| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Wan, P Nass, M D Duncan, J W Harmo. Acidic fibroblast growth factor overexpression partially protects 3T3 fibroblasts from apoptosis induced by synthetic retinoid CD437. Journal of molecular medicine (Berlin, Germany). vol 79. issue 2-3. 2001-09-27. PMID:11357938. |
we further hypothesized that afgf would protect against cd437 apoptosis by preserving the activity of akt. |
2001-09-27 |
2023-08-12 |
Not clear |
| O Zugasti, W Rul, P Roux, C Peyssonnaux, A Eychene, T F Franke, P Fort, U Hibne. Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt. Molecular and cellular biology. vol 21. issue 19. 2001-09-27. PMID:11533257. |
our data demonstrate that the gtpases of the rho family control three major components of cellular signal transduction, namely, p53, akt, and erks, which collaborate in the induction of apoptosis due to the loss of anchorage. |
2001-09-27 |
2023-08-12 |
mouse |
| Y Osawa, Y Banno, M Nagaki, D A Brenner, T Naiki, Y Nozawa, S Nakashima, H Moriwak. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 1. 2001-09-20. PMID:11418646. |
in contrast, exogenous sphingosine 1-phosphate, a product of sphk, was found to activate akt and partially rescued the cells from tnf-alpha-induced apoptosis. |
2001-09-20 |
2023-08-12 |
mouse |
| Y Osawa, Y Banno, M Nagaki, D A Brenner, T Naiki, Y Nozawa, S Nakashima, H Moriwak. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 1. 2001-09-20. PMID:11418646. |
furthermore, apoptosis mediated by fas ligand (fasl) involving akt activation also was potentiated by dms pretreatment in hc cells. |
2001-09-20 |
2023-08-12 |
mouse |
| M V Chuenkova, F B Furnari, W K Cavenee, M A Pereir. Trypanosoma cruzi trans-sialidase: a potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 17. 2001-09-20. PMID:11481434. |
in contrast, the cys-rich domain of ts did not block apoptosis in schwann cells overexpressing dominant-negative akt or constitutively active pten, a negative regulator of pi3k/akt signaling. |
2001-09-20 |
2023-08-12 |
human |
| J P Gratton, M Morales-Ruiz, Y Kureishi, D Fulton, K Walsh, W C Sess. Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. The Journal of biological chemistry. vol 276. issue 32. 2001-09-06. PMID:11387313. |
blockade of the pi 3-kinase or akt pathways in conjunction with serum withdrawal stimulates p38-dependent apoptosis. |
2001-09-06 |
2023-08-12 |
Not clear |
| J P Gratton, M Morales-Ruiz, Y Kureishi, D Fulton, K Walsh, W C Sess. Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. The Journal of biological chemistry. vol 276. issue 32. 2001-09-06. PMID:11387313. |
thus, cross-talk between the akt and p38 mapk pathways may regulate the level of cytoprotection versus apoptosis and is a new mechanism to explain the cytoprotective actions of akt. |
2001-09-06 |
2023-08-12 |
Not clear |
| D Tang, H Okada, J Ruland, L Liu, V Stambolic, T W Mak, A J Ingra. Akt is activated in response to an apoptotic signal. The Journal of biological chemistry. vol 276. issue 32. 2001-09-06. PMID:11399756. |
akt is cleaved during mitochondrial-mediated apoptosis in a caspase-dependent manner. |
2001-09-06 |
2023-08-12 |
Not clear |
| D Tang, H Okada, J Ruland, L Liu, V Stambolic, T W Mak, A J Ingra. Akt is activated in response to an apoptotic signal. The Journal of biological chemistry. vol 276. issue 32. 2001-09-06. PMID:11399756. |
accordingly, we explored whether the well described mitochondrial apoptotic stimuli staurosporine (sts) and etoposide activate akt and whether such activation impacts apoptosis. |
2001-09-06 |
2023-08-12 |
Not clear |
| D Tang, H Okada, J Ruland, L Liu, V Stambolic, T W Mak, A J Ingra. Akt is activated in response to an apoptotic signal. The Journal of biological chemistry. vol 276. issue 32. 2001-09-06. PMID:11399756. |
both sts and etoposide activated akt in nih 3t3 cells, maximally at 8 and 2 h, respectively, preceding the onset of apoptosis and poly(adp-ribose) polymerase cleavage. |
2001-09-06 |
2023-08-12 |
Not clear |
| D Tang, H Okada, J Ruland, L Liu, V Stambolic, T W Mak, A J Ingra. Akt is activated in response to an apoptotic signal. The Journal of biological chemistry. vol 276. issue 32. 2001-09-06. PMID:11399756. |
the overexpression of akt delayed sts-induced apoptosis with an even more pronounced delay observed with overexpression of constitutively active akt. |
2001-09-06 |
2023-08-12 |
Not clear |
| D Tang, H Okada, J Ruland, L Liu, V Stambolic, T W Mak, A J Ingra. Akt is activated in response to an apoptotic signal. The Journal of biological chemistry. vol 276. issue 32. 2001-09-06. PMID:11399756. |
these data demonstrate that mitochondrial apoptotic stimuli also activate akt and such activation modulates apoptosis in this setting. |
2001-09-06 |
2023-08-12 |
Not clear |
| A H Chen, D S Gortler, S Kilaru, O Araim, S G Frangos, B E Sumpi. Cyclic strain activates the pro-survival Akt protein kinase in bovine aortic smooth muscle cells. Surgery. vol 130. issue 2. 2001-09-06. PMID:11490374. |
this study examined whether akt, a serine/threonine protein kinase known to promote cell survival by inhibiting apoptosis, is activated by cyclic strain in bovine aortic smcs. |
2001-09-06 |
2023-08-12 |
cattle |
| G Fuhrmann, C Leisser, G Rosenberger, M Grusch, S Huettenbrenner, T Halama, I Mosberger, S Sasgary, C Cerni, G Krupitz. Cdc25A phosphatase suppresses apoptosis induced by serum deprivation. Oncogene. vol 20. issue 33. 2001-09-06. PMID:11494150. |
inhibition of apoptosis by su4984, nf023 and rapamycin placed cdc25a and akt function downstream of fgf.r, pdgf.r, and compensated g-protein- and pp2a- activity. |
2001-09-06 |
2023-08-12 |
human |
| H L Cheng, M Steinway, C L Delaney, T F Franke, E L Feldma. IGF-I promotes Schwann cell motility and survival via activation of Akt. Molecular and cellular endocrinology. vol 170. issue 1-2. 2001-08-23. PMID:11162904. |
in the current study, we examined the role of akt, a downstream kinase of pi-3k, in sc motility and igf-i mediated protection from apoptosis. |
2001-08-23 |
2023-08-12 |
Not clear |
| S A Beresford, M A Davies, G E Gallick, N J Donat. Differential effects of phosphatidylinositol-3/Akt-kinase inhibition on apoptotic sensitization to cytokines in LNCaP and PCc-3 prostate cancer cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 21. issue 5. 2001-08-23. PMID:11429162. |
adenovirus-mediated pten/mmac1 expression in lncap cells reduced akt activation, activated apoptosis, and sensitized cells to tnf but not to trail. |
2001-08-23 |
2023-08-12 |
Not clear |
| T Suhara, T Mano, B E Oliveira, K Wals. Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP). Circulation research. vol 89. issue 1. 2001-08-23. PMID:11440972. |
these data suggest that inhibition of fas-mediated apoptosis, via promotion of flip expression, is a mechanism through which akt signaling can promote endothelial cell survival. |
2001-08-23 |
2023-08-12 |
Not clear |
| H G Zhang, Y Wang, J F Xie, X Liang, D Liu, P Yang, H C Hsu, R B Ray, J D Mount. Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt. Arthritis and rheumatism. vol 44. issue 7. 2001-08-16. PMID:11465707. |
regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase akt. |
2001-08-16 |
2023-08-12 |
Not clear |
| J B Klein, A Buridi, P Y Coxon, M J Rane, T Manning, R Kettritz, K R McLeis. Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis. Cellular signalling. vol 13. issue 5. 2001-08-09. PMID:11369515. |
the present study examined the role of mitogen-activated protein kinases (mapks) and phosphatidylinositol-3 kinase-stimulated akt (pi-3k/akt) in the regulation of constitutive human neutrophil apoptosis by bacterial lipopolysaccharide (lps) and two chemoattractants, fmlp and leukotriene b(4) (ltb(4)). |
2001-08-09 |
2023-08-12 |
human |
| H C Chang, L H Tsai, L Y Chuang, W C Hun. Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells. Journal of cellular physiology. vol 188. issue 2. 2001-08-09. PMID:11424085. |
role of akt kinase in sphingosine-induced apoptosis in human hepatoma cells. |
2001-08-09 |
2023-08-12 |
human |