| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Milo\\xc5\\xa1 Stanojlovi\\xc4\\x87, Ivana Gu\\xc5\\xa1evac, Ivana Grkovi\\xc4\\x87, Nata\\xc5\\xa1a Mitrovi\\xc4\\x87, Jelena Zlatkovi\\xc4\\x87, Anica Horvat, Dunja Drakuli\\xc4\\x8. Repeated Estradiol Treatment Attenuates Chronic Cerebral Hypoperfusion-Induced Neurodegeneration in Rat Hippocampus. Cellular and molecular neurobiology. vol 36. issue 6. 2017-03-22. PMID:26689702.' |
the present study attempted to verify whether post-ischemic estradiol treatment (33.3 μg/kg for seven consecutive days) affects previously reported number of hippocampal apoptotic cells and amount of dna fragmentation characteristic for apoptosis as well as the expression of key elements within synaptosomal akt and erk signal transduction pathways (nf-κb, bax, bcl-2, cytochrome c, caspase 3, and parp). |
2017-03-22 |
2023-08-13 |
rat |
| Dong Hwan Kim, Min Jeong Kim, Bokyung Sung, Hongsuk Suh, Jee H Jung, Hae Young Chung, Nam Deuk Ki. Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. Oncology reports. vol 37. issue 1. 2017-03-22. PMID:27840966. |
in addition, hs-1793 suppressed akt and the phosphatidylinositol-3 kinase/akt inhibitor ly294002 was found to enhance its induction of apoptosis. |
2017-03-22 |
2023-08-13 |
human |
| Hong-Yan Gong, Fang Zheng, Chao Zhang, Xi-Yan Chen, Jing-Jing Liu, Xiu-Qin Yu. Propofol protects hippocampal neurons from apoptosis in ischemic brain injury by increasing GLT-1 expression and inhibiting the activation of NMDAR via the JNK/Akt signaling pathway. International journal of molecular medicine. vol 38. issue 3. 2017-03-21. PMID:27430327. |
the sirna-mediated knockdown of glt‑1 in the hypoxia-exposed hippocampal neuronal cells led to an increase in cell apoptosis, jun n-terminal kinase (jnk) activation and n-methyl-d‑aspartate (nmda) receptor (nr1 and nr2b) activation, as well as to a decrease in cell viability and a decrease in akt activation. |
2017-03-21 |
2023-08-13 |
Not clear |
| Hong-Yan Gong, Fang Zheng, Chao Zhang, Xi-Yan Chen, Jing-Jing Liu, Xiu-Qin Yu. Propofol protects hippocampal neurons from apoptosis in ischemic brain injury by increasing GLT-1 expression and inhibiting the activation of NMDAR via the JNK/Akt signaling pathway. International journal of molecular medicine. vol 38. issue 3. 2017-03-21. PMID:27430327. |
the effects of rna interference-mediated glt‑1 gene silencing on cell viability, jnk activation, nmdar activation, cell apoptosis and akt activation in the hippocampal neuronal cells were slightly reversed by propofol treatment. |
2017-03-21 |
2023-08-13 |
Not clear |
| Hong-Yan Gong, Fang Zheng, Chao Zhang, Xi-Yan Chen, Jing-Jing Liu, Xiu-Qin Yu. Propofol protects hippocampal neurons from apoptosis in ischemic brain injury by increasing GLT-1 expression and inhibiting the activation of NMDAR via the JNK/Akt signaling pathway. International journal of molecular medicine. vol 38. issue 3. 2017-03-21. PMID:27430327. |
the jnk agonist, anisomycin, and the akt inhibitor, ly294002, both significantly blocked the effects of propofol on hippocampal neuronal cell viability and apoptosis in ibi. |
2017-03-21 |
2023-08-13 |
Not clear |
| Melissa Skibba, Yuanyuan Qian, Yuyan Bao, Junjie Lan, Kesong Peng, Yunjie Zhao, Peng Zhong, Jie Hu, Xiaokun Li, Guang Lian. New EGFR inhibitor, 453, prevents renal fibrosis in angiotensin II-stimulated mice. European journal of pharmacology. vol 789. 2017-03-21. PMID:27497883. |
along with the inhibition of egfr and its downstream signaling pathways (akt and erk), 453 also prevented the activation of fibrotic (collagen, cfgf, tgf-β), inflammatory (cox2, il-6, il-1β, tnf-α), apoptosis and oxidative stress pathways. |
2017-03-21 |
2023-08-13 |
mouse |
| Eun Gyeong Lim, Guen Tae Kim, Se Hee Lee, Sang-Yong Kim, Young Min Ki. Apoptotic effects of extract from Cnidium monnieri (L.) Cusson by adenosine monosphosphate-activated protein kinase-independent pathway in HCT116 colon cancer cells. Molecular medicine reports. vol 13. issue 6. 2017-03-20. PMID:27082059. |
therefore, the present study determined, for the first time, that cme induced apoptosis as a result of causing metabolic stresses due to directly regulation of the de‑phosphorylation of akt, whereas it did not control the ampk-dependent pathway in hct116 colon cancer cells. |
2017-03-20 |
2023-08-13 |
Not clear |
| Feng Chen, Xiaochi Chen, Deyong Yang, Xiangyu Che, Jianbo Wang, Xiancheng Li, Zhiwei Zhang, Qifei Wang, Wei Zheng, Lina Wang, Xuejian Wang, Xishuang Son. Isoquercitrin inhibits bladder cancer progression in vivo and in vitro by regulating the PI3K/Akt and PKC signaling pathways. Oncology reports. vol 36. issue 1. 2017-03-13. PMID:27177091. |
isoquercitrin inhibited phosphatidylinositol 3-kinase (pi3k) and akt phosphorylation expression levels, thus inhibiting proliferation and inducing apoptosis in the cancer cells. |
2017-03-13 |
2023-08-13 |
mouse |
| Jian-Ying Li, Jun Yu, Xu-Sheng Du, Hui-Min Zhang, Bo Wang, Hua Guo, Jie Bai, Juan-Hong Wang, An Liu, Yi-Li Wan. Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway. Oncology reports. vol 36. issue 1. 2017-03-13. PMID:27177149. |
safflower polysaccharide induces nsclc cell apoptosis by inhibition of the akt pathway. |
2017-03-13 |
2023-08-13 |
mouse |
| Yinghua Li, Zhengfang Lin, Mingqi Zhao, Tiantian Xu, Changbing Wang, Huimin Xia, Hanzhong Wang, Bing Zh. Multifunctional selenium nanoparticles as carriers of HSP70 siRNA to induce apoptosis of HepG2 cells. International journal of nanomedicine. vol 11. 2017-03-13. PMID:27462151. |
moreover, se@pei@sirna exhibited enhanced cytotoxic effects on cancer cells and triggered intracellular reactive oxygen species, and the signaling pathways of p53 and akt were activated to advance cell apoptosis. |
2017-03-13 |
2023-08-13 |
human |
| Xiaoyu Jiang, Huiren Tao, Cuiting Qiu, Xiaolei Ma, Shan Li, Xian Guo, Anlin Lv, Huan L. Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats. European journal of pharmacology. vol 786. 2017-03-10. PMID:27212383. |
alizarin red s staining measured aortic calcium depositions; alkaline phosphatase activity in serum was measured by a kit; apoptosis was evaluated by tunel assay; protein expression levels of gas6, axl, phosphorylated akt (p-akt), and bcl-2 were determined by western blotting. |
2017-03-10 |
2023-08-13 |
rat |
| Kunihiro Ito, Akinobu Ota, Takayuki Ono, Toshiki Nakaoka, Md Wahiduzzaman, Sivasundaram Karnan, Hiroyuki Konishi, Akifumi Furuhashi, Tomio Hayashi, Yoichi Yamada, Yoshitaka Hosokawa, Yoshiaki Kazaok. Inhibition of Nox1 induces apoptosis by attenuating the AKT signaling pathway in oral squamous cell carcinoma cell lines. Oncology reports. vol 36. issue 5. 2017-03-10. PMID:27600098. |
inhibition of nox1 induces apoptosis by attenuating the akt signaling pathway in oral squamous cell carcinoma cell lines. |
2017-03-10 |
2023-08-13 |
Not clear |
| Shengcheng Yao, Yingnan Zhang, Xiaoyu Wang, Fengchao Zhao, Maji Sun, Xin Zheng, Hongyan Dong, Kaijin Gu. Pigment Epithelium-Derived Factor (PEDF) Protects Osteoblastic Cell Line from Glucocorticoid-Induced Apoptosis via PEDF-R. International journal of molecular sciences. vol 17. issue 5. 2017-03-09. PMID:27187377. |
our results suggest that pedf attenuated dex-induced apoptosis in mc3t3-e1 pre-osteoblasts through lpa-dependent akt activation via pedf-r. |
2017-03-09 |
2023-08-13 |
Not clear |
| Mengxuan Yang, Yingying Qu, Rongliang Shi, Xubo Wu, Chang Su, Zhiqiu Hu, Qimeng Chang, Shaoqun Liu, Gaofeng Pan, Ming Lei, Fubo Xie, Shiwei Tu, Weikang Tao, He Zhou, Gang Hu, Ziping Zhan. Ubiquitin-conjugating enzyme UbcH10 promotes gastric cancer growth and is a potential biomarker for gastric cancer. Oncology reports. vol 36. issue 2. 2017-03-08. PMID:27349176. |
knockdown of ubch10 expression using sirna in gastric cancer cell lines with high expression of ubch10 resulted in reduced proliferation, increased cisplatin-induced apoptosis and reduced serum-induced erk, akt and p38 phosphorylation signaling. |
2017-03-08 |
2023-08-13 |
Not clear |
| Xinsheng Shen, Yaqing Si, Zhao Wang, Jiachen Wang, Yongqiang Guo, Xiefu Zhan. Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling. International journal of molecular medicine. vol 38. issue 2. 2017-03-06. PMID:27278820. |
additionally, a marked decrease in akt phosphorylation levels was observed following treatment with quercetin, whereas pre-treatment with fumonisin b1 (fb1, akt activator) significantly attenuated the inhibitory effects of quercetin on cell growth and its promoting effects on mitochondrial-dependent apoptosis. |
2017-03-06 |
2023-08-13 |
human |
| Fen Cai, Liang Zhang, Xiangling Xiao, Chao Duan, Qiuyue Huang, Chunsheng Fan, Jian Li, Xuewen Liu, Shan Li, Ying Li. Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/adriamycin cells. Oncology reports. vol 36. issue 2. 2017-03-06. PMID:27350399. |
cub treatment also induced caspase-dependent apoptosis, decreased phosphorylation of akt (pakt). |
2017-03-06 |
2023-08-13 |
human |
| Yunjun Zou, Bo Wang, Wan Fu, Shouhong Zhou, Yaxiong Nie, Shaowen Tia. Apelin-13 Protects PC12 Cells from Corticosterone-Induced Apoptosis Through PI3K and ERKs Activation. Neurochemical research. vol 41. issue 7. 2017-03-03. PMID:26961889. |
the viability of the cells, the apoptosis of the cells, the level of phosphorylation of akt (p-akt) and extracellular signal-regulated kinases (p-erks) and cleaved caspase-3 expression were detected by mtt, hoechst staining and flow cytometer assays and western blotting. |
2017-03-03 |
2023-08-13 |
Not clear |
| Jiming Liu, Qiang Li, Zhilong Liu, Liuming Lin, Xiangqiang Zhang, Mingrong Cao, Jianwei Jian. Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. Oncology reports. vol 35. issue 6. 2017-03-03. PMID:27004568. |
harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in sw620 cells via inhibition of the akt and erk signaling pathways. |
2017-03-03 |
2023-08-13 |
human |
| Jiming Liu, Qiang Li, Zhilong Liu, Liuming Lin, Xiangqiang Zhang, Mingrong Cao, Jianwei Jian. Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. Oncology reports. vol 35. issue 6. 2017-03-03. PMID:27004568. |
in conclusion, harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in sw620 cells via inhibition of the akt and erk signaling pathways. |
2017-03-03 |
2023-08-13 |
human |
| Chan Qiu, Xiaona Bu, Zheng Jian. Protocadherin-10 acts as a tumor suppressor gene, and is frequently downregulated by promoter methylation in pancreatic cancer cells. Oncology reports. vol 36. issue 1. 2017-03-03. PMID:27176920. |
pcdh10 may induce cancer cell apoptosis via the akt pathway. |
2017-03-03 |
2023-08-13 |
human |