| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pan Huang, Zhengrong Zhou, Fangxiong Shi, Genbao Shao, Ran Wang, Jintian Wang, Kangxin Wang, Wei Din. Effects of the IGF-1/PTEN/Akt/FoxO signaling pathway on male reproduction in rats subjected to water immersion and restraint stress. Molecular medicine reports. vol 14. issue 6. 2017-04-07. PMID:27779666. |
in addition, the expression levels and immunolocalization of igf‑1, pten, akt and foxo proteins, as well as the rate of cell apoptosis in rat testes, were investigated. |
2017-04-07 |
2023-08-13 |
rat |
| Miao Li, Yonghao Qi, Jing Wei, Lulu Lu, Xuan Zhao, Lijun Zho. N6-Isopentenyladenosine promoted HeLa cell apoptosis through inhibitions of AKT and transforming growth factor β-activated kinase 1 activation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 3. 2017-04-07. PMID:28345459. |
n6-isopentenyladenosine promoted hela cell apoptosis through inhibitions of akt and transforming growth factor β-activated kinase 1 activation. |
2017-04-07 |
2023-08-13 |
Not clear |
| Miao Li, Yonghao Qi, Jing Wei, Lulu Lu, Xuan Zhao, Lijun Zho. N6-Isopentenyladenosine promoted HeLa cell apoptosis through inhibitions of AKT and transforming growth factor β-activated kinase 1 activation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 3. 2017-04-07. PMID:28345459. |
ipa could reduce hela cell proliferation through apoptosis, and such anti-cancer activity is associated with inhibitions of both akt and transforming growth factor β-activated kinase 1 signaling pathways. |
2017-04-07 |
2023-08-13 |
Not clear |
| Youming Ding, Bin Wang, Xiaoyan Chen, Yu Zhou, Jianhui G. Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 3. 2017-04-07. PMID:28349827. |
we found that staurosporine significantly decreased cell viability and increased cell apoptosis in a concentration- and time-dependent manner in hepg2 cancer cells, along with the decreased expressions of pdk1 protein and akt phosphorylation. |
2017-04-07 |
2023-08-13 |
human |
| Ruixia Du, Zhe Liu, Xuedong Hou, Gongbi Fu, Ning An, Liping Wan. Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27121018. |
in conclusion, the present study demonstrated that, with the involvement of tsa, genistein exhibited substantial advantages in inhibiting laryngeal carcinoma cell growth, invasion and emt, and induced apoptosis, compared with genistein treatment alone, which occurred through the regulation of akt activation and the apoptotic pathway. |
2017-04-06 |
2023-08-13 |
Not clear |
| Yan Wang, Yigang Li, Lei Song, Yanyan Li, Shan Jiang, Song Zhan. The transplantation of Akt-overexpressing amniotic fluid-derived mesenchymal stem cells protects the heart against ischemia-reperfusion injury in rabbits. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27151366. |
a significant decrease in cardiomyocyte apoptosis, accompanying an increase in phosphorylated akt and b‑cell lymphoma 2 (bcl-2) and a decrease in caspase‑3, was also observed. |
2017-04-06 |
2023-08-13 |
Not clear |
| Yan Wang, Yigang Li, Lei Song, Yanyan Li, Shan Jiang, Song Zhan. The transplantation of Akt-overexpressing amniotic fluid-derived mesenchymal stem cells protects the heart against ischemia-reperfusion injury in rabbits. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27151366. |
these observations suggested that the protective effect of afmscs may be due to the delivery of secreted cytokines, promotion of neoangiogenesis, prevention of cardiomyocyte apoptosis, transdifferentiation into cardiomyocytes and promotion of the viability of afmscs, which are assisted by akt gene modification. |
2017-04-06 |
2023-08-13 |
Not clear |
| Junzheng Hu, Yanqing Gu, Weimin Fa. Rg1 protects rat bone marrow stem cells against hydrogen peroxide-induced cell apoptosis through the PI3K/Akt pathway. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27177125. |
the aim of the present study was to investigate the protective mechanism of ginsenoside rg1 against the apoptosis of rat bone marrow stem cells (rbmscs) under oxidative stress, and to determine the association with the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt) pathway. |
2017-04-06 |
2023-08-13 |
rat |
| Junzheng Hu, Yanqing Gu, Weimin Fa. Rg1 protects rat bone marrow stem cells against hydrogen peroxide-induced cell apoptosis through the PI3K/Akt pathway. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27177125. |
in the akt pathway blockage group, no significant alterations in the levels of cell apoptosis were observed compared with the h2o2 model group. |
2017-04-06 |
2023-08-13 |
rat |
| Hongyan Zhao, Dali Zhao, Huilin Jin, Hongwei Li, Xiaoying Yang, Liwei Zhuang, Tiefu Li. Bufalin reverses intrinsic and acquired drug resistance to cisplatin through the AKT signaling pathway in gastric cancer cells. Molecular medicine reports. vol 14. issue 2. 2017-04-06. PMID:27357249. |
effects of cisplatin and bufalin on gc cells were measured by a cell counting kit, apoptosis was analyzed by flow cytometry, and immunoblotting was used to detect proteins associated with the akt signaling pathway. |
2017-04-06 |
2023-08-13 |
human |
| Hongyan Zhao, Dali Zhao, Huilin Jin, Hongwei Li, Xiaoying Yang, Liwei Zhuang, Tiefu Li. Bufalin reverses intrinsic and acquired drug resistance to cisplatin through the AKT signaling pathway in gastric cancer cells. Molecular medicine reports. vol 14. issue 2. 2017-04-06. PMID:27357249. |
it was demonstrated that bufalin synergized with cisplatin to inhibit proliferation and promote apoptosis of gc cells by diminishing the activation of cisplatin-induced akt under normoxic and hypoxic conditions. |
2017-04-06 |
2023-08-13 |
human |
| Hongyan Zhao, Dali Zhao, Huilin Jin, Hongwei Li, Xiaoying Yang, Liwei Zhuang, Tiefu Li. Bufalin reverses intrinsic and acquired drug resistance to cisplatin through the AKT signaling pathway in gastric cancer cells. Molecular medicine reports. vol 14. issue 2. 2017-04-06. PMID:27357249. |
bufalin also inhibits cisplatin-activated molecules downstream of akt that affect proliferation and apoptosis, including glycogen synthase kinase, mammalian target of rapamycin, ribosomal protein s6 kinase and eukaryotic translation initiation factor-4e-binding protein-1. |
2017-04-06 |
2023-08-13 |
human |
| Hongyan Zhao, Dali Zhao, Huilin Jin, Hongwei Li, Xiaoying Yang, Liwei Zhuang, Tiefu Li. Bufalin reverses intrinsic and acquired drug resistance to cisplatin through the AKT signaling pathway in gastric cancer cells. Molecular medicine reports. vol 14. issue 2. 2017-04-06. PMID:27357249. |
it was demonstrated that bufalin reversed acquired cisplatin resistance and significantly induced apoptosis through the akt pathway. |
2017-04-06 |
2023-08-13 |
human |
| Peng Yang, Jiaying Zhao, Liying Hou, Lei Yang, Kun Wu, Linyou Zhan. Vitamin E succinate induces apoptosis via the PI3K/AKT signaling pathways in EC109 esophageal cancer cells. Molecular medicine reports. vol 14. issue 2. 2017-04-06. PMID:27357907. |
the apoptosis induced by ves was increased by inhibition of akt or mtor with their respective inhibitor in esophageal cancer cells. |
2017-04-06 |
2023-08-13 |
human |
| Feng Ding, Tianfeng Liu, Nina Yu, Shihong Li, Xiaofei Zhang, Guanghong Zheng, Chunming Lv, Kai Mou, Jia Xu, Bo Li, Surong Wang, Haibo Son. Nitidine chloride inhibits proliferation, induces apoptosis via the Akt pathway and exhibits a synergistic effect with doxorubicin in ovarian cancer cells. Molecular medicine reports. vol 14. issue 3. 2017-04-06. PMID:27485415. |
nitidine chloride inhibits proliferation, induces apoptosis via the akt pathway and exhibits a synergistic effect with doxorubicin in ovarian cancer cells. |
2017-04-06 |
2023-08-13 |
Not clear |
| Feng Ding, Tianfeng Liu, Nina Yu, Shihong Li, Xiaofei Zhang, Guanghong Zheng, Chunming Lv, Kai Mou, Jia Xu, Bo Li, Surong Wang, Haibo Son. Nitidine chloride inhibits proliferation, induces apoptosis via the Akt pathway and exhibits a synergistic effect with doxorubicin in ovarian cancer cells. Molecular medicine reports. vol 14. issue 3. 2017-04-06. PMID:27485415. |
the current study demonstrated that nc inhibited the proliferation and induced the apoptosis of ovarian cancer cells via the akt signaling pathway and highlighted its potential clinical application for the treatment of ovarian cancer. |
2017-04-06 |
2023-08-13 |
Not clear |
| Nerea Rebolleda, Ignacio Losada-Fernandez, Gema Perez-Chacon, Raquel Castejon, Silvia Rosado, Marta Morado, Maria Teresa Vallejo-Cremades, Andrea Martinez, Juan A Vargas-Nuñez, Paloma Perez-Acieg. Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. PloS one. vol 11. issue 4. 2017-04-05. PMID:27101369. |
in both of them, deguelin dowregulates akt, nfκb and several downstream antiapoptotic proteins (xiap, ciap, bcl2, bcl-xl and survivin), activating the mitochondrial pathway of apoptosis. |
2017-04-05 |
2023-08-13 |
mouse |
| Hui Liu, Yonghui Dong, Yutong Gao, Zhipeng Du, Yuting Wang, Peng Cheng, Anmin Chen, Hui Huan. The Fascinating Effects of Baicalein on Cancer: A Review. International journal of molecular sciences. vol 17. issue 10. 2017-03-31. PMID:27735841. |
the anti-tumor functions of baicalein are mainly due to its capacities to inhibit complexes of cyclins to regulate the cell cycle, to scavenge oxidative radicals, to attenuate mitogen activated protein kinase (mapk), protein kinase b (akt) or mammalian target of rapamycin (mtor) activities, to induce apoptosis by activating caspase-9/-3 and to inhibit tumorinvasion and metastasis by reducing the expression of matrix metalloproteinase-2/-9 (mmp-2/-9). |
2017-03-31 |
2023-08-13 |
Not clear |
| Minhee Ku, Myounghwa Kang, Jin-Suck Suh, Jaemoon Yan. Effects for Sequential Treatment of siAkt and Paclitaxel on Gastric Cancer Cell Lines. International journal of medical sciences. vol 13. issue 9. 2017-03-27. PMID:27648001. |
specifically, treatment of paclitaxel (ptx) after down-regulating akt gene expression using rnai reduces the cell proliferation and increases apoptosis. |
2017-03-27 |
2023-08-13 |
Not clear |
| Do Luong Huynh, Neelesh Sharma, Amit Kumar Singh, Simrinder Singh Sodhi, Jiao-Jiao Zhang, Raj Kumar Mongre, Mrinmoy Ghosh, Nameun Kim, Yang Ho Park, Dong Kee Jeon. Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways. Chinese journal of natural medicines. vol 15. issue 1. 2017-03-23. PMID:28259249. |
the anti-cancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase akt (also known as protein kinase b) and amp-activated protein kinase (ampk) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. |
2017-03-23 |
2023-08-13 |
Not clear |