| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Fan, Y X Ma, J A Wang, R Q Yuan, Q Meng, Y Cao, J J Laterra, I D Goldberg, E M Rose. The cytokine hepatocyte growth factor/scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3' kinase. Oncogene. vol 19. issue 18. 2000-06-02. PMID:10822371. |
consistent with this finding, hgf/sf induced the phosphorylation of c-akt (protein kinase-b), a pi3k substrate implicated in apoptosis inhibition; and an expression vector encoding a dominant negative kinase inactive akt partially but significantly inhibited hgf/sf-mediated cell protection and dna repair. |
2000-06-02 |
2023-08-12 |
Not clear |
| X P Zhou, D J Marsh, H Hampel, J B Mulliken, O Gimm, C En. Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis. Human molecular genetics. vol 9. issue 5. 2000-06-01. PMID:10749983. |
pten is a tumour suppressor and dual-specificity phosphatase which affects apoptosis via its lipid phosphatase activity in the phosphoinositol-3-kinase and akt pathway as well as inhibiting cell spreading via the focal adhesion kinase pathway. |
2000-06-01 |
2023-08-12 |
Not clear |
| T G Cross, D Scheel-Toellner, N V Henriquez, E Deacon, M Salmon, J M Lor. Serine/threonine protein kinases and apoptosis. Experimental cell research. vol 256. issue 1. 2000-05-12. PMID:10739649. |
the kinases of this family that have been suggested to play a role in apoptosis are the mitogen-activated protein kinase (mapk) family, specifically p42/44 erk, p38 mapk and c-jun n-terminal kinase (jnk), cyclic amp-dependent protein kinase (pka), protein kinase b (pkb), or akt and protein kinase c (pkc). |
2000-05-12 |
2023-08-12 |
Not clear |
| J Haendeler, M Ishida, L Hunyady, B C Ber. The third cytoplasmic loop of the angiotensin II type 1 receptor exerts differential effects on extracellular signal-regulated kinase (ERK1/ERK2) and apoptosis via Ras- and Rap1-dependent pathways. Circulation research. vol 86. issue 7. 2000-05-12. PMID:10764405. |
overexpression of constitutively active akt significantly reduced serum deprivation-induced apoptosis in cells transfected with at1r(del221/222). |
2000-05-12 |
2023-08-12 |
Not clear |
| C Page, H J Lin, Y Jin, V P Castle, G Nunez, M Huang, J Li. Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis. Anticancer research. vol 20. issue 1A. 2000-05-11. PMID:10769688. |
we sought to determine whether akt might play a role in the development of resistance to apoptosis induced by chemotherapy. |
2000-05-11 |
2023-08-12 |
human |
| A L Hsu, T T Ching, D S Wang, X Song, V M Rangnekar, C S Che. The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. The Journal of biological chemistry. vol 275. issue 15. 2000-05-05. PMID:10753955. |
the cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking akt activation in human prostate cancer cells independently of bcl-2. |
2000-05-05 |
2023-08-12 |
human |
| A L Hsu, T T Ching, D S Wang, X Song, V M Rangnekar, C S Che. The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. The Journal of biological chemistry. vol 275. issue 15. 2000-05-05. PMID:10753955. |
this correlation is supported by studies showing that overexpression of constitutively active akt protects pc-3 cells from celecoxib-induced apoptosis. |
2000-05-05 |
2023-08-12 |
human |
| A L Hsu, T T Ching, D S Wang, X Song, V M Rangnekar, C S Che. The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. The Journal of biological chemistry. vol 275. issue 15. 2000-05-05. PMID:10753955. |
in summary, our data demonstrate that inhibition of akt activation may play a crucial role in the induction of apoptosis by celecoxib. |
2000-05-05 |
2023-08-12 |
human |
| Y Tang, H Zhou, A Chen, R N Pittman, J Fiel. The Akt proto-oncogene links Ras to Pak and cell survival signals. The Journal of biological chemistry. vol 275. issue 13. 2000-05-04. PMID:10734042. |
akt protects cells from apoptosis through phosphorylation of downstream targets such as the bcl-2 family member, bad. |
2000-05-04 |
2023-08-12 |
Not clear |
| B P Zhou, M C Hu, S A Miller, Z Yu, W Xia, S Y Lin, M C Hun. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway. The Journal of biological chemistry. vol 275. issue 11. 2000-04-12. PMID:10713122. |
blocking of the akt pathway by a dominant-negative akt sensitizes the her-2/neu-overexpressing cells to tnf-induced apoptosis and inhibits ikappab kinases, ikappab phosphorylation, and nf-kappab activation. |
2000-04-12 |
2023-08-12 |
Not clear |
| S Cho, G Dawso. Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737604. |
consistent with increased resistance to apoptosis, we found increased phosphorylation of the antiapoptotic protein akt (protein kinase b) in ppt1-overexpressing cells. |
2000-04-11 |
2023-08-12 |
human |
| M G Hunter, B R Avalo. Granulocyte colony-stimulating factor receptor mutations in severe congenital neutropenia transforming to acute myelogenous leukemia confer resistance to apoptosis and enhance cell survival. Blood. vol 95. issue 6. 2000-04-07. PMID:10706885. |
in this paper, we show that the most frequently isolated mutant g-csfr form from patients with scn/aml (delta716) confers resistance to apoptosis and prolongs cell survival through a mechanism involving akt, a downstream target of pi3-kinase. |
2000-04-07 |
2023-08-12 |
Not clear |
| K Migita, S Honda, S Yamasaki, Y Hirai, T Fukuda, T Aoyagi, M Kita, H Ida, T Tsukada, A Kawakami, Y Kawabe, K Eguch. Regulation of rheumatoid synovial cell growth by ceramide. Biochemical and biophysical research communications. vol 269. issue 1. 2000-03-31. PMID:10694479. |
our data demonstrated that inhibition of anti-apoptotic kinases, such as akt and erk1/2, may play an important role in ceramide-mediated apoptosis of rheumatoid synovial cells. |
2000-03-31 |
2023-08-12 |
human |
| T J Moran, S Gray, C A Mikosz, S D Conze. The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer research. vol 60. issue 4. 2000-03-20. PMID:10706096. |
the mechanism through which glucocorticoid inhibits apoptosis is also independent of phosphatidylinositol 3-kinase activity and its downstream target akt, thus establishing the existence of a novel epithelial cell survival pathway mediated by glucocorticoids. |
2000-03-20 |
2023-08-12 |
human |
| L V Madrid, C Y Wang, D C Guttridge, A J Schottelius, A S Baldwin, M W May. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Molecular and cellular biology. vol 20. issue 5. 2000-03-16. PMID:10669740. |
akt suppresses apoptosis by stimulating the transactivation potential of the rela/p65 subunit of nf-kappab. |
2000-03-16 |
2023-08-12 |
Not clear |
| L V Madrid, C Y Wang, D C Guttridge, A J Schottelius, A S Baldwin, M W May. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Molecular and cellular biology. vol 20. issue 5. 2000-03-16. PMID:10669740. |
oncogenic ras, an upstream activator of akt, requires nf-kappab to initiate transformation, at least partially through the ability of nf-kappab to suppress transformation-associated apoptosis. |
2000-03-16 |
2023-08-12 |
Not clear |
| L V Madrid, C Y Wang, D C Guttridge, A J Schottelius, A S Baldwin, M W May. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Molecular and cellular biology. vol 20. issue 5. 2000-03-16. PMID:10669740. |
inhibition of endogenous akt activity sensitized cells to h-ras(v12)-induced apoptosis, which was associated with a loss of nf-kappab transcriptional activity. |
2000-03-16 |
2023-08-12 |
Not clear |
| C Hermann, B Assmus, C Urbich, A M Zeiher, S Dimmele. Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells. Arteriosclerosis, thrombosis, and vascular biology. vol 20. issue 2. 2000-03-03. PMID:10669636. |
the present study demonstrates an important role for insulin-mediated akt activation in the prevention of endothelial cell apoptosis, which may importantly contribute to cell homeostasis and the integrity of the endothelium. |
2000-03-03 |
2023-08-12 |
human |
| R A Roberts, N H James, S C Cosulic. The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor alpha-mediated rat hepatocyte survival and apoptosis. Hepatology (Baltimore, Md.). vol 31. issue 2. 2000-02-24. PMID:10655266. |
in contrast, suppression of tgf-beta(1)-induced apoptosis by tnf-alpha does not require pi 3-kinase and protein kinase b (pkb or akt)-mediated pathways, but is dependent on erk and p38 map kinase activity. |
2000-02-24 |
2023-08-12 |
rat |
| K Marushige, Y Marushig. Changes in the mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling associated with the induction of apoptosis. Anticancer research. vol 19. issue 5B. 2000-02-18. PMID:10628325. |
a concomitant inhibition of erk and akt activation induced apoptosis without jnk activation, although with a considerable delay of its onset. |
2000-02-18 |
2023-08-12 |
Not clear |