| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiwen Yu, Jiye Li, Mengwei Cui, Chaopeng Mei, Qianqian He, Xiaoxiao D. 6-Gingerol attenuates hepatic ischemia/reperfusion injury through regulating MKP5-mediated P38/JNK pathway. Scientific reports. vol 14. issue 1. 2024-04-02. PMID:38565569. |
the results show that 6-gingerol decreased serum alanine aminotransferase (alt), aspartate aminotransferase (ast) levels, liver necrosis, inflammatory cytokines il-1β, il-6, mcp-1, tnf-α expression, ly6g+ inflammatory cell infiltration, protein phosphorylation of nf-κb signaling pathway, terminal deoxynucleotidyl transferase dutp nick-end labeling (tunel) positive cells, cell apoptosis rate, the protein expression of pro-apoptotic protein bax and c-caspase3, increased cell viability, and expression of anti-apoptotic protein bcl-2. |
2024-04-02 |
2024-04-05 |
mouse |
| Lidan Zhang, Ge Kuang, Xia Gong, Rui Huang, Zizuo Zhao, Yan Li, Jingyuan Wan, Bin Wan. Piperine attenuates hepatic ischemia/reperfusion injury via suppressing the TLR4 signaling cascade in mice. Transplant immunology. 2024-03-14. PMID:38484898. |
the results showed that plasma aminotransferase (alt), aspartate aminotransferase (ast), hepatocyte apoptosis, oxidative stress, and inflammatory cell infiltration significantly increased in hiri mice. |
2024-03-14 |
2024-03-17 |
mouse |
| Ling Liu, Jun Liu, Junshuai Wang, Yu Chen, Gang Li. Ulinastatin protects against myocardial ischemia/reperfusion injury in rats via Rho/ROCK signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 15. 2024-01-27. PMID:38279430. |
the myocardial infarction area in the ir group was markedly larger than that in the c group (p<0.01) but was significantly reduced after ulinastatin treatment (p<0.05), and the ir group had higher levels of ast, ctni, ck-mb and ldh than c group, but the levels of those indexes were significantly reduced after ulinastatin treatment.the cardiomyocyte apoptosis was increased in the ir group compared with that in the c group, while it was decreased in the ur group in comparison with that in the ir group. |
2024-01-27 |
2024-01-29 |
rat |
| Chenglong Fei, Lei Liu, Hedong Qi, Yuyang Peng, Jingfen Han, Chunru Wang, Xue L. Curdlan-Decorated Fullerenes Mitigate Immune-Mediated Hepatic Injury for Autoimmune Hepatitis Therapeutics via Reducing Macrophage Infiltration. ACS applied materials & interfaces. 2024-01-24. PMID:38267397. |
the regulation of hepatic inflammation contributes to inhibiting inflammatory cytokines-induced hepatocyte apoptosis, decreasing the serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) contents and thus ameliorating immune-mediated hepatic injury. |
2024-01-24 |
2024-01-27 |
mouse |
| Min Wu, Xudong Liu, Qiwen Yu, Jihua Shi, Wenzhi Guo, Shuijun Zhan. Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway. European journal of pharmacology. 2023-12-18. PMID:38110141. |
serum alt and ast levels, and h&e staining were used to measure liver damage; mda content, superoxide dismutase and glutathione activities, and dihydroethidium staining were used to measure oxidative stress; mrna expression levels of tumor necrosis factor-α, interleukin(il)-1β, il-6, mcp-1, and ly6g staining were used to measure inflammatory response; and protein expression of bax, bcl-2, c-caspase3, and terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling staining were used to measure apoptosis. |
2023-12-18 |
2023-12-21 |
mouse |
| Yanli Zou, Ting Zhan, Jiaxi Liu, Jie Tan, Weijie Liu, Shasha Huang, Yisan Cai, Ming Huang, Xiaodong Huang, Xia Tia. CXCL6 promotes the progression of NAFLD through regulation of PPARα. Cytokine. vol 174. 2023-12-06. PMID:38056250. |
after transfecting nafld cells with sirna targeting cxcl6 (si-cxcl6), a series of functional experiments were carried out, and these data indicated that the inhibition of cxcl6 reduced intracellular lipid deposition, decreased ast, alt and tg level, facilitate cell proliferation and suppress their apoptosis. |
2023-12-06 |
2023-12-10 |
Not clear |
| Jingwen Yu, Bingtao Mu, Minfang Guo, Chunyun Liu, Tao Meng, Yuqing Yan, Lijuan Song, Jiezhong Yu, Gajendra Kumar, Cungen M. Astragaloside IV inhibits experimental autoimmune encephalomyelitis by modulating the polarization of both microglia/macrophages and astrocytes. Folia neuropathologica. vol 61. issue 3. 2023-10-11. PMID:37818688. |
ast iv improved paralysis and pathology of eae by inhibiting the neurotoxic m1 microglia/macrophage phenotype, promoting m2 phenotype, shifting astrocytes towards a neuroprotective a2 phenotype, and protecting neurons from apoptosis through inhibition of tlr4/myd88/nf-kb signalling pathway. |
2023-10-11 |
2023-10-15 |
Not clear |
| Ming Chen, Jing Luo, Hongwu Ji, Wenkui Song, Di Zhang, Weiming Su, Shucheng Li. The Preventive Mechanism of Anserine on Tert-Butyl Hydroperoxide-Induced Liver Injury in L-02 Cells via Regulating the Keap1-Nrf2 and JNK-Caspase-3 Signaling Pathways. Marine drugs. vol 21. issue 9. 2023-09-27. PMID:37755089. |
the l-02 cells were pretreated with anserine (10, 20, and 40 mmol/l) and then induced with 400 μmol/l of tbhp for 4 h. the results showed that the survival rates of l-02 cells and the contents of gsh were significantly increased with the pretreatment of anserine; the activities of alanine aminotransferase (alt) and aspartate aminotransferase (ast) in the extracellular fluid were sharply decreased; and the formation of reactive oxygen species (ros), nuclear fragmentation, and apoptosis were significantly inhibited. |
2023-09-27 |
2023-10-07 |
human |
| Ning Liu, Xiaohong Lyu, Xianglin Zhang, Fan Zhang, Yiming Chen, Gang L. Astaxanthin attenuates cognitive deficits in Alzheimer's disease models by reducing oxidative stress via the SIRT1/PGC-1α signaling pathway. Cell & bioscience. vol 13. issue 1. 2023-09-14. PMID:37710272. |
therefore, this study aimed to investigate and validate the protective effect of ast on neuronal senescence and apoptosis caused by oxidative stress induced by aβ25-35 peptide, with the goal of preventing the onset of cognitive dysfunction. |
2023-09-14 |
2023-10-07 |
Not clear |
| Hongmei Tang, Yun Zhang, Qiao Wang, Ziling Zeng, Xiaoyun Wang, Yuejiao Li, Zhibin Wang, Ning Ma, Guofeng Xu, Xiaolin Zhong, Linlin Guo, Xiefang Yuan, Xing Wan. Astaxanthin attenuated cigarette smoke extract-induced apoptosis via decreasing oxidative DNA damage in airway epithelium. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-12. PMID:37699317. |
in this study, we released that ast could attenuate cigarette smoke-induced dna damage and apoptosis in vivo and in vitro. |
2023-09-12 |
2023-10-07 |
mouse |
| Hongmei Tang, Yun Zhang, Qiao Wang, Ziling Zeng, Xiaoyun Wang, Yuejiao Li, Zhibin Wang, Ning Ma, Guofeng Xu, Xiaolin Zhong, Linlin Guo, Xiefang Yuan, Xing Wan. Astaxanthin attenuated cigarette smoke extract-induced apoptosis via decreasing oxidative DNA damage in airway epithelium. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-12. PMID:37699317. |
ast administration ameliorated cigarette smoke extract (cse)-induced activation of caspase-3 and apoptosis. |
2023-09-12 |
2023-10-07 |
mouse |
| Hongmei Tang, Yun Zhang, Qiao Wang, Ziling Zeng, Xiaoyun Wang, Yuejiao Li, Zhibin Wang, Ning Ma, Guofeng Xu, Xiaolin Zhong, Linlin Guo, Xiefang Yuan, Xing Wan. Astaxanthin attenuated cigarette smoke extract-induced apoptosis via decreasing oxidative DNA damage in airway epithelium. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-12. PMID:37699317. |
taken together, this study suggested that ast can decrease cse-induced dna damage and apoptosis by inhibiting nox4/duox1 expression that promotes ros generation. |
2023-09-12 |
2023-10-07 |
mouse |
| Bruna Santana Silva Pinheiro, Julia Gonçalves Rodrigues, Fernanda Carolina Ribeiro Dias, Angelica de Oliveira Gomes, Marcos de Lucca Moreira Gome. Hepatic damage caused by flaviviruses: A systematic review. Life sciences. 2023-09-08. PMID:37683724. |
it is evident that there is a strong hepatic interaction with flaviviruses, and the main hepatic alterations found were steatosis, apoptosis, necrosis, hemorrhage, elevation of alt and ast levels, and total bilirubin. |
2023-09-08 |
2023-10-07 |
mouse |
| Lixing Liang, Yaqin Huang, Liuyin Chen, Zhiling Shi, Housheng Wang, Tingting Zhang, Zhixun Li, Jinglin Mi, Ting Fan, Yushuang Lu, Fuli Chen, Weimei Huang, Kai H. Radioprotective efficacy of Astilbin in mitigating radiation-induced lung injury through inhibition of p53 acetylation. Environmental toxicology. 2023-08-20. PMID:37598414. |
we observed that ast reduced radiation-induced apoptosis, dna damage, inflammatory reactions, and the reactive oxygen species (ros) level in human normal lung epithelial cells beas-2b. |
2023-08-20 |
2023-09-07 |
mouse |
| Linqi Ouyang, Zhiqiang Fan, Yang He, Long Tan, Guoyan Deng, Qin He, Yiran He, Ting Ouyang, Congjie Li, Qin Zhang, Hongyu Liu, Yajie Zu. 4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L. Toxicology letters. 2023-08-20. PMID:37598872. |
the results showed that the activities of alt, ast, and ldh in the culture medium increased, and hepatocyte apoptosis increased. |
2023-08-20 |
2023-09-07 |
Not clear |
| Chen Wu, Lin Xia, Bin Zhang, Zhongying Bai, Ling Yuan, Dongsheng X. Astragaloside reduces toxic effect of periodontal ligament fibroblasts induced by lipopolysaccharide. Archives of biochemistry and biophysics. 2023-07-16. PMID:37454920. |
we found that ast could promote cell proliferation and reduce apoptosis induced by lps. |
2023-07-16 |
2023-08-14 |
human |
| Hengjie Yuan, Ye Tian, Rongcai Jiang, Yuanzhi Wang, Meng Nie, Xiaochun Li, Yifan He, Xuanhui Liu, Ruiting Zhao, Jingyue Zhan. Susceptibility to Hepatotoxic Drug-induced Liver Injury Increased after Traumatic Brain Injury in Mice. Journal of neurotrauma. 2023-06-02. PMID:37265124. |
the results suggested that liver injury induced in the early stages of brain injury recovered in three days, but this state could still significantly aggravate dili, represented by higher liver enzymes (ast and alt), oxidative stress (increase in malondialdehyde concentration and deregulation of glutathione and superoxide dismutase activities), inflammatory response (activation of hmgb1/tlr4/nf-κb signaling pathway, and increased mrna and protein levels of pro-inflammatory cytokines including tnf-α, il-6, and il-1β), and apoptosis (tunel assay, upregulation of bax protein and deregulation of bcl-2 protein). |
2023-06-02 |
2023-08-14 |
mouse |
| Jing-Nan Fu, Shu-Chang Liu, Yi Chen, Jie Zhao, Ning Lu, Tao M. Forsythiaside A alleviates Lipopolysacchrride-induced acute liver Injury through inhibiting endoplasmic reticulum stress and NLRP3 inflammasome activation. Biological & pharmaceutical bulletin. 2023-05-14. PMID:37183023. |
forsythiaside a (fta), an active constituent of forsythia suspensa, has been reported to have anti-inflammatory properties, antioxidant properties, and protective properties against neuroinflammation, sepsis, and edema.therefore, the purpose of the present study was to examine fta's potential effects on lipopolysaccharide (lps)-induced sali in mice.our results indicated that pretreatment with fta significantly attenuated aspartate aminotransferase (ast) and aminoleucine transferase (alt) levels in plasma, ameliorated histopathological damage, inhibited hepatocyte apoptosis, diminished the expression of tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6 in the liver from mice exposed to lps. |
2023-05-14 |
2023-08-14 |
mouse |
| Xiaomei Zhang, Huifeng Zhang, Weidong Qiang, Yongxin Guo, Di Wu, Xin Su. Oral administration of human FGF21 expressed by mycelium of Cordyceps militaris improves blood glucose and lipid in type II diabetes mellitus. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 10. 2023-04-28. PMID:37114272. |
in animal experiments, oral rhfgf21 obviously reduced the levels of glucose, insulin, tg, t-cho, nefa, and ldl-c in the blood, the contents of alt, ast, tnf-α, mcp-1, f4/80, cd68 and cd11b in the fatty liver, and the apoptosis of pancreatic cells. |
2023-04-28 |
2023-08-14 |
human |
| Dalia S Morsi, Ibrahim O Barnawi, Hany M Ibrahim, Asmaa M El-Morsy, Mahmoud A El Hassab, Heba M Abd El Lati. Immunomodulatory, apoptotic and anti-proliferative potentials of sildenafil in Ehrlich ascites carcinoma murine model: In vivo and in silico insights. International immunopharmacology. vol 119. 2023-04-20. PMID:37080065. |
apoptosis, cell cycle distribution, alterations in tumor cells and splenocytes proliferation, changes in splenocytes immunophenotyping using flowcytometry, plasma levels of malondialdehyde (mda), reduced glutathione (gsh), interferone (ifn)-γ, granzyme b, alanine aminotransferase (alt), aspartate aminotransferase (ast), urea, creatinine and hematological alterations were detected. |
2023-04-20 |
2023-08-14 |
Not clear |