| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I V Kurbatova, L V Topchieva, O P Dudanov. Gene TNF Polymorphism -308G>A (rs1800629) and Its Relationship with the Efficiency of Ursodeoxycholic Acid Therapy in Patients with Nonalcoholic Stetohepatitis. Bulletin of experimental biology and medicine. vol 164. issue 2. 2018-07-16. PMID:29181663. |
patients with nonalcoholic steatohepatitis, differing by the tnf gene -308g>a marker genotype, differ by the time course of the markers of hepatocellular damage (alt, ast), activity of hepatocyte apoptosis (tissue polypeptide-specific antigen), and activation of specific humoral immunity (γ-globulin) in response to therapy with ursodeoxycholic acid in a dose of 10-15 mg/kg over 4-6 weeks. |
2018-07-16 |
2023-08-13 |
human |
| Xin He, Chun-Yan Liu, Ji-Feng Yin, Ai-Hua Jin, Xue-Zhe Yin, Ji-Shu Qua. [Rhaponticum uniflorum inhibits H2O2-induced apoptosis of liver cells via JNK and NF-κB pathways]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 6. 2018-06-25. PMID:29027437. |
unifloru could increase the cell viability, reduce ldh, alt and ast leakage, reduce the mda formation, increase the sod and gsh levels,reduce the relative activities of caspase-3, 8 and 9, down-regulated the protein expressions of casp-3 and cytoplasmic cyto c, and down-regulate the p-jnk and nuclear nf-κb levels.the results indicated that r. unifloru had the inhibitory effect on apoptosis induced by h2o2in hepg2 cells, and the mechanism maybe associated with inhibiting jnk activation and nf-κb nuclear translocation. |
2018-06-25 |
2023-08-13 |
human |
| Long Li, Chaoli Duan, Yan Zhao, Xiaofang Zhang, Hongyan Yin, Tianxi Wang, Caoxin Huang, Suhuan Liu, Shuyu Yang, Xuejun L. Preventive effects of interleukin-6 in lipopolysaccharide/d-galactosamine induced acute liver injury via regulating inflammatory response in hepatic macrophages. International immunopharmacology. vol 51. 2018-05-10. PMID:28822324. |
the results indicated that il-6 treatment could protect mice from lps/d-gal-induced tissue damage, alanine aminotransferase (alt) and aspartate aminotransferase (ast) elevation, as well as hepatocyte apoptosis and inflammation. |
2018-05-10 |
2023-08-13 |
mouse |
| Hongling Wang, Xiangwen Peng, Fenglin Cao, Ying Wang, Huijie Shi, Shuai Lin, Weijie Zhong, Jingxia Su. Cardiotoxicity and Mechanism of Particulate Matter 2.5 (PM2.5) Exposure in Offspring Rats During Pregnancy. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-05-07. PMID:28801545. |
the pathological changes of heart tissue, the rate of myocardial cell apoptosis, the levels of ldh, ast, and cm-kb in serum, and the difference in mitochondrial fusion genes (opa1 and mfn1) and mitochondrial genes (drp1 and fis1) were compared among groups. |
2018-05-07 |
2023-08-13 |
mouse |
| Jianhong Liu, Qinggang Meng, Hanguang Jing, Sheng Zho. Astragaloside IV protects against apoptosis in human degenerative chondrocytes through autophagy activation. Molecular medicine reports. vol 16. issue 3. 2018-04-24. PMID:28714008. |
however, the role of ast on chondrocyte apoptosis and its underlying mechanism remains unknown. |
2018-04-24 |
2023-08-13 |
human |
| Jianhong Liu, Qinggang Meng, Hanguang Jing, Sheng Zho. Astragaloside IV protects against apoptosis in human degenerative chondrocytes through autophagy activation. Molecular medicine reports. vol 16. issue 3. 2018-04-24. PMID:28714008. |
results indicated that ast protected against chondrocyte apoptosis induced by il‑1β. |
2018-04-24 |
2023-08-13 |
human |
| Yujiao Lu, Qin Luo, Hengmin Cui, Huidan Deng, Ping Kuang, Huan Liu, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zha. Sodium fluoride causes oxidative stress and apoptosis in the mouse liver. Aging. vol 9. issue 6. 2018-03-29. PMID:28657544. |
naf-caused oxidative stress and apoptosis finally impaired hepatic function, which was strongly supported by the histopathological lesions and increased serum alanine amino transferase (alt), aspartic acid transferase (ast), alkaline phosphatase (akp) activities and tbil contents. |
2018-03-29 |
2023-08-13 |
mouse |
| Alireza Masoudi, Leila Dargahi, Fatemeh Abbaszadeh, Mohammad Hosein Pourgholami, Alireza Asgari, Mehdi Manoochehri, Masoumeh Jorjan. Neuroprotective effects of astaxanthin in a rat model of spinal cord injury. Behavioural brain research. vol 329. 2018-03-15. PMID:28442361. |
this study is the first to report that ast reduces neuronal apoptosis, diminishes pathological tissue damage and improves functional recovery after sci. |
2018-03-15 |
2023-08-13 |
rat |
| Hui Zhao, Wei Meng, Yang Li, Wei Liu, Binsheng Fu, Yang Yang, Qi Zhang, Guihua Che. The protective effects of CHIR99021 against oxidative injury in LO2 cells. Die Pharmazie. vol 71. issue 11. 2018-03-08. PMID:29441966. |
the results showed that a cell oxidative injury model was established by treating lo2 cells with 200 μmol/l h2o2 for 6 h. cells exposed to h2o2 resulted in a significant decrease of cell viability and increase of cell apoptosis, which was accompanied by increasing ros levels, disruption of mitochondrial membrane potential, excessive lipid peroxidation, reduction of sod activity, and increased levels of alt and ast. |
2018-03-08 |
2023-08-13 |
Not clear |
| Genling Yang, Li Zhang, Li Ma, Rong Jiang, Ge Kuang, Ke Li, Hongtao Tie, Bin Wang, Xinyu Chen, Tianjun Xie, Xia Gong, Jingyuan Wa. Glycyrrhetinic acid prevents acetaminophen-induced acute liver injury via the inhibition of CYP2E1 expression and HMGB1-TLR4 signal activation in mice. International immunopharmacology. vol 50. 2018-02-21. PMID:28668488. |
our results showed that pretreatment with ga significantly reduced serum alt and ast activities, alleviated hepatic pathological damages with hepatocellular apoptosis, down-regulated expression of cyp2e1 mrna and protein, increased gsh levels, and reduced reactive oxygen species (ros) productions in the liver of apap-exposed mice. |
2018-02-21 |
2023-08-13 |
mouse |
| Hang Lu, Xue-Feng Yang, Xiao-Qing Tian, Shou-Long Tang, Lian-Qian Li, Shuang Zhao, Hua-Chuan Zhen. The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) and MG132 on the aggressive phenotypes of gastric cancer cells. Oncotarget. vol 7. issue 35. 2018-02-20. PMID:27447743. |
saha and mg132 exposure suppressed tumor growth by inhibiting proliferation and inducing apoptosis in nude mice, increased serum alt and ast levels and decreased hemaglobin level, white blood cell and neutrophil numbers. |
2018-02-20 |
2023-08-13 |
mouse |
| Hou-Qin Zhou, Wei Liu, Jian Wang, Yin-Qiu Huang, Peng-Yan Li, Yun Zhu, Jia-Bo Wang, Xiao Ma, Rui-Sheng Li, Shi-Zhang Wei, Kun Li, Hao-Tian Li, Jian-Yu Li, Xiao-He Xiao, Yan-Ling Zha. Paeoniflorin attenuates ANIT-induced cholestasis by inhibiting apoptosis in vivo via mitochondria-dependent pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-14. PMID:28267673. |
experimental results indicated that pf pretreatment could attenuate liver damage and cholestasis by anit in rats, lift the biliary excretion in addition to decrease serum indices (alt, ast, dbil, tbil, tba, alp and ϒ-gt) and conspicuous neutrophil infiltration and cell apoptosis in liver evidenced by tunel staining. |
2018-02-14 |
2023-08-13 |
rat |
| Ching-Ping Chang, Yu-Fan Liu, Hung-Jung Lin, Chien-Chin Hsu, Bor-Chih Cheng, Wen-Pin Liu, Mao-Tsun Lin, Shu-Fen Hsu, Li-Sheng Chang, Kao-Chang Li. Beneficial Effect of Astragaloside on Alzheimer's Disease Condition Using Cultured Primary Cortical Cells Under β-amyloid Exposure. Molecular neurobiology. vol 53. issue 10. 2017-12-25. PMID:26696494. |
this study aimed to investigate whether astragalosides (ast) could inhibit aβ-induced apoptosis in vivo and in vitro and to explore the underlying mechanisms. |
2017-12-25 |
2023-08-13 |
Not clear |
| Poorigali Raghavendra-Rao Sowmya, Bangalore Prabhashankar Arathi, Kariyappa Vijay, Vallikannan Baskaran, Rangaswamy Lakshminarayan. Astaxanthin from shrimp efficiently modulates oxidative stress and allied cell death progression in MCF-7 cells treated synergistically with β-carotene and lutein from greens. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 106. issue Pt A. 2017-11-22. PMID:28511808. |
mcf-7 cells were treated with either of carotenoid (20 μm, ast or bc or l) separately or the mixture of them (an equimolar concentration of carotenoids mixture, cm) or saponified carotenoid extract from shrimp (ssce) for 48 h and analyzed cellular uptake, cytotoxicity, and apoptosis. |
2017-11-22 |
2023-08-13 |
Not clear |
| Zhu Meng, Mei-Yan Song, Chuan-Fang Li, Jia-Qi Zha. shRNA interference of NLRP3 inflammasome alleviate ischemia reperfusion-induced myocardial damage through autophagy activation. Biochemical and biophysical research communications. vol 494. issue 3-4. 2017-11-21. PMID:29069583. |
nlrp3 silence had nearly no impact on myocardial enzymes (ast, ldh and ck) expressions, inflammatory factors (tnf-α and il-1β) expressions and cell apoptosis in rats without i/r injury. |
2017-11-21 |
2023-08-13 |
rat |
| Xiaotong Lin, Yan Zhao, Shanhe L. Astaxanthin attenuates glutamate-induced apoptosis via inhibition of calcium influx and endoplasmic reticulum stress. European journal of pharmacology. vol 806. 2017-11-17. PMID:28400209. |
in this study, it was found that ast significantly inhibited glutamate-induced loss of cell viability and apoptosis. |
2017-11-17 |
2023-08-13 |
Not clear |
| Xiaotong Lin, Yan Zhao, Shanhe L. Astaxanthin attenuates glutamate-induced apoptosis via inhibition of calcium influx and endoplasmic reticulum stress. European journal of pharmacology. vol 806. 2017-11-17. PMID:28400209. |
furthermore, ast treatment greatly reduced the elevation of intracellular calcium level induced by glutamate and inhibited the activity of calpain, a calcium-dependent protease that plays an important role in mediating apoptosis stimulated by calcium overload in cytoplasm. |
2017-11-17 |
2023-08-13 |
Not clear |
| Xiaotong Lin, Yan Zhao, Shanhe L. Astaxanthin attenuates glutamate-induced apoptosis via inhibition of calcium influx and endoplasmic reticulum stress. European journal of pharmacology. vol 806. 2017-11-17. PMID:28400209. |
overall, these results suggested that ast might protect cells against glutamate-induced apoptosis through maintaining redox balance and inhibiting glutamate-induced calcium influx and er stress. |
2017-11-17 |
2023-08-13 |
Not clear |
| Chao Huang, Jia Wang, Zhuo Chen, Yuzhe Wang, Wei Zhan. 2-phenylethynesulfonamide Prevents Induction of Pro-inflammatory Factors and Attenuates LPS-induced Liver Injury by Targeting NHE1-Hsp70 Complex in Mice. PloS one. vol 8. issue 6. 2017-10-17. PMID:23805318. |
we found that i. pes prevented lps-induced increase in serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) activity, infiltration of inflammatory cells, and liver cell apoptosis; ii. |
2017-10-17 |
2023-08-12 |
mouse |
| Jessica P Otis, Amanda C Pike, Jose R Torrealba, Hannah V Care. Hibernation reduces cellular damage caused by warm hepatic ischemia-reperfusion in ground squirrels. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 187. issue 4. 2017-07-28. PMID:28144740. |
this model of liver ir successfully induced hepatocellular damage as indicated by increased plasma liver enzymes (alt, ast) and hepatocyte apoptosis index compared to sham in both seasons, with greater elevations in spring squirrels. |
2017-07-28 |
2023-08-13 |
human |