| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Zhou Meng, Xiao-Feng Ni, Hai-Ning Yu, Shan-Shan Wang, Sheng-Rong She. Effects of astaxanthin on oxidative stress induced by Cu Journal of Zhejiang University. Science. B. vol 18. issue 2. 2017-07-11. PMID:28124844. |
in the current paper, the effects of ast on viability of prostate cells were investigated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (mtt) assay; cell apoptosis and intracellular reactive oxygen species (ros) levels were determined by flow cytometry; the mitochondrial membrane potential (mmp) was measured by fluorospectrophotometer; and activities of malondialdehyde (mda), superoxide dismutase (sod), catalase (cat), and glutathione peroxidase (gsh-px) were evaluated by a detection kit. |
2017-07-11 |
2023-08-13 |
cat |
| Heba A Abdelaziz, Mohamed E Shaker, Mohamed F Hamed, Nariman M Gamei. Repression of acetaminophen-induced hepatotoxicity by a combination of celastrol and brilliant blue G. Toxicology letters. vol 275. 2017-06-26. PMID:28435131. |
the results indicated that both celastrol and bbg pretreatments, especially when combined together, curbed apap-induced hepatocellular injury (alt, ast and ldh) and death (necrosis and apoptosis). |
2017-06-26 |
2023-08-13 |
mouse |
| Hong-Li Guo, Hozeifa M Hassan, Ping-Ping Ding, Shao-Jie Wang, Xi Chen, Tao Wang, Li-Xin Sun, Lu-Yong Zhang, Zhen-Zhou Jian. Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2α-ATF4-CHOP pathway. Toxicology. vol 378. 2017-05-12. PMID:28063906. |
we found that pza induces apoptosis in hepg2 cells, and causes liver damage in rats, characterized by increased serum alt, ast and tba levels. |
2017-05-12 |
2023-08-13 |
rat |
| Renyu Ding, Jiali Han, Dongmei Zhao, Ziwei Hu, Xiaochun M. Pretreatment with Rho-kinase inhibitor ameliorates lethal endotoxemia-induced liver injury by improving mitochondrial function. International immunopharmacology. vol 40. 2017-05-02. PMID:27588912. |
this was confirmed by decreased plasma alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels, and by reduced hepatocellular apoptosis and histologic damage. |
2017-05-02 |
2023-08-13 |
mouse |
| P Roman, G Budziński, A Suszka-Świtek, A Caban, G Oczkowicz, E Czech, F Ryszka, R Wiaderkiewicz, Z Smorąg, L Cierpk. Caspase-3 Expression and ALT, AST, and GGT Activity After 24 Hours of Porcine Liver Cold Storage, Depending on the Type of Transgenesis. Transplantation proceedings. vol 48. issue 5. 2017-04-26. PMID:27496501. |
we aimed to analyze if the type of transgenesis has an influence on the hepatic caspase-3 expression, the enzyme that executes apoptosis as well as alt, ast, and ggt activity after 24 hours of cold storage. |
2017-04-26 |
2023-08-13 |
human |
| Weiping Zhang, Lihong Chen, Yuxian Shen, Jianming X. Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicology in vitro : an international journal published in association with BIBRA. vol 36. 2017-03-24. PMID:27470132. |
additionally, 4-pba reduced cell apoptosis, increased cell survival and decreased the level of alt, ast, akp, ldh and atp in the cell culture supernatant. |
2017-03-24 |
2023-08-13 |
Not clear |
| Diao He, Zhen Guo, Jun-Liang Pu, Dao-Feng Zheng, Xu-Fu Wei, Rui Liu, Cheng-Yong Tang, Zhong-Jun W. Resveratrol preconditioning protects hepatocytes against hepatic ischemia reperfusion injury via Toll-like receptor 4/nuclear factor-κB signaling pathway in vitro and in vivo. International immunopharmacology. vol 35. 2017-03-21. PMID:27064547. |
in vivo assays revealed that resveratrol reduced levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast), and liver pathological changes, while it alleviated hepatocyte apoptosis, negatively mediated the production of tnf-α and il-1β in serum, and reversed tlr4/nf-κb signaling pathway caused by hepatic ischemia/reperfusion stimulation in liver tissues. |
2017-03-21 |
2023-08-13 |
rat |
| Xiao Han, Wenfeng Li, Di Huang, Xingbin Yan. Polyphenols from hawthorn peels and fleshes differently mitigate dyslipidemia, inflammation and oxidative stress in association with modulation of liver injury in high fructose diet-fed mice. Chemico-biological interactions. vol 257. 2017-01-31. PMID:27531227. |
administration of hpp was better than hfp to alleviate liver injury and hepatocyte apoptosis, reflected by the reduction of alt, ast and alp activities, as well as the ratio of bax/bcl-2 in mice. |
2017-01-31 |
2023-08-13 |
mouse |
| Chang-Chi Lai, Po-Hsun Huang, An-Han Yang, Shu-Chiung Chiang, Chia-Yu Tang, Kuo-Wei Tseng, Cheng-Hsiung Huan. Baicalein Reduces Liver Injury Induced by Myocardial Ischemia and Reperfusion. The American journal of Chinese medicine. vol 44. issue 3. 2017-01-12. PMID:27109160. |
intravenous pretreatment with baicalein (3, 10, or 30[formula: see text]mg/kg) 10[formula: see text]min before myocardial i/r significantly reduced the serum level increase of ast and alt, apoptosis in the liver, and the elevation of tnf-[formula: see text], il-1[formula: see text], and il-6 levels. |
2017-01-12 |
2023-08-13 |
rat |
| Nuriye Ezgi Bektur, Erhan Sahin, Cengiz Baycu, Gonul Unve. Protective effects of silymarin against acetaminophen-induced hepatotoxicity and nephrotoxicity in mice. Toxicology and industrial health. vol 32. issue 4. 2016-12-28. PMID:24193058. |
treatment of mice with overdose of apap resulted in the elevation of aspartate aminotransferase (ast), alanine transaminase (alt), blood urea nitrogen (bun), and serum creatinine (scr) levels in serum, liver, and kidney nitric oxide (no) levels and significant histological changes including decreased body weight, swelling of hepatocytes, cell infiltration, dilatation and congestion, necrosis and apoptosis in liver, and dilatation of bowman's capsular space and glomerular capillaries, pale-stained tubules epithelium, cell infiltration, and apoptosis in kidney. |
2016-12-28 |
2023-08-12 |
mouse |
| Lian-Yun Chen, Qin Chen, Yi-Feng Cheng, Huan-Huan Jin, De-Song Kong, Feng Zhang, Li Wu, Jiang-Juan Shao, Shi-Zhong Zhen. Diallyl trisulfide attenuates ethanol-induced hepatic steatosis by inhibiting oxidative stress and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 79. 2016-12-26. PMID:27044810. |
our results demonstrated that dats prevented ethanol-induced injury, as indicated by the reduced activities of aspartate transaminase (ast) and alanine aminotransferase (alt) in the serum and culture medium, and inhibition of cell apoptosis. |
2016-12-26 |
2023-08-13 |
rat |
| Kaliappan Gopal, Munusamy Gowtham, Singh Sachin, Mani Ravishankar Ram, Esaki M Shankar, Tunku Kamaru. Attrition of Hepatic Damage Inflicted by Angiotensin II with α-Tocopherol and β-Carotene in Experimental Apolipoprotein E Knock-out Mice. Scientific reports. vol 5. 2016-10-28. PMID:26670291. |
investigations showed fibrosis, kupffer cell hyperplasia, hepatocyte degeneration and hepatic cell apoptosis; sinusoidal dilatation along with haemorrhages; evidence of fluid accumulation; increased ros level and increased ast and alt activities. |
2016-10-28 |
2023-08-13 |
mouse |
| F Ren, H Shi, L Zhang, X Zhang, T Wen, B Xie, S Zheng, Y Chen, L Li, D Chen, Z Dua. The dysregulation of endoplasmic reticulum stress response in acute-on-chronic liver failure patients caused by acute exacerbation of chronic hepatitis B. Journal of viral hepatitis. vol 23. issue 1. 2016-10-19. PMID:26234401. |
among the three pathways of unfolded protein responses, the pkr-like er kinase and inositol-requiring enzyme 1 signalling pathway were activated in chb subjects and inactivated in aoclf subjects, while the activating transcription factor 6 signalling pathway was sustained in the activated form during the progression of aoclf; the expression of glucose-regulated protein (grp)78 and grp94 was gradually decreased in aoclf subjects compared to healthy individuals and chb subjects, showing a negative correlation with serum alt, ast and tbil; moreover, the er stress-related apoptosis molecules were activated in the progression of acute exacerbation of chb. |
2016-10-19 |
2023-08-13 |
human |
| Mahmoud Elshal, Nashwa Abu-Elsaad, Amr El-Karef, Tarek Mostafa Ibrahi. The multi-kinase inhibitor pazopanib targets hepatic stellate cell activation and apoptosis alleviating progression of liver fibrosis. Naunyn-Schmiedeberg's archives of pharmacology. vol 388. issue 12. 2016-09-12. PMID:26269412. |
levels of liver function biomarkers (alanine aminotransferase (alt), aspartate aminotransferase (ast), albumin, and total bilirubin), malondialdehyde, transforming growth factor-β1 (tgf-β1), caspase-3, factor-related apoptosis (fas), vascular endothelial growth factor (vegf) receptor-1, and pigment endothelial derived factor (pedf) were measured. |
2016-09-12 |
2023-08-13 |
Not clear |
| Renwei Huang, Qunwen Pan, Xiaotang Ma, Yan Wang, Yaolong Liang, Bingyan Dai, Xiaorong Liao, Mingyi Li, Huilai Mia. Hepatic Stellate Cell-Derived Microvesicles Prevent Hepatocytes from Injury Induced by APAP/H2O2. Stem cells international. vol 2016. 2016-05-30. PMID:27239205. |
results showed that (1) hsc-mvs derived from lx-2 and hst-t6 were positive to cd90 and annexin v surface markers; (2) hsc-mvs dose-dependently improved the viability of hepatocytes in both injury models; (3) hsc-mvs dose-dependently inhibited the apap/h2o2 induced hepatocytes apoptosis and activated caspase-3 expression and leakage of ldh, alt, and ast. |
2016-05-30 |
2023-08-13 |
human |
| Young-Ok Son, Poyil Pratheeshkumar, Ram Vinod Roy, John Andrew Hitron, Lei Wang, Sasidharan Padmaja Divya, Mei Xu, Jia Luo, Gang Chen, Zhuo Zhang, Xianglin Sh. Antioncogenic and Oncogenic Properties of Nrf2 in Arsenic-induced Carcinogenesis. The Journal of biological chemistry. vol 290. issue 45. 2016-05-06. PMID:26385919. |
the present study shows that as(3+)-transformed human lung bronchial epithelial beas-2b cells (ast cells) exhibit the property of apoptosis resistance. |
2016-05-06 |
2023-08-13 |
human |
| Poorigali Raghavendra-Rao Sowmya, Bangalore Prabhashankar Arathi, Kariyappa Vijay, Vallikannan Baskaran, Rangaswamy Lakshminarayan. Role of different vehicles in carotenoids delivery and their influence on cell viability, cell cycle progression, and induction of apoptosis in HeLa cells. Molecular and cellular biochemistry. vol 406. issue 1-2. 2016-04-25. PMID:25998494. |
the % induction of apoptosis by bc or l delivered with thf and ast in dmso was higher than other treated groups. |
2016-04-25 |
2023-08-13 |
cattle |
| Xiqiang Liu, Zhiqiu Hu, Bin Zhou, Xiang Li, Ran Ta. Chinese Herbal Preparation Xuebijing Potently Inhibits Inflammasome Activation in Hepatocytes and Ameliorates Mouse Liver Ischemia-Reperfusion Injury. PloS one. vol 10. issue 7. 2016-04-25. PMID:26132490. |
in the current study, we found that xbj treatment potently ameliorated mouse hepatic ischemia-reperfusion (ir) injury, manifested as decreased liver function tests (ldh, alt, ast), improved inflammation and less hepatocyte apoptosis. |
2016-04-25 |
2023-08-13 |
mouse |
| Jung-Ran Noh, Yong-Hoon Kim, Jung Hwan Hwang, Dong-Hee Choi, Kyoung-Shim Kim, Won-Keun Oh, Chul-Ho Le. Sulforaphane protects against acetaminophen-induced hepatotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 80. 2016-01-25. PMID:25818464. |
apap alone caused severe liver injuries as characterized by increased plasma ast and alt levels, gsh depletion, apoptosis, and 4-hydroxynonenal (4-hne) formations. |
2016-01-25 |
2023-08-13 |
mouse |
| Yuhong Ma, Weizu Li, Yanyan Yin, Weiping L. AST IV inhibits H₂O₂-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-β1/Smad2 pathway. International journal of molecular medicine. vol 35. issue 6. 2016-01-25. PMID:25891879. |
ast iv inhibits h₂o₂-induced human umbilical vein endothelial cell apoptosis by suppressing nox4 expression through the tgf-β1/smad2 pathway. |
2016-01-25 |
2023-08-13 |
human |