| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuanwei Liang, Yangliang Zhou, Shulin Deng, Tianfeng Che. Microwave-Assisted Syntheses of Benzimidazole-Containing Selenadiazole Derivatives That Induce Cell-Cycle Arrest and Apoptosis in Human Breast Cancer Cells by Activation of the ROS/AKT Pathway. ChemMedChem. vol 11. issue 20. 2017-06-13. PMID:27677422. |
our results demonstrate that bseds can cause cell-cycle arrest and apoptosis in mda-mb-231 cells by inducing dna damage, inhibiting protein kinase b (akt), and activating mitogen-activated protein kinase (mapk) family members through the overproduction of reactive oxygen species (ros). |
2017-06-13 |
2023-08-13 |
human |
| Xin Chen, Zheng Jian. [Overexpression of aplysia Ras homolog I (ARHI) increases apoptosis in colon cancer SW480 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 11. 2017-06-13. PMID:27774944. |
conclusion the overexpression of arhi promotes colon cancer sw480 cell apoptosis by inhibiting the level of akt. |
2017-06-13 |
2023-08-13 |
human |
| Xiaofei Zhu, Mingde Ji, Yue Han, Yuanyuan Guo, Wenqiang Zhu, Feng Gao, Xuewen Yang, Chunbing Zhan. PGRMC1-dependent autophagy by hyperoside induces apoptosis and sensitizes ovarian cancer cells to cisplatin treatment. International journal of oncology. vol 50. issue 3. 2017-06-13. PMID:28197632. |
additionally, akt signaling and bcl-2 family were also involved in the hyperoside-induced autophagy and apoptosis. |
2017-06-13 |
2023-08-13 |
Not clear |
| Shixin Gu, Rong Xie, Xiaodong Liu, Jiajun Shou, Wentao Gu, Xiaoming Ch. Long Coding RNA XIST Contributes to Neuronal Apoptosis through the Downregulation of AKT Phosphorylation and Is Negatively Regulated by miR-494 in Rat Spinal Cord Injury. International journal of molecular sciences. vol 18. issue 4. 2017-06-13. PMID:28368292. |
long coding rna xist contributes to neuronal apoptosis through the downregulation of akt phosphorylation and is negatively regulated by mir-494 in rat spinal cord injury. |
2017-06-13 |
2023-08-13 |
rat |
| Shixin Gu, Rong Xie, Xiaodong Liu, Jiajun Shou, Wentao Gu, Xiaoming Ch. Long Coding RNA XIST Contributes to Neuronal Apoptosis through the Downregulation of AKT Phosphorylation and Is Negatively Regulated by miR-494 in Rat Spinal Cord Injury. International journal of molecular sciences. vol 18. issue 4. 2017-06-13. PMID:28368292. |
these results suggested that lncrna-xist knockdown may play an important role in limiting neuronal apoptosis in rats following sci, and that the observed protective effects of lncrna-xist knockdown might have been mediated by its regulation on the phosphorylation of akt by competitively binding mir-494. |
2017-06-13 |
2023-08-13 |
rat |
| Wanli Xie, Huiqing Wang, Qing Liu, Yongsheng Li, Jianjun Wang, Shanglong Yao, Qingping W. ResolvinD1 reduces apoptosis and inflammation in primary human alveolar epithelial type 2 cells. Laboratory investigation; a journal of technical methods and pathology. vol 96. issue 5. 2017-06-12. PMID:26878131. |
rvd1 reduces apoptosis of lps-exposed aec2 cells by inducing the phosphorylation of akt and attenuates the inflammatory response by suppressing the degradation and phosphorylation of iκb-α. |
2017-06-12 |
2023-08-13 |
human |
| Man Li, Zhen-Hua Zhou, Xue-Hua Sun, Xin Zhang, Xiao-Jun Zhu, Shu-Gen Jin, Ya-Ting Gao, Yun Jiang, Yue-Qiu Ga. Hepatitis B core antigen upregulates B7-H1 on dendritic cells by activating the AKT/ERK/P38 pathway: a possible mechanism of hepatitis B virus persistence. Laboratory investigation; a journal of technical methods and pathology. vol 96. issue 11. 2017-06-12. PMID:27617403. |
the data suggest that hbcag induced b7-h1 upregulation by activating akt, erk, and p38 signaling pathways, which inhibited the clearance of hbv-dna and the reduction of dcs contributed to immune tolerance, which may correlate with apoptosis. |
2017-06-12 |
2023-08-13 |
human |
| Gamal Badr, Leila H Sayed, Hossam El-Din M Omar, Ali M Abd El-Rahim, Emad A Ahmed, Mohamed H Mahmou. Camel Whey Protein Protects B and T Cells from Apoptosis by Suppressing Activating Transcription Factor-3 (ATF-3)-Mediated Oxidative Stress and Enhancing Phosphorylation of AKT and IκB-α in Type I Diabetic Mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 41. issue 1. 2017-06-06. PMID:28142150. |
camel whey protein protects b and t cells from apoptosis by suppressing activating transcription factor-3 (atf-3)-mediated oxidative stress and enhancing phosphorylation of akt and iκb-α in type i diabetic mice. |
2017-06-06 |
2023-08-13 |
mouse |
| Ni Zeng, Yuetao Zhou, Shaqiu Zhang, Yogesh Singh, Bing Shi, Madhuri S Salker, Florian Lan. 1α,25(OH) 2D3 Sensitive Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Ishikawa Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 41. issue 2. 2017-06-06. PMID:28222424. |
as cytosolic ph impacts on apoptosis, the study further explored the effect of 1,25(oh)2d3 on apoptosis and on the apoptosis regulating kinase akt, transcription factor forkhead box o-3 (foxo3a) and b-cell lymphoma protein bcl-2. |
2017-06-06 |
2023-08-13 |
human |
| Cynthia R L Webster, M Sawkat Anwe. Hydrophobic bile acid apoptosis is regulated by sphingosine-1-phosphate receptor 2 in rat hepatocytes and human hepatocellular carcinoma cells. American journal of physiology. Gastrointestinal and liver physiology. vol 310. issue 10. 2017-06-05. PMID:26999807. |
in conclusion, sipr2 inhibition attenuates gcdc-induced apoptosis and inhibits and augments gcdc-induced jnk and akt phosphorylation, respectively. |
2017-06-05 |
2023-08-13 |
human |
| SubbaRao V Madhunapantula, Gavin P Robertso. Targeting protein kinase-b3 (akt3) signaling in melanoma. Expert opinion on therapeutic targets. vol 21. issue 3. 2017-06-05. PMID:28064546. |
deregulated akt activity leading to apoptosis inhibition, enhanced proliferation and drug resistance has been shown to be responsible for 35-70% of advanced metastatic melanomas. |
2017-06-05 |
2023-08-13 |
Not clear |
| Constance Agamasu, Ruba H Ghanam, Fei Xu, Yong Sun, Yabing Chen, Jamil S Saa. The Interplay between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt. The Journal of biological chemistry. vol 292. issue 1. 2017-06-02. PMID:27872186. |
the akt protein, a serine/threonine kinase, plays important roles in cell survival, apoptosis, and oncogenes. |
2017-06-02 |
2023-08-13 |
Not clear |
| Chongshan Wang, Qiongren Wang, Xiezhao Li, Zhong Jin, Peng Xu, Naijin Xu, Abai Xu, Yawen Xu, Shaobo Zheng, Junxia Zheng, Chunxiao Liu, Peng Huan. Lycorine induces apoptosis of bladder cancer T24 cells by inhibiting phospho-Akt and activating the intrinsic apoptotic cascade. Biochemical and biophysical research communications. vol 483. issue 1. 2017-06-01. PMID:28042037. |
collectively, our findings suggest that lycorine suppressed the akt pathway and activated the intrinsic apoptotic cascade, leading to the apoptosis of bladder cancer cells. |
2017-06-01 |
2023-08-13 |
mouse |
| C Pan, Y Wang, M K Qiu, S Q Wang, Y B Liu, Z W Quan, J M O. Knockdown of HMGB1 inhibits cell proliferation and induces apoptosis in hemangioma via downregulation of AKT pathway. Journal of biological regulators and homeostatic agents. vol 31. issue 1. 2017-06-01. PMID:28337869. |
knockdown of hmgb1 inhibits cell proliferation and induces apoptosis in hemangioma via downregulation of akt pathway. |
2017-06-01 |
2023-08-13 |
human |
| Leif D Nelin, Hilary A White, Yi Jin, Jennifer K Trittmann, Bernadette Chen, Yusen Li. The Src family tyrosine kinases src and yes have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 310. issue 9. 2017-05-30. PMID:26919896. |
together, our data demonstrate that, in hpmvec, yes activation blunts the erk cascade in response to cytomix, resulting in greater apoptosis, while cytomix-induced src activation induces the phosphatidylinositol 3-kinase pathway, which leads to activation of akt and erk and attenuation of apoptosis. |
2017-05-30 |
2023-08-13 |
human |
| Chen Chen, Yancun Yin, Chunling Li, Jinliang Chen, Jingjing Xie, Zhigang Lu, Minjing Li, Yuesi Wang, Cheng Cheng Zhan. ACER3 supports development of acute myeloid leukemia. Biochemical and biophysical research communications. vol 478. issue 1. 2017-05-29. PMID:27470583. |
the acer3 deficiency resulted in decreased cell growth and colony formation, elevated apoptosis, and lower akt signaling of leukemia cells. |
2017-05-29 |
2023-08-13 |
human |
| Jinzhong Yu, Ruijie Wang, Jianshe Chen, Jinfeng Wu, Zhongqin Dang, Qinsheng Zhang, Bo L. miR-340 Inhibits Proliferation and Induces Apoptosis in Gastric Cancer Cell Line SGC-7901, Possibly via the AKT Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2017-05-26. PMID:28057912. |
mir-340 inhibits proliferation and induces apoptosis in gastric cancer cell line sgc-7901, possibly via the akt pathway. |
2017-05-26 |
2023-08-13 |
human |
| Jing Sun, Fangyan Wang, Zongxin Ling, Xichong Yu, Wenqian Chen, Haixiao Li, Jiangtao Jin, Mengqi Pang, Huiqing Zhang, Junjie Yu, Jiaming Li. Clostridium butyricum attenuates cerebral ischemia/reperfusion injury in diabetic mice via modulation of gut microbiota. Brain research. vol 1642. 2017-05-23. PMID:27037183. |
the cognitive impairment, the blood glucose level, neuronal injury, apoptosis, and expressions of akt, phospho-akt (p-akt), and caspase-3 level were assessed. |
2017-05-23 |
2023-08-13 |
mouse |
| Bing Pei, Miaomiao Yang, Xiaoyan Qi, Xin Shen, Xing Chen, Fayong Zhan. Quercetin ameliorates ischemia/reperfusion-induced cognitive deficits by inhibiting ASK1/JNK3/caspase-3 by enhancing the Akt signaling pathway. Biochemical and biophysical research communications. vol 478. issue 1. 2017-05-23. PMID:27450812. |
in conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the akt signaling pathway. |
2017-05-23 |
2023-08-13 |
mouse |
| Olesea Cojohari, Megan A Peppenelli, Gary C Cha. Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes. Journal of virology. vol 90. issue 14. 2017-05-18. PMID:27147739. |
here, we show that hcmv glycoprotein gb binding to cellular epidermal growth factor receptor (egfr) during hcmv entry initiated a rapid (within 15 min) activation of the apoptosis suppressor akt, which was maintained through 72 h. the virus-induced activation of akt was more robust than that with the normal myeloid growth factor macrophage colony-stimulating factor (m-csf) and was essential for infected monocytes to bypass the 48-h viability checkpoint. |
2017-05-18 |
2023-08-13 |
human |