| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esin Sakallı Çetin, Hamdi Sozen, Ozgur Ilhan Celik, Ibrahim Hakkı Cigerci, Nigar Yılma. Mistletoe (Viscum album L.) extract attenuates ıtraconazole-ınduced acute oxidative stress and hepatocellular ınjury in rats. Pakistan journal of pharmaceutical sciences. vol 36. issue 1. 2023-03-27. PMID:36967491. |
highest genotoxicity, higher levels of plasma ast and alt, higher tos, more degeneration of liver histopathology including hepatocyte degeneration, hepatocyte apoptosis and necrosis, portal/periportal inflammation, bile ductus hyperplasia and multinuclear giant cell formation were observed in itz group (p<0.05). |
2023-03-27 |
2023-08-14 |
rat |
| Yufen Li, Ruixue Tong, Zeyuan Li, Xin Zhang, Luqing Pan, Yaobing Li, Ning Zhan. Toxicological mechanism of ammonia-N on haematopoiesis and apoptosis of haemocytes in Litopenaeus vannamei. The Science of the total environment. 2023-03-26. PMID:36966842. |
rna interference (rnai) was performed to understand the function of astakine (ast) in haematopoiesis and apoptosis in litopenaeus vannamei under ammonia-n exposure. |
2023-03-26 |
2023-08-14 |
Not clear |
| Yufen Li, Ruixue Tong, Zeyuan Li, Xin Zhang, Luqing Pan, Yaobing Li, Ning Zhan. Toxicological mechanism of ammonia-N on haematopoiesis and apoptosis of haemocytes in Litopenaeus vannamei. The Science of the total environment. 2023-03-26. PMID:36966842. |
the results showed that the total haemocytes count (thc) decreased under ammonia-n stress and the knockdown of ast resulted in a further decrease of thc, suggesting that 1) the proliferation was decreased through the reduction of ast and hedgehog, the differentiation was interfered by wnt4, wnt5 and notch, and the migration was inhibited by the decrease of vegf; 2) oxidative stress was induced under ammonia-n stress, leading to the increase of dna damage with the up-regulated gene expression of death receptor, mitochondrial and endoplasmic reticulum stress pathways; 3) the changes of thc resulted from the decrease of proliferation, differentiation and migration of haematopoiesis cells and the increase of apoptosis of haemocytes. |
2023-03-26 |
2023-08-14 |
Not clear |
| Yudong Jia, Fenglin Wang, Yuntao Gao, Hongyu Qin, Changtao Gua. Hypoxia stress induces hepatic antioxidant activity and apoptosis, but stimulates immune response and immune-related gene expression in black rockfish Sebastes schlegelii. Aquatic toxicology (Amsterdam, Netherlands). vol 258. 2023-03-25. PMID:36965427. |
in this study, hepatic anti-oxidant enzymes (superoxide dismutase [sod], catalase [cat], glutathione peroxidase [gsh-px]), aminotransferase (ast) and alanine aminotransferase (alt) activities, lipid peroxidation (lpo), malondialdehyde (mda) and glutathione (gsh) content, immunological parameters and the expression of apoptosis (bax, bcl2, p53, caspase3, xiap) and immune-related genes (c3, il-1β, ccl25, saa, hap, isg15) of black rockfish were determined during hypoxia and reoxygenation to illustrate the underlying defense response mechanisms. |
2023-03-25 |
2023-08-14 |
human |
| Cai Zhang, Sudan Meng, Chenxu Li, Zijun Yang, Guoyong Wang, Xueying Wang, Yanbo M. Primary Broiler Hepatocytes for Establishment of a Steatosis Model. Veterinary sciences. vol 9. issue 7. 2023-03-08. PMID:35878333. |
in the second experiment, steatosis was induced by incubating hepatocytes with 10% fat emulsion for 48 h. in consequence, the apoptosis rate decreased (p > 0.05) and the concentration of alt (p < 0.001), ast (p < 0.01), and tg (p < 0.05) increased significantly; the expression level of srebp-1c (p < 0.05) increased, and the expression levels of pparα (p < 0.001), cpt1 (p < 0.001), and cpt2 (p < 0.05) were lower in the fat emulsion group than in the control group. |
2023-03-08 |
2023-08-16 |
Not clear |
| Fei Luan, Zi-Qin Lei, Li-Xia Peng, Zhi-Li Rao, Ruo-Cong Yang, Nan Zen. [Experimental study of cardioprotective effects of Cinnamomi Ramulus and Cinnamomi Cortex formula granules on myocardial ischemia/reperfusion injury in rats based on efficacy of "warming and coordinating heart Yang"]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 3. 2023-03-05. PMID:36872236. |
the results showed that both crfg and ccfg pretreatments significantly improved cardiac function, decreased the cardiac infarct size, inhibited cardiomyocyte apoptosis, and reduced the content of lactic dehydrogenase(ldh), creatine kinase mb isoenzyme(ck-mb), aspartate transaminase(ast), and cardiac troponin Ⅰ(ctnⅠ). |
2023-03-05 |
2023-08-14 |
rat |
| Jaeeun Lee, Min-Hyun Kim, Hyeyoung Ki. Anti-Oxidant and Anti-Inflammatory Effects of Astaxanthin on Gastrointestinal Diseases. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555112. |
in addition, ast has been shown to inhibit cancer cell growth and metastasis via modulating cell proliferation-related pathways, apoptosis, and autophagy. |
2022-12-23 |
2023-08-14 |
Not clear |
| Dan Tang, Ruo-Yu Wang, Ke-Wei Sun, Yunan Wu, Lin Ding, Yang M. Network pharmacology-based prediction of active compounds in the Wenyang Jiedu Huayu formula acting on acute-on-chronic liver failure with experimental support Frontiers in pharmacology. vol 13. 2022-11-07. PMID:36339606. |
lps stimulation inhibited rat hepatocytes' brl 3a cell viability, promoted cell apoptosis, increased the levels of alt, ast, il-6, and vcam-1 within the culture medium, and activated nf-κb signaling, whereas at-1 treatment significantly attenuated lps-induced toxicity on brl 3a cells. |
2022-11-07 |
2023-08-14 |
rat |
| Taoguang Huo, Weiwei Zhang, Jing Yang, Jian Li, Yuwei Zhang, Haoqi Guo, Xinyu Wu, Aihong Li, Cong Feng, Hong Jian. Effects of chronic realgar exposure on liver lipidome in mice and identification sensitive lipid biomarker model for realgar-induced liver damage. Toxicology letters. 2022-10-22. PMID:36272663. |
it was found that realgar exposure induced arsenic accumulation in the liver, increased ros generation, elevated mda levels, decreased antioxidant enzymes levels, induced cell apoptosis, changed hepatocyte ultrastructure and morphology, and altered alt, ast levels. |
2022-10-22 |
2023-08-14 |
mouse |
| Mahmoud Elshal, Sara H Haze. Escin suppresses immune cell infiltration and selectively modulates Nrf2/HO-1, TNF-α/JNK, and IL-22/STAT3 signaling pathways in concanavalin A-induced autoimmune hepatitis in mice. Inflammopharmacology. 2022-09-05. PMID:36063304. |
our results showed that escin inhibited con a-induced elevation in liver enzymes (alt, ast, and ldh) and curbed the con a-induced hepatocyte necrosis and apoptosis together with abrogating the death pathway, jnk. |
2022-09-05 |
2023-08-14 |
mouse |
| Qian-Nan Li, Jin-Feng Shang, Ting-Yue Jiang, Lei Bi, Jia-Kang Jiao, Ying-Hui Lu, Qi Song, Shabuer-Jiang Lizha, Xin Li. [Exploration of mechanism of "simultaneous treatment of brain and heart" of Naoxintong Capsules based on Toll-like receptor signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 15. 2022-09-01. PMID:36046901. |
at the same time, the reduction in apoptosis rate of cardiocytes and the content of serum aspartate aminotransferase(ast), alanine aminotransferase(alt), creatine kinase(ck), and lactate dehydrogenase(ldh) were decreased in the nxt group.systems pharmacological results and previous research showed that tlr signaling pathway played an important role in immune inflammatory response.the study of tlr signaling pathway and related proteins is helpful to elucidate the mechanism of "simultaneous treatment of the brain and the heart". |
2022-09-01 |
2023-08-14 |
rat |
| Lin He, Yanbo Wang, Jin Lu. Epigenetic modification mechanism of histone demethylase KDM1A in regulating cardiomyocyte apoptosis after myocardial ischemia-reperfusion injury. PeerJ. vol 10. 2022-08-12. PMID:35959481. |
the cell viability, markers of myocardial injury (ldh, ast, and ck-mb) and apoptosis (bax and bcl-2), and caspase-3 and caspase-9 protein activities were detected, respectively. |
2022-08-12 |
2023-08-14 |
Not clear |
| Cai Zhang, Sudan Meng, Qi Shao, Xueying Wang, Chenxu Li, Wenbin Chen, Yuanxiao Li, Shucheng Huang, Yanbo M. Protective effects of monoammonium glycyrrhizinate on fatty deposit degeneration induced in primary calf hepatocytes by sodium oleate administration in vitro. Research in veterinary science. vol 150. 2022-07-22. PMID:35868152. |
to evaluate the effect of mag on fat-induced degradation of primary hepatocytes, we evaluated lipid deposition, cell viability, apoptosis rate, alanine aminotransferase (alt) and aspartate aminotransferase (ast) activity in the culture supernatant, and expression of oxidant and antioxidant enzymes (ldh, mda, gsh, and cat), as well as the expression of lipid metabolism-related genes (pparα, srebp-1c, chrebp, cpt1, cpt2, and mtp) and apoptosis-related genes (cyt-c, caspase 9, caspase 8, caspase 3, bax, and bcl-2). |
2022-07-22 |
2023-08-14 |
cat |
| Cai Zhang, Sudan Meng, Qi Shao, Xueying Wang, Chenxu Li, Wenbin Chen, Yuanxiao Li, Shucheng Huang, Yanbo M. Protective effects of monoammonium glycyrrhizinate on fatty deposit degeneration induced in primary calf hepatocytes by sodium oleate administration in vitro. Research in veterinary science. vol 150. 2022-07-22. PMID:35868152. |
mag significantly reduced lipid accumulation in hepatocytes induced by sodium oleate (p < 0.05), increased cell viability, decreased the apoptosis rate (p < 0.05), and significantly decreased alt and ast activity in the culture supernatant (p < 0.05). |
2022-07-22 |
2023-08-14 |
cat |
| Qiang-Ming Li, Xiu-Rong Yang, Xue-Qiang Zha, Li-Hua Pan, Dan-Dan Zang, Feng-Yun Zhang, Jian-Ping Lu. Protective effects of three flavonoids from Dendrobium huoshanense flowers on alcohol-induced hepatocyte injury via activating Nrf2 and inhibiting NF-κB pathways. Chemistry & biodiversity. 2022-07-01. PMID:35774029. |
results exhibited that flavonoids 1-3 could enhance the cell viability, decrease the expression of alt and ast, inhibit the cell apoptosis, alleviate the oxidative stress, and mitigate the inflammatory response of alcohol-induced l02 cells. |
2022-07-01 |
2023-08-14 |
Not clear |
| Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhan. Astilbin attenuates apoptosis induced by cadmium through oxidative stress in carp (Cyprinus carpio L.) head kidney lymphocyte. Fish & shellfish immunology. 2022-05-16. PMID:35577320. |
ast treatment reduced oxidative stress and apoptosis induced by cd. |
2022-05-16 |
2023-08-13 |
Not clear |
| Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhan. Astilbin attenuates apoptosis induced by cadmium through oxidative stress in carp (Cyprinus carpio L.) head kidney lymphocyte. Fish & shellfish immunology. 2022-05-16. PMID:35577320. |
our results suggested that ast can alleviate the apoptosis of carp head kidney lymphocytes induced by cd through oxidative stress. |
2022-05-16 |
2023-08-13 |
Not clear |
| Dan Li, Jiang Qian, Junfeng Li, Jia Wang, Wenhong Liu, Qinfei Li, Dan W. Dexmedetomidine attenuates acute stress-induced liver injury in rats by regulating the miR-34a-5p/ROS/JNK/p38 signaling pathway. The Journal of toxicological sciences. vol 47. issue 5. 2022-05-08. PMID:35527005. |
dex attenuated the increase in the levels of ne, alt, ast, mda, ros, apoptosis, sod2, cox-2, cytochrome c, cleaved caspase 3, bax, and p-jnk, p-p38, c-amp, p-pka and mir-34a-5p, and the decrease in the levels of sod, gpx, gsh and bcl-2 in model rats. |
2022-05-08 |
2023-08-13 |
rat |
| Fatemeh Abbaszadeh, Masoumeh Jorjani, Mohammad Taghi Joghataei, Soraya Mehrab. Astaxanthin Modulates Autophagy, Apoptosis, and Neuronal Oxidative Stress in a Rat Model of Compression Spinal Cord Injury. Neurochemical research. 2022-04-18. PMID:35435619. |
the effects of astaxanthin (ast) were evaluated on oxidative mediators, neuronal apoptosis, and autophagy in functional motor recovery after spinal cord injury (sci). |
2022-04-18 |
2023-08-13 |
rat |
| Yi-Liang Wang, Ying Zhang, Da-Sheng Ca. Hepatoprotective effects of sevoflurane against hepatic ischemia-reperfusion injury by regulating microRNA-124-3p-mediated TRAF3/CREB axis. Cell death discovery. vol 8. issue 1. 2022-03-09. PMID:35260558. |
in addition, mir-124-3p, traf3 and creb expression in hepatocytes was altered to identify their roles in modulating the levels of glutathione transferase (gst), aspartate aminotransferase (ast) and alanine aminotransferase (alt), and inflammation-related factors and hepatocyte apoptosis by elisa and flow cytometry respectively. |
2022-03-09 |
2023-08-13 |
mouse |