| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Summers, L A Garza, H Zhou, M J Birnbau. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Molecular and cellular biology. vol 18. issue 9. 1998-09-10. PMID:9710629. |
these studies demonstrate ceramide's capacity to inhibit activation of akt and imply that this is a mechanism of antagonism of insulin-dependent physiological events, such as the peripheral activation of glucose transport and the suppression of apoptosis. |
1998-09-10 |
2023-08-12 |
Not clear |
| S Dimmeler, B Assmus, C Hermann, J Haendeler, A M Zeihe. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circulation research. vol 83. issue 3. 1998-09-01. PMID:9710127. |
fluid shear stress stimulates phosphorylation of akt in human endothelial cells: involvement in suppression of apoptosis. |
1998-09-01 |
2023-08-12 |
human |
| S Dimmeler, B Assmus, C Hermann, J Haendeler, A M Zeihe. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circulation research. vol 83. issue 3. 1998-09-01. PMID:9710127. |
most important, overexpression of a dominant-negative akt mutant significantly inhibited the apoptosis-suppressive effect of shear stress against serum depletion-induced apoptosis, thus indicating the direct involvement of shear stress-induced akt phosphorylation for inhibition of endothelial cell apoptosis. |
1998-09-01 |
2023-08-12 |
human |
| C Murga, L Laguinge, R Wetzker, A Cuadrado, J S Gutkin. Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma. The Journal of biological chemistry. vol 273. issue 30. 1998-08-20. PMID:9668091. |
using ectopic expression of gpcrs in cos-7 cells as a model, we have observed that both m1 and m2 muscarinic acetylcholine receptors, representative of those gpcrs coupled to gq and gi proteins, respectively, can readily activate an epitope-tagged form of akt kinase and prevent uv-induced apoptosis. |
1998-08-20 |
2023-08-12 |
Not clear |
| H Zhou, S A Summers, M J Birnbaum, R N Pittma. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. The Journal of biological chemistry. vol 273. issue 26. 1998-08-03. PMID:9632728. |
inhibition of akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. |
1998-08-03 |
2023-08-12 |
Not clear |
| H Zhou, S A Summers, M J Birnbaum, R N Pittma. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. The Journal of biological chemistry. vol 273. issue 26. 1998-08-03. PMID:9632728. |
our data show that c2-ceramide induces apoptosis in hmn1 motor neuron cells and decreases both basal and insulin- or serum-stimulated akt kinase activity 65-70%. |
1998-08-03 |
2023-08-12 |
Not clear |
| H Zhou, S A Summers, M J Birnbaum, R N Pittma. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. The Journal of biological chemistry. vol 273. issue 26. 1998-08-03. PMID:9632728. |
in sum, our results suggest that inhibition of the key antiapoptotic kinase, akt, may play an important role in ceramide-induced apoptosis. |
1998-08-03 |
2023-08-12 |
Not clear |
| D C Heimbrook, A Olif. Therapeutic intervention and signaling. Current opinion in cell biology. vol 10. issue 2. 1998-06-18. PMID:9561854. |
new pathways controlling growth factor-dependent inhibition of apoptosis involving phosphoinositide 3'-hydroxykinase and the protein kinase akt have also been clarified. |
1998-06-18 |
2023-08-12 |
Not clear |
| E Berra, M T Diaz-Meco, J Mosca. The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway. The Journal of biological chemistry. vol 273. issue 17. 1998-05-22. PMID:9553146. |
consistent with this, expression of active mutants of pi 3-kinase and akt inhibits p38 activation and apoptosis. |
1998-05-22 |
2023-08-12 |
Not clear |
| E M Eves, W Xiong, A Bellacosa, S G Kennedy, P N Tsichlis, M R Rosner, N Ha. Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Molecular and cellular biology. vol 18. issue 4. 1998-05-21. PMID:9528786. |
akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. |
1998-05-21 |
2023-08-12 |
rat |
| R J Crowder, R S Freema. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 8. 1998-04-20. PMID:9526010. |
conversely, expression of dominant negative forms of pi 3-kinase or akt induces apoptosis in the presence of ngf. |
1998-04-20 |
2023-08-12 |
rat |
| J Dahl, A Jurczak, L A Cheng, D C Baker, T L Benjami. Evidence of a role for phosphatidylinositol 3-kinase activation in the blocking of apoptosis by polyomavirus middle T antigen. Journal of virology. vol 72. issue 4. 1998-04-17. PMID:9525648. |
activation of akt, a serine/threonine kinase whose activity has been correlated with regulation of apoptosis, was roughly twofold higher in f111 cells transformed by either wild-type virus or mutant 250ys blocked in binding shc compared to cells transformed by mutant 315yf. |
1998-04-17 |
2023-08-12 |
rat |
| J Dahl, A Jurczak, L A Cheng, D C Baker, T L Benjami. Evidence of a role for phosphatidylinositol 3-kinase activation in the blocking of apoptosis by polyomavirus middle T antigen. Journal of virology. vol 72. issue 4. 1998-04-17. PMID:9525648. |
in the same cells, levels of apoptosis were inversely correlated with akt activity. |
1998-04-17 |
2023-08-12 |
rat |
| Z Songyang, D Baltimore, L C Cantley, D R Kaplan, T F Frank. Interleukin 3-dependent survival by the Akt protein kinase. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 21. 1997-11-24. PMID:9326612. |
overexpression of akt or oncogenic v-akt protects 32d cells from apoptosis induced by il-3 withdrawal. |
1997-11-24 |
2023-08-12 |
Not clear |
| Z Songyang, D Baltimore, L C Cantley, D R Kaplan, T F Frank. Interleukin 3-dependent survival by the Akt protein kinase. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 21. 1997-11-24. PMID:9326612. |
apoptosis after il-3 withdrawal is accelerated by expression of dominant-negative mutants of akt, indicating that a functional akt signaling pathway is necessary for cell survival mediated by the cytokine il-3. |
1997-11-24 |
2023-08-12 |
Not clear |
| N N Ahmed, H L Grimes, A Bellacosa, T O Chan, P N Tsichli. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 8. 1997-05-22. PMID:9108028. |
expression of catalytically active akt mutants in baf/3 cells expressing il-2r beta[a0]delta s promotes the expression of bcl-2 and c-myc, inhibits apoptosis induced by il-3 deprivation or staurosporine, and stimulates cell cycle progression. |
1997-05-22 |
2023-08-12 |
Not clear |
| S G Kennedy, A J Wagner, S D Conzen, J Jordán, A Bellacosa, P N Tsichlis, N Ha. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes & development. vol 11. issue 6. 1997-05-02. PMID:9087425. |
we studied five downstream effectors of growth factor receptors--ras, raf, src, phosphoinositide 3-kinase (pi 3-kinase), and akt (pkb)--for their abilities to block apoptosis. |
1997-05-02 |
2023-08-12 |
Not clear |
| S G Kennedy, A J Wagner, S D Conzen, J Jordán, A Bellacosa, P N Tsichlis, N Ha. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes & development. vol 11. issue 6. 1997-05-02. PMID:9087425. |
in contrast, inhibition of pi 3-kinase accelerated apoptosis, and an activated form of the serine/threonine kinase akt, a downstream effector of pi 3-kinase, blocked apoptosis. |
1997-05-02 |
2023-08-12 |
Not clear |
| G Kulik, A Klippel, M J Webe. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Molecular and cellular biology. vol 17. issue 3. 1997-03-14. PMID:9032287. |
we found that membrane-targeted akt was sufficient to protect against apoptosis but that kinase-dead akt was not. |
1997-03-14 |
2023-08-12 |
Not clear |