| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Asselin, G B Mills, B K Tsan. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer research. vol 61. issue 5. 2001-04-19. PMID:11280739. |
xiap down-regulation induced akt cleavage and apoptosis, and treatment of whole cell lysate with human recombinant active caspase-3 resulted in a similar pattern of akt cleavage. |
2001-04-19 |
2023-08-12 |
human |
| E Asselin, G B Mills, B K Tsan. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer research. vol 61. issue 5. 2001-04-19. PMID:11280739. |
in the presence of the pi 3-k inhibitor (ly294002), xiap overexpression failed to block cisplatin-induced apoptosis and to induce akt phosphorylation, suggesting that the site of action of xiap is upstream of akt in this cell survival pathway. |
2001-04-19 |
2023-08-12 |
human |
| L Simpson, R Parson. PTEN: life as a tumor suppressor. Experimental cell research. vol 264. issue 1. 2001-04-12. PMID:11237521. |
by blocking the activation of akt, pten regulates cellular processes such as cell cycling, translation, and apoptosis. |
2001-04-12 |
2023-08-12 |
Not clear |
| A von Gise, P Lorenz, C Wellbrock, B Hemmings, F Berberich-Siebelt, U R Rapp, J Troppmai. Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals. Molecular and cellular biology. vol 21. issue 7. 2001-04-12. PMID:11259582. |
moreover, a constitutively active form of akt synergizes with raf-1 in apoptosis suppression. |
2001-04-12 |
2023-08-12 |
Not clear |
| Y Ibuki, R Got. Suppression of apoptosis by UVB irradiation: survival signaling via PI3-kinase/Akt pathway. Biochemical and biophysical research communications. vol 279. issue 3. 2001-03-29. PMID:11162442. |
these results suggested that uvb irradiation transduced a survival signal via pi3 kinase activation and phosphorylation of akt, and induced some apoptosis inhibition factors upstream of the caspase cascade. |
2001-03-29 |
2023-08-12 |
cattle |
| Y C Kim, K S Song, G Yoon, M J Nam, W S Ry. Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis. Oncogene. vol 20. issue 1. 2001-03-29. PMID:11244501. |
further, we found that hbx mediated apoptosis was suppressed by activated h-ras through activation of the phosphatidylinositol-3 kinase and akt pathway. |
2001-03-29 |
2023-08-12 |
mouse |
| S Gatel. The contributions of cyclooxygenase-2 to tumor angiogenesis. Cancer metastasis reviews. vol 19. issue 1-2. 2001-03-22. PMID:11191059. |
the contributions of cox-2 in tumor angiogenesis include: (a) the increased expression of the proangiogenic growth factor vegf; (b) the production of the eicosanoid products thromboxane a2, pge2 and pgi2 that can directly stimulate endothelial cell migration and growth factor-induced angiogenesis; and potentially, (c) the inhibition of endothelial cell apoptosis by stimulation of bcl-2 or akt activation. |
2001-03-22 |
2023-08-12 |
Not clear |
| W Miao, Z Luo, R N Kitsis, K Wals. Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo. Journal of molecular and cellular cardiology. vol 32. issue 12. 2001-03-15. PMID:11113015. |
previous data have shown that enhanced akt signaling inhibits cardiac myocyte apoptosis in vitro and in vivo. |
2001-03-15 |
2023-08-12 |
Not clear |
| W Miao, Z Luo, R N Kitsis, K Wals. Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo. Journal of molecular and cellular cardiology. vol 32. issue 12. 2001-03-15. PMID:11113015. |
to elucidate the contribution of apoptosis to the pathogenesis of the infarct, we investigated whether intra-coronary akt gene delivery could reduce gross infarct size following ischemia/reperfusion injury. |
2001-03-15 |
2023-08-12 |
Not clear |
| L Xing, A M Venegas, A Chen, L Garrett-Beal, B F Boyce, H E Varmus, P L Schwartzber. Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. Genes & development. vol 15. issue 2. 2001-03-15. PMID:11157779. |
induction of apoptosis by src251 requires a functional sh2, but not an sh3, domain and is associated with reduced akt kinase activity. |
2001-03-15 |
2023-08-12 |
mouse |
| S Tachiiri, K Sasai, N Oya, M Hiraok. Enhanced cell killing by overexpression of dominant-negative phosphatidylinositol 3-kinase subunit, Deltap85, following genotoxic stresses. Japanese journal of cancer research : Gann. vol 91. issue 12. 2001-03-01. PMID:11123431. |
it is also well known that a survival signal from the receptor tyrosine kinases utilizes akt via pi3-k to protect cells from apoptosis. |
2001-03-01 |
2023-08-12 |
human |
| W H Zheng, S Kar, R Quirio. Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. The Journal of biological chemistry. vol 275. issue 50. 2001-02-08. PMID:10995739. |
the forkhead family transcription factor fkhrl1, a mammalian homolog of daf16 in the nematode caenorhabditis elegans, is an inducer of apoptosis in its unphosphorylated form and was recently reported as a substrate of akt kinases. |
2001-02-08 |
2023-08-12 |
caenorhabditis_elegans |
| A H Kim, G Khursigara, X Sun, T F Franke, M V Cha. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Molecular and cellular biology. vol 21. issue 3. 2001-02-08. PMID:11154276. |
akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. |
2001-02-08 |
2023-08-12 |
Not clear |
| A H Kim, G Khursigara, X Sun, T F Franke, M V Cha. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Molecular and cellular biology. vol 21. issue 3. 2001-02-08. PMID:11154276. |
here we describe a novel functional interaction between akt and apoptosis signal-regulating kinase 1 (ask1), a mitogen-activated protein kinase kinase kinase. |
2001-02-08 |
2023-08-12 |
Not clear |
| A Brunet, J Park, H Tran, L S Hu, B A Hemmings, M E Greenber. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Molecular and cellular biology. vol 21. issue 3. 2001-02-08. PMID:11154281. |
the efficient phosphorylation of these three sites on fkhrl1 by sgk and akt appears to be critical to the ability of growth factors to suppress fkhrl1-dependent transcription, thereby preventing fkhrl1 from inducing cell cycle arrest and apoptosis. |
2001-02-08 |
2023-08-12 |
Not clear |
| Z Gao, B S Li, Y J Day, J Linde. A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis. Molecular pharmacology. vol 59. issue 1. 2001-01-25. PMID:11125027. |
the data suggest that adenosine and inosine activate gi-coupled a3 ars to protect mast cells from apoptosis by a pathway involving the betagamma subunits of gi, phosphatidylinositol 3-kinase beta, and akt. |
2001-01-25 |
2023-08-12 |
rat |
| B B Whitlock, S Gardai, V Fadok, D Bratton, P M Henso. Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms. The Journal of cell biology. vol 151. issue 6. 2001-01-17. PMID:11121444. |
differential roles for alpha(m)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and erk survival mechanisms. |
2001-01-17 |
2023-08-12 |
Not clear |
| B B Whitlock, S Gardai, V Fadok, D Bratton, P M Henso. Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms. The Journal of cell biology. vol 151. issue 6. 2001-01-17. PMID:11121444. |
when proapoptotic stimuli were combined with either alpha(m)beta(2) clustering or activation, akt activity was blocked, allowing integrin activation to enhance apoptosis. |
2001-01-17 |
2023-08-12 |
Not clear |
| O S Bang, B G Ha, E K Park, S S Kan. Activation of Akt is induced by heat shock and involved in suppression of heat-shock-induced apoptosis of NIH3T3 cells. Biochemical and biophysical research communications. vol 278. issue 2. 2001-01-04. PMID:11097835. |
activation of akt is induced by heat shock and involved in suppression of heat-shock-induced apoptosis of nih3t3 cells. |
2001-01-04 |
2023-08-12 |
Not clear |
| O S Bang, B G Ha, E K Park, S S Kan. Activation of Akt is induced by heat shock and involved in suppression of heat-shock-induced apoptosis of NIH3T3 cells. Biochemical and biophysical research communications. vol 278. issue 2. 2001-01-04. PMID:11097835. |
however, heat shock for 60 min failed to activate akt, resulting in apoptosis. |
2001-01-04 |
2023-08-12 |
Not clear |