| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi-Liang Wang, Ying Zhang, Da-Sheng Ca. Hepatoprotective effects of sevoflurane against hepatic ischemia-reperfusion injury by regulating microRNA-124-3p-mediated TRAF3/CREB axis. Cell death discovery. vol 8. issue 1. 2022-03-09. PMID:35260558. |
in addition, mir-124-3p, traf3 and creb expression in hepatocytes was altered to identify their roles in modulating the levels of glutathione transferase (gst), aspartate aminotransferase (ast) and alanine aminotransferase (alt), and inflammation-related factors and hepatocyte apoptosis by elisa and flow cytometry respectively. |
2022-03-09 |
2023-08-13 |
mouse |
| Yi-Liang Wang, Ying Zhang, Da-Sheng Ca. Hepatoprotective effects of sevoflurane against hepatic ischemia-reperfusion injury by regulating microRNA-124-3p-mediated TRAF3/CREB axis. Cell death discovery. vol 8. issue 1. 2022-03-09. PMID:35260558. |
moreover, sev was observed to suppress i/r-induced liver damage, gst, alt, and ast levels, hepatocyte apoptosis and inflammation. |
2022-03-09 |
2023-08-13 |
mouse |
| Yi-Liang Wang, Ying Zhang, Da-Sheng Ca. Hepatoprotective effects of sevoflurane against hepatic ischemia-reperfusion injury by regulating microRNA-124-3p-mediated TRAF3/CREB axis. Cell death discovery. vol 8. issue 1. 2022-03-09. PMID:35260558. |
sev could impede i/r-induced liver damage, gst, alt, and ast levels, hepatocyte apoptosis and inflammation via mediation of the mir-124-3p/traf3/creb axis in vitro and in vivo. |
2022-03-09 |
2023-08-13 |
mouse |
| Yu-Ling Wang, Chung-Ching Chio, Shu-Chun Kuo, Chao-Hung Yeh, Jui-Ti Ma, Wen-Pin Liu, Mao-Tsun Lin, Kao-Chang Lin, Ching-Ping Chan. Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction. Molecular neurobiology. 2022-03-09. PMID:35262870. |
in vitro studies also confirmed that topical application of bdnf and/or ast reversed the aβ-induced cytotoxicity, apoptosis, mitochondrial distress, and synaptotoxicity and decreased expression of p-trkb, p-akt, p-gsk3β, and β-catenin in rat cortical neurons. |
2022-03-09 |
2023-08-13 |
rat |
| Xiang-Fen Ji, Yu-Chen Fan, Fei Sun, Jing-Wei Wang, Kai Wan. Noncanonical Wnt5a/JNK Signaling Contributes to the Development of D-Gal/LPS-Induced Acute Liver Failure. Inflammation. 2022-01-31. PMID:35098406. |
box5 pretreatment reversed jnk activation and eventually decreased the mortality rate of d-gal/lps-treated mice, with reduced hepatic necrosis and apoptosis, serum alt and ast levels, and liver inflammatory cytokine expression, although the latter was not significant. |
2022-01-31 |
2023-08-13 |
mouse |
| Mohamed E Shaker, Omnia M Hendawy, Mohamed El-Mesery, Sara H Haze. The JAK inhibitor ruxolitinib abrogates immune hepatitis instigated by concanavalin A in mice. International immunopharmacology. vol 103. 2021-12-24. PMID:34952468. |
the results showed that rxb pretreatments were efficient in abrogating con a-instigated hepatocellular injury (alt, ast, ldh), necrosis (histopathology), apoptosis (cleaved caspase-3) and nuclear proliferation due to damage (pcna). |
2021-12-24 |
2023-08-13 |
mouse |
| V S B Wies Mancini, A A Di Pietro, S de Olmos, P R Silva, M Vence, M Marder, L M Igaz, M S Marcora, J M Pasquini, J D Correale, L A Pasquin. Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model. Journal of neurochemistry. 2021-12-22. PMID:34935149. |
the progressive form of ms can be modelled by the prolonged administration to cuprizone (cpz) in adult mice, as cpz induces highly reproducible demyelination of different brain regions through oligodendrocyte (olg) apoptosis, accompanied by mg and ast activation and axonal damage. |
2021-12-22 |
2023-08-13 |
mouse |
| Qiangqiang Shi, Guangfen Zhao, Susu Wei, Chuanlong Guo, Xianggen Wu, Robert Chunhua Zhao, Guohu D. Pterostilbene alleviates liver ischemia/reperfusion injury via PINK1-mediated mitophagy. Journal of pharmacological sciences. vol 148. issue 1. 2021-12-20. PMID:34924126. |
our findings showed that pretreatment with pt ameliorated hepatic i/r injury by improving liver histology, decreasing hepatocyte apoptosis, and reducing plasma alt and ast levels. |
2021-12-20 |
2023-08-13 |
mouse |
| Fatemeh Ebrahimi, Sahar Rostami, Saeid Nekoonam, Zahra Rashidi, Aligholi Sobhani, Fardin Amid. The Effect of Astaxanthin and Metformin on Oxidative Stress in Granulosa Cells of BALB C Mouse Model of Polycystic Ovary Syndrome. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 10. 2021-11-29. PMID:33876387. |
we found that ast administration leads to a significant reduction in oxidative stress (p<0.01) and consequently a significant decrease in the rate of apoptosis (p<0.01). |
2021-11-29 |
2023-08-13 |
mouse |
| Xu Yan, Jinlan Ho. miR-22 Host Gene Enhances Nuclear Factor-kappa B Activation to Aggravate Hypoxia-induced Injury in AC16 Cardiomyocytes. Cell transplantation. vol 30. 2021-11-17. PMID:33631962. |
cell viability, lactate dehydrogenase release, levels of aspartate aminotransferase (ast) and creatine kinase-mb (ck-mb), and apoptosis were detected by cell counting kit-8, lactate dehydrogenase (ldh) release assay, commercial enzyme-linked immune sorbent assay kits, and flow cytometry analysis, respectively. |
2021-11-17 |
2023-08-13 |
Not clear |
| Xu Yan, Jinlan Ho. miR-22 Host Gene Enhances Nuclear Factor-kappa B Activation to Aggravate Hypoxia-induced Injury in AC16 Cardiomyocytes. Cell transplantation. vol 30. 2021-11-17. PMID:33631962. |
mir22hg overexpression aggravated hypoxia-induced viability reduction, leakage of myocardial injury markers ldh, ast, and ck-mb, and apoptosis in ac16 cardiomyocytes, while mir22hg knockdown elicited the reverse effects. |
2021-11-17 |
2023-08-13 |
Not clear |
| Qiwen Yu, Sanyang Chen, Hongwei Tang, Xiaodan Zhang, Ruolin Tao, Zhiping Yan, Jihua Shi, Wenzhi Guo, Shuijun Zhan. Veratric acid alleviates liver ischemia/reperfusion injury by activating the Nrf2 signaling pathway. International immunopharmacology. vol 101. issue Pt B. 2021-11-17. PMID:34749250. |
va alleviated liver i/r injury, as manifested by decreased alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels, liver necrotic area, oxidative stress, and hepatocyte apoptosis. |
2021-11-17 |
2023-08-13 |
mouse |
| Somow S Kamel, Naiyra A Abdel Baky, Riham M Karkeet, Abdel-Moneim M Osman, Mohamed M Sayed-Ahmed, Mariam A Foua. Astaxanthin extenuates the inhibition of aldehyde dehydrogenase and Klotho protein expression in cyclophosphamide-induced acute cardiomyopathic rat model. Clinical and experimental pharmacology & physiology. 2021-11-03. PMID:34597426. |
ast supplementation attenuates cp-induced cardiotoxicity by modulating aldh2 and klotho protein expression in heart tissues, along with its downstream apoptosis effector markers. |
2021-11-03 |
2023-08-13 |
rat |
| Xiaoxiang Xu, Guorong Yan, Juan Chang, Ping Wang, Qingqiang Yin, Chaoqi Liu, Shuo Liu, Qun Zhu, Fushan L. Astilbin ameliorates deoxynivalenol-induced oxidative stress and apoptosis in intestinal porcine epithelial cells (IPEC-J2). Journal of applied toxicology : JAT. vol 40. issue 10. 2021-11-01. PMID:32324309. |
the addition of 20 μg/ml ast significantly increased cell viability, superoxide dismutase and catalase activities, bcl-2 gene expression and the bcl-2/bax ratio (p < .05), and decreased lactate dehydrogenase release, malondialdehyde content and the relative expressions of genes associated with inflammation and apoptosis such as interleukin-6 and -8, tumor necrosis factor-alpha, cyclooxygenase-2, nuclear factor-kappab, bax and caspase-3 (p < .05). |
2021-11-01 |
2023-08-13 |
Not clear |
| Xiaoxiang Xu, Guorong Yan, Juan Chang, Ping Wang, Qingqiang Yin, Chaoqi Liu, Shuo Liu, Qun Zhu, Fushan L. Astilbin ameliorates deoxynivalenol-induced oxidative stress and apoptosis in intestinal porcine epithelial cells (IPEC-J2). Journal of applied toxicology : JAT. vol 40. issue 10. 2021-11-01. PMID:32324309. |
these results indicated that 20 μg/ml ast could ameliorate oxidative stress, inflammation and apoptosis by enhancing antioxidant enzyme activities and intestinal barrier function, and reducing the expressions of inflammation and apoptosis genes, as well as improve the barrier function and nutrient transport and absorption in don-induced ipec-j2 cells. |
2021-11-01 |
2023-08-13 |
Not clear |
| Yifan Chen, Tianzheng Yu, Patricia Deuste. Astaxanthin Protects Against Heat-induced Mitochondrial Alterations in Mouse Hypothalamus. Neuroscience. vol 476. 2021-11-01. PMID:34543676. |
we previously reported that heat exposure causes mitochondrial dysfunction and apoptosis in mouse skeletal muscle, and pretreatment with astaxanthin (ast), an antioxidant, prevents this effect. |
2021-11-01 |
2023-08-13 |
mouse |
| Jia-Huan Sun, Hong-Xia Yang, Ting-Ting Yao, Yuan Li, Lin Ruan, Geng-Rui Xu, Chuang Zhang, Guo-Xin Guo, Ai-Ying L. Gentianella acuta prevents acute myocardial infarction induced by isoproterenol in rats via inhibition of galectin-3/TLR4/MyD88/NF-кB inflammatory signalling. Inflammopharmacology. vol 29. issue 1. 2021-10-19. PMID:32356088. |
the results revealed that pre-treatment with g. acuta decreased the elevation in the st segment; reduced serum ldh, ck and ast levels; alleviated cardiac structure disorder; and reduced inflammatory infiltration, abnormal collagen deposition and cardiomyocyte apoptosis that were induced by iso. |
2021-10-19 |
2023-08-13 |
rat |
| Mehdi Khaksari, Samira Esmaili, Reyhane Abedloo, Hossein Khasta. Palmatine ameliorates nephrotoxicity and hepatotoxicity induced by gentamicin in rats. Archives of physiology and biochemistry. vol 127. issue 3. 2021-08-26. PMID:31241354. |
palmatine treatment caused reduction in plasma ast, alt, urine flow rate, creatinine clearance, renal and hapatic malondialdehyde, apoptosis and increase in renal and hapatic glutathione, fractional excretion of na and k, plasma bun and creatinine in contrast to gm group. |
2021-08-26 |
2023-08-13 |
rat |
| Tengfang Lai, Yong Shen, Chengcai Chen, Bo Huang, Tongyuan Deng, Zhuangzhi Zhao, Zhuohua Zhang, Zhaohe Huang, Xingshou Pa. Glycyrrhizic acid ameliorates myocardial ischemia-reperfusion injury in rats through inhibiting endoplasmic reticulum stress. European journal of pharmacology. vol 908. 2021-08-20. PMID:34274339. |
ga treatment significantly reduced apoptosis in h9c2 cells, while it alleviated left ventricular dysfunction, fibrosis and myocardial apoptosis, down-regulated the levels of ck, ck-mb, ldh, ast, tnf-α, il-6, and mda, and up-regulated sod levels in i/r rats. |
2021-08-20 |
2023-08-13 |
rat |
| Pan Shen, Liang Han, Guang Chen, Zhe Cheng, Qiong Li. Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway. Inflammation. 2021-08-19. PMID:34409550. |
emodin pretreatment significantly reduced the levels of alt, ast, and alp; increased the levels of alb; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of gsh and sod and the accumulation of mda; and increased the expression of antioxidative enzymes, including nuclear factor erythroid 2-related factor 2 (nrf2), heme oxygenase 1 (ho-1), and nad(p)h quinone dehydrogenase 1 (nqo1). |
2021-08-19 |
2023-08-13 |
mouse |