| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhongyang Ding, Ying Li, Zhangfeng Tang, Xiaoyi Song, Fa Jing, Haotian Wu, Bei L. Role of gambogenic acid in regulating PI3K/Akt/NF-kβ signaling pathways in rat model of acute hepatotoxicity. Bioscience, biotechnology, and biochemistry. vol 85. issue 3. 2021-07-27. PMID:33624779. |
the levels of mda, gsh, sod, cat, gpx, gst, alp, ast, alt, proinflammatory cytokines (tnf-α, il-1β, il-6), apoptosis markers (caspase-3 and -9, bax, bcl-2), 4-hydroxynonenal (4-hne), and prostaglandin e2 (pge2) were evaluated. |
2021-07-27 |
2023-08-13 |
rat |
| Hongyan Ma, Ying Liu, Zhengtian Li, Lu Yu, Yang Gao, Xiangmei Ye, Baoyi Yang, Hulun Li, Jinghui Sh. Propofol Protects Against Hepatic Ischemia Reperfusion Injury via Inhibiting Bnip3-Mediated Oxidative Stress. Inflammation. vol 44. issue 4. 2021-07-19. PMID:33496895. |
pro ameliorated the abnormal histopathology, reduced cell apoptosis and the levels of ast, alt, bnip3, cleaved caspase-3, and bax, but upregulated the bcl-2 level in the liver tissues of i/r mice. |
2021-07-19 |
2023-08-13 |
mouse |
| Junhua Weng, Xin Wang, Baohong Xu, Wen L. Augmenter of liver regeneration ameliorates ischemia-reperfusion injury in steatotic liver via inhibition of the TLR4/NF-κB pathway. Experimental and therapeutic medicine. vol 22. issue 2. 2021-06-29. PMID:34178136. |
alr maintained liver function and alleviated hepatic injury as indicated by the decreased levels of serum alanine aminotransferase (alt) and aspartate aminotransferase (ast), preserved hepatic structure and reduced apoptosis. |
2021-06-29 |
2023-08-13 |
mouse |
| Rongsheng Zhou, Shuang Li, Xiaopeng Mei, Tao Jiang, Qiang Wan. Remifentanil up-regulates HIF1α expression to ameliorate hepatic ischaemia/reperfusion injury via the ZEB1/LIF axis. Journal of cellular and molecular medicine. vol 24. issue 22. 2021-06-21. PMID:32996684. |
the levels of blood glucose, lipids, alanine transaminase (alt) and aspartate transaminase (ast) in mouse serum were measured using automatic chemistry analyser, while the viability and apoptosis of cells were detected using cck8 assay and flow cytometry. |
2021-06-21 |
2023-08-13 |
mouse |
| Zhihua Ren, Huidan Deng, Youtian Deng, Wenjiao Tang, Qiang Wu, Zhicai Zuo, Hengmin Cui, Yanchun Hu, Shumin Yu, Sheng-Yu Xu, Junliang Den. Effects of Selenium on Arsenic-Induced Liver Lesions in Broilers. Biological trace element research. vol 199. issue 3. 2021-06-18. PMID:32476085. |
adding 3 mg/kg arsenic to the diet caused the growth and development of chicken liver to be blocked, resulting in decrease of protein contents in liver tissue, decrease of sod and gsh-px activities, increase of mda contents, decrease of no contents, decrease of inos and tnos activities, increase of alt and ast activities, increase of apoptosis rates of liver cells. |
2021-06-18 |
2023-08-13 |
chicken |
| Zhihua Ren, Huidan Deng, Youtian Deng, Wenjiao Tang, Qiang Wu, Zhicai Zuo, Hengmin Cui, Yanchun Hu, Shumin Yu, Sheng-Yu Xu, Junliang Den. Effects of Selenium on Arsenic-Induced Liver Lesions in Broilers. Biological trace element research. vol 199. issue 3. 2021-06-18. PMID:32476085. |
compared to the 3-mg/kg arsenic group, adding 5 mg/kg and 10 mg/kg selenium, respectively, could repair the liver growth retardation and steatosis caused by arsenic, increase the protein contents in liver tissue, increase the activities of sod and gsh-px, reduce the contents of mda, increase the contents of no, enhance the activities of inos and tnos, reduce the activities of alt and ast, and reduce the rates of apoptosis of liver cells, in which the best effects are to add 10 mg/kg selenium. |
2021-06-18 |
2023-08-13 |
chicken |
| Fa-Chun Wan, Chen Zhang, Qing Jin, Chen Wei, Hong-Bo Zhao, Xiang-Lun Zhang, Wei You, Xiao-Mu Liu, Gui-Fen Liu, Yi-Fan Liu, Xiu-Wen Ta. Protective effects of astaxanthin on lipopolysaccharide-induced inflammation in bovine endometrial epithelial cells†. Biology of reproduction. vol 102. issue 2. 2021-06-16. PMID:31566218. |
the effects of ast were mediated through the downregulation of b-cell lymphoma 2 (bcl-2) associated x, apoptosis regulator (bax), and cleaved caspase-3 and through the upregulation of bcl-2. |
2021-06-16 |
2023-08-13 |
cattle |
| Fa-Chun Wan, Chen Zhang, Qing Jin, Chen Wei, Hong-Bo Zhao, Xiang-Lun Zhang, Wei You, Xiao-Mu Liu, Gui-Fen Liu, Yi-Fan Liu, Xiu-Wen Ta. Protective effects of astaxanthin on lipopolysaccharide-induced inflammation in bovine endometrial epithelial cells†. Biology of reproduction. vol 102. issue 2. 2021-06-16. PMID:31566218. |
collectively, these results demonstrated that treatment with ast protected against oxidative stress, prevented cell apoptosis, promoted bend cells viability, and increased the production of growth factors, in addition to activating the endometrial defense barrier. |
2021-06-16 |
2023-08-13 |
cattle |
| Yan Li, Qiang Wang, Cuiying Chu, Shu Li. Astaxanthin protects retinal ganglion cells from acute glaucoma via the Nrf2/HO-1 pathway. Journal of chemical neuroanatomy. vol 110. 2021-06-16. PMID:33129943. |
the apoptosis of rgcs induced by ischemia and reperfusion was repressed by ast. |
2021-06-16 |
2023-08-13 |
mouse |
| Yan Li, Qiang Wang, Cuiying Chu, Shu Li. Astaxanthin protects retinal ganglion cells from acute glaucoma via the Nrf2/HO-1 pathway. Journal of chemical neuroanatomy. vol 110. 2021-06-16. PMID:33129943. |
ast protected the rgcs from apoptosis during acute glaucoma and alleviated the severe retinopathy symptoms through the nrf2/ho-1 pathway. |
2021-06-16 |
2023-08-13 |
mouse |
| Azita Afzali, Fardin Amidi, Morteza Koruji, Hassan Nazari, Mohammad Ali Sadighi Gilani, Aligholi Sobhani Sanjba. Astaxanthin Relieves Busulfan-Induced Oxidative Apoptosis in Cultured Human Spermatogonial Stem Cells by Activating the Nrf-2/HO-1 pathway. Reproductive sciences (Thousand Oaks, Calif.). 2021-06-15. PMID:34129218. |
ast activated the nrf-2/ho-1 pathway that could remarkably restrain bu-induced apoptosis in sscs. |
2021-06-15 |
2023-08-13 |
human |
| Azita Afzali, Fardin Amidi, Morteza Koruji, Hassan Nazari, Mohammad Ali Sadighi Gilani, Aligholi Sobhani Sanjba. Astaxanthin Relieves Busulfan-Induced Oxidative Apoptosis in Cultured Human Spermatogonial Stem Cells by Activating the Nrf-2/HO-1 pathway. Reproductive sciences (Thousand Oaks, Calif.). 2021-06-15. PMID:34129218. |
interestingly, ast upregulated the expression level of apoptosis genes in the k562 cell line. |
2021-06-15 |
2023-08-13 |
human |
| Azita Afzali, Fardin Amidi, Morteza Koruji, Hassan Nazari, Mohammad Ali Sadighi Gilani, Aligholi Sobhani Sanjba. Astaxanthin Relieves Busulfan-Induced Oxidative Apoptosis in Cultured Human Spermatogonial Stem Cells by Activating the Nrf-2/HO-1 pathway. Reproductive sciences (Thousand Oaks, Calif.). 2021-06-15. PMID:34129218. |
the results of this study indicated that ast reduces the side effects of bu on sscs without interference with its chemotherapy effect on cancerous cells through modulation of the nrf-2/ho-1 and mitochondria-mediated apoptosis pathways. |
2021-06-15 |
2023-08-13 |
human |
| Dong-Fang Shen, Hui-Ping Qi, Chi Ma, Ming-Xiu Chang, Wei-Na Zhang, Rong-Rong Son. Astaxanthin suppresses endoplasmic reticulum stress and protects against neuron damage in Parkinson's disease by regulating miR-7/SNCA axis. Neuroscience research. vol 165. 2021-05-14. PMID:32333925. |
in this study, we found that ast treatment significantly not only abolished the cell viability inhibition and apoptosis promotion induced by 1-methyl-4-phenylpyridinium (mpp+) in sh-sy5y cells via inhibiting endoplasmic reticulum (er) stress, but also reversed the mpp+ caused dysregulation of mir-7 and snca expression. |
2021-05-14 |
2023-08-13 |
Not clear |
| Haoyang Ma, Jiaye Liu, Yang Du, Shengnan Zhang, Weidong Cao, Zhanjun Jia, Wei Gong, Aihua Zhan. Estrogen-Related Receptor γ Agonist DY131 Ameliorates Lipopolysaccharide-Induced Acute Liver Injury. Frontiers in pharmacology. vol 12. 2021-05-13. PMID:33967760. |
pretreatment with dy131 ameliorated lps-induced liver injury as demonstrated by reduced liver enzyme release (alt, ast, and ldh), improved liver morphological damage, and attenuated oxidative stress, inflammation and apoptosis. |
2021-05-13 |
2023-08-13 |
mouse |
| Wenhan Wang, Tinghao Liu, Yuanyuan Liu, Lechu Yu, Xiaoqing Yan, Wenya Weng, Xuemian Lu, Chi Zhan. Astaxanthin attenuates alcoholic cardiomyopathy via inhibition of endoplasmic reticulum stress-mediated cardiac apoptosis. Toxicology and applied pharmacology. vol 412. 2021-05-11. PMID:33352188. |
the present study aimed to investigate whether ast induces beneficial effects on acm by suppressing cardiac apoptosis mediated by er stress. |
2021-05-11 |
2023-08-13 |
mouse |
| Wenhan Wang, Tinghao Liu, Yuanyuan Liu, Lechu Yu, Xiaoqing Yan, Wenya Weng, Xuemian Lu, Chi Zhan. Astaxanthin attenuates alcoholic cardiomyopathy via inhibition of endoplasmic reticulum stress-mediated cardiac apoptosis. Toxicology and applied pharmacology. vol 412. 2021-05-11. PMID:33352188. |
this study highlights that administration of ast ablated chronic excessive ethanol consumption-induced cardiomyopathy by suppressing cardiac er stress and subsequent apoptosis. |
2021-05-11 |
2023-08-13 |
mouse |
| Yi-Chao Du, Li Lai, Hao Zhang, Fu-Rui Zhong, Huan-Li Cheng, Bao-Lin Qian, Peng Tan, Xian-Ming Xia, Wen-Guang F. Kaempferol from Food & function. vol 11. issue 9. 2021-05-06. PMID:32820776. |
the results revealed that ka pretreatment significantly reduced the levels of aspartate aminotransferase (ast) and alanine aminotransferase (alt), relieved hepatocellular damage and apoptosis, attenuated the exhaustion of glutathione (gsh) and accumulation of malondialdehyde (mda), increased the expression of antioxidative enzymes (e.g., heme oxygenase 1 (ho-1) and nadph quinone oxidoreductase 1 (nqo1)), and thus restrained apap-induced oxidative damage in the liver. |
2021-05-06 |
2023-08-13 |
Not clear |
| Cheng-Cheng Wang, Hao-Hao Shi, Jie Xu, Teruyoshi Yanagita, Chang-Hu Xue, Tian-Tian Zhang, Yu-Ming Wan. Docosahexaenoic acid-acylated astaxanthin ester exhibits superior performance over non-esterified astaxanthin in preventing behavioral deficits coupled with apoptosis in MPTP-induced mice with Parkinson's disease. Food & function. vol 11. issue 9. 2021-05-06. PMID:32845953. |
dha-ast was superior to ast in preventing behavioral deficits coupled with apoptosis rather than oxidative stress, and might provide a valuable reference for the prevention and treatment of neurodegenerative diseases. |
2021-05-06 |
2023-08-13 |
mouse |
| Desheng Liu, Yuntao Gu, Wenting Wang, Wendao Che. Astragalin alleviates ischemia/reperfusion‑induced brain injury via suppression of endoplasmic reticulum stress. Molecular medicine reports. vol 22. issue 5. 2021-04-30. PMID:33000226. |
thapsigargin‑induced er stress activation and apoptosis were also attenuated by ast in an in vitro neuronal cell culture model. |
2021-04-30 |
2023-08-13 |
rat |