baird, Donghui Zhou, Lakshmi Reddy Palam, Dan F Spandau, Ronald C We. Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response. The Journal of biological chemistry. vol 285. issue 43. 2010-11-24. PMID:20732869. |
atf4 is a transcriptional activator of the integrated stress response, a program of gene expression involved in metabolism, nutrient uptake, anti-oxidation, and the activation of additional transcription factors, such as chop/gadd153, that can induce apoptosis. |
2010-11-24 |
2023-08-12 |
human |
| Kristine P Malabanan, Levon M Khachigia. Activation transcription factor-4 and the acute vascular response to injury. Journal of molecular medicine (Berlin, Germany). vol 88. issue 6. 2010-08-17. PMID:20306012. |
in this context, atf4 is thought to regulate pro-inflammatory signalling cascades and subsequent apoptosis. |
2010-08-17 |
2023-08-12 |
mouse |
| Tomasz Rzymski, Manuela Milani, Dean C Singleton, Adrian L Harri. Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia. Cell cycle (Georgetown, Tex.). vol 8. issue 23. 2010-02-03. PMID:19887912. |
atf4 decreases the antitumor activity of chemotherapy by mechanisms involving expression of genes involved in oxidative stress resistance, redox homeostasis and inhibitors of apoptosis. |
2010-02-03 |
2023-08-12 |
Not clear |
| Xiaoyan Zhang, Shibing Yu, Deborah L Galson, Min Luo, Jie Fan, Jian Zhang, Youfei Guan, Guozhi Xia. Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts. Journal of cellular biochemistry. vol 105. issue 3. 2008-12-31. PMID:18729081. |
in addition, apoptosis was significantly increased in atf4(-/-) bmscs and calvarial periosteal osteoblasts relative to wt controls. |
2008-12-31 |
2023-08-12 |
mouse |
| Nima Niknejad, Melissa Morley, Jim Dimitroulako. Activation of the integrated stress response regulates lovastatin-induced apoptosis. The Journal of biological chemistry. vol 282. issue 41. 2007-11-27. PMID:17699156. |
furthermore, the eif2alpha kinase gcn2 mediates lovastatin induction of atf4 and lovastatin-induced apoptosis was also attenuated in gcn2(-/-) mefs. |
2007-11-27 |
2023-08-12 |
human |