| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Sun, Kang Huo, Fude Liu, Yawen Cheng, Chen Chen, Jianfeng Han, Jia Y. Regulation and molecular mechanism of adiponectin on the proliferation, apoptosis, autophagy, and chemosensitivity of LN18 Glioma cell line. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 6. 2024-06-05. PMID:38836664. |
this study aimed to explore the regulatory effects and associated mechanisms of adiponectin on apoptosis and proliferation in the ln18 glioma cell line through the ampk and akt signaling pathways. |
2024-06-05 |
2024-06-07 |
Not clear |
| Jiali Chen, Qinghe Zeng, Xu Wang, Rui Xu, Weidong Wang, Yuliang Huang, Qi Sun, Wenhua Yuan, Pinger Wang, Di Chen, Peijian Tong, Hongting Ji. Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling. eLife. vol 13. 2024-05-31. PMID:38819423. |
aberrant methylation and expression of tnxb promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via akt signaling. |
2024-05-31 |
2024-06-02 |
mouse |
| Yichao Liao, Feng Wei, Zhelin He, Jingxue He, Yanlin Ai, Cui Guo, Li Zhou, Dan Luo, Chengen Li, Yueqiang Wen, Jinhao Zeng, Xiao M. Animal-derived natural products for hepatocellular carcinoma therapy: current evidence and future perspectives. Frontiers in pharmacology. vol 15. 2024-05-29. PMID:38803433. |
the mechanism of action involving apoptosis induction, autophagy induction, anti-proliferation, anti-migration, and anti-drug resistance via phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor), ras/extracellular signal regulated kinases (erk)/mitogen-activated protein kinase (mapk), wnt/β-catenin, and janus kinase (jak)/signal transducer and activator of transcription (stat) pathways. |
2024-05-29 |
2024-06-03 |
human |
| Zhansheng Zhu, Shanwen Liang, Yu Hong, Yangzhi Qi, Qian Sun, Xinyi Zhu, Yuxin Wei, Yang Xu, Qianxue Che. Bufotalin enhances apoptosis and TMZ chemosensitivity of glioblastoma cells by promoting mitochondrial dysfunction via AKT signaling pathway. Aging. vol 16. 2024-05-29. PMID:38809514. |
bufotalin enhances apoptosis and tmz chemosensitivity of glioblastoma cells by promoting mitochondrial dysfunction via akt signaling pathway. |
2024-05-29 |
2024-06-03 |
Not clear |
| Chi Teng Vong, Dechao Tan, Fengyun Liao, Zhejie Chen, Zhangmei Chen, Hisa Hui Ling Tseng, Wai San Cheang, Shengpeng Wang, Yitao Wan. Ginsenoside Rk1 Ameliorates ER Stress-Induced Apoptosis through Directly Activating IGF-1R in Mouse Pancreatic [Formula: see text]-Cells and Diabetic Pancreas. The American journal of Chinese medicine. 2024-05-27. PMID:38798150. |
we demonstrated that ginsenoside rk1 alleviated er stress-induced apoptosis in min6 cells, which was accomplished by directly targeting and activating insulin-like growth factor 1 receptor (igf-1r), thus activating the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/bcl-2-associated agonist of cell death (bad)-b-cell lymphoma-2 (bcl-2) pathway. |
2024-05-27 |
2024-05-31 |
mouse |
| Janice M Santiago-O'Farrill, Alicia Blessing Bollu, Hailing Yang, Vivian Orellana, Marc Pina, Xudong Zhang, Jinsong Liu, Robert C Bast, Zhen L. Crizotinib enhances PARP inhibitor efficacy in ovarian cancer cells and xenograft models by inducing autophagy. Molecular cancer research : MCR. 2024-05-23. PMID:38780897. |
mechanistically, the combination resulted in increased levels of reactive oxygen species (ros), induced dna damage, and decreased the phosphorylation of akt, mtor, and ulk-1, contributing to increased olaparib-induced autophagy and apoptosis. |
2024-05-23 |
2024-05-27 |
human |
| Jiani Wang, Xiang Wu, Jincai Fang, Qian L. Intervention of exogenous VEGF protect brain microvascular endothelial cells from hypoxia-induced injury by regulating PLCγ/RAS/ERK and PI3K/AKT pathways. Experimental gerontology. vol 192. 2024-05-22. PMID:38718888. |
interference from exogenous vegf-e activated plcγ1/erk-1/2 and akt pathways, promoting cell proliferation and inhibiting apoptosis of hypoxic brain microvascular endothelial cells. |
2024-05-22 |
2024-05-27 |
Not clear |
| Ju-Bin Kang, Phil-Ok Ko. Retinoic acid alleviates the reduction of Akt and Bad phosphorylation and regulates Bcl-2 family protein interactions in animal models of ischemic stroke. PloS one. vol 19. issue 5. 2024-05-16. PMID:38753710. |
phosphorylated akt is important in regulating survival and apoptosis. |
2024-05-16 |
2024-05-27 |
Not clear |
| Ju-Bin Kang, Phil-Ok Ko. Retinoic acid alleviates the reduction of Akt and Bad phosphorylation and regulates Bcl-2 family protein interactions in animal models of ischemic stroke. PloS one. vol 19. issue 5. 2024-05-16. PMID:38753710. |
we demonstrate that retinoic acid prevented apoptosis against cerebral ischemia through phosphorylation of akt and bad, maintenance of phospho-bad and 14-3-3 binding, and regulation of bcl-2 family protein interactions. . |
2024-05-16 |
2024-05-27 |
Not clear |
| Fatemeh Sadat Hosseini, Abdolreza Ahmadi, Prashant Kesharwani, Hossein Hosseini, Amirhossein Sahebka. Regulatory effects of statins on Akt signaling for prevention of cancers. Cellular signalling. vol 120. 2024-05-11. PMID:38729324. |
akt signaling plays a crucial role in key cancer cell features like proliferation, invasion, and apoptosis by activating multiple effectors in downstream pathways such as foxo, pten, nf-κb, gsk3β, and mtor. |
2024-05-11 |
2024-05-27 |
Not clear |
| Abeer Al Otaibi, Sindiyan Al Shaikh Mubarak, Fatimah Al Hejji, Abdulrahman Almasaud, Haya Al Jami, Jahangir Iqbal, Ali Al Qarni, Naif Khalaf Al Harbi, Ahmed Bakilla. Thapsigargin and Tunicamycin Block SARS-CoV-2 Entry into Host Cells via Differential Modulation of Unfolded Protein Response (UPR), AKT Signaling, and Apoptosis. Cells. vol 13. issue 9. 2024-05-10. PMID:38727305. |
thapsigargin and tunicamycin block sars-cov-2 entry into host cells via differential modulation of unfolded protein response (upr), akt signaling, and apoptosis. |
2024-05-10 |
2024-05-27 |
Not clear |
| Rui Wang, Wenrui Cui, Lanxin Li, Xiangkai Wei, Chunhong Chu, Guoliang Zhang, Chenxue Liu, Huixia Xu, Chenyang Liu, Ke Wang, Yanming Li, Lei A. BDTX-189, a novel tyrosine kinase inhibitor, inhibits cell activity via ERK and AKT pathways in the EGFR C797S triple mutant cells. Chemico-biological interactions. vol 395. 2024-05-09. PMID:38710274. |
meanwhile, bdtx-189 reduces the protein phosphorylation levels of egfr, erk, and akt, promoting apoptosis. |
2024-05-09 |
2024-05-27 |
Not clear |
| Xixi Wang, Yanfei Wang, Jing Chen, Qinyao Wang, Zhongjian Liu, Yijie Yin, Tonghua Yang, Tao Shen, Yalian S. On the mechanism of wogonin against acute monocytic leukemia using network pharmacology and experimental validation. Scientific reports. vol 14. issue 1. 2024-05-02. PMID:38698063. |
the antiproliferative effects of wogonin on thp-1 cells of aml-m5 presented a dose-dependent and time-dependent manner, inducing apoptosis, blocking the cell cycle at the g2/m phase, decreasing the expressions of ccnd1, cdk2, and cyclina2 mrna, as well as akt and p-akt proteins. |
2024-05-02 |
2024-05-05 |
Not clear |
| Siqi Xu, Xin Qin, Jiale Liang, Xiao Fu, Dexuan Xiao, Yunfeng Lin, Tao Wan. Harnessing tetrahedral framework nucleic acids for enhanced delivery of microRNA-149-3p: A new frontier in oral squamous cell carcinoma therapy. Cell proliferation. 2024-04-27. PMID:38671577. |
the use of tfnas as carriers to assemble the t-mir-149 complex reduced the expression of pi3k and akt involved in tumorigenesis and alterations in proteins related to cell apoptosis. |
2024-04-27 |
2024-04-29 |
mouse |
| Hui-E Bi, Jie Zhang, Yujia Yao, Suyu Wang, Jin Yao, Zhijiang Shao, Qin Jian. Expression and functional significance of phosphoenolpyruvate carboxykinase 1 in uveal melanoma. Cell death discovery. vol 10. issue 1. 2024-04-26. PMID:38670942. |
restoring akt phosphorylation through a constitutively active mutant akt1 (s473d) ameliorated the growth inhibition, migration suppression, and apoptosis induced by pck1 silencing in uvm cells. |
2024-04-26 |
2024-04-29 |
human |
| Hui-E Bi, Jie Zhang, Yujia Yao, Suyu Wang, Jin Yao, Zhijiang Shao, Qin Jian. Expression and functional significance of phosphoenolpyruvate carboxykinase 1 in uveal melanoma. Cell death discovery. vol 10. issue 1. 2024-04-26. PMID:38670942. |
pck1 depletion, gαi3 downregulation, akt inhibition, proliferation arrest, and apoptosis were detected in pck1-silenced uvm xenografts. |
2024-04-26 |
2024-04-29 |
human |
| Qiulu Li, Kaixin Ping, Yannan Xiang, YingSun, Zunhan Hu, Shujuan Liu, Xinying Guan, Mian F. Ferulic acid alleviates avermectin induced renal injury in carp by inhibiting inflammation, oxidative stress and apoptosis. Fish & shellfish immunology. 2024-04-25. PMID:38663463. |
at the same time, fa inhibited the apoptosis of renal cells induced by avm by decreasing the transcription level and protein expression level of bax, and increasing the transcription level and protein expression level of bcl2, pi3k and akt. |
2024-04-25 |
2024-04-28 |
cat |
| Bing Liao, Jialing Wang, Yilin Xie, Hongliang Luo, Jun Mi. LINK-A: unveiling its functional role and clinical significance in human tumors. Frontiers in cell and developmental biology. vol 12. 2024-04-22. PMID:38645412. |
notably, link-a is involved in regulating critical cancer-related pathways, such as akt and hif1α signaling, and is implicated in a range of oncogenic activities, including cell proliferation, apoptosis, epithelial-mesenchymal transition (emt), cell invasion and migration, and glycolysis reprogramming. |
2024-04-22 |
2024-04-24 |
human |
| Li Wang, Shuqin Zhao, Yongling Wang, Jianying Liu, Xiaoli Wan. UBE2C promotes the proliferation of acute myeloid leukemia cells through PI3K/AKT activation. BMC cancer. vol 24. issue 1. 2024-04-18. PMID:38637730. |
ube2c knockdown inhibited the viability and promoted apoptosis in aml cells by regulating the phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt) signaling pathway. |
2024-04-18 |
2024-04-21 |
Not clear |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |