| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T D King, G N Bijur, R S Jop. Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium. Brain research. vol 919. issue 1. 2002-01-03. PMID:11689167. |
to test if glycogen synthase kinase-3beta (gsk3beta), a pro-apoptotic kinase that is inhibited by akt, is involved in regulating mpp-induced apoptosis, overexpression of gsk3beta and lithium, a selective inhibitor of gsk3beta, were used to directly alter gsk3beta activity. |
2002-01-03 |
2023-08-12 |
human |
| N Noshita, A Lewén, T Sugawara, P H Cha. Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 12. 2002-01-03. PMID:11740206. |
the serine-threonine kinase, akt, prevents apoptosis by phosphorylation at serine-473 in several cell systems. |
2002-01-03 |
2023-08-12 |
mouse |
| M Nakamura, A J Barber, D A Antonetti, K F LaNoue, K A Robinson, M G Buse, T W Gardne. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. The Journal of biological chemistry. vol 276. issue 47. 2001-12-20. PMID:11560942. |
exposure of r28 cells, a model of retinal neurons, to 20 mm glucose for 24 h attenuated the ability of 10 nm insulin to rescue them from serum deprivation-induced apoptosis and to phosphorylate akt compared with 5 mm glucose. |
2001-12-20 |
2023-08-12 |
Not clear |
| M Nakamura, A J Barber, D A Antonetti, K F LaNoue, K A Robinson, M G Buse, T W Gardne. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. The Journal of biological chemistry. vol 276. issue 47. 2001-12-20. PMID:11560942. |
via perturbation of the neuroprotective effect of insulin mediated by akt and via induction of apoptosis possibly by altered glycosylation of proteins. |
2001-12-20 |
2023-08-12 |
Not clear |
| E Hatano, D A Brenne. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. American journal of physiology. Gastrointestinal and liver physiology. vol 281. issue 6. 2001-12-20. PMID:11705740. |
akt protects mouse hepatocytes from tnf-alpha- and fas-mediated apoptosis through nk-kappa b activation. |
2001-12-20 |
2023-08-12 |
mouse |
| E Hatano, D A Brenne. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. American journal of physiology. Gastrointestinal and liver physiology. vol 281. issue 6. 2001-12-20. PMID:11705740. |
the expression of dominant-negative akt blocks nf-kappa b activation and sensitizes hepatocytes to tnf-alpha- and fas-mediated apoptosis. |
2001-12-20 |
2023-08-12 |
mouse |
| E Hatano, D A Brenne. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. American journal of physiology. Gastrointestinal and liver physiology. vol 281. issue 6. 2001-12-20. PMID:11705740. |
the expression of constitutively active akt rescues ly-294002-pretreated cells from tnf-alpha- and fas-mediated apoptosis. |
2001-12-20 |
2023-08-12 |
mouse |
| L Banerji, J Glassford, N C Lea, N S Thomas, G G Klaus, E W La. BCR signals target p27(Kip1) and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells. Oncogene. vol 20. issue 50. 2001-12-13. PMID:11704865. |
furthermore, ectopic expression of a constitutively active form of akt blocked the cell cycle arrest and apoptosis triggered by anti-igm and also abrogated down-regulation of cyclin d2 and up-regulation of p27(kip1) expression induced by bcr-engagement. |
2001-12-13 |
2023-08-12 |
Not clear |
| A Tenzer, D Zingg, S Rocha, B Hemmings, D Fabbro, C Glanzmann, P A Schubiger, S Bodis, M Prusch. The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Cancer research. vol 61. issue 22. 2001-12-12. PMID:11719451. |
experiments with apaf-1-deficient cells revealed that pkc412-induced cytotoxicity depends on an intact apoptosome but that the decrease of akt phosphorylation is not attributable to apoptosis execution. |
2001-12-12 |
2023-08-12 |
Not clear |
| J Kijowski, M Baj-Krzyworzeka, M Majka, R Reca, L A Marquez, M Christofidou-Solomidou, A Janowska-Wieczorek, M Z Ratajcza. The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells. Stem cells (Dayton, Ohio). vol 19. issue 5. 2001-12-07. PMID:11553854. |
we evaluated the phosphorylation of mapk p42/44, akt, and stat proteins and examined the ability of the ligands for these receptors (stromal-derived factor-1 [sdf-1] and macrophage inflammatory protein-1beta [mip-1beta]) to influence cell growth, apoptosis, adhesion, and production of vascular endothelial growth factors (vegf), matrix metalloproteinases (mmps) and their tissue inhibitors (timps) in these cell lines. |
2001-12-07 |
2023-08-12 |
human |
| X A Li, C Bianchi, F W Sellk. Rat aortic smooth muscle cell density affects activation of MAP kinase and Akt by menadione and PDGF homodimer BB. The Journal of surgical research. vol 100. issue 2. 2001-12-07. PMID:11592793. |
mitogen-activated protein kinases (mapk) and protein kinase b (pkb or akt) are major signal transduction molecules regulating cell proliferation, differentiation, and apoptosis. |
2001-12-07 |
2023-08-12 |
rat |
| X A Li, C Bianchi, F W Sellk. Rat aortic smooth muscle cell density affects activation of MAP kinase and Akt by menadione and PDGF homodimer BB. The Journal of surgical research. vol 100. issue 2. 2001-12-07. PMID:11592793. |
in addition while pdgf may function as a survival factor by inducing akt activation, menadione could promote apoptosis by inhibiting pdgf-induced akt activation independent of cell density. |
2001-12-07 |
2023-08-12 |
rat |
| J V Virbasius, X Song, D P Pomerleau, Y Zhan, G W Zhou, M P Czec. Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 23. 2001-12-07. PMID:11606732. |
protein kinases of the akt and related serum- and glucocorticoid-regulated kinase (sgk) families are major downstream mediators of phosphatidylinositol (pi) 3-kinase signaling to many cellular processes including metabolic flux, membrane trafficking, and apoptosis. |
2001-12-07 |
2023-08-12 |
Not clear |
| H Thakkar, X Chen, F Tyan, S Gim, H Robinson, C Lee, S K Pandey, C Nwokorie, N Onwudiwe, R K Srivastav. Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11461904. |
the cell lines expressing the highest level of constitutively active akt were more resistant to undergo apoptosis by trail than those expressing the lowest level. |
2001-12-04 |
2023-08-12 |
human |
| H Thakkar, X Chen, F Tyan, S Gim, H Robinson, C Lee, S K Pandey, C Nwokorie, N Onwudiwe, R K Srivastav. Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11461904. |
transfecting dominant negative akt decreased akt activity and increased trail-induced apoptosis in cells with high akt activity. |
2001-12-04 |
2023-08-12 |
human |
| H Thakkar, X Chen, F Tyan, S Gim, H Robinson, C Lee, S K Pandey, C Nwokorie, N Onwudiwe, R K Srivastav. Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11461904. |
conversely, transfecting constitutively active akt into cells with low akt activity increased akt activity and attenuated trail-induced apoptosis. |
2001-12-04 |
2023-08-12 |
human |
| A Ghose, J Fleming, K El-Bayoumy, P R Harriso. Enhanced sensitivity of human oral carcinomas to induction of apoptosis by selenium compounds: involvement of mitogen-activated protein kinase and Fas pathways. Cancer research. vol 61. issue 20. 2001-12-04. PMID:11606383. |
three novel findings are reported: (a) sccs were found to be significantly more sensitive to induction of apo ptosis by sdg than normal human oral mucosa cells, though the differences were marginal with p-xsc; (b) both se compounds induced the expression of fas ligand (fas-l) in oral cells to a degree that correlated with the extent of apoptosis induction; and (c) both sdg and p-xsc induced the stress pathway kinases, jun nh2-terminal kinase (jnk) and p38 kinase, at concentrations causing apoptosis; p-xsc, and to a lesser extent sdg, also activated extracellular regulated kinases 1&2 (erks 1&2) and protein kinase-b or akt. |
2001-12-04 |
2023-08-12 |
human |
| A Ghose, J Fleming, K El-Bayoumy, P R Harriso. Enhanced sensitivity of human oral carcinomas to induction of apoptosis by selenium compounds: involvement of mitogen-activated protein kinase and Fas pathways. Cancer research. vol 61. issue 20. 2001-12-04. PMID:11606383. |
inhibiting the erks 1&2 or akt pathways with specific chemical inhibitors (pd98059 or ly294002, respectively) did not affect the extent of apoptosis induced by sdg or p-xsc (with the exception of ly294002, which actually enhanced the level of induction of apoptosis by sdg). |
2001-12-04 |
2023-08-12 |
human |
| R R Hoover, M J Gerlach, E Y Koh, G Q Dale. Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells. Oncogene. vol 20. issue 41. 2001-11-01. PMID:11593388. |
ras or stat5, but not akt, also drives cytokine-independent proliferation and imparts sustained resistance to dna damage-induced apoptosis. |
2001-11-01 |
2023-08-12 |
Not clear |
| R R Hoover, M J Gerlach, E Y Koh, G Q Dale. Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells. Oncogene. vol 20. issue 41. 2001-11-01. PMID:11593388. |
we also show that dominant negative (dn) inhibition of stat5, but not ras or akt, significantly reduces resistance to dna damage-induced apoptosis in bcr/abl transformed baf3 cells. |
2001-11-01 |
2023-08-12 |
Not clear |