| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang-Yang Wu, Wang-Yang Wu, Hui-Ling Gong, Wei-Zu Li, Yan-Yan Yi. Astragalosides attenuate learning and memory impairment in rats following ischemia‑reperfusion injury. Molecular medicine reports. vol 9. issue 4. 2014-10-21. PMID:24567111. |
these findings indicated that ast has protective effects that may be correlated with the inhibition of neuronal cell apoptosis and the regulation of p‑erk, p‑akt and p‑jnk expression. |
2014-10-21 |
2023-08-12 |
rat |
| Hui Liu, Xiaolan Guo, Yi Chu, Shaoping L. Heart protective effects and mechanism of quercetin preconditioning on anti-myocardial ischemia reperfusion (IR) injuries in rats. Gene. vol 545. issue 1. 2014-08-27. PMID:24769323. |
the results showed that quercetin significantly reduced apoptosis rate, improved cardiac function, decreased levels of creatine kinase (ck), aspartate aminotransferase (ast) and lactate dehydrogenase (ldh). |
2014-08-27 |
2023-08-13 |
rat |
| Guanghao Ge, Qiong Zhang, Jiangwei Ma, Zengyong Qiao, Jianhua Huang, Wenbo Cheng, Hongwei Wan. Protective effect of Salvia miltiorrhiza aqueous extract on myocardium oxidative injury in ischemic-reperfusion rats. Gene. vol 546. issue 1. 2014-08-13. PMID:24831834. |
myocardial injuries during ir were determined by changes in electrocardiogram analysis of arrhythmias, antioxidant enzyme activities, ast, ck-mb, lactate dehydrogenase (ldh) levels, and myocyte apoptosis. |
2014-08-13 |
2023-08-13 |
rat |
| Guanghao Ge, Qiong Zhang, Jiangwei Ma, Zengyong Qiao, Jianhua Huang, Wenbo Cheng, Hongwei Wan. Protective effect of Salvia miltiorrhiza aqueous extract on myocardium oxidative injury in ischemic-reperfusion rats. Gene. vol 546. issue 1. 2014-08-13. PMID:24831834. |
results showed that s. miltiorrhiza aqueous extract (same) pre-treatment significantly decreased the st-segment (Σst120) and myocardium mda, ast, ck-mb, lactate dehydrogenase (ldh) levels, increased myocardium antioxidant enzyme activities, and inhibit myocardium cell apoptosis. |
2014-08-13 |
2023-08-13 |
rat |
| Dan Liu, Huan He, Dong Yin, Ailing Que, Lei Tang, Zhangping Liao, Qiren Huang, Ming H. Mechanism of chronic dietary iron overload-induced liver damage in mice. Molecular medicine reports. vol 7. issue 4. 2014-07-25. PMID:23404080. |
it has been demonstrated that when ferrocene-induced iron-overloaded mice were fed the cyclosporin a (csa), a specific inhibitor of the mptp, diet (10 mg/kg/day) for 50 days, liver-to-body weight ratio, serum levels of alanine transaminase (alt) and aspartate transaminase (ast), ros production, mitochondrial swelling, loss of mitochondrial membrane potential (Δψ) and hepatocyte apoptosis decreased. |
2014-07-25 |
2023-08-12 |
mouse |
| Jian Liu, Dicheng Yang, Sheng Shi, Lei Lin, Mingdi Xiao, Zhongxiang Yuan, Min Y. Overexpression of vasostatin-1 protects hypoxia/reoxygenation injuries in cardiomyocytes-endothelial cells transwell co-culture system. Cell biology international. vol 38. issue 1. 2014-07-24. PMID:23956006. |
the cardiomyocytes apoptosis rate, aspartate aminotransferase (ast) and creatine kinase isozyme mb (ck-mb) were recorded. |
2014-07-24 |
2023-08-12 |
rat |
| Jian Liu, Dicheng Yang, Sheng Shi, Lei Lin, Mingdi Xiao, Zhongxiang Yuan, Min Y. Overexpression of vasostatin-1 protects hypoxia/reoxygenation injuries in cardiomyocytes-endothelial cells transwell co-culture system. Cell biology international. vol 38. issue 1. 2014-07-24. PMID:23956006. |
as expected, cardiomyocytes apoptosis, ast and ck-mb were significantly increased in the t-ad-null group than in the c-ad-null group. |
2014-07-24 |
2023-08-12 |
rat |
| Jian Liu, Dicheng Yang, Sheng Shi, Lei Lin, Mingdi Xiao, Zhongxiang Yuan, Min Y. Overexpression of vasostatin-1 protects hypoxia/reoxygenation injuries in cardiomyocytes-endothelial cells transwell co-culture system. Cell biology international. vol 38. issue 1. 2014-07-24. PMID:23956006. |
however, apoptosis, ast and ck-mb levels were increased again after hb treatment, returning to the similar level of the c-ad-null group in the c-hb group, but still significantly lower in the t-hb group compared with the t-ad-null group. |
2014-07-24 |
2023-08-12 |
rat |
| Jian Liu, Dicheng Yang, Sheng Shi, Lei Lin, Mingdi Xiao, Zhongxiang Yuan, Min Y. Overexpression of vasostatin-1 protects hypoxia/reoxygenation injuries in cardiomyocytes-endothelial cells transwell co-culture system. Cell biology international. vol 38. issue 1. 2014-07-24. PMID:23956006. |
raec injury caused cardiomyocyte injury, and vs-1 transfection of the raec decreased apoptosis and the levels of ast and ck-mb. |
2014-07-24 |
2023-08-12 |
rat |
| Xiaodong Song, Meirong Wang, Lixia Zhang, Jinjin Zhang, Xiuwen Wang, Wenbo Liu, Xinbin Gu, Changjun L. Changes in cell ultrastructure and inhibition of JAK1/STAT3 signaling pathway in CBRH-7919 cells with astaxanthin. Toxicology mechanisms and methods. vol 22. issue 9. 2013-03-04. PMID:22889354. |
the results showed that ast could induce cancer cell apoptosis. |
2013-03-04 |
2023-08-12 |
rat |
| Xiaodong Song, Meirong Wang, Lixia Zhang, Jinjin Zhang, Xiuwen Wang, Wenbo Liu, Xinbin Gu, Changjun L. Changes in cell ultrastructure and inhibition of JAK1/STAT3 signaling pathway in CBRH-7919 cells with astaxanthin. Toxicology mechanisms and methods. vol 22. issue 9. 2013-03-04. PMID:22889354. |
overall, our findings demonstrate that ast could induce the apoptosis of cbrh-7919 cells, which are involved in cell ultrastructure and the jak1/stat3 signaling pathway. |
2013-03-04 |
2023-08-12 |
rat |
| Nazan Keskin, Ramazan Mammadov, Pinar Il. The effects of Crataegus aronia var. dentata Browicz extract on biochemical indices and apoptosis in partially hepatectomized liver in rats. Bosnian journal of basic medical sciences. vol 12. issue 3. 2013-01-25. PMID:22938545. |
dentata browicz extract can decrease the levels of serum alt and ast and play a role in apoptosis of hepatocytes in the liver of partially hepatectomized rats. |
2013-01-25 |
2023-08-12 |
rat |
| b' Igor Kova\\xc4\\x8devi\\xc4\\x87, Aleksandra Radosavljevi\\xc4\\x87, Bojan Kalezi\\xc4\\x87, Jelena Poti\\xc4\\x87, Goran Damjanovi\\xc4\\x87, Ivan Stefanovi\\xc4\\x8. Persistent submacular fluid diagnosed with optical coherence tomography after successful scleral buckle surgery for macula-off retinal detachment. Bosnian journal of basic medical sciences. vol 12. issue 3. 2013-01-25. PMID:22938546.' |
dentata browicz extract can decrease the levels of serum alt and ast and play a role in apoptosis of hepatocytes in the liver of partially hepatectomized rats. |
2013-01-25 |
2023-08-12 |
rat |
| Renan Qin, Jianyu Zhang, Chuyuan Li, Xiaoqi Zhang, Aihua Xiong, Feng Huang, Zhen Yin, Kongyan Li, Wenyu Qin, Mingzhen Chen, Shubing Zhang, Lingyi Liang, Huiye Zhang, Hong Nie, Wencai Y. Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats. Archives of pharmacal research. vol 35. issue 7. 2012-12-18. PMID:22864747. |
compared with model group, levels of serum triglyceride (tg), total cholesterol (tc), free fatty acid (ffa), and low density lipoprotein cholesterol (ldl-c) level, malondialdehyde (mda), serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) activity, and hepatocyte apoptosis were significantly decreased in gypenosides groups; while serum high density lipoprotein cholesterol (hdl-c), superoxide dismutase (sod) activity in both serum and hepatic tissue and mrna and protein level of peroxisome proliferator-activated receptor α (ppar-α) were significantly increased. |
2012-12-18 |
2023-08-12 |
rat |
| Jeremy Bechelli, Myra Coppage, Karen Rosell, Jane Liesvel. Cytotoxicity of algae extracts on normal and malignant cells. Leukemia research and treatment. vol 2011. 2012-12-06. PMID:23213541. |
primary cll cells showed apoptosis at 24 hours after exposure to dun, ast, spir, and afa. |
2012-12-06 |
2023-08-12 |
Not clear |
| Xiaoming Zhao, Xiaonan Cong, Lingli Zheng, Lina Xu, Lianhong Yin, Jinyong Pen. Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo. Toxicology letters. vol 214. issue 1. 2012-11-27. PMID:22939915. |
dioscin improved ast release, mitochondrial dysfunction, apoptosis and necrosis of hepg2 cells induced by apap. |
2012-11-27 |
2023-08-12 |
mouse |
| Kenji Wakayama, Moto Fukai, Kenichiro Yamashita, Taichi Kimura, Gentaro Hirokata, Susumu Shibasaki, Daisuke Fukumori, Sanae Haga, Mitsuru Sugawara, Tomomi Suzuki, Masahiko Taniguchi, Tsuyoshi Shimamura, Hiroyuki Furukawa, Michitaka Ozaki, Toshiya Kamiyama, Satoru Tod. Successful transplantation of rat hearts subjected to extended cold preservation with a novel preservation solution. Transplant international : official journal of the European Society for Organ Transplantation. vol 25. issue 6. 2012-09-19. PMID:22471391. |
dsol diminished graft injury significantly, as revealed by the lower levels of infarction, apoptosis, serum ldh and ast release, and graft fibrosis at 7-day. |
2012-09-19 |
2023-08-12 |
rat |
| X-M Ding, Ke-Ying Zhang, L Wang, S-P Ba. Toxicity of melamine and cyanuric acid in broilers and residues in tissues. Human & experimental toxicology. vol 31. issue 2. 2012-07-24. PMID:22027504. |
on day 21, the uric acid (ua) content of group iv was increased in serum (p < 0.05); on day 42, the serum aspartate aminotransferase (ast) activity and the level of tumor necrosis factor (tnf)-α and interleukin (il)-8 increased in group iv (p < 0.05); 100 mg/kg mel alone increased the level of tnf-α and the rate of renal apoptosis (p < 0.05); and 33.3 mg/kg cya alone increased the level of il-8 and the rate of renal apoptosis (p < 0.05). |
2012-07-24 |
2023-08-12 |
Not clear |
| Shuang Zhang, Hong Li, Hui Xu, Shi-Jie Yan. [Effect of gross saponins of Tribulus terrestris on cardiocytes impaired by adriamycin]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 45. issue 1. 2012-02-23. PMID:21351446. |
mtt colorimetric method was deployed to detect cardiocyte survival rate, activities of ck, ldh, ast, sod, mda and no were detected, and apoptosis was detected with flow cytometry. |
2012-02-23 |
2023-08-12 |
rat |
| Kuo-Hsin Chen, Bor-Ru Lin, Chiang-Ting Chien, Chien-Hsin H. Emblica officinalis Gaertn. attentuates N-nitrosodiethylamine-induced apoptosis, autophagy, and inflammation in rat livers. Journal of medicinal food. vol 14. issue 7-8. 2011-10-21. PMID:21761987. |
we elucidated the effects of supplementary amla (100 mg/kg of body weight) on n-nitrosodiethylamine-induced injury by evaluating reactive oxygen species (ros) responses in the liver and bile, the degree of accumulated leukocytes and kupffer cell infiltration, 3-nitrotyrosine and 4-hydroxynonenal stains, apoptosis and autophagy, plasma aspartate aminotransferase (ast), alanine aminotransferase (alt), and γ-glutamyl transpeptidase (γ-gt) levels, and antioxidant/oxidant enzymes in rats. |
2011-10-21 |
2023-08-12 |
rat |