| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasuo Ido, David Carling, Neil Ruderma. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes. vol 51. issue 1. 2002-02-13. PMID:11756336. |
the results indicate that alterations in fatty-acid metabolism, impaired akt activation by insulin, and increased caspase-3 activity precede visible evidence of apoptosis in huvec incubated in a hyperglycemic medium. |
2002-02-13 |
2023-08-12 |
human |
| Kohjiro Ueki, David A Fruman, Saskia M Brachmann, Yu-Hua Tseng, Lewis C Cantley, C Ronald Kah. Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Molecular and cellular biology. vol 22. issue 3. 2002-02-11. PMID:11784871. |
heterozygous disruption of pik3r1 results in increased akt activity and decreased apoptosis by insulin-like growth factor 1 (igf-1) through up-regulated phosphatidylinositol (3,4,5)-triphosphate production. |
2002-02-11 |
2023-08-12 |
Not clear |
| J L Maller, S D Gross, M S Schwab, C V Finkielstein, F E Taieb, Y W Qia. Cell cycle transitions in early Xenopus development. Novartis Foundation symposium. vol 237. 2002-02-07. PMID:11444050. |
resistance to apoptosis is associated with increased p27xic1, the relative fraction of bcl-2 or bax in pro- versus anti-apoptotic complexes, and the activity of the protein kinase akt. |
2002-02-07 |
2023-08-12 |
xenopus_laevis |
| B C Berk, J I Abe, W Min, J Surapisitchat, C Ya. Endothelial atheroprotective and anti-inflammatory mechanisms. Annals of the New York Academy of Sciences. vol 947. 2002-02-01. PMID:11795313. |
steady laminar flow inhibits ec apoptosis by preventing cell cycle entry, by increasing antioxidant mechanisms (e.g., superoxide dismutase), and by stimulating nitric oxide-dependent protective pathways that involve enzymes pi3-kinase and akt. |
2002-02-01 |
2023-08-12 |
human |
| Erin Kelly, Angela Won, Yosef Refaeli, Luk Van Parij. IL-2 and related cytokines can promote T cell survival by activating AKT. Journal of immunology (Baltimore, Md. : 1950). vol 168. issue 2. 2002-01-31. PMID:11777951. |
in this study, we show that an active form of akt can protect t cells from apoptosis following growth factor withdrawal and that il-2 family cytokines can promote t cell survival by activating this kinase. |
2002-01-31 |
2023-08-12 |
Not clear |
| Toshimitsu Suhara, Hyo-Soo Kim, Lorrie A Kirshenbaum, Kenneth Wals. Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation. Molecular and cellular biology. vol 22. issue 2. 2002-01-29. PMID:11756562. |
here we report that fasl is not expressed by normal vsmc, but its expression is upregulated by stresses that induce apoptosis, including serum deprivation, exposure to the phosphatidylinositol 3-kinase (pi 3-kinase) inhibitor wortmannin, and ablation of akt signaling. |
2002-01-29 |
2023-08-12 |
Not clear |
| M Vestling, B Wiehager, H Tanii, R F Cowbur. Akt activity in presenilin 1 wild-type and mutation transfected human SH-SY5Y neuroblastoma cells after serum deprivation and high glucose stress. Journal of neuroscience research. vol 66. issue 3. 2002-01-25. PMID:11746362. |
the present study investigates whether the susceptibility of ps1 mutation transfected sh-sy5y cells to undergo apoptosis is likely due to a downregulation of akt/protein kinase b (akt), a key intermediate in the phosphatidylinositol 3 (pi3)-kinase arm of the igf-i signaling pathway. |
2002-01-25 |
2023-08-12 |
human |
| Fei Su, Michael Overholtzer, Daniel Besser, Arnold J Levin. WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes & development. vol 16. issue 1. 2002-01-25. PMID:11782444. |
wisp-1 attenuates p53-mediated apoptosis in response to dna damage through activation of the akt kinase. |
2002-01-25 |
2023-08-12 |
Not clear |
| M T Abreu, E T Arnold, J Y Chow, K E Barret. Phosphatidylinositol 3-kinase-dependent pathways oppose Fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells. Implications for inflammatory diarrheal states. The Journal of biological chemistry. vol 276. issue 50. 2002-01-24. PMID:11551934. |
expression of constitutively active akt, a principal downstream effector of the pi3-kinase pathway, protected against fas-mediated apoptosis to an extent that was comparable with expression of a genetic caspase inhibitor, p35. |
2002-01-24 |
2023-08-12 |
human |
| M T Abreu, E T Arnold, J Y Chow, K E Barret. Phosphatidylinositol 3-kinase-dependent pathways oppose Fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells. Implications for inflammatory diarrheal states. The Journal of biological chemistry. vol 276. issue 50. 2002-01-24. PMID:11551934. |
pi3-kinase-dependent pathways, especially akt, protect iec against fas-mediated apoptosis. |
2002-01-24 |
2023-08-12 |
human |
| Karl W Thomas, Martha M Monick, Janice M Staber, Timor Yarovinsky, A Brent Carter, Gary W Hunninghak. Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway. The Journal of biological chemistry. vol 277. issue 1. 2002-01-24. PMID:11687577. |
both nf-kappab activity and apoptosis regulation have been linked to phosphatidylinositol 3-kinase (pi 3-k) and its downstream effector enzymes, akt and gsk-3. |
2002-01-24 |
2023-08-12 |
Not clear |
| Karl W Thomas, Martha M Monick, Janice M Staber, Timor Yarovinsky, A Brent Carter, Gary W Hunninghak. Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway. The Journal of biological chemistry. vol 277. issue 1. 2002-01-24. PMID:11687577. |
further evidence for the central role of a pathway involving pi 3-k and akt in preserving cell viability during rsv infection was established by the observation that constitutively active akt transfected into a549 cells prevented the cytotoxicity and apoptosis of combined rsv and ly294002 treatment. |
2002-01-24 |
2023-08-12 |
Not clear |
| Yukitaka Shizukuda, Peter M Buttric. Protein kinase C-zeta modulates thromboxane A(2)-mediated apoptosis in adult ventricular myocytes via Akt. American journal of physiology. Heart and circulatory physiology. vol 282. issue 1. 2002-01-24. PMID:11748077. |
protein kinase c-zeta modulates thromboxane a(2)-mediated apoptosis in adult ventricular myocytes via akt. |
2002-01-24 |
2023-08-12 |
rat |
| Yukitaka Shizukuda, Peter M Buttric. Protein kinase C-zeta modulates thromboxane A(2)-mediated apoptosis in adult ventricular myocytes via Akt. American journal of physiology. Heart and circulatory physiology. vol 282. issue 1. 2002-01-24. PMID:11748077. |
therefore, our results suggest that the activation of pkc-zeta modulates txa(2) receptor-mediated apoptosis at least, in part, through akt activity in adult cardiac myocytes. |
2002-01-24 |
2023-08-12 |
rat |
| D A Flusberg, Y Numaguchi, D E Ingbe. Cooperative control of Akt phosphorylation, bcl-2 expression, and apoptosis by cytoskeletal microfilaments and microtubules in capillary endothelial cells. Molecular biology of the cell. vol 12. issue 10. 2002-01-22. PMID:11598193. |
cooperative control of akt phosphorylation, bcl-2 expression, and apoptosis by cytoskeletal microfilaments and microtubules in capillary endothelial cells. |
2002-01-22 |
2023-08-12 |
Not clear |
| David S McClintock, Matthew T Santore, Vivian Y Lee, Joslyn Brunelle, G R Scott Budinger, Wei-Xing Zong, Craig B Thompson, Nissim Hay, Navdeep S Chande. Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Molecular and cellular biology. vol 22. issue 1. 2002-01-15. PMID:11739725. |
in contrast, although activated akt has been shown to inhibit apoptosis induced by a variety of apoptotic stimuli, it did not prevent cell death during oxygen deprivation. |
2002-01-15 |
2023-08-12 |
mouse |
| X Q Wang, P Sun, A S Palle. Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosis. The Journal of biological chemistry. vol 276. issue 48. 2002-01-10. PMID:11577096. |
consistently, blockade of gt1b function with anti-gt1b antibody specifically activated the ser-473 site of akt, markedly suppressing apoptosis. |
2002-01-10 |
2023-08-12 |
Not clear |
| H Yamaguchi, H G Wan. The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene. vol 20. issue 53. 2002-01-10. PMID:11753656. |
in this report we demonstrate that akt inhibits a conformational change in the pro-apoptotic bax protein and its translocation to mitochondria, thus preventing the disruption of the mitochondrial inner membrane potential (deltapsi(m)), caspase-3 activation, and apoptosis in pre-b hematopoietic cells fl5.12 following interleukin-3 (il-3) withdrawal. |
2002-01-10 |
2023-08-12 |
Not clear |
| H Yamaguchi, H G Wan. The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene. vol 20. issue 53. 2002-01-10. PMID:11753656. |
moreover, overexpression of akt suppresses the relocalization of gfp-bax to mitochondria and apoptosis in hela cells induced by the dna-damaging agent methyl methanesulphonate. |
2002-01-10 |
2023-08-12 |
Not clear |
| H Yamaguchi, H G Wan. The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene. vol 20. issue 53. 2002-01-10. PMID:11753656. |
however, akt does not abolish the ability of a conformationally changed bax mutant, gfp-bax (deltas184), to translocate to mitochondria and to induce apoptosis. |
2002-01-10 |
2023-08-12 |
Not clear |