| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanying Wang, Kailun Xu, Beilei Wang, Jinghui Liu, Xiaofeng Wang, Mingluan Xing, Pu Huang, Zonglou Guo, Lihong X. Microcystin-LR induces a wide variety of biochemical changes in the A549 human non-small cell lung cancer cell line: Roles for protein phosphatase 2A and its substrates. Environmental toxicology. vol 32. issue 3. 2017-03-03. PMID:27352821. |
however, exposure to mc-lr for 24 h failed to trigger either apoptosis or proliferation, which might be related to pp2a-inhibition-induced hyperphosphorylation of bcl-2 and bad and the activation status of akt. |
2017-03-03 |
2023-08-13 |
human |
| Jingjing Zhao, Xue Zeng, Ping Song, Xiaohong Wu, Hongbo Sh. AKT1 as the PageRank hub gene is associated with melanoma and its functional annotation is highly related to the estrogen signaling pathway that may regulate the growth of melanoma. Oncology reports. vol 36. issue 4. 2017-03-03. PMID:27573172. |
high expression of akt is involved in the resistance of cell apoptosis as well as adaptive resistance to treatment in melanoma. |
2017-03-03 |
2023-08-13 |
Not clear |
| Yao-Yao Yang, Hui-Qiong He, Jia-Hua Cui, Yun-Juan Nie, Ya-Xian Wu, Rui Wang, Gang Wang, Jun-Nian Zheng, Richard D Ye, Qiong Wu, Shao-Shun Li, Feng Qia. Shikonin Derivative DMAKO-05 Inhibits Akt Signal Activation and Melanoma Proliferation. Chemical biology & drug design. vol 87. issue 6. 2017-03-01. PMID:26804061. |
collectively, dmako-05 has a strong cytotoxicity in b16f0 cells via inhibiting akt activation, inducing g1 arrest, and promoting b16f0 cell apoptosis. |
2017-03-01 |
2023-08-13 |
mouse |
| Yang Zhao, Ying Han, Ding-Fang Bu, Jing Zhang, Qin-Rui Li, Hong-Fang Jin, Jun-Bao Du, Jiong Qi. Reduced AKT phosphorylation contributes to endoplasmic reticulum stress-mediated hippocampal neuronal apoptosis in rat recurrent febrile seizure. Life sciences. vol 153. 2017-02-27. PMID:27084529. |
reduced akt phosphorylation contributes to endoplasmic reticulum stress-mediated hippocampal neuronal apoptosis in rat recurrent febrile seizure. |
2017-02-27 |
2023-08-13 |
rat |
| MacRae F Linton, Vladimir R Babaev, Jiansheng Huang, Edward F Linton, Huan Tao, Patricia G Yance. Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis. Circulation journal : official journal of the Japanese Circulation Society. vol 80. issue 11. 2017-02-23. PMID:27725526. |
however, akt isoforms are redundant with regard to apoptosis. |
2017-02-23 |
2023-08-13 |
Not clear |
| Caihong Bai, Xiaojiao Yang, Kun Zou, Haibo He, Junzhi Wang, Huilin Qin, Xiaoqin Yu, Chengxiong Liu, Juyan Zheng, Fan Cheng, Jianfeng Che. Anti-proliferative effect of RCE-4 from Reineckia carnea on human cervical cancer HeLa cells by inhibiting the PI3K/Akt/mTOR signaling pathway and NF-κB activation. Naunyn-Schmiedeberg's archives of pharmacology. vol 389. issue 6. 2017-02-21. PMID:26935715. |
the results indicated that the hela cell was the most sensitive with an ic50 of 7.01 μm; rce-4 significantly promoted the release of cellular lactate dehydrogenase (ldh); increased dna fragmentation and apoptosis; reduced pi3k, akt, mtor, and nf-κbp65 phosphorylation levels; increased the bax and cleaved poly (adp-ribose) polymerase (parp) protein levels; suppressed bcl-2 protein expression; elevated the bax/bcl-2 expression ratio; and decreased the interleukin-1 beta (il-1β) and interleukin-6 (il-6) mrna expressions in hela cells in a concentration-dependent manner. |
2017-02-21 |
2023-08-13 |
human |
| Rong Yang, Liang Zhong, Xiao-Qun Yang, Kai-Ling Jiang, Liu Li, Hao Song, Bei-Zhong Li. Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling. Molecular medicine reports. vol 13. issue 5. 2017-02-17. PMID:27035679. |
the results showed that ne significantly promoted the proliferation of nb4 cells, inhibited cell apoptosis and apoptotic signaling, and led the activation of akt. |
2017-02-17 |
2023-08-13 |
Not clear |
| Xiaoxia Zhong, Erhu Zhao, Chunling Tang, Weibo Zhang, Juan Tan, Zhen Dong, Han-Fei Ding, Hongjuan Cu. Antibiotic drug tigecycline reduces neuroblastoma cells proliferation by inhibiting Akt activation in vitro and in vivo. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 6. 2017-02-14. PMID:26687647. |
furthermore, it was found that tigecycline induced g1-phase cell cycle arrest instead of apoptosis by means of akt pathway inhibition. |
2017-02-14 |
2023-08-13 |
human |
| S T Stephenson, V Bostik, P Bosti. Differential Phosphorylation of Akt and signaling in CD4+ T Cells in Pathogenic and Apathogenic SIV Infection. Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne. vol 65. issue 2. 2017-02-14. PMID:27467331. |
in addition, cd4+ t cells from siv+ rm, but not other animals show an increase in both total akt, a kinase directly interacting with gsk-3β and p-aktthr308 in response to stimulation via cd3/cd28, which is associated with an increase in apoptosis. |
2017-02-14 |
2023-08-13 |
Not clear |
| Yinghao Lu, Yan Li, Xiao Chai, Qian Kang, Peng Zhao, Jie Xiong, Jishi Wan. Long noncoding RNA HULC promotes cell proliferation by regulating PI3K/AKT signaling pathway in chronic myeloid leukemia. Gene. vol 607. 2017-02-14. PMID:28069548. |
further experiments demonstrated that hulc silencing markedly suppressed the phosphorylation of pi3k and akt, indicating that enhancement of imatinib-induced apoptosis by hulc inhibition is related with the reduction of c-myc expression and inhibition of pi3k/akt pathway activity. |
2017-02-14 |
2023-08-13 |
human |
| Birendra Behera, Debasish Mishra, Bibhas Roy, K Sanjana P Devi, Rajan Narayan, Joyjyoti Das, Sudip K Ghosh, Tapas K Mait. Abrus precatorius agglutinin-derived peptides induce ROS-dependent mitochondrial apoptosis through JNK and Akt/P38/P53 pathways in HeLa cells. Chemico-biological interactions. vol 222. 2017-02-13. PMID:25305377. |
ros further led to symptoms of early apoptosis by deregulating akt (protein kinase b) and activating c-jun n-terminal kinase (jnk), p38 mitogen activated protein kinase (mapk), p53, and autophagy starting from ∼8h of incubation. |
2017-02-13 |
2023-08-13 |
mouse |
| Yan-Ran Wu, Hai-Jun Qi, Dan-Fang Deng, Ying-Ying Luo, Sheng-Lan Yan. MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 9. 2017-02-13. PMID:27188433. |
western blot was used for detection of pten, p13k, and akt protein expressions, mtt method for cell proliferation, transwell assay for cell migration and invasion, and flow cytometry for cell cycle and apoptosis. |
2017-02-13 |
2023-08-13 |
human |
| Zhen Rang, Zong-Yang Wang, Qiu-Yu Pang, You-Wei Wang, Ge Yang, Fan Cu. MiR-181a Targets PHLPP2 to Augment AKT Signaling and Regulate Proliferation and Apoptosis in Human Keloid Fibroblasts. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 40. issue 3-4. 2017-02-13. PMID:27915346. |
mir-181a targets phlpp2 to augment akt signaling and regulate proliferation and apoptosis in human keloid fibroblasts. |
2017-02-13 |
2023-08-13 |
human |
| Elham Baghbani, Behzad Baradaran, Fatemeh Pak, Leila Mohammadnejad, Daryoush Shanehbandi, Behzad Mansoori, Vahid Khaze, Noushin Montazami, Ali Mohammadi, Parviz Kokhae. Suppression of protein tyrosine phosphatase PTPN22 gene induces apoptosis in T-cell leukemia cell line (Jurkat) through the AKT and ERK pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 86. 2017-02-09. PMID:27936393. |
suppression of protein tyrosine phosphatase ptpn22 gene induces apoptosis in t-cell leukemia cell line (jurkat) through the akt and erk pathways. |
2017-02-09 |
2023-08-13 |
Not clear |
| Dan Zhang, Hexia Xia, Wei Zhang, Bo Fan. The anti-ovarian cancer activity by WYE-132, a mTORC1/2 dual inhibitor. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 1. 2017-02-07. PMID:26293898. |
interestingly, introducing a constitutively active akt (caakt), which restored mtorc1/2 activation in wye-132-treated ovarian cancer cells, only mitigated (but not abolished) wye-132-mediated growth inhibition and apoptosis. |
2017-02-07 |
2023-08-13 |
human |
| Jinghui Jia, Zehua Wang, Jing Cai, Yuan Zhan. PMS2 expression in epithelial ovarian cancer is posttranslationally regulated by Akt and essential for platinum-induced apoptosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 3. 2017-02-07. PMID:26423401. |
pms2 expression in epithelial ovarian cancer is posttranslationally regulated by akt and essential for platinum-induced apoptosis. |
2017-02-07 |
2023-08-13 |
Not clear |
| Yingwei Chang, Li Li, Luping Zhang, Xuyan Guo, Zhuoying Feng, Junchen Zhou, Shuai Zhou, Guoying Feng, Fengchan Han, Wenhua Huang, Jun Yang, Fei Huan. Plexin-B1 indirectly affects glioma invasiveness and angiogenesis by regulating the RhoA/αvβ3 signaling pathway and SRPK1. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 8. 2017-02-07. PMID:26944058. |
by using multiple and diverse experimental techniques, we investigated cell apoptosis, mitochondrial membrane potential, cell migration and invasion, angiogenesis, pi3k and akt phosphorylation, and also the levels of srpk1 and αvβ3 in glioma cells and animal glioma tissues. |
2017-02-07 |
2023-08-13 |
human |
| Lei Bao, Feng Liu, Huai-Bin Guo, Yong Li, Bi-Bo Tan, Wan-Xing Zhang, Yan-Hui Pen. Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 8. 2017-02-07. PMID:26960693. |
naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer sgc7901 cell line by downregulation of akt pathway. |
2017-02-07 |
2023-08-13 |
Not clear |
| Xiao-Lang Tan, Lei Guo, Gui-Hua Wan. Polyporus umbellatus inhibited tumor cell proliferation and promoted tumor cell apoptosis by down-regulating AKT in breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-07. PMID:27447121. |
polyporus umbellatus inhibited tumor cell proliferation and promoted tumor cell apoptosis by down-regulating akt in breast cancer. |
2017-02-07 |
2023-08-13 |
mouse |
| Xiao-Lang Tan, Lei Guo, Gui-Hua Wan. Polyporus umbellatus inhibited tumor cell proliferation and promoted tumor cell apoptosis by down-regulating AKT in breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-07. PMID:27447121. |
and akt has been known as an essential signaling pathway to regulate cell proliferation and apoptosis via mdm2/p53 and caspase-3 signaling pathways respectively. |
2017-02-07 |
2023-08-13 |
mouse |