| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo-Yi Zhang, Gen-Lin He, Ze-Ze Wang, Huan Zhou, Xue-Yan Huang, Ting-Ting Shen, Xiao-Qian Liu, Yi-Shan Liu, Zhen Luo, Ping Li, Yu-Long Tan, Xue Luo, Xue-Sen Yan. L-carnitine ameliorates myocardial injury by alleviating endoplasmic reticulum stress via inhibition of PERK pathway in exertional heatstroke rats. Heliyon. vol 10. issue 22. 2024-12-06. PMID:39641050. |
here, we found that lc exerted a greater protective effect on ehs-induced cardiac dysfunction and mortality, which also significantly attenuated certain negative effects, including increased myocardial apoptosis, pathological changes, and ultrastructural impairment, enhanced activity levels of such serum enzymes as ast, ldh, ck, and ck-mb, reduced bcl-2 expression, increased the expression of cleaved caspase-3 and the critical endoplasmic reticulum stress (ers) indices like chop and grp78 in ehs rats. |
2024-12-06 |
2024-12-08 |
rat |
| Tianyu Liu, Ling Li, Yanchao Yang, Jiarou Li, Xutong Yang, Lei Li, Ziyao Zheng, Boyu Yang, Peiyu Zhang, Haiyan Li. Effects of chronic cold stress and thermal stress on growth performance, hepatic apoptosis, oxidative stress, immune response and gut microbiota of juvenile hybrid sturgeon (Acipenser baerii ♀ × A. schrenkii ♂). Fish & shellfish immunology. 2024-12-06. PMID:39642947. |
interestingly, cold stress increased hepatocyte apoptosis revealed by tunel staining, along with nuclear disappearance in h&e-stained sections and elevated serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels. |
2024-12-06 |
2024-12-10 |
Not clear |
| Fei Wang, Xiang Li, Qi Wang, Qian Jin, Shujie Xu, Li Tang, Zihan Zeng, Aikun Fu, Jinhui Zhu, Qiao Zhang, Rongchang Yang, Yingping Xiao, Weifen L. Screening of Lactic Acid Bacteria Strains from Chinese Fermented Food (Suanshui) and its Protective Effect on Acute Liver Injury in Mice. Probiotics and antimicrobial proteins. 2024-12-02. PMID:39621210. |
in vivo experiments, lab36 pretreatment significantly decreased the levels of alt, ast, and inflammatory factors (il-1β and il-6) in the serum, improved the antioxidant capacity, and reduced apoptosis in the livers of the model mice (liver injury induced by d-galn/lps). |
2024-12-02 |
2024-12-06 |
mouse |
| Zeping Luo, Liwei Pa. Synthesis of Formononetin Derivatives and Cardioprotective Effects. Chemical & pharmaceutical bulletin. vol 72. issue 11. 2024-11-17. PMID:39551522. |
further mechanistic investigations revealed that c4 could mitigate apoptosis rates, reduce the activity of myocardial enzyme (such as aspartate aminotransferase (ast), lactate dehydrogenase (ldh), and ck), diminish the number of autophagic vesicles, and restore excessive autophagy. |
2024-11-17 |
2024-11-22 |
Not clear |
| Wenyue Qiu, Wenxin Jiang, Yiman Su, Hui Huang, Jiali Ye, Rongmei Wang, Zhaoxin Tang, Rongsheng S. Asiatic Acid Alleviates LPS-Induced Pyroptosis and Endoplasmic Reticulum Stress-Mediated Apoptosis via Inhibiting the HMGB1/TLR4/NF-κB Pathway in Broiler Hepatocytes. Journal of animal physiology and animal nutrition. 2024-11-15. PMID:39543935. |
our results founded that intraperitoneal injection of lps in broilers increased the activities of ast and alt, as well as raising the related gene and protein expression of the hmgb1/tlr4/nf-κb pathway, pyroptosis, and ers-mediated apoptosis. |
2024-11-15 |
2024-11-17 |
Not clear |
| Fu Han Wang, Eskandar Qaed, Waleed Aldahmash, Mueataz A Mahyoub, Zhongyuan Tang, Peng Chu, Ze Yao Tan. Phosphocreatine ameliorates hepatocellular apoptosis mediated by protecting mitochondrial damage in liver ischemia/reperfusion injury through inhibiting TLR4 and Agonizing Akt Pathway. Tissue & cell. vol 91. 2024-11-01. PMID:39486133. |
importantly, pcr exerted its protective effects by downregulating tlr4 and activating the akt signaling pathway, which suppressed inflammation, mitigated oxidative stress, inhibited apoptosis, and modulated key biomarkers, including alt, ast, il-6, il-1β, tnf-α, sod, mda, and reactive oxygen species (ros). |
2024-11-01 |
2024-11-05 |
mouse |
| Yuexiao Sun, Yang Zhou, Dongli Xie, Xuejiao Wang, Ya Wang, Yunxia Liang, Xiaogang Lu. Preclinical Evaluation of Protective Effects of Terpenoids Against Nanomaterial-Induced Toxicity: A Meta-Analysis. Journal of applied toxicology : JAT. 2024-10-30. PMID:39477689. |
the meta-analysis by stata 15.0 showed that terpenoid supplementation significantly improved cell viability and altered oxidative stress (decreased ros, no, mda, and toc and increased sod, cat, gpx, gsh, gsh-px, and tac)-, inflammation (decreased il-6, il-1β, tnf-α, nf-κb, monocytes, and increased il-10)-, apoptosis (reduced bax, caspase-3, caspase-9, p53, and elevated bcl-2)-, genotoxic (reduced tail length, % tail dna, tail moment, dna fragmentation, chromosomal aberration, and mnpces)-, liver function (reduced alt, ast, and alp)-, renal function (reduced creatinine, urea, and uric acid)-, reproductive function (increased sperm count, testosterone, johnsen's score, and number of progeny)-, lipid profile (lower cholesterol, tg, ldl, and higher hdl)-, and carcinogenesis (downregulated afp and cea)-related biomarkers induced by nanomaterials. |
2024-10-30 |
2024-11-02 |
cat |
| Ge Zhao, Hu Qi, Minghua Liu, Ting Zhou, Li Chen, Chunhong Wu, Xiongwei Zhang, Nan Zeng, Yue Ton. Rhoifolin Attenuates Concanavalin A-Induced Autoimmune Hepatitis in Mice via JAKs/STATs Mediated Immune and Apoptotic Processes. ACS omega. vol 9. issue 42. 2024-10-28. PMID:39464476. |
the results showed that rof significantly decreased serum biochemical indices (alt, ast, alp, and ldh) and regulated related oxidative stress indicators (mda, sod, and gsh), reduced hepatic necrosis areas and immune cells infiltration, inhibited the release of various inflammatory factors (tnf-α, ifn-γ, il-2, and il-17), and improved hepatic tissue apoptosis, thereby alleviating hepatic damage induced by con a. additionally, we have also confirmed that rof efficiently inhibited th1/th17 cells polarization via modulation of the jak2/jak3/stat1/stat3 signaling pathways both |
2024-10-28 |
2024-10-30 |
mouse |
| Mustafa Cengiz, Bahri Gür, Fatma Gür, Varol Şahintürk, Alpaslan Bayrakdar, Ilknur Kulcanay Şahin, Sıla Appak Başkoy, Namık Bilici, Suzan Onur, Yağmur Kaya, İsa Kıran, Özge Yıldırım, Nur Banu Akkaya, Canan Vejselova Sezer, Adnan Ayhanc. The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats. Heliyon. vol 10. issue 19. 2024-10-17. PMID:39416834. |
administration of cp leads to an increase in the levels of apoptotic markers (bax, caspase-3), the apoptotic signaling pathway (nrf2), oxidative stress indicators (tos, osi), lipid peroxidation markers (mpo, mda), inflammation levels (nf-kb, tnf-α, il-1β, il -6), liver function markers (alt, ast, alp), while apoptosis markers (bcl-2), apoptosis pathway (keap-1), oxidative stress indicator (tas), inflammation (il -10) and intracellular antioxidant defense system (sod, cat, gpx and gsh) decreased. |
2024-10-17 |
2024-10-19 |
rat |
| Qian Yang, Qi-Ming Zhong, Mei-Qing Song, Li-Guo Tong, Chong-Zhi Ba. Exosomes derived from Danshen decoction-pretreated bone marrow mesenchymal stem cells alleviate myocardial infarction via anti-apoptosis and up-regulation of autophagy. Heliyon. vol 10. issue 18. 2024-09-30. PMID:39347388. |
on the 7th, 14th and 28th days, serum ck, ldh, α-hbdh, alt, and ast were measured and electrocardiogram changes were monitored to identify cardiac function; triphenyltetrazolium chloride staining, hematein&eosin staining, masson trichrome staining and transmission electron microscope were adopted to analyze infarct area, cardiac morphology, histopathology, and fibrosis and cardiomyocyte ultrastructure; tunel assay, real-time pcr and western blot were performed to detect cardiomyocyte apoptosis and autophagy. |
2024-09-30 |
2024-10-02 |
rat |
| Alireza Shahmohammadi, Seyed-Mohamad-Sadegh Mirahmadi, Ali-Mohammad Rousta, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Protective effect of sinomenine against CCl4-induced acute liver injury through regulation of mitochondrial biogenesis. Naunyn-Schmiedeberg's archives of pharmacology. 2024-09-16. PMID:39283527. |
sinomenine pretreatment significantly lowered alt and ast, mda, il-6, apoptosis intensity, and tnf-α and restored mitochondrial biogenesis besides enhancement of sod, sirtuin-1, and ampk. |
2024-09-16 |
2024-09-19 |
Not clear |
| Hussam A Bukhari, Muhammad Afzal, Fahad A Al-Abbasi, Ryan A Sheikh, May M Alqurashi, Azizah Salim Bawadood, Sami I Alzarea, Abdulaziz Alamri, Nadeem Sayyed, Imran Kazm. In vivo and computational investigation of butin against alloxan-induced diabetes via biochemical, histopathological, and molecular interactions. Scientific reports. vol 14. issue 1. 2024-09-04. PMID:39232184. |
various diabetic parameters (blood glucose, insulin, hba1c), lipid profile, inflammatory (tnf-α, il-1β, il-6 and nf-κb), antioxidant enzymes (cat, sod and gsh), oxidative stress indicators (mda), apoptosis marker (caspase-3), hepatic markers (alt and ast), and histopathological changes were assessed. |
2024-09-04 |
2024-09-08 |
human |
| Xu Xiaomin, Lu Fang, Wang Yu, Liu Shumi. Investigation on the mechanism of hepatotoxicity of dictamnine on juvenile zebrafish by integrating metabolomics and transcriptomics. Gene. 2024-08-18. PMID:39154970. |
the results showed that the liver function indexes such as alt and ast were affected after the exposure treatment with dictamnine, and the hepatic damage, lipid droplet formation, and increased apoptosis were observed in zebrafish by he, oil red o(oro), and acridine orange hydrochloride(ao)staining. |
2024-08-18 |
2024-08-21 |
zebrafish |
| Xuan Shen, Wenxing Zheng, Xinna Du, Yuping Chen, Xianping Song, Liucai Yang, Qi Yua. The role of C5aR1-mediated hepatic macrophage efferocytosis in NASH. Scientific reports. vol 14. issue 1. 2024-07-26. PMID:39060563. |
in vivo and in vitro experiments revealed that knocking down c5ar1 in liver significantly reduced liver weight ratio and serum alt and ast levels and attenuated inflammatory cell infiltration and cell apoptosis in the liver of nash mice as well as enhanced the efferocytotic ability of liver macrophages, suggesting that c5ar1 may play a crucial role in the efferocytosis of liver macrophages. |
2024-07-26 |
2024-07-29 |
mouse |
| Zhenkun Xiong, Zhenhua Li, Xueqin Sima, Zhi Zen. Astaxanthin reduces TBPH-induced neurobehavioral deficits in mice by the ROS-ERK1/2-FOS pathway. Ecotoxicology and environmental safety. vol 281. 2024-07-04. PMID:38964056. |
ast, through its antioxidant action, was able to significantly reduce the increase in reactive oxygen species (ros) levels induced by tbph, the increased expression of apoptosis markers, and the activation of the erk1/2-fos signaling pathway, alleviating tbph-induced apoptosis in hippocampal neurons and improving neurobehavioral outcomes. |
2024-07-04 |
2024-07-11 |
mouse |
| Zhenkun Xiong, Zhenhua Li, Xueqin Sima, Zhi Zen. Astaxanthin reduces TBPH-induced neurobehavioral deficits in mice by the ROS-ERK1/2-FOS pathway. Ecotoxicology and environmental safety. vol 281. 2024-07-04. PMID:38964056. |
these findings suggest that ast may alleviate the neurotoxicity of tbph by modulating molecular events related to apoptosis and the erk1/2-fos signaling pathway. |
2024-07-04 |
2024-07-11 |
mouse |
| Hadis Elyasi, Masoud Ghanbari, Farshad Nadr. Investigation of the Adverse Health Effects of Cell Phone Radiation and Propose Solutions to Minimize Them: A Systematic Review. Indian journal of occupational and environmental medicine. vol 28. issue 1. 2024-05-24. PMID:38783888. |
the result revealed that exposure to cell phone radiation can lead to disturb in the metabolic activity of the cerebellum by increasing the migration of granulosa cells, decrease the water around the fetus in pregnant women, decrease in the number of blood plates, increasing levels of alt and ast that they are the key biomarkers of liver damage, decrease of phagocytosis and induced apoptosis of neutrophils, changes at the level of glucose and even at the microscopic level of pancreas this may be a predisposing factor for diabetes, increment in tissue temperature in all depth of the brain tissue, emf increase the volume, weight, and atresia follicles of the ovaries of the children, also it can cause oxidative stress, dna fragmentation, etc. |
2024-05-24 |
2024-05-27 |
Not clear |
| Xiao Zhang, Silong Yuan, Hui Fan, Wei Zhang, Honggang Zhan. Liensinine alleviates sepsis-induced acute liver injury by inhibiting the NF-κB and MAPK pathways in an Nrf2-dependent manner. Chemico-biological interactions. 2024-05-01. PMID:38692452. |
the results suggested that lie could decrease ast and alt levels in serum, ameliorate histopathological changes and inhibit cell apoptosis in mice with lps-induced septic liver injury. |
2024-05-01 |
2024-05-04 |
mouse |
| Zhi Qin, Min Zho. [Tanshinone Ⅱ_A inhibits ferroptosis via Nrf2 signaling pathway to protect liver in rats of non-alcoholic fatty liver disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 6. 2024-04-15. PMID:38621946. |
the result showed that tsⅡ_a significantly reduced the content of mda, ast, alt, tc, and tg in the serum, increased the activity of sod, decreased the apoptosis rate, lipid deposition, ros, and iron deposition in the liver tissue, up-regulated the expression of nrf2, ho-1, fsp1, gpx, and bcl-2, and inhibited the expression of bax in the liver tissue of nafld rats. |
2024-04-15 |
2024-04-18 |
rat |
| Qiwen Yu, Jiye Li, Mengwei Cui, Chaopeng Mei, Qianqian He, Xiaoxiao D. 6-Gingerol attenuates hepatic ischemia/reperfusion injury through regulating MKP5-mediated P38/JNK pathway. Scientific reports. vol 14. issue 1. 2024-04-02. PMID:38565569. |
the results show that 6-gingerol decreased serum alanine aminotransferase (alt), aspartate aminotransferase (ast) levels, liver necrosis, inflammatory cytokines il-1β, il-6, mcp-1, tnf-α expression, ly6g+ inflammatory cell infiltration, protein phosphorylation of nf-κb signaling pathway, terminal deoxynucleotidyl transferase dutp nick-end labeling (tunel) positive cells, cell apoptosis rate, the protein expression of pro-apoptotic protein bax and c-caspase3, increased cell viability, and expression of anti-apoptotic protein bcl-2. |
2024-04-02 |
2024-04-05 |
mouse |