| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Nesterov, X Lu, M Johnson, G J Miller, Y Ivashchenko, A S Kraf. Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis. The Journal of biological chemistry. vol 276. issue 14. 2001-05-24. PMID:11278284. |
elevated akt activity protects the prostate cancer cell line lncap from trail-induced apoptosis. |
2001-05-24 |
2023-08-12 |
Not clear |
| A Nesterov, X Lu, M Johnson, G J Miller, Y Ivashchenko, A S Kraf. Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis. The Journal of biological chemistry. vol 276. issue 14. 2001-05-24. PMID:11278284. |
thus, the pi 3-kinase-dependent blockage of trail-induced apoptosis in lncap cells appears to be mediated by akt through the inhibition of bid cleavage. |
2001-05-24 |
2023-08-12 |
Not clear |
| D R Plas, S Talapatra, A L Edinger, J C Rathmell, C B Thompso. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. The Journal of biological chemistry. vol 276. issue 15. 2001-05-24. PMID:11278698. |
thus, akt and bcl-x(l) suppress mitochondrion-initiated apoptosis by distinct mechanisms. |
2001-05-24 |
2023-08-12 |
Not clear |
| D Beitner-Johnson, R T Rust, T C Hsieh, D E Millhor. Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells. Cellular signalling. vol 13. issue 1. 2001-05-21. PMID:11257444. |
akt is a serine/threonine kinase that has been shown to play a central role in promoting cell survival and opposing apoptosis. |
2001-05-21 |
2023-08-12 |
rat |
| J J Peluso, A Pappalardo, G Fernande. E-cadherin-mediated cell contact prevents apoptosis of spontaneously immortalized granulosa cells by regulating Akt kinase activity. Biology of reproduction. vol 64. issue 4. 2001-05-21. PMID:11259266. |
e-cadherin-mediated cell contact prevents apoptosis of spontaneously immortalized granulosa cells by regulating akt kinase activity. |
2001-05-21 |
2023-08-12 |
Not clear |
| J J Peluso, A Pappalardo, G Fernande. E-cadherin-mediated cell contact prevents apoptosis of spontaneously immortalized granulosa cells by regulating Akt kinase activity. Biology of reproduction. vol 64. issue 4. 2001-05-21. PMID:11259266. |
because akt kinase controls caspase-3 activity, an important activator of apoptosis, caspase-3 activity was monitored. |
2001-05-21 |
2023-08-12 |
Not clear |
| K Yamashita, J Kajstura, D J Discher, B J Wasserlauf, N H Bishopric, P Anversa, K A Webste. Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1. Circulation research. vol 88. issue 6. 2001-05-21. PMID:11282895. |
reperfusion-activated akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1. |
2001-05-21 |
2023-08-12 |
mouse |
| K Yamashita, J Kajstura, D J Discher, B J Wasserlauf, N H Bishopric, P Anversa, K A Webste. Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1. Circulation research. vol 88. issue 6. 2001-05-21. PMID:11282895. |
pretreatment of transgenic hearts with wortmannin immediately before and during ischemia eliminated reperfusion-mediated activation of akt and neutralized the resistance to apoptosis. |
2001-05-21 |
2023-08-12 |
mouse |
| K Yamashita, J Kajstura, D J Discher, B J Wasserlauf, N H Bishopric, P Anversa, K A Webste. Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1. Circulation research. vol 88. issue 6. 2001-05-21. PMID:11282895. |
perfusion with the p38 inhibitor sb203580 (10 micromol/l) blocked both p38 activation and phosphorylation of akt and differentially modulated apoptosis in wild-type and transgenic hearts. |
2001-05-21 |
2023-08-12 |
mouse |
| K Yamashita, J Kajstura, D J Discher, B J Wasserlauf, N H Bishopric, P Anversa, K A Webste. Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1. Circulation research. vol 88. issue 6. 2001-05-21. PMID:11282895. |
these results demonstrate that akt phosphorylation during i/r is modulated by igf-1 and prevents apoptosis in hearts that overexpress the igf-1 transgene. |
2001-05-21 |
2023-08-12 |
mouse |
| K Shimoke, H Chib. Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease. Journal of neuroscience research. vol 63. issue 5. 2001-05-17. PMID:11223915. |
it has been revealed that the akt pathway contributes to the prevention of apoptosis. |
2001-05-17 |
2023-08-12 |
Not clear |
| R A Campbell, P Bhat-Nakshatri, N M Patel, D Constantinidou, S Ali, H Nakshatr. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. The Journal of biological chemistry. vol 276. issue 13. 2001-05-10. PMID:11139588. |
we demonstrate that akt protects breast cancer cells from tamoxifen-induced apoptosis. |
2001-05-10 |
2023-08-12 |
Not clear |
| M Sumitomo, M I Milowsky, R Shen, D Navarro, J Dai, T Asano, M Hayakawa, D M Nanu. Neutral endopeptidase inhibits neuropeptide-mediated transactivation of the insulin-like growth factor receptor-Akt cell survival pathway. Cancer research. vol 61. issue 8. 2001-05-10. PMID:11309283. |
recombinant nep and induced nep expression in tsu-pr1 cells using a tetracycline-repressive expression system inhibited et-1-mediated phosphorylation of igf-irbeta and akt, and blocked the protective effects of et-1 against apoptosis induced by serum starvation. |
2001-05-10 |
2023-08-12 |
Not clear |
| T Högnason, S Chatterjee, T Vartanian, R R Ratan, K M Ernewein, A A Habi. Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling. FEBS letters. vol 491. issue 1-2. 2001-04-26. PMID:11226409. |
we propose that potentiation of egfr induced apoptosis by dominant negative ras results, at least in part, by a block of akt activation. |
2001-04-26 |
2023-08-12 |
Not clear |
| C Bäumler, G O Kim, K B Elko. Growth regulation of activated lymphocytes: defects in homeostasis lead to autoimmunity and/or lymphoma. Reviews in immunogenetics. vol 2. issue 2. 2001-04-26. PMID:11258424. |
in this review, we briefly discuss how well-defined pathways that promote cell survival pi-3 kinase, akt, bcl-2 family and inhibitors of apoptosis (iaps)-function within the cell. |
2001-04-26 |
2023-08-12 |
Not clear |
| S Montaner, A Sodhi, S Pece, E A Mesri, J S Gutkin. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B. Cancer research. vol 61. issue 6. 2001-04-26. PMID:11289142. |
furthermore, we found that kshv-gpcr is able to protect human umbilical vein endothelial cells from the apoptosis induced by serum deprivation and that both wortmannin and the expression of a kinase-deficient akt k179m mutant are able to block this effect. |
2001-04-26 |
2023-08-12 |
human |
| G Kulik, J P Carson, T Vomastek, K Overman, B D Gooch, S Srinivasula, E Alnemri, G Nunez, M J Webe. Tumor necrosis factor alpha induces BID cleavage and bypasses antiapoptotic signals in prostate cancer LNCaP cells. Cancer research. vol 61. issue 6. 2001-04-26. PMID:11289152. |
furthermore, tnf-alpha induced apoptosis under conditions in which akt was active. |
2001-04-26 |
2023-08-12 |
Not clear |
| G H Xiao, M Jeffers, A Bellacosa, Y Mitsuuchi, G F Vande Woude, J R Test. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 1. 2001-04-19. PMID:11134526. |
furthermore, transiently transfected tpr-met activates akt (both akt1 and akt2) and protects cells from apoptosis. |
2001-04-19 |
2023-08-12 |
human |
| E Asselin, G B Mills, B K Tsan. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer research. vol 61. issue 5. 2001-04-19. PMID:11280739. |
xiap regulates akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. |
2001-04-19 |
2023-08-12 |
human |
| E Asselin, G B Mills, B K Tsan. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer research. vol 61. issue 5. 2001-04-19. PMID:11280739. |
cisplatin decreased xiap protein levels and induced akt cleavage and apoptosis in chemosensitive, but not in resistant, ovarian cancer cells. |
2001-04-19 |
2023-08-12 |
human |