| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhen-Ye Zhang, Lu Pan, Shipeng Dang, Ning Wang, Shan-Ying Zhao, Feng Li, Li-Da Wu, Lei Zhang, Huan-Huan Liu, Ning Zhao, Ya-Juan Yang, Ling-Ling Qian, Tong Liu, Ru-Xing Wan. Glucose fluctuations aggravate cardiomyocyte apoptosis by enhancing the interaction between Txnip and Akt. BMC cardiovascular disorders. vol 24. issue 1. 2024-09-03. PMID:39223509. |
glucose fluctuations aggravate cardiomyocyte apoptosis by enhancing the interaction between txnip and akt. |
2024-09-03 |
2024-09-05 |
Not clear |
| Jiaqiao Zhu, Zhonggui Gong, Xueru Wang, Kanglei Zhang, Yonggang Ma, Hui Zou, Ruilong Song, Hongyan Zhao, Zongping Liu, Wenxuan Don. mTORC1 and mTORC2 Co-Protect against Cadmium-Induced Renal Tubular Epithelial Cell Apoptosis and Acute Kidney Injury by Regulating Protein Kinase B. Journal of agricultural and food chemistry. 2024-09-02. PMID:39219293. |
we further found that the akt activation plays a key role in mtorc1/torc2-mediated antiapoptosis, protecting cd-exposed kidney cells from apoptosis. |
2024-09-02 |
2024-09-04 |
mouse |
| Vahid Pourbarkhordar, Sohrab Rahmani, Ali Roohbakhsh, A Wallace Hayes, Gholamreza Karim. Melatonin effect on breast and ovarian cancers by targeting the PI3K/Akt/mTOR pathway. IUBMB life. 2024-08-30. PMID:39212097. |
b: apoptosis induction by decreasing mdm2 expression, a downstream target of akt, and mtor, which leads to bad activation in addition to bcl-xl and p53 inhibition. |
2024-08-30 |
2024-09-04 |
Not clear |
| Chae Hyun Lee, Sangsu Shin, Sang In Le. 10-Eicosanol Alleviates Patulin-Induced Cell Cycle Arrest and Apoptosis by Activating AKT (Protein Kinase B) in Porcine Intestinal Epithelial Cells. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201284. |
10-eicosanol alleviates patulin-induced cell cycle arrest and apoptosis by activating akt (protein kinase b) in porcine intestinal epithelial cells. |
2024-08-29 |
2024-09-01 |
Not clear |
| Mu-Kuei Shieu, Chia-Chieh Lin, Hsin-Yu Ho, Yu-Sheng Lo, Yi-Ching Chuang, Ming-Ju Hsie. Picrasidine I Regulates Apoptosis in Melanoma Cell Lines by Activating ERK and JNK Pathways and Suppressing AKT Signaling. Environmental toxicology. 2024-08-28. PMID:39194337. |
picrasidine i regulates apoptosis in melanoma cell lines by activating erk and jnk pathways and suppressing akt signaling. |
2024-08-28 |
2024-08-30 |
human |
| Anna Basile, Valentina Giudice, Laura Mettivier, Antonia Falco, Anna Lisa Cammarota, Angela D'Ardia, Carmine Selleri, Margot De Marco, Nicola De Maio, Maria Caterina Turco, Liberato Marzullo, Alessandra Rosat. Tuning the B-CLL microenvironment: evidence for BAG3 protein- mediated regulation of stromal fibroblasts activity. Cell death discovery. vol 10. issue 1. 2024-08-28. PMID:39198407. |
in co-culture experiments with pbmcs from b-cll patients, bag3 silencing in hs-5 cells increased apoptosis and decreased phosphorylation of btk, akt, and erk in b-cll cells, thus disrupting their pro-survival key signaling pathways. |
2024-08-28 |
2024-09-01 |
Not clear |
| Ziqiang Lin, Suo Wang, Yu Cao, Jialing Lin, Ailing Sun, Wei Huang, Jun Zhou, Qingxiong Hon. Bioinformatics and Validation Reveal the Potential Target of Curcumin in the Treatment of Diabetic Peripheral Neuropathy. Neuropharmacology. 2024-08-23. PMID:39179172. |
subsequently, qrt-pcr, mtt assay, flow cytometry, caspase-3 activity detection and westernblot showed that curcumin treatment increased rsc96 cell viability, reduced cell apoptosis, increased hmox1, pten, vegfa and myc expression, and up-regulated akt phosphorylation level under high glucose environment. |
2024-08-23 |
2024-08-27 |
rat |
| Shuibang Wang, Keytam S Awad, Li-Yuan Chen, Mohammad A H Siddique, Gabriela A Ferreyra, Caroline L Wang, Thea Joseph, Zu-Xi Yu, Kazuyo Takeda, Cumhur Y Demirkale, You-Yang Zhao, Jason M Elinoff, Robert L Danne. Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α. American journal of physiology. Lung cellular and molecular physiology. 2024-08-19. PMID:39159362. |
endothelial phd2 deficiency induces apoptosis resistance and inflammation via akt activation and aip1 loss independent of hif2α. |
2024-08-19 |
2024-08-22 |
human |
| Qiyuan Song, Ning Zhang, Yujiao Zhang, An Zhang, Huilin Li, Shuting Bai, Luxiang Shang, Juanjuan Du, Yinglong Ho. Multiomics analysis of canine myocardium after circumferential pulmonary vein ablation: Effect of neuropeptide Y on long-term reinduction of atrial fibrillation. Journal of cellular and molecular medicine. vol 28. issue 15. 2024-08-07. PMID:39107876. |
atrial myocyte apoptosis was alleviated by npy intervention, and akt activation was inhibited in cardiac fibroblasts. |
2024-08-07 |
2024-08-09 |
Not clear |
| Qiyuan Song, Ning Zhang, Yujiao Zhang, An Zhang, Huilin Li, Shuting Bai, Luxiang Shang, Juanjuan Du, Yinglong Ho. Multiomics analysis of canine myocardium after circumferential pulmonary vein ablation: Effect of neuropeptide Y on long-term reinduction of atrial fibrillation. Journal of cellular and molecular medicine. vol 28. issue 15. 2024-08-07. PMID:39107876. |
these results suggest that long-term suppression of npy after cpva may lead to induction of af through promoting cardiomyocyte apoptosis and activating the akt pathway in cardiac fibroblasts, which may make af more likely to reinduce. |
2024-08-07 |
2024-08-09 |
Not clear |
| Meng-Nan Zeng, Yu-Han Zhang, Peng-Li Guo, Zi-Yu Zhang, Yan-Ling Liu, Ru Wang, Qi-Mei Tie, Yuan-Yuan Wang, Fang-Zhuo Chang, Wei-Sheng Feng, Xiao-Ke Zhen. [Effect of 2-phenylethyl-beta-glucopyranoside isolated from Huaizhong No. 1 Rehmannia glutinosa on hypoxic pulmonary hypertension by regulating PI3K/Akt/m TOR/HIF-1α pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 14. 2024-08-05. PMID:39099359. |
the cardiopulmonary function, right ventricular pressure, cough and asthma index, lung injury, cell apoptosis, oxidative stress-related indicators, immune cells, and phosphatidylinositol 3-kinase(pi3k)/protein kinase b(akt)/mammalian target of rapamycin(mtor)/hypoxic inducible factor 1α(hif-1α) pathway-related proteins or mrna levels were examined. |
2024-08-05 |
2024-08-07 |
mouse |
| Meng-Nan Zeng, Yu-Han Zhang, Peng-Li Guo, Zi-Yu Zhang, Yan-Ling Liu, Ru Wang, Qi-Mei Tie, Yuan-Yuan Wang, Fang-Zhuo Chang, Wei-Sheng Feng, Xiao-Ke Zhen. [Effect of 2-phenylethyl-beta-glucopyranoside isolated from Huaizhong No. 1 Rehmannia glutinosa on hypoxic pulmonary hypertension by regulating PI3K/Akt/m TOR/HIF-1α pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 14. 2024-08-05. PMID:39099359. |
the results showed that phe significantly improved the cardiopulmonary function of mice with ph, decreased right ventricular pressure, cough and asthma index, and lung injury, reduced cell apoptosis, oxidative stress-related indicators, and nuclear levels of phosphorylated akt(p-akt) and phosphorylated mtor(p-mtor), inhibited the expression levels of hif-1α and pi3k mrna and proteins, and maintained the immune cell homeostasis in mice. |
2024-08-05 |
2024-08-07 |
mouse |
| Kholoud A Elzanaty, Gamal A Omran, Ehab Kotb Elmahallawy, Ashraf Albrakati, Ayman A Saleh, Naief Dahran, Alaa S Alhegaili, Ahmad Salahuddin, Heba Abd-El-Azim, Ahmed Noreldin, Tarek M Okd. Design and Optimization of Sesamol Nanosuspensions to Potentiate the Anti-Tumor Activity of Epirubicin against Ehrlich Solid Carcinoma-Bearing Mice. Pharmaceutics. vol 16. issue 7. 2024-07-27. PMID:39065634. |
the findings revealed reductions in tumor growth and proliferation using ses either alone or combined and evidenced by decreased akt (akt serine/threonine kinase1) levels, angiogenesis indicated by lower levels of vegfr (vascular endothelial growth factor), and apoptosis demonstrated by elevated caspase3 and bax levels. |
2024-07-27 |
2024-07-29 |
mouse |
| Nágila Monteiro da Silva, Izabella Carla Silva Lopes, Adan Jesus Galué-Parra, Irlon Maciel Ferreira, Chubert Bernardo Castro de Sena, Edilene Oliveira da Silva, Barbarella de Matos Macchi, Fábio Rodrigues de Oliveira, José Luiz Martins do Nasciment. Fatty Acid Amides Suppress Proliferation via Cannabinoid Receptors and Promote the Apoptosis of C6 Glioma Cells in Association with Akt Signaling Pathway Inhibition. Pharmaceuticals (Basel, Switzerland). vol 17. issue 7. 2024-07-27. PMID:39065724. |
fatty acid amides suppress proliferation via cannabinoid receptors and promote the apoptosis of c6 glioma cells in association with akt signaling pathway inhibition. |
2024-07-27 |
2024-07-29 |
Not clear |
| Jingchao Wang, Daoyuan Huang, Thu Anh Thai Nguyen, Liem Minh Phan, Wenyi Wei, Abdol-Hossein Rezaeia. CD74-AKT Axis Is a Potential Therapeutic Target in Triple-Negative Breast Cancer. Biology. vol 13. issue 7. 2024-07-26. PMID:39056676. |
as such, selective targeting of the cd74/fas complex using the akt inhibitor along with the cd74-derived peptide could synergistically restore and activate fas-mediated apoptosis. |
2024-07-26 |
2024-07-28 |
Not clear |
| Mehlika Dilek Altıntop, İpek Ertorun, Gülşen Akalın Çiftçi, Ahmet Özdemi. Design, synthesis and biological evaluation of a new series of imidazothiazole-hydrazone hybrids as dual EGFR and Akt inhibitors for NSCLC therapy. European journal of medicinal chemistry. vol 276. 2024-07-24. PMID:39047611. |
in vitro mechanistic studies were performed to assess their effects on apoptosis, caspase-3, cell cycle, egfr and akt in a549 cells. |
2024-07-24 |
2024-07-28 |
human |
| Ye Ding, Hao Li, Saisai Cao, Yong Y. Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway. Toxicology and applied pharmacology. 2024-07-15. PMID:39009138. |
the proliferation ability, cell cycle, apoptosis and migration of gastric cancer cells were detected, as well as the protein expression levels of pi3k, p-akt, and akt and the mrna expression levels of akt1, vegfa, egfr, hras, and hsp90aa1 in gastric cancer cells. |
2024-07-15 |
2024-07-18 |
Not clear |
| Nianping Zhang, Peng Guo, Yan Zhao, Xiao Qiu, Shuai Shao, Zhenzhong Liu, Zong Ga. Pharmacological mechanisms of puerarin in the treatment of Parkinson's disease: An overview. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-13. PMID:39002442. |
puerarin inhibits cell apoptosis through the phosphatidylinositol-4,5-bisphosphate 3-kinase (pi3k)/protein kinase b (akt) and c-jun n-terminal kinase (jnk) signaling pathways. |
2024-07-13 |
2024-07-16 |
Not clear |
| Liu-Dan Liang, Hui-Xin Peng, Mei-Jin Huang, Li-Ye Su, Jia-Wei Huang, Jian-le Lao, Zhao-He Huang, Yan Li. HGF ameliorates cardiomyocyte apoptosis and inflammatory response in septic patients via the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway. Gene. 2024-07-13. PMID:39002784. |
hgf ameliorates cardiomyocyte apoptosis and inflammatory response in septic patients via the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) pathway. |
2024-07-13 |
2024-07-16 |
Not clear |
| Shuangmei Tong, Jian Wu, Yun Song, Wenhuan Fu, Yifan Yuan, Pin Zhong, Yinlong Liu, Bin Wan. IDH1-mutant metabolite D-2-hydroxyglutarate inhibits proliferation and sensitizes glioma to temozolomide via down-regulating ITGB4/PI3K/AKT. Cell death discovery. vol 10. issue 1. 2024-07-09. PMID:38982076. |
in subsequent cellular experiments, we found that the idh1-mutant metabolite d-2hg suppresses integrin subunit beta 4 (itgb4) expression, and down-regulate the phosphorylation levels of pi3k and akt, ultimately inhibiting cell proliferation while promoting apoptosis, thereby improving glioma prognosis. |
2024-07-09 |
2024-07-12 |
Not clear |