| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Lang Tan, Lei Guo, Gui-Hua Wan. Polyporus umbellatus inhibited tumor cell proliferation and promoted tumor cell apoptosis by down-regulating AKT in breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-07. PMID:27447121. |
in conclusion, our data indicated that polyporus umbellatus had a potential role in controlling human breast cancer through inhibiting tumor cell proliferation, inducing apoptosis regulated by akt, which might provide a therapeutic strategy for breast cancer suppression in the future. |
2017-02-07 |
2023-08-13 |
mouse |
| Bo Tang, Fang Tang, Zhenran Wang, Guangying Qi, Xingsi Liang, Bo Li, Shengguang Yuan, Jie Liu, Shuiping Yu, Songqing H. Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle. International journal of nanomedicine. vol 11. 2017-02-07. PMID:27942213. |
akt has been suggested to play an essential role in the progression of inflammation response and apoptosis. |
2017-02-07 |
2023-08-13 |
mouse |
| Bo Tang, Fang Tang, Zhenran Wang, Guangying Qi, Xingsi Liang, Bo Li, Shengguang Yuan, Jie Liu, Shuiping Yu, Songqing H. Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle. International journal of nanomedicine. vol 11. 2017-02-07. PMID:27942213. |
our results indicated that the downstream signals, including cytokines regulated by nf-κb and caspase-3-activated apoptosis affected by bad, were re-modulated for knockout of akt. |
2017-02-07 |
2023-08-13 |
mouse |
| Bo Tang, Fang Tang, Zhenran Wang, Guangying Qi, Xingsi Liang, Bo Li, Shengguang Yuan, Jie Liu, Shuiping Yu, Songqing H. Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle. International journal of nanomedicine. vol 11. 2017-02-07. PMID:27942213. |
these findings demonstrated that the nanoparticulate drug ca performed its effective role owing to its ability to reduce inflammatory action and enhance apoptosis for the overexpression of nf-κb and bad via akt signaling pathway, playing a direct role in liver cancer progression. |
2017-02-07 |
2023-08-13 |
mouse |
| Jie Shen, Yue Hong, Qiong Zhao, Jian-Li Zhan. Preclinical evaluation of perifosine as a potential promising anti-rhabdomyosarcoma agent. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 1. 2017-02-06. PMID:26269112. |
thus, perifosine induces growth inhibition and apoptosis in rms cells through mechanisms more than just blocking akt. |
2017-02-06 |
2023-08-13 |
mouse |
| Ming Liu, Weiyi Zhang, Genzhu Wang, Xiaoping Song, Xingzeng Zhao, Xiangyun Wang, Xin Qi, Jing L. 13-Oxyingenol dodecanoate, a cytotoxic ingenol derivative, induces mitochondrial apoptosis and caspase-dependent Akt decrease in K562 cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26615422. |
13-oxyingenol dodecanoate, a cytotoxic ingenol derivative, induces mitochondrial apoptosis and caspase-dependent akt decrease in k562 cells. |
2017-02-06 |
2023-08-13 |
Not clear |
| X Wang, X J He, H Q Xu, Z W Chen, H H Fa. Inhibition of subcutaneously implanted human pituitary tumor cells in nude mice by LRIG1. Genetics and molecular research : GMR. vol 15. issue 2. 2017-02-06. PMID:27173312. |
we then calculated the volume inhibition rate of the tumors, as well as the apoptosis index of tumor cells and the expression of ras, raf, akt, and erk mrna in tumor cells. |
2017-02-06 |
2023-08-13 |
mouse |
| Ryuji Yamaguchi, Hiroshi Harada, Kiichi Hirot. VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 10. 2017-02-06. PMID:27460078. |
vhl-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating akt through the igf1r-pi3k pathway. |
2017-02-06 |
2023-08-13 |
Not clear |
| Ryuji Yamaguchi, Hiroshi Harada, Kiichi Hirot. VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 10. 2017-02-06. PMID:27460078. |
thus, in vhl-deficient cells, igf1r activated akt and stabilized the bak-mcl-1 complex, thereby conferring cell resistance to apoptosis. |
2017-02-06 |
2023-08-13 |
Not clear |
| Gao Tianqin, Cheng Chunlei, Wang Jingjin. Synergistic Anti-glioma Effects in Vitro and in Vivo of Enediyne Antibiotic Neocarzinostatin and Paclitaxel via Enhanced Growth Delay and Apoptosis-Induction. Biological & pharmaceutical bulletin. vol 39. issue 10. 2017-02-02. PMID:27431785. |
western blot revealed that the cell signaling pathways of proliferation and apoptosis were synergistically regulated, in which akt was synergistically inactivated, p53 was up-regulated with down-regulation of bcl-2. |
2017-02-02 |
2023-08-13 |
human |
| Gao Tianqin, Cheng Chunlei, Wang Jingjin. Synergistic Anti-glioma Effects in Vitro and in Vivo of Enediyne Antibiotic Neocarzinostatin and Paclitaxel via Enhanced Growth Delay and Apoptosis-Induction. Biological & pharmaceutical bulletin. vol 39. issue 10. 2017-02-02. PMID:27431785. |
this study demonstrates that the combination of ncs and ptx can potentiate the effect on survival and apoptosis of glioma cells via suppression of akt, bcl-2, and activations of p53; meanwhile, the in vivo studies also confirmed that the combination of ncs and ptx synergistically inhibit the gliom growth. |
2017-02-02 |
2023-08-13 |
human |
| Kaushik Banerjee, Satyajit Das, Avijit Sarkar, Mitali Chatterjee, Jaydip Biswas, Soumitra Kumar Choudhur. A copper chelate induces apoptosis and overcomes multidrug resistance in T-cell acute lymphoblastic leukemia through redox imbalance and inhibition of EGFR/PI3K/Akt expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-02. PMID:27639544. |
moreover cu-5-smag targets t-all cells more than cu-obpha because cu-5-smag generates greater extent of redox imbalance compared to cu-obpha and when this redox imbalance is reduced by application of nac and peg-catalase, highest abrogation of apoptosis is observed following cu-5-smag treatment in addition, cu-5-smag significantly down-regulates the activation and expression of egfr1, akt and pi3k in drug-resistant t-all cells. |
2017-02-02 |
2023-08-13 |
mouse |
| Yinghua Li, Min Guo, Zhengfang Lin, Mingqi Zhao, Misi Xiao, Changbing Wang, Tiantian Xu, Tianfeng Chen, Bing Zh. Polyethylenimine-functionalized silver nanoparticle-based co-delivery of paclitaxel to induce HepG2 cell apoptosis. International journal of nanomedicine. vol 11. 2017-02-02. PMID:27994465. |
furthermore, ag@pei@ptx enhanced cytotoxic effects on hepg2 cells and triggered intracellular reactive oxygen species; the signaling pathways of akt, p53, and mapk were activated to advance cell apoptosis. |
2017-02-02 |
2023-08-13 |
Not clear |
| Lu Liu, Weiwei Huang, Jianhong Wang, Huiling Song, Juan Cen, Biansheng J. Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway. Chemico-biological interactions. vol 262. 2017-02-01. PMID:27923643. |
anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced pc12 cells via erk and akt activated nrf2/ho-1 signaling pathway. |
2017-02-01 |
2023-08-13 |
Not clear |
| Ming Xiao, Yi Tang, Wen-Wen Chen, Ya-Lan Wang, Lian Yang, Xian Li, Guang-Lin Song, Jing Kuan. Tubb3 regulation by the Erk and Akt signaling pathways: a mechanism involved in the effect of arginine ADP-ribosyltransferase 1 (Art1) on apoptosis of colon carcinoma CT26 cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 2. 2017-01-31. PMID:26373733. |
tubb3 regulation by the erk and akt signaling pathways: a mechanism involved in the effect of arginine adp-ribosyltransferase 1 (art1) on apoptosis of colon carcinoma ct26 cells. |
2017-01-31 |
2023-08-13 |
mouse |
| Ming Xiao, Yi Tang, Wen-Wen Chen, Ya-Lan Wang, Lian Yang, Xian Li, Guang-Lin Song, Jing Kuan. Tubb3 regulation by the Erk and Akt signaling pathways: a mechanism involved in the effect of arginine ADP-ribosyltransferase 1 (Art1) on apoptosis of colon carcinoma CT26 cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 2. 2017-01-31. PMID:26373733. |
furthermore, activity of akt and erk cell signal pathways and expression of an apoptosis biomarker, βiii-tubulin (tubb3), decrease when art1 was silenced and increase when art1 was overexpressed. |
2017-01-31 |
2023-08-13 |
mouse |
| Ming Xiao, Yi Tang, Wen-Wen Chen, Ya-Lan Wang, Lian Yang, Xian Li, Guang-Lin Song, Jing Kuan. Tubb3 regulation by the Erk and Akt signaling pathways: a mechanism involved in the effect of arginine ADP-ribosyltransferase 1 (Art1) on apoptosis of colon carcinoma CT26 cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 2. 2017-01-31. PMID:26373733. |
inhibiting akt pathway or erk pathway both downregulates expression of tubb3 on protein and messenger rna (mrna) level, indicating that tubb3 could be regulated by both akt and erk pathways, and plays a role in the influence of art1 on apoptosis of balb/c mice allograft transplant tumor. |
2017-01-31 |
2023-08-13 |
mouse |
| C Liu, Z Chen, J Wang, H H. Overexpression of X chromosome-linked inhibitor of apoptosis by inhibiting microRNA-24 protects periodontal ligament cells against hydrogen peroxide-induced cell apoptosis. Cellular and molecular biology (Noisy-le-Grand, France). vol 62. issue 4. 2017-01-31. PMID:27188727. |
in addition, the gene silencing of xiap significantly reduced akt activity and blocked the protective effect of the mir-24 inhibitor against h2o2-induced cell apoptosis. |
2017-01-31 |
2023-08-13 |
Not clear |
| Guanmin Meng, Kequn Chai, Xinda Li, Yongqiang Zhu, Weihua Huan. Luteolin exerts pro-apoptotic effect and anti-migration effects on A549 lung adenocarcinoma cells through the activation of MEK/ERK signaling pathway. Chemico-biological interactions. vol 257. 2017-01-31. PMID:27474067. |
in the present study, we investigated whether luteolin exhibits the anti-cancer effect in lung cancer through the induction of cell apoptosis and inhibition of cell migration, and whether mitogen-activated protein kinases (mapks) and akt signaling pathways are required. |
2017-01-31 |
2023-08-13 |
Not clear |
| Guanmin Meng, Kequn Chai, Xinda Li, Yongqiang Zhu, Weihua Huan. Luteolin exerts pro-apoptotic effect and anti-migration effects on A549 lung adenocarcinoma cells through the activation of MEK/ERK signaling pathway. Chemico-biological interactions. vol 257. 2017-01-31. PMID:27474067. |
results revealed that luteolin exerted an anti-proliferation effect in a dose- and time-dependent manner in a549 lung adenocarcinoma cells, and induced apoptosis with a concomitant increase in the activation of caspases-3 and -9, diminution of bcl-2, elevation in bax expression, and the phosphorylation of mek and its down-stream kinase erk, as well as the activation of akt. |
2017-01-31 |
2023-08-13 |
Not clear |