| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuhong Ma, Weizu Li, Yanyan Yin, Weiping L. AST IV inhibits H₂O₂-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-β1/Smad2 pathway. International journal of molecular medicine. vol 35. issue 6. 2016-01-25. PMID:25891879. |
treatment with diphenyliodonium (dpi), a specific inhibitor of nox4 or astragaloside iv (ast iv), a monomer located in an extract of astragaloside, decreased nox4 expression and the levels of ros, decreased tgf-β1 and smad2 expression, altered the expression of apoptosis-related genes and decreased the apoptosis of huvecs. |
2016-01-25 |
2023-08-13 |
human |
| Yuhong Ma, Weizu Li, Yanyan Yin, Weiping L. AST IV inhibits H₂O₂-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-β1/Smad2 pathway. International journal of molecular medicine. vol 35. issue 6. 2016-01-25. PMID:25891879. |
our data indicate that the protective effects of ast iv against vascular endothelial cell apoptosis in dm are mainly associated with the decrease in nox4 expression through the tgf-β1/smad2 signaling pathway. |
2016-01-25 |
2023-08-13 |
human |
| Jingwen Si, Ning Wang, Huan Wang, Juan Xie, Jian Yang, Hui Yi, Zixuan Shi, Jing Ma, Wen Wang, Lifang Yang, Shiqiang Yu, Junchang L. HIF-1α signaling activation by post-ischemia treatment with astragaloside IV attenuates myocardial ischemia-reperfusion injury. PloS one. vol 9. issue 9. 2015-11-25. PMID:25238237. |
the post-ischemia treatment with ast iv protected cardiomyocytes from the apoptosis and death induced by simulated iri (siri). |
2015-11-25 |
2023-08-13 |
rat |
| Shun-Tai Yang, Jia-Wei Lin, Bi-Ying Chiu, Yao-Chin Hsu, Ching-Ping Chang, Cheng-Kuei Chan. Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation. The American journal of Chinese medicine. vol 42. issue 6. 2015-08-27. PMID:25384449. |
ast causes the attenuation of tbi-induced cerebral contusion, neuronal apoptosis, and neurological motor dysfunction. |
2015-08-27 |
2023-08-13 |
rat |
| Shun-Tai Yang, Jia-Wei Lin, Bi-Ying Chiu, Yao-Chin Hsu, Ching-Ping Chang, Cheng-Kuei Chan. Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation. The American journal of Chinese medicine. vol 42. issue 6. 2015-08-27. PMID:25384449. |
our results indicate that ast may protect against brain contusion and neuronal apoptosis after tbi by attenuating microglia activation in male rats. |
2015-08-27 |
2023-08-13 |
rat |
| Peng Liu, Xiang Jin, Hao Lv, Jing Li, Wen Xu, Hai-hua Qian, Zhengfeng Yi. Icaritin ameliorates carbon tetrachloride-induced acute liver injury mainly because of the antioxidative function through estrogen-like effects. In vitro cellular & developmental biology. Animal. vol 50. issue 10. 2015-07-21. PMID:25148823. |
biochemical parameters (alanine aminotransferase (alt), aspartate aminotransferase (ast), malondialdehyde (mda), and superoxide dismutase (sod)) and cell apoptosis were detected to evaluate the injury degree. |
2015-07-21 |
2023-08-13 |
rat |
| Xiaodong Song, Bingsi Wang, Shengcui Lin, Lili Jing, Cuiping Mao, Pan Xu, Changjun Lv, Wen Liu, Ji Zu. Astaxanthin inhibits apoptosis in alveolar epithelial cells type II in vivo and in vitro through the ROS-dependent mitochondrial signalling pathway. Journal of cellular and molecular medicine. vol 18. issue 11. 2015-07-03. PMID:25215580. |
our data show that ast blocks h2 o2 - or blm-induced ros generation and dose-dependent apoptosis in aecs-ii, as characterized by changes in cell and mitochondria morphology, translocation of apoptotic proteins, inhibition of cytochrome c (cyt c) release, and the activation of caspase-9, caspase-3, nrf-2 and other cytoprotective genes. |
2015-07-03 |
2023-08-13 |
Not clear |
| Xiaodong Song, Bingsi Wang, Shengcui Lin, Lili Jing, Cuiping Mao, Pan Xu, Changjun Lv, Wen Liu, Ji Zu. Astaxanthin inhibits apoptosis in alveolar epithelial cells type II in vivo and in vitro through the ROS-dependent mitochondrial signalling pathway. Journal of cellular and molecular medicine. vol 18. issue 11. 2015-07-03. PMID:25215580. |
these data suggest that ast inhibits apoptosis in aecs-ii cells through the ros-dependent mitochondrial signalling pathway and may be of potential therapeutic value in lung fibrosis treatment. |
2015-07-03 |
2023-08-13 |
Not clear |
| Qing Zhu, Liwei Gu, Yimei Wang, Li Jia, Zengming Zhao, Shuangqing Peng, Linsheng Le. The role of alpha-1 and alpha-2 adrenoceptors in restraint stress-induced liver injury in mice. PloS one. vol 9. issue 3. 2015-06-01. PMID:24682087. |
assessment of liver injury (serum alanine aminotransferase (alt), aspartate aminotransferase (ast) , hepatic total gsh, gssg and gsh/gssg ratio) , histopathology and of apoptosis, by tunel (terminal deoxynucleotidyl transferase-mediated dutp nick-end labelling) assay and western blotting, was performed. |
2015-06-01 |
2023-08-12 |
mouse |
| Nanzheng Chen, Qianqian Geng, Jianbao Zheng, Sai He, Xiongwei Huo, Xuejun Su. Suppression of the TGF-β/Smad signaling pathway and inhibition of hepatic stellate cell proliferation play a role in the hepatoprotective effects of curcumin against alcohol-induced hepatic fibrosis. International journal of molecular medicine. vol 34. issue 4. 2015-05-26. PMID:25069637. |
in this study, serum alkaline phosphatase (alp), aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels were measured to assess hepatic function; histopathological and immunohistochemical observations were used to evaluate pathological and specific molecular changes in liver tissue and flow cytometry was used to detect the apoptosis in cultured hepatic stellate cells (hscs), the major fibrogenic cells in the liver; pcr and western blot analysis were employed to evaluate the changes in the expression of molecules and signaling pathways. |
2015-05-26 |
2023-08-13 |
Not clear |
| Xiao-Xia Lu, Si-Qian Wang, Zhi Zhang, Hong-Rui Xu, Bin Liu, Chao-Shen Huangf. [Protective effects of sodium nitrite preconditioning against alcohol-induced acute liver injury in mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 3. 2015-05-16. PMID:22717636. |
the results showed that, compared with acute alcohol-induced liver injury group, pretreatment with low doses of sn decreased liver index and serum levels of alt and ast, weakened acute alcohol-induced hepatocyte necrosis, improved pathological changes in liver tissue, increased live tissue sod, gsh-px and cat activities, reduced mda content and apoptosis index of hepatocytes, and up-regulated hif-1α protein level in liver tissue. |
2015-05-16 |
2023-08-12 |
mouse |
| Hai-Guang Xin, Bei-Bei Zhang, Zhi-Qin Wu, Xiao-Feng Hang, Wen-Sheng Xu, Wu Ni, Rui-Qi Zhang, Xiao-Hui Mia. Treatment with baicalein attenuates methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats. European journal of pharmacology. vol 738. 2015-04-06. PMID:24937020. |
treatment with baicalein prevented mcd-diet-induced nash, as evidenced by reduced histological scores, apoptosis, activities of alt and ast, and hepatic fat accumulation in rats. |
2015-04-06 |
2023-08-13 |
human |
| Bi-Ying Chiu, Ching-Ping Chang, Jia-Wei Lin, Jung-Sheng Yu, Wen-Pin Liu, Yao-Chin Hsu, Mao-Tsun Li. Beneficial effect of astragalosides on stroke condition using PC12 cells under oxygen glucose deprivation and reperfusion. Cellular and molecular neurobiology. vol 34. issue 6. 2015-03-31. PMID:24807460. |
a key finding was that ogd-r decreased cell viability, increased lactate dehydrogenase, increased reactive oxygen species, apoptosis, autophagy, functional impairment of mitochondria, and endoplasmic reticulum stress in pc12 cells, all of which ast treatment significantly reduced. |
2015-03-31 |
2023-08-13 |
rat |
| Bi-Ying Chiu, Ching-Ping Chang, Jia-Wei Lin, Jung-Sheng Yu, Wen-Pin Liu, Yao-Chin Hsu, Mao-Tsun Li. Beneficial effect of astragalosides on stroke condition using PC12 cells under oxygen glucose deprivation and reperfusion. Cellular and molecular neurobiology. vol 34. issue 6. 2015-03-31. PMID:24807460. |
our data suggest that both apoptosis and autophagy are important characteristics of ogd-r-induced pc12 death and that treating pc12 cells with ast blocked ogd-r-induced apoptosis and autophagy by suppressing intracellular oxidative stress, functional impairment of mitochondria, and endoplasmic reticulum stress. |
2015-03-31 |
2023-08-13 |
rat |
| Yu-Jung Cheng, Woei-Cherng Shyu, Yi-Hsien Teng, Yu-Hsuan Lan, Shin-Da Le. Antagonistic interaction between cordyceps sinensis and exercise on protection in fulminant hepatic failure. The American journal of Chinese medicine. vol 42. issue 5. 2015-03-31. PMID:25242080. |
either exercise or 40 mg/kg cs pretreatment alone significantly decreased d-galn/lps-induced tnf-α, ast, no, apoptotic-related proteins, and hepatocyte apoptosis. |
2015-03-31 |
2023-08-13 |
mouse |
| Yu-Jung Cheng, Woei-Cherng Shyu, Yi-Hsien Teng, Yu-Hsuan Lan, Shin-Da Le. Antagonistic interaction between cordyceps sinensis and exercise on protection in fulminant hepatic failure. The American journal of Chinese medicine. vol 42. issue 5. 2015-03-31. PMID:25242080. |
tnf-α, ast, no level, caspase-3 activity, and hepatocytes apoptosis were not significantly different in the exercise combined with 40 mg/kg cs compared to mice challenged with d-galn/lps. |
2015-03-31 |
2023-08-13 |
mouse |
| Yoko Yoshihisa, Mati Ur Rehman, Tadamichi Shimiz. Astaxanthin, a xanthophyll carotenoid, inhibits ultraviolet-induced apoptosis in keratinocytes. Experimental dermatology. vol 23. issue 3. 2014-11-06. PMID:24521161. |
the protective effects of ast against uv-induced apoptosis were investigated in the present study. |
2014-11-06 |
2023-08-12 |
Not clear |
| Yoko Yoshihisa, Mati Ur Rehman, Tadamichi Shimiz. Astaxanthin, a xanthophyll carotenoid, inhibits ultraviolet-induced apoptosis in keratinocytes. Experimental dermatology. vol 23. issue 3. 2014-11-06. PMID:24521161. |
these results suggest that ast effectively protects against uv-induced inflammation by decreasing inos and cox-2, and thereby inhibiting the apoptosis of keratinocytes. |
2014-11-06 |
2023-08-12 |
Not clear |
| Yu-Jung Cheng, Shiu-Min Cheng, Yi-Hsien Teng, Woei-Cherng Shyu, Hsiu-Ling Chen, Shin-Da Le. Cordyceps sinensis prevents apoptosis in mouse liver with D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure. The American journal of Chinese medicine. vol 42. issue 2. 2014-10-28. PMID:24707872. |
data demonstrated that galn/lps increased hepatocyte degeneration, circulating ast, tnf-α, il-10, and hepatic apoptosis and caspase activity. |
2014-10-28 |
2023-08-13 |
mouse |
| Yang-Yang Wu, Wang-Yang Wu, Hui-Ling Gong, Wei-Zu Li, Yan-Yan Yi. Astragalosides attenuate learning and memory impairment in rats following ischemia‑reperfusion injury. Molecular medicine reports. vol 9. issue 4. 2014-10-21. PMID:24567111. |
the data revealed that ast improved the rats learning and memory abilities, attenuated neuronal cells apoptosis, increased the expression of p‑erk and p‑akt, and decreased the expression of p‑jnk. |
2014-10-21 |
2023-08-12 |
rat |