| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng Yu, Xingliang Zhou, Hang Xiang, Shaoping Wang, Zhonglin Cui, Jie Zho. Resveratrol Reduced Liver Damage After Liver Resection in a Rat Model by Upregulating Sirtuin 1 (SIRT1) and Inhibiting the Acetylation of High Mobility Group Box 1 (HMGB1). Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-18. PMID:31041919. |
results resveratrol reduced postoperative liver injury as shown by reduced alt, ast, γ-gt, and total bilirubin levels, maintained liver structure, and reduced cell apoptosis. |
2019-09-18 |
2023-08-13 |
human |
| Yu Zhang, Qiang Shen, Yuanxing Liu, Hui Chen, Xiaoxiao Zheng, Shangzhi Xie, Haofeng Ji, Shusen Zhen. Hepatic Ischemic Preconditioning Alleviates Ischemia-Reperfusion Injury by Decreasing TIM4 Expression. International journal of biological sciences. vol 14. issue 10. 2019-08-20. PMID:30123068. |
liver function was evaluated using the level of alanine transaminase (alt) and aspartate transaminase (ast), cell apoptosis and pathological examination. |
2019-08-20 |
2023-08-13 |
mouse |
| Yu Zhang, Qiang Shen, Yuanxing Liu, Hui Chen, Xiaoxiao Zheng, Shangzhi Xie, Haofeng Ji, Shusen Zhen. Hepatic Ischemic Preconditioning Alleviates Ischemia-Reperfusion Injury by Decreasing TIM4 Expression. International journal of biological sciences. vol 14. issue 10. 2019-08-20. PMID:30123068. |
we found that compared with the control group, ischemic preconditioning reduced iri by decreasing hepatocyte apoptosis, alt, ast, cd68 and cd3 positive cells, tissue myeloperoxidase activity(mpo), and downregulating tim-4 expression. |
2019-08-20 |
2023-08-13 |
mouse |
| Yu Zhang, Qiang Shen, Yuanxing Liu, Hui Chen, Xiaoxiao Zheng, Shangzhi Xie, Haofeng Ji, Shusen Zhen. Hepatic Ischemic Preconditioning Alleviates Ischemia-Reperfusion Injury by Decreasing TIM4 Expression. International journal of biological sciences. vol 14. issue 10. 2019-08-20. PMID:30123068. |
furthermore, activated monocytes transfusion significantly abolished the protect effect of ipc with increased hepatocyte apoptosis, alt, ast, cd68 and cd3 positive cells while tim-4 knockdown monocytes lost this effect. |
2019-08-20 |
2023-08-13 |
mouse |
| Yong Luo, Qing Wan, Min Xu, Qing Zhou, Xuepiao Chen, Dong Yin, Huan He, Ming H. Nutritional preconditioning induced by astragaloside Ⅳ on isolated hearts and cardiomyocytes against myocardial ischemia injury via improving Bcl-2-mediated mitochondrial function. Chemico-biological interactions. vol 309. 2019-08-19. PMID:31228469. |
the effects of ast treatment against a/r injury were also reflected by increased antioxidant potential, inhibited reactive oxygen species (ros) burst, increased oxygen consumption rate, maintained mitochondrial membrane potential (mmp), inhibited mitochondrial permeability transition pore (mptp) opening, and prevented apoptosis. |
2019-08-19 |
2023-08-13 |
rat |
| Shanshan Zhu, Tao Wang, Fei Luo, Huawen Li, Qing Jia, Taiping He, Hongfu Wu, Tangbin Zo. Astaxanthin inhibits proliferation and induces apoptosis of LX‑2 cells by regulating the miR‑29b/Bcl‑2 pathway. Molecular medicine reports. vol 19. issue 5. 2019-08-01. PMID:30896849. |
rt‑qpcr and western blotting demonstrated that ast induced lx‑2 cells apoptosis which may be by regulating mir‑29b, as indicated by inhibited bcl‑2 expression levels and elevated bax and caspase‑3 expression levels. |
2019-08-01 |
2023-08-13 |
human |
| Shanshan Zhu, Tao Wang, Fei Luo, Huawen Li, Qing Jia, Taiping He, Hongfu Wu, Tangbin Zo. Astaxanthin inhibits proliferation and induces apoptosis of LX‑2 cells by regulating the miR‑29b/Bcl‑2 pathway. Molecular medicine reports. vol 19. issue 5. 2019-08-01. PMID:30896849. |
these results highlight an important role of mir‑29b in the ast modulating lx‑2 cells proliferation and apoptosis and implicate a potential mechanism of mir‑29b and ast preventing liver fibrosis. |
2019-08-01 |
2023-08-13 |
human |
| Lingjian Zhang, Yalei Zhao, Linxiao Fan, Kai Xu, Feiyang Ji, Zhongyang Xie, Xiaoxi Ouyang, Daxian Wu, Lanjuan L. Tectorigenin protects against experimental fulminant hepatic failure by regulating the TLR4/mitogen-activated protein kinase and TLR4/nuclear factor-κB pathways and autophagy. Phytotherapy research : PTR. vol 33. issue 4. 2019-06-10. PMID:30701601. |
pretreatment with tectorigenin significantly reduced the serum levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast), histological injury, apoptosis, and the mortality of fhf mice, by suppressing the production of inflammatory cytokines such as tnf-α and il-6. |
2019-06-10 |
2023-08-13 |
mouse |
| Hailong Guo, Boshun Wan, Jiansong Wang, Jie Zhang, Wenfei Yao, Zhiyong She. Astragalus saponins inhibit cell growth, aerobic glycolysis and attenuate the inflammatory response in a DSS-induced colitis model. International journal of molecular medicine. vol 43. issue 2. 2019-05-20. PMID:30569176. |
the present study aimed to explore cell growth, proliferation, apoptosis and a series of glycolysis metabolic alterations associated with ast treatment in colorectal cancer (crc) cells. |
2019-05-20 |
2023-08-13 |
mouse |
| Hailong Guo, Boshun Wan, Jiansong Wang, Jie Zhang, Wenfei Yao, Zhiyong She. Astragalus saponins inhibit cell growth, aerobic glycolysis and attenuate the inflammatory response in a DSS-induced colitis model. International journal of molecular medicine. vol 43. issue 2. 2019-05-20. PMID:30569176. |
mtt, a colony formation assay and flow cytometry demonstrated that ast dose‑dependently inhibited cell viability and induced apoptosis. |
2019-05-20 |
2023-08-13 |
mouse |
| Maria Lucia Cocato, Alexandre Rodrigues Lobo, Anna Karenina Azevedo-Martins, Jorge Mancini Filho, Lilian Rose Marques de Sá, Célia Coll. Effects of a moderate iron overload and its interaction with yacon flour, and/or phytate, in the diet on liver antioxidant enzymes and hepatocyte apoptosis in rats. Food chemistry. vol 285. 2019-04-11. PMID:30797332. |
for this purpose the following parameters were analyzed: (1) apparent iron (fe), copper (cu) and zinc (zn) absorption; (2) blood fe; (3) blood lipids (cholesterol, tryacylglicerol); (4) blood ast and alt; (5) liver histology (histopathology, hemosiderin depots, apoptosis index; (6) liver fatty acid incorporation; (7) liver antioxidant enzyme activity. |
2019-04-11 |
2023-08-13 |
rat |
| Peng Xia, Xu Gao, Lian Duan, Wei Zhang, Yi-Fu Su. Mulberrin (Mul) reduces spinal cord injury (SCI)-induced apoptosis, inflammation and oxidative stress in rats via miroRNA-337 by targeting Nrf-2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30257365. |
in vitro, ast transfected with mir-337 inhibitor showed attenuated inflammation, apoptosis and oxidative stress in lps-treated ast, which was, intriguingly, abolished by nrf-2 knockdown. |
2019-01-22 |
2023-08-13 |
mouse |
| Jia Xiao, Fei Wang, Emily C Liong, Kwok-Fai So, George L Tipo. Lycium barbarum polysaccharides improve hepatic injury through NFkappa-B and NLRP3/6 pathways in a methionine choline deficient diet steatohepatitis mouse model. International journal of biological macromolecules. vol 120. issue Pt B. 2019-01-22. PMID:30266645. |
lbp significantly ameliorated nash-induced injuries, including the increase of serum alt and ast levels, hepatic oxidative stress, fibrosis, inflammation, and apoptosis. |
2019-01-22 |
2023-08-13 |
mouse |
| Tianjun Xie, Ke Li, Xia Gong, Rong Jiang, Wenya Huang, Xiahong Chen, Hongtao Tie, Qin Zhou, Shengwang Wu, Jingyuan Wan, Bin Wan. Paeoniflorin protects against liver ischemia/reperfusion injury in mice via inhibiting HMGB1-TLR4 signaling pathway. Phytotherapy research : PTR. vol 32. issue 11. 2018-11-21. PMID:30047580. |
the results showed that pf pretreatment significantly inhibited i/r-induced serum alt and ast activities (40.3% and 53.8% those of i/r group, respectively), hepatic pathological damages and hepatic apoptosis (p < 0.01), and infiltration of neutrophils into liver. |
2018-11-21 |
2023-08-13 |
mouse |
| Wei Liu, Zi Wang, Jin-Gang Hou, Yan-Dan Zhou, Yu-Fang He, Shuang Jiang, Ying-Ping Wang, Shen Ren, Wei L. The Liver Protection Effects of Maltol, a Flavoring Agent, on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Inhibiting Apoptosis and Inflammatory Response. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-11-19. PMID:30142916. |
in the mouse model of ccl₄-induced liver injury, we have demonstrated that the inflammatory responses were inhibited, the serum levels of alt and ast were reduced, cell apoptosis was suppressed, and liver injury caused by ccl₄ was alleviated by maltol, demonstrating that maltol may be an efficient hepatoprotective agent. |
2018-11-19 |
2023-08-13 |
mouse |
| Qi Liang, Lingling Deng, Zhichao Feng, Xiao Liu, Jingsong Ding, Pengzhi Hu, Wei Wan. [Transhepatic arterial embolization with superparamagnetic iron oxide and lipiodol for the treatment of VX2 tumor in rabbits]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 42. issue 11. 2018-10-22. PMID:29187650. |
the histopathologic examinations were performed including he staining, prussian blue staining and tunel assay, and then the tumor necrosis percentage and apoptosis index were calculated.
results: compared to the dox group, the levels of ast and alt in other 3 groups were significantly elevated at 1 and 3 d after embolization (p<0.05). |
2018-10-22 |
2023-08-13 |
rabbit |
| Hui Zhou, Ying Yu, Jinna Zhang, Yunfang Zhang, Qi Luan, Gongming Wan. Protective Effects the Akt Activator SC79 in Hepatic Ischemia-Reperfusion Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-10-19. PMID:29936516. |
the serum alt, ast, histologic examination, cellular viability, and cell apoptosis were assessed. |
2018-10-19 |
2023-08-13 |
rat |
| Hui Zhou, Ying Yu, Jinna Zhang, Yunfang Zhang, Qi Luan, Gongming Wan. Protective Effects the Akt Activator SC79 in Hepatic Ischemia-Reperfusion Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-10-19. PMID:29936516. |
sc79 decreased serum ast and alt, markedly improved pathology, and decreased cell apoptosis in livers following i/r. |
2018-10-19 |
2023-08-13 |
rat |
| Peng Cao, Jinlu Sun, Mitchell A Sullivan, Xiao Huang, Hanxiang Wang, Yu Zhang, Na Wang, Kaiping Wan. Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro. International journal of biological macromolecules. vol 111. 2018-08-29. PMID:29415408. |
specifically, serum and hepatic biochemical parameters including alanine aminotransferase (alt), aspartate transaminase (ast), glutathione (gsh), malondialdehyde (mda) and superoxide dismutase (sod) were evaluated, and key proteins involved in hepatic apoptosis, including cleaved caspase-3, bax and bcl-2 were quantified. |
2018-08-29 |
2023-08-13 |
rat |
| Dongxu Wang, Qiang Gao, Guangshan Zhao, Zhipeng Kan, Xiaoxiao Wang, Haisong Wang, Jinbao Huang, Taotao Wang, Frank Qian, Chi-Tang Ho, Yijun Wan. Protective Effect and Mechanism of Theanine on Lipopolysaccharide-Induced Inflammation and Acute Liver Injury in Mice. Journal of agricultural and food chemistry. vol 66. issue 29. 2018-08-14. PMID:29969892. |
the results showed that compared with the lps group, the liver damage and oxidative stress of the theanine-treated group decreased significantly, based on plasma alanine aminotransferase (alt) and aspartate aminotransferase (ast) concentrations, hepatic total superoxide dismutase (t-sod), and malondialdehyde (mda) levels, and histological scores and apoptosis [terminal deoxynucleotide transferase-mediated deoxyuridine triphosphate nick end-labeling (tunel) staining and caspase-3 activity] in the liver tissues. |
2018-08-14 |
2023-08-13 |
mouse |