| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Huo, Y Ma, J-J Liu, Y S Ho, S Liu, L Y Soh, S Chen, S Xu, W Han, A Hong, S C Lim, K-P La. Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis. Cell death & disease. vol 7. 2016-12-13. PMID:26866272. |
fas apoptosis inhibitory molecule (faim), a ubiquitously expressed antiapoptotic protein, functions as a mediator of akt signalling. |
2016-12-13 |
2023-08-13 |
mouse |
| Mi-Hua Liu, Guo-Hua Li, Li-Jun Peng, Shun-Lin Qu, Yuan Zhang, Juan Peng, Xin-Yuan Luo, Heng-Jing Hu, Zhong Ren, Yao Liu, Hui Tang, Lu-Shan Liu, Zhi-Han Tang, Zhi-Sheng Jian. PI3K/Akt/FoxO3a signaling mediates cardioprotection of FGF-2 against hydrogen peroxide-induced apoptosis in H9c2 cells. Molecular and cellular biochemistry. vol 414. issue 1-2. 2016-12-13. PMID:26899709. |
stimulation with h2o2 decreased the phosphorylation of akt and foxo3a, and induced nuclear localization of foxo3a and apoptosis of h9c2 cells. |
2016-12-13 |
2023-08-13 |
Not clear |
| Tingting Hu, Hua Cao, Chengli Yang, Lijing Zhang, Xiaohua Jiang, Xiang Gao, Fan Yang, Gu He, Xiangrong Song, Aiping Tong, Gang Guo, Changyang Gong, Rui Li, Xiaoning Zhang, Xinchun Wang, Yu Zhen. LHD-Modified Mechanism-Based Liposome Coencapsulation of Mitoxantrone and Prednisolone Using Novel Lipid Bilayer Fusion for Tissue-Specific Colocalization and Synergistic Antitumor Effects. ACS applied materials & interfaces. vol 8. issue 10. 2016-12-13. PMID:26907854. |
the deduced synergistic mechanism is regulation of akt signaling pathway including the targets of p-akt, p-gsk-3β, p-s6 ribosomal protein, and p-ampk by mto reactivating plp-induced apoptosis. |
2016-12-13 |
2023-08-13 |
mouse |
| Hui Ren, Jianjun Mu, Jingjing Ma, Jie Gong, Jing Li, Jiawen Wang, Tianlin Gao, Peng Zhu, Shikang Zheng, Jing Xie, Bo Yua. Selenium Inhibits Homocysteine-Induced Endothelial Dysfunction and Apoptosis via Activation of AKT. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 38. issue 3. 2016-12-13. PMID:26909517. |
selenium inhibits homocysteine-induced endothelial dysfunction and apoptosis via activation of akt. |
2016-12-13 |
2023-08-13 |
Not clear |
| T P Das, S Suman, H Alatassi, M K Ankem, C Damodara. Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer. Cell death & disease. vol 7. 2016-12-13. PMID:26913603. |
inhibition of akt promotes foxo3a-dependent apoptosis in prostate cancer. |
2016-12-13 |
2023-08-13 |
mouse |
| A-X Liu, D Zhang, Y-M Zhu, H-J Gao, J-Y Jiang, X-L Hu, P-P Lv, P C K Leung, H-F Huan. Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. Current molecular medicine. vol 16. issue 3. 2016-12-13. PMID:26917260. |
jmr-132 inhibited cellular viability and induced apoptosis in jeg-3 cell in a time and dosedependent manners through activation of caspase-3, p38, and p53, as well as inhibition of phosphorylation of akt. |
2016-12-13 |
2023-08-13 |
human |
| A-X Liu, D Zhang, Y-M Zhu, H-J Gao, J-Y Jiang, X-L Hu, P-P Lv, P C K Leung, H-F Huan. Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. Current molecular medicine. vol 16. issue 3. 2016-12-13. PMID:26917260. |
inhibition of ghrh-r by using ghrh antagonist in jeg-3 cell may reduce cell viability and induce apoptosis through inactivation of akt and er stress via phosphorylation of eif2α. |
2016-12-13 |
2023-08-13 |
human |
| A-X Liu, D Zhang, Y-M Zhu, H-J Gao, J-Y Jiang, X-L Hu, P-P Lv, P C K Leung, H-F Huan. Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. Current molecular medicine. vol 16. issue 3. 2016-12-13. PMID:26917260. |
the most important aspect of the paper: our present study for the first time provided evidences that ghrh and ghrh-r loops involve in jeg-3 cell viability and apoptosis through akt and eif2α pathways. |
2016-12-13 |
2023-08-13 |
human |
| Mohamed Bejaoui, Eirini Pantazi, Maria Calvo, Emma Folch-Puy, Anna Serafín, Gianfranco Pasut, Arnau Panisello, René Adam, Joan Roselló-Catafa. Polyethylene Glycol Preconditioning: An Effective Strategy to Prevent Liver Ischemia Reperfusion Injury. Oxidative medicine and cellular longevity. vol 2016. 2016-12-13. PMID:26981166. |
in addition, peg 35 protective mechanisms were correlated with the activation of the prosurvival kinase akt and the cytoprotective factor ampk and the inhibition of apoptosis. |
2016-12-13 |
2023-08-13 |
rat |
| Wei Yu, Wenliang Zha, Zhiqiang Ke, Qing Min, Cairong Li, Huirong Sun, Chao Li. Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3K/Akt Signalling Pathway. Journal of diabetes research. vol 2016. 2016-12-13. PMID:26989696. |
cell viability, apoptosis, superoxide formation, the expression of nadph oxidase subunits, and potential regulatory molecules, akt and gsk-3β, were assessed in cardiomyocytes. |
2016-12-13 |
2023-08-13 |
rat |
| Liwen Cui, Yaling Bai, Junxia Zhang, Shenglei Zhang, Jinsheng X. Effects of extracellular acid stimulation on rat vascular smooth muscle cell in Gas6/Axl or PI3K/Akt signaling pathway. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 38. issue 5. 2016-12-13. PMID:27362907. |
our study demonstrated that a high concentration of phosphorus induced apoptosis and calcification of vsmcs, decreased expression of axl, and reduced phosphorylation of akt. |
2016-12-13 |
2023-08-13 |
rat |
| Liwen Cui, Yaling Bai, Junxia Zhang, Shenglei Zhang, Jinsheng X. Effects of extracellular acid stimulation on rat vascular smooth muscle cell in Gas6/Axl or PI3K/Akt signaling pathway. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 38. issue 5. 2016-12-13. PMID:27362907. |
stimulation of extracellular acid counteracted the effects as above by increasing the expression of axl and akt phosphorylation and decreasing the expression of activated caspase3, which thereby decreased cell apoptosis and calcification. |
2016-12-13 |
2023-08-13 |
rat |
| Ji-Sue Baik, Seo-Won Mun, Kyoung-Sook Kim, Shin-Ji Park, Hyun-Kyoung Yoon, Dong-Hyun Kim, Min-Kyu Park, Cheorl-Ho Kim, Young-Choon Le. Apoptotic Effects of Cordycepin Through the Extrinsic Pathway and p38 MAPK Activation in Human Glioblastoma U87MG Cells. Journal of microbiology and biotechnology. vol 26. issue 2. 2016-11-11. PMID:26597532. |
these results suggest that cordycepin triggered apoptosis in u87mg cells through p38 mapk activation and inhibition of the akt survival pathway. |
2016-11-11 |
2023-08-13 |
human |
| Hui Lyu, Xiao He Yang, Susan M Edgerton, Ann D Thor, Xiaoying Wu, Zhimin He, Bolin Li. The erbB3- and IGF-1 receptor-initiated signaling pathways exhibit distinct effects on lapatinib sensitivity against trastuzumab-resistant breast cancer cells. Oncotarget. vol 7. issue 3. 2016-11-11. PMID:26621843. |
knockdown of erbb3 inhibited akt in skbr3-pool2 and bt474-hr20 cells, significantly increased lapatinib efficacy, and dramatically re-sensitized the cells to lapatinib-induced apoptosis. |
2016-11-11 |
2023-08-13 |
Not clear |
| Ayunadirah Ayub, Wai Kien Yip, Heng Fong Seo. Dual treatments targeting IGF-1R, PI3K, mTORC or MEK synergize to inhibit cell growth, induce apoptosis, and arrest cell cycle at G1 phase in MDA-MB-231 cell line. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 75. 2016-11-08. PMID:26463630. |
these dual treatments increased apoptosis and/or cell cycle arrest at g0/g1 phase and enhanced the inhibition of phosphorylation of akt or downstream molecules of mtorc1, as compared to the single treatments. |
2016-11-08 |
2023-08-13 |
Not clear |
| S H Jung, H C Lee, D-M Yu, B C Kim, S M Park, Y-S Lee, H J Park, Y-G Ko, J-S Le. Heparan sulfation is essential for the prevention of cellular senescence. Cell death and differentiation. vol 23. issue 3. 2016-11-01. PMID:26250908. |
thus, blockade of either fgfr1 or akt prohibited p53 and p21 accumulation and cell fate switched from cellular senescence to apoptosis. |
2016-11-01 |
2023-08-13 |
mouse |
| Hyeong Sim Choi, Min Kyoung Kim, Youn Kyung Choi, Yong Cheol Shin, Sung-Gook Cho, Seong-Gyu K. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC complementary and alternative medicine. vol 16. 2016-11-01. PMID:27121110. |
rhus verniciflua stokes (rvs) and butein induce apoptosis of paclitaxel-resistant skov-3/pax ovarian cancer cells through inhibition of akt phosphorylation. |
2016-11-01 |
2023-08-13 |
Not clear |
| Hyeong Sim Choi, Min Kyoung Kim, Youn Kyung Choi, Yong Cheol Shin, Sung-Gook Cho, Seong-Gyu K. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC complementary and alternative medicine. vol 16. 2016-11-01. PMID:27121110. |
rvs and butein, a major compound of rvs, were known to induce apoptosis via akt inhibition in cancer cells. |
2016-11-01 |
2023-08-13 |
Not clear |
| Wallace Martins de Araujo, Bruno Kaufmann Robbs, Lilian G Bastos, Waldemir F de Souza, Flávia C B Vidal, João P B Viola, Jose A Morgado-Dia. PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells. Journal of cellular biochemistry. vol 117. issue 2. 2016-10-31. PMID:26224641. |
furthermore, high doses of lithium increased apoptosis, which was accompanied by decreased proteins levels of akt and pten. |
2016-10-31 |
2023-08-13 |
Not clear |
| Yi Rong Li, Shiming Li, Chi-Tang Ho, Ya-Han Chang, Kok-Tong Tan, Ting-Wen Chung, Bing-Yen Wang, Yu-Kuo Chen, Chi-Chen Li. Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo. Cancer biology & therapy. vol 17. issue 1. 2016-10-31. PMID:26569090. |
over-expression of akt by akt cdna transfection decreased 5-actmf mediated apoptosis and autophagy, supporting the induction of apoptosis and autophagy by inhibition of akt pathway. |
2016-10-31 |
2023-08-13 |
mouse |