| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kuo-Hsin Chen, Bor-Ru Lin, Chiang-Ting Chien, Chien-Hsin H. Emblica officinalis Gaertn. attentuates N-nitrosodiethylamine-induced apoptosis, autophagy, and inflammation in rat livers. Journal of medicinal food. vol 14. issue 7-8. 2011-10-21. PMID:21761987. |
n-nitrosodiethylamine increased ros production in liver and bile, hepatic kupffer cell and leukocyte infiltration, 3-nitrotyrosine and 4-hydroxynonenal accumulations, apoptosis and autophagy, and plasma alt, ast, and γ-gt levels in the rats, decreased hepatic manganese superoxide dismutase (mnsod) and catalase protein expressions, and enhanced inducible nitric oxide synthase (inos) and cytochrome p450 2e1 (cyp2e1) protein expressions. |
2011-10-21 |
2023-08-12 |
rat |
| Jie Ma, Ying Cao, Jian-Li Hu, Hui Sun, Lin-Xiang Liu, Chun-Hua Zha. [Therapeutic efficacy of bone marrow-derived mesenchymal stem cells infused into mice with liver injury induced by concanavalin A]. Zhongguo shi yan xue ye xue za zhi. vol 17. issue 5. 2011-09-08. PMID:19840469. |
the results indicated that msc transplantation significantly reduced cona-induced acute liver injury, including the decrease of the level of serum alanine aminotransferase (alt), serum aspartate aminotransferase (ast) and the extenuation of liver necrosis and in situ apoptosis. |
2011-09-08 |
2023-08-12 |
mouse |
| Dhermendra K Tiwari, Takashi Jin, Jitendra Behar. Bio-distribution and toxicity assessment of intravenously injected anti-HER2 antibody conjugated CdSe/ZnS quantum dots in Wistar rats. International journal of nanomedicine. vol 6. 2011-08-24. PMID:21499435. |
for toxicity evaluation of injected qds sample, body weight, organ coefficient, complete blood count (cbc), biochemistry panel assay (ast, alt, alp, and ggtp), comet assay, reactive oxygen species, histology, and apoptosis were determined. |
2011-08-24 |
2023-08-12 |
rat |
| Jui-Chih Chang, Shou-Jen Kou, Wei-Ting Lin, Chin-San Li. Regulatory role of mitochondria in oxidative stress and atherosclerosis. World journal of cardiology. vol 2. issue 6. 2011-07-14. PMID:21160733. |
in this review, the first section discusses the possible association between ast-inducing factors and the molecular regulatory mechanisms of mitochondrial biogenesis and dynamics, and explains the role of mitochondria-dependent regulation in cell apoptosis during ast development. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ponnuraj Nagendraprabhu, Ganapasam Sudhandira. Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. Investigational new drugs. vol 29. issue 2. 2011-05-27. PMID:19876598. |
the ability of ast to induce apoptosis in the colon of dmh-induced rats was confirmed by annexin-v/pi staining in a confocal microscopy, dna fragmentation analysis and expression of caspase-3 by western blotting. |
2011-05-27 |
2023-08-12 |
rat |
| Dae-Hee Lee, Cuk-Seong Kim, Yong J Le. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 1. 2011-05-05. PMID:21056612. |
we have investigated the role of ast in preventing 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced apoptosis of the substantia nigra (sn) neurons in the mouse model of parkinson's disease (pd) and 1-methyl-4-phenylpyridinium (mpp+)-induced cytotoxicity of sh-sy5y human neuroblastoma cells. |
2011-05-05 |
2023-08-12 |
mouse |
| Dae-Hee Lee, Cuk-Seong Kim, Yong J Le. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 1. 2011-05-05. PMID:21056612. |
our results suggest that the protective effects of ast on mpp+-induced apoptosis may be due to its anti-oxidative properties and anti-apoptotic activity via induction of expression of superoxide dismutase (sod) and catalase and regulating the expression of bcl-2 and bax. |
2011-05-05 |
2023-08-12 |
mouse |
| Dae-Hee Lee, Cuk-Seong Kim, Yong J Le. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 1. 2011-05-05. PMID:21056612. |
in summary, ast shows protection from mpp+/mptp-induced apoptosis in the sh-sy5y cells and pd model mouse sn neurons, and this effect may be attributable to upregulation of the expression of bcl-2 protein, downregulation of the expression of bax and α-synuclein, and inhibition of the activation of caspase-3. |
2011-05-05 |
2023-08-12 |
mouse |
| Ya-Peng Lu, Si-Yuan Liu, Hua Sun, Xiao-Mei Wu, Jie-Jia Li, Li Zh. Neuroprotective effect of astaxanthin on H(2)O(2)-induced neurotoxicity in vitro and on focal cerebral ischemia in vivo. Brain research. vol 1360. 2011-02-03. PMID:20846510. |
500nm ast pretreatment significantly inhibited h(2)o(2)-induced apoptosis measured by hoechst 33342 staining and restored the mitochondrial membrane potential (mmp) measured by a fluorescent dye, rhodamine 123. |
2011-02-03 |
2023-08-12 |
rat |
| Guiying Li, Chang Han, Lihong Xu, Kyu Lim, Kumiko Isse, Tong W. Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor. Hepatology (Baltimore, Md.). vol 50. issue 3. 2009-09-18. PMID:19585617. |
the cox-2 tg mice showed resistance to fas-induced liver injury in comparison with the wild-type mice; this was reflected by the lower alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels, less liver damage, and less hepatocyte apoptosis (p < 0.01). |
2009-09-18 |
2023-08-12 |
mouse |
| Guiying Li, Chang Han, Lihong Xu, Kyu Lim, Kumiko Isse, Tong W. Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor. Hepatology (Baltimore, Md.). vol 50. issue 3. 2009-09-18. PMID:19585617. |
in contrast, the cox-2 ko mice showed significantly higher serum alt and ast levels, more prominent hepatocyte apoptosis, and higher levels of caspase-8, caspase-9, and caspase-3 activity than the wild-type mice (p < 0.01). |
2009-09-18 |
2023-08-12 |
mouse |
| Kathy K W Auyeung, Chi-Hin Cho, Joshua K S K. A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene. International journal of cancer. vol 125. issue 5. 2009-08-25. PMID:19384947. |
ast caused overexpression of nag-1, leading to parp cleavage and apoptosis. |
2009-08-25 |
2023-08-12 |
human |
| Kathy Ka-wai Auyeung, Pui-ching Law, Joshua Ka-shun K. Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. International journal of molecular medicine. vol 23. issue 2. 2009-04-20. PMID:19148542. |
we demonstrated here that ast downregulated expression of the hcc tumor marker alpha-fetoprotein and suppressed hepg2 cell growth by inducing apoptosis. |
2009-04-20 |
2023-08-12 |
human |
| Kathy Ka-wai Auyeung, Pui-ching Law, Joshua Ka-shun K. Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. International journal of molecular medicine. vol 23. issue 2. 2009-04-20. PMID:19148542. |
taken together, these results exemplify that ast induced growth inhibition and promoted apoptosis in hepg2 cells through modulation of an erk-independent nf-kappab signaling pathway. |
2009-04-20 |
2023-08-12 |
human |
| T J Miller, A Knapton, O Adeyemo, L Noory, J Weaver, J P Hani. Cytochrome c: a non-invasive biomarker of drug-induced liver injury. Journal of applied toxicology : JAT. vol 28. issue 7. 2008-11-13. PMID:18418843. |
adult sprague-dawley rats treated with acetaminophen or d-galactosamine (galn) showed dose- and time-dependent histomorphological changes and tunel staining in liver consistent with hepatocellular necrosis, apoptosis and inflammation up to 72 h. matching changes in serum alanine transaminase (alt), aspartate transaminase (ast) and cyt c peaked at 24 h for either drug at the highest dose, cyt c falling rapidly at 48 hours with alt and ast remained high. |
2008-11-13 |
2023-08-12 |
human |
| Vladimir Lesnikov, Nicholas Gorden, Nelson Fausto, Emily Spaulding, Jean Campbell, Howard Shulman, Robert E Fleming, H Joachim Dee. Transferrin fails to provide protection against Fas-induced hepatic injury in mice with deletion of functional transferrin-receptor type 2. Apoptosis : an international journal on programmed cell death. vol 13. issue 8. 2008-09-17. PMID:18561026. |
here we show in c57bl6j/129 mice with genetic inactivation of transferrin receptor 2 (tfr2(y245x)), that fas-induced hepatotoxicity (apoptosis; rise in plasma aspartate aminotransferase (ast) levels) was comparable to that in wild-type mice, but was not modified by pretreatment with tf. |
2008-09-17 |
2023-08-12 |
mouse |
| Agni D Grypioti, Georgia Kostopanagiotou, Constantinos A Demopoulos, Anastasios Roussos, Michael Mykoniati. Platelet activating factor (PAF) antagonism with ginkgolide B protects the liver against acute injury. importance of controlling the receptor of PAF. Digestive diseases and sciences. vol 53. issue 4. 2008-06-03. PMID:17934819. |
apap was found to cause an acute hepatic injury, evident by alterations of biochemical (serum enzymes: alt, ast and alp) and liver histopathological (degree of inflammation and apoptosis) indices, which was followed by liver regeneration evident by three independent indices ([3h] thymidine incorporation into hepatic dna, liver thymidine kinase activity and hepatocyte mitotic index). |
2008-06-03 |
2023-08-12 |
rat |
| A D Grypioti, G Kostopanagiotou, M Mykoniati. Platelet-activating factor inactivator (rPAF-AH) enhances liver's recovery after paracetamol intoxication. Digestive diseases and sciences. vol 52. issue 10. 2007-10-25. PMID:17410443. |
apap was found to cause acute hepatic injury, evident by alterations of biochemical (serum enzymes: alt, ast, and alp) and liver histopathological (degree of inflammation and apoptosis) indexes, which was followed by liver regeneration evident by three independent indexes ([(3)h]thymidine incorporation into hepatic dna, liver thymidine kinase activity, and hepatocyte mitotic index). |
2007-10-25 |
2023-08-12 |
rat |
| Jason S Soden, Michael W Devereaux, Joel E Haas, Eric Gumpricht, Rolf Dahl, Jane Gralla, Maret G Traber, Ronald J Soko. Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis. Hepatology (Baltimore, Md.). vol 46. issue 2. 2007-08-30. PMID:17659596. |
bile acid-induced injury (serum ast and alt and liver histology) was more severe in the obese rats than in the lean rats, characterized predominantly by extensive cell necrosis with minimal evidence of apoptosis. |
2007-08-30 |
2023-08-12 |
rat |
| Mandy M Y Tin, Chi-Hin Cho, Kelvin Chan, Anthony E James, Joshua K S K. Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft. Carcinogenesis. vol 28. issue 6. 2007-08-07. PMID:17148504. |
besides, ast promotes apoptosis in ht-29 cells through caspase 3 activation and poly(adp-ribose) polymerase cleavage, which is indicated by dna fragmentation and nuclear chromatin condensation. |
2007-08-07 |
2023-08-12 |
mouse |