| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Zhang, Yuanxing Liu, Hui Chen, Xiaoxiao Zheng, Shangzhi Xie, Wei Chen, Haofeng Ji, Shusen Zhen. TIM-1 attenuates the protection of ischemic preconditioning for ischemia reperfusion injury in liver transplantation. American journal of translational research. vol 9. issue 8. 2020-09-29. PMID:28861157. |
graft function was assessed using the levels of alanine transaminase (alt) and aspartate transaminase (ast), percentage of apoptosis cells and pathological examination. |
2020-09-29 |
2023-08-13 |
Not clear |
| Long Li, Hongyan Yin, Yan Zhao, Xiaofang Zhang, Chaoli Duan, Jing Liu, Caoxin Huang, Suhuan Liu, Shuyu Yang, Xuejun L. Protective role of puerarin on LPS/D-Gal induced acute liver injury via restoring autophagy. American journal of translational research. vol 10. issue 3. 2020-09-29. PMID:29636885. |
the results showed that administration of puerarin substantially alleviated lps/d-gal-induced acute liver injury in mice by increased survival rates, improved liver histopathology, reduced plasma alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels, alleviated production of pro-inflammatory cytokines, and suppressed hepatocyte apoptosis. |
2020-09-29 |
2023-08-13 |
mouse |
| Xiaolin Deng, Ming Wang, Sihui Hu, Yonghao Feng, Yiye Shao, Yangmei Xie, Men Wu, Yinghui Chen, Xiaohong Sh. The Neuroprotective Effect of Astaxanthin on Pilocarpine-Induced Status Epilepticus in Rats. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:30983975. |
a recent study indicated that preventive astaxanthin (ast) alleviated epilepsy-induced oxidative stress and neuronal apoptosis in the brain. |
2020-09-29 |
2023-08-13 |
rat |
| Tso-Ting Lai, Chung-May Yang, Chang-Hao Yan. Astaxanthin Protects Retinal Photoreceptor Cells against High Glucose-Induced Oxidative Stress by Induction of Antioxidant Enzymes via the PI3K/Akt/Nrf2 Pathway. Antioxidants (Basel, Switzerland). vol 9. issue 8. 2020-09-28. PMID:32785112. |
we treated high glucose-cultured mouse photoreceptor cells (661w) with different concentrations of ast and analyzed ros production and cell apoptosis in the different regimens. |
2020-09-28 |
2023-08-13 |
mouse |
| Tso-Ting Lai, Chung-May Yang, Chang-Hao Yan. Astaxanthin Protects Retinal Photoreceptor Cells against High Glucose-Induced Oxidative Stress by Induction of Antioxidant Enzymes via the PI3K/Akt/Nrf2 Pathway. Antioxidants (Basel, Switzerland). vol 9. issue 8. 2020-09-28. PMID:32785112. |
our results showed that ast dose-dependently reduced ros production and attenuated 661w cell apoptosis in a high glucose environment. |
2020-09-28 |
2023-08-13 |
mouse |
| Mai M Elkeiy, Abeer A Khamis, Mona M El-Gamal, Maha M Abo Gazia, Zeinb A Zalat, Mohammed A El-Mag. Chitosan nanoparticles from Artemia salina inhibit progression of hepatocellular carcinoma in vitro and in vivo. Environmental science and pollution research international. vol 27. issue 16. 2020-07-10. PMID:30293105. |
administration of cnps decreased hcc progression as evidenced by (1) induced hepg2 cell death as detected by mtt assay; (2) induced necrosis as indicated by acridine orange/propidium iodide (ao/pi) red staining, annexin v/7-aad positive staining (detected by flow cytometry), and upregulated expression of necrosis markers (parp1 and its downstream target, rip1 genes), but no effect on apoptosis as revealed by insignificant changes in caspase 3 activity and mrna levels of bax and aif; (3) increased intracellular ros and decreased mitochondrial membrane potential in hepg2; (4) decreased liver relative weight, serum levels of liver enzymes (alt, ast, and alp), total bilirubin, and cancer markers (afp and ggt), number and area of gst-p positive tumor nodules; and (5) reduced oxidative stress (decrease in mda levels) and increased activities of sod, cat, and gpx enzymes in rat liver. |
2020-07-10 |
2023-08-13 |
rat |
| Pei-Lei Chou, Kuo-Hsin Chen, Tzu-Ching Chang, Chiang-Ting Chie. Repetitively hypoxic preconditioning attenuates ischemia/reperfusion-induced liver dysfunction through upregulation of hypoxia-induced factor-1 alpha-dependent mitochondrial Bcl-xl in rat. The Chinese journal of physiology. vol 63. issue 2. 2020-07-08. PMID:32341232. |
hepatic i/r increased ros levels, myeloperoxidase activity, kupffer cell infiltration, alt and ast levels associated with the enhancement of cytosolic bad translocation to mitochondria, release of cytochrome c to cytosol, and activation of caspase 3/parp-mediated apoptosis. |
2020-07-08 |
2023-08-13 |
rat |
| Xingxing Meng, Zhenghui Gu, Xiaoping Xie, Yuting Su, Xi Zhang, Hongzhe Ma, Yibin Guo, Xincheng Liu, Yaoping Cheng, Yaoming Chang, Junxiang Ba. Acid sphingomyelinase mediates the noise-induced liver disorder in mice. Clinical and experimental pharmacology & physiology. vol 46. issue 6. 2020-07-01. PMID:30854677. |
moreover, the noise promoted apoptosis and superoxide generation in hepatocytes significantly, enhancing activity of aspartate aminotransferase (ast) or alanine amino transferase (alt) in serum. |
2020-07-01 |
2023-08-13 |
mouse |
| Fengwu Li, Zhiying Yang, Christopher Stone, Jamie Y Ding, Lauren Previch, Jiamei Shen, Yu Ji, Xiaokun Geng, Yuchuan Din. Phenothiazines Enhance the Hypothermic Preservation of Liver Grafts: A Pilot in Vitro Study. Cell transplantation. vol 28. issue 3. 2020-04-30. PMID:30666889. |
c+p augmentation induced significant reductions in alt and ast activities; the ast/alt ratio; as well as in cellular swelling, vacuolar degeneration, apoptosis, and bax expression. |
2020-04-30 |
2023-08-13 |
rat |
| Jian-Qiao Li, Wen-Feng Huang, Hai-Bo He, Dong-Xiao Zhao, Jian-Zhong Hu, Shun-Guang Lu, Jia-Xin Ye, Kun Zo. [Study on protective effect of water extract from Sabia parviflora on liver injury in mice induced by acetaminophen]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 6. 2020-04-14. PMID:32281358. |
the results showed that s. parviflora could alleviate the lipid peroxidation damage in the liver caused by acetaminophen, reduce the alt and ast activities in serum, increase the levels of sod and gsh in liver tissue, decrease the content of mda in liver tissue, and inhibit the apoptosis. |
2020-04-14 |
2023-08-13 |
mouse |
| Yangyang Ding, Yongchao Liu, Fan Fei, Liuqing Yang, Guanghua Mao, Ting Zhao, Zhehan Zhang, Mengjiao Yan, Weiwei Feng, Xiangyang W. Study on the metabolism toxicity, susceptibility and mechanism of di-(2-ethylhexyl) phthalate on rat liver BRL cells with insulin resistance in vitro. Toxicology. vol 422. 2020-04-03. PMID:31152848. |
the results showed that dehp could cause cell damage with alt and ast activities and mda levels increased, cell apoptosis with caspase-3 levels increased and insulin resistance with ir-β levels decreased in brl cells with resistance and normal brl cells. |
2020-04-03 |
2023-08-13 |
rat |
| Ramakrishnan Sabitha, Kumari Nishi, Vinoth Prasanna Gunasekaran, Balupillai Agilan, Ernest David, Govindhan Annamalai, Rajamanickam Vinothkumar, Malliga Perumal, Latha Subbiah, Mathan Ganesha. p-Coumaric acid attenuates alcohol exposed hepatic injury through MAPKs, apoptosis and Nrf2 signaling in experimental models. Chemico-biological interactions. vol 321. 2020-03-30. PMID:32151596. |
we also noticed that the pca protected ethanol induced apoptosis and liver markers by inhibiting the expression of bax, caspases; ast, alt, als, and ldh in liver tissue. |
2020-03-30 |
2023-08-13 |
rat |
| Xujie Jiang, Ge Kuang, Xia Gong, Rong Jiang, Tianjun Xie, Hongtao Tie, Shengwang Wu, Ting Wang, Jingyuan Wan, Bin Wan. Glycyrrhetinic acid pretreatment attenuates liver ischemia/reperfusion injury via inhibiting TLR4 signaling cascade in mice. International immunopharmacology. vol 76. 2020-03-17. PMID:31493667. |
we found that mice performed with liver i/r showed a significantly increase in plasma aminotransferase (alt), aspartate aminotransferase (ast), liver cell apoptosis and infiltration of neutrophils compared with the control group. |
2020-03-17 |
2023-08-13 |
mouse |
| Sen Yang, Ge Kuang, Rong Jiang, Shengwang Wu, Tao Zeng, Yuanyuan Wang, Fangzhi Xu, Lingyi Xiong, Xia Gong, Jingyuan Wa. Geniposide protected hepatocytes from acetaminophen hepatotoxicity by down-regulating CYP 2E1 expression and inhibiting TLR 4/NF-κB signaling pathway. International immunopharmacology. vol 74. 2020-01-28. PMID:31302451. |
the results showed that gp pretreatment reduced the levels of alt and ast in a dose-dependent manner and alleviated hepatocyte necrosis and apoptosis in mice exposed at apap. |
2020-01-28 |
2023-08-13 |
mouse |
| Yugang Xue, Chuang Sun, Qimeng Hao, Jin Chen. Astaxanthin ameliorates cardiomyocyte apoptosis after coronary microembolization by inhibiting oxidative stress via Nrf2/HO-1 pathway in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 3. 2019-12-06. PMID:30506291. |
ast pretreatment dramatically attenuated cme-induced cardiac dysfunction, myocardial infarction, and cardiomyocyte apoptosis. |
2019-12-06 |
2023-08-13 |
rat |
| Yugang Xue, Chuang Sun, Qimeng Hao, Jin Chen. Astaxanthin ameliorates cardiomyocyte apoptosis after coronary microembolization by inhibiting oxidative stress via Nrf2/HO-1 pathway in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 3. 2019-12-06. PMID:30506291. |
conclusion: ast suppresses oxidative stress via activating nrf2/ho-1 pathway and thus prevents cme-induced cardiomyocyte apoptosis and ameliorates cardiac dysfunction in rats. |
2019-12-06 |
2023-08-13 |
rat |
| Rumeng Tan, Hongzhe Tian, Bo Yang, Bo Zhang, Chen Dai, Zhenyi Han, Meixi Wang, Yakun Li, Lai Wei, Dong Chen, Guangyao Wang, Huifang Yang, Fan He, Zhishui Che. Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice. Scientific reports. vol 8. issue 1. 2019-11-13. PMID:30279567. |
we assessed alanine aminotransferase (alt), aspartate aminotransferase (ast) and lactate dehydrogenase (ldh) levels in mouse sera, and performed haematoxylin/eosin (he) staining, immunohistochemistry, electron microscopy, immunofluorescence microscopy, and western blotting on liver tissue to detect the degree of liver injury, liver apoptosis, autophagy, and the expression of microtubule associated protein 1 light chain 3 alpha (map1lc3, or lc3), beclin 1, phospho-mtor, mtor, phospho-akt (p-akt), and akt. |
2019-11-13 |
2023-08-13 |
mouse |
| RuiJin Xie, Mei Liu, ShuJie L. Emodin weakens liver inflammatory injury triggered by lipopolysaccharide through elevating microRNA-145 in vitro and in vivo. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-11-04. PMID:31079494. |
in vivo, we found that emodin pre-treatment weakened the lps-triggered increases of pro-inflammatory factors expression, up-regulations of ast and alt level, liver cell apoptosis, reduction of mir-145 and enhancement of irak1. |
2019-11-04 |
2023-08-13 |
Not clear |
| Ying-Ying Miao, Lan Luo, Ting Shu, Hao Wang, Zhen-Zhou Jiang, Lu-Yong Zhan. [Study on difference of liver toxicity and its molecular mechanisms caused by Tripterygium wilfordii multiglycoside and equivalent amount of triptolid in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 16. 2019-10-21. PMID:31602911. |
then after oral administration of gtw( 100,150 mg·kg-1) and tp( 12 μg·kg-1) in female wistar rats for 24 h,it was found that 150 mg·kg-1 gtw showed more serious acute liver injury than 12 μg·kg-1 tp,with the significantly increased lever of serum alt,ast,tba,tbi l,tg and bile duct hyperplasia even hepatocyte apoptosis. |
2019-10-21 |
2023-08-13 |
rat |
| Sheng Yu, Xingliang Zhou, Hang Xiang, Shaoping Wang, Zhonglin Cui, Jie Zho. Resveratrol Reduced Liver Damage After Liver Resection in a Rat Model by Upregulating Sirtuin 1 (SIRT1) and Inhibiting the Acetylation of High Mobility Group Box 1 (HMGB1). Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-18. PMID:31041919. |
liver injury was assessed by serum liver function tests, including alanine aminotransferase (alt), aspartate aminotransferase (ast), γ-glutamyl-transferase (γ-gt) and total bilirubin, histological examination of the rat liver, and liver cell apoptosis using the tunel assay. |
2019-09-18 |
2023-08-13 |
human |