| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H C Chang, L H Tsai, L Y Chuang, W C Hun. Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells. Journal of cellular physiology. vol 188. issue 2. 2001-08-09. PMID:11424085. |
we investigated the effect of sphingosine on akt kinase, a serine/threonine kinase which was found to protect cells from apoptosis induced by a variety of extracellular stresses. |
2001-08-09 |
2023-08-12 |
human |
| H C Chang, L H Tsai, L Y Chuang, W C Hun. Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells. Journal of cellular physiology. vol 188. issue 2. 2001-08-09. PMID:11424085. |
additionally, sphingosine-induced inhibition of akt kinase was correlated with induction of apoptosis in these cells. |
2001-08-09 |
2023-08-12 |
human |
| H C Chang, L H Tsai, L Y Chuang, W C Hun. Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells. Journal of cellular physiology. vol 188. issue 2. 2001-08-09. PMID:11424085. |
expression of activated akt kinase partially protected cells from sphingosine-induced apoptosis, whereas expression of kinase-dead akt kinase had no effect. |
2001-08-09 |
2023-08-12 |
human |
| H C Chang, L H Tsai, L Y Chuang, W C Hun. Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells. Journal of cellular physiology. vol 188. issue 2. 2001-08-09. PMID:11424085. |
taken together, these findings suggest that suppression of akt kinase is one of the mechanisms by which sphingosine induces apoptosis in hepatoma cells and activation of akt kinase may inhibit sphingosine-induced apoptosis by blocking a step upstream of cytochrome c release and caspase-3 activation. |
2001-08-09 |
2023-08-12 |
human |
| T Matsui, J Tao, F del Monte, K H Lee, L Li, M Picard, T L Force, T F Franke, R J Hajjar, A Rosenzwei. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation. vol 104. issue 3. 2001-08-09. PMID:11457753. |
akt activation reduces cardiomyocyte apoptosis in models of transient ischemia. |
2001-08-09 |
2023-08-12 |
Not clear |
| K Kimura, M Markowski, C Bowen, E P Gelman. Androgen blocks apoptosis of hormone-dependent prostate cancer cells. Cancer research. vol 61. issue 14. 2001-08-02. PMID:11454715. |
inhibition of phosphoinositol-3-kinase activity by wortmannin induced apoptosis that was also blocked by androgen, but there was no effect on protein levels or phosphorylation of akt, indicating that r1881 did not interact with survival signaling of phosphoinositol-3-kinase. |
2001-08-02 |
2023-08-12 |
Not clear |
| L V Madrid, M W Mayo, J Y Reuther, A S Baldwi. Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. The Journal of biological chemistry. vol 276. issue 22. 2001-07-26. PMID:11259436. |
previously, it has been shown that akt can activate the transcription factor nf-kappab and that this functions to block apoptosis induced by certain stimuli. |
2001-07-26 |
2023-08-12 |
Not clear |
| H K Lin, S Yeh, H Y Kang, C Chan. Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 13. 2001-07-26. PMID:11404460. |
akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. |
2001-07-26 |
2023-08-12 |
Not clear |
| H K Lin, S Yeh, H Y Kang, C Chan. Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 13. 2001-07-26. PMID:11404460. |
together, these findings provide a molecular basis for cross-talk between two signaling pathways at the level of akt and ar-ar coregulators that may help us to better understand the roles of akt in the androgen/ar-mediated apoptosis. |
2001-07-26 |
2023-08-12 |
Not clear |
| N Simakajornboon, N J Szerlip, E Gozal, J W Anonetapipat, D Goza. In vivo PDGF beta receptor activation in the dorsocaudal brainstem of the rat prevents hypoxia-induced apoptosis via activation of Akt and BAD. Brain research. vol 895. issue 1-2. 2001-07-19. PMID:11259767. |
in vivo pdgf beta receptor activation in the dorsocaudal brainstem of the rat prevents hypoxia-induced apoptosis via activation of akt and bad. |
2001-07-19 |
2023-08-12 |
rat |
| N Simakajornboon, N J Szerlip, E Gozal, J W Anonetapipat, D Goza. In vivo PDGF beta receptor activation in the dorsocaudal brainstem of the rat prevents hypoxia-induced apoptosis via activation of Akt and BAD. Brain research. vol 895. issue 1-2. 2001-07-19. PMID:11259767. |
since hypoxia does not induce apoptosis in the caudal brainstem, pdgfr could underlie such protective mechanism via a pi3 kinase-dependent phosphorylation of both akt and bad pathways. |
2001-07-19 |
2023-08-12 |
rat |
| N Simakajornboon, N J Szerlip, E Gozal, J W Anonetapipat, D Goza. In vivo PDGF beta receptor activation in the dorsocaudal brainstem of the rat prevents hypoxia-induced apoptosis via activation of Akt and BAD. Brain research. vol 895. issue 1-2. 2001-07-19. PMID:11259767. |
we conclude that pdgfr-dependent in vivo activation of both akt and bad during hypoxia prevents induction of apoptosis, and may contribute to the increased hypoxic tolerance of brainstem neurons. |
2001-07-19 |
2023-08-12 |
rat |
| M Alvarez-Tejado, S Naranjo-Suarez, C Jiménez, A C Carrera, M O Landázuri, L del Pes. Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. The Journal of biological chemistry. vol 276. issue 25. 2001-07-19. PMID:11294857. |
finally, inhibition of pi3k impairs both the protection against apoptosis and the activation of akt in response to hypoxia, suggesting a functional link between these two phenomena. |
2001-07-19 |
2023-08-12 |
rat |
| P P Roux, A L Bhakar, T E Kennedy, P A Barke. The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway. The Journal of biological chemistry. vol 276. issue 25. 2001-07-19. PMID:11312266. |
the akt kinase plays a crucial role in supporting trk-dependent cell survival, whereas the p75 neurotrophin receptor (p75ntr) facilitates cellular apoptosis. |
2001-07-19 |
2023-08-12 |
human |
| P P Roux, A L Bhakar, T E Kennedy, P A Barke. The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway. The Journal of biological chemistry. vol 276. issue 25. 2001-07-19. PMID:11312266. |
to test this hypothesis, we developed a system for examining p75ntr-dependent apoptosis and determined the effect of p75ntr on akt activation. |
2001-07-19 |
2023-08-12 |
human |
| P P Roux, A L Bhakar, T E Kennedy, P A Barke. The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway. The Journal of biological chemistry. vol 276. issue 25. 2001-07-19. PMID:11312266. |
the p75ntr expression level required to elicit akt phosphorylation was much lower than that required to activate the jnk pathway or to mediate apoptosis. |
2001-07-19 |
2023-08-12 |
human |
| W G Tatton, R M Chalmers-Redman, A Sud, S M Podos, T W Mitta. Maintaining mitochondrial membrane impermeability. an opportunity for new therapy in glaucoma? Survey of ophthalmology. vol 45 Suppl 3. 2001-07-19. PMID:11377449. |
phosphorylated protein kinase b (akt) serves as an integrator for cellular survival signals and facilitates the megapore actions of bcl-2 and bcl-x(l), which could protect retinal ganglion cells against insults that induce apoptosis. |
2001-07-19 |
2023-08-12 |
rat |
| W G Tatton, R M Chalmers-Redman, A Sud, S M Podos, T W Mitta. Maintaining mitochondrial membrane impermeability. an opportunity for new therapy in glaucoma? Survey of ophthalmology. vol 45 Suppl 3. 2001-07-19. PMID:11377449. |
several anti-apoptotic agents are being evaluated for use in glaucoma, including brimonidine and propargylamines, which oppose mitochondrially dependent apoptosis through pathways involving phosphorylated akt. |
2001-07-19 |
2023-08-12 |
rat |
| P Li, S V Nicosia, W Ba. Antagonism between PTEN/MMAC1/TEP-1 and androgen receptor in growth and apoptosis of prostatic cancer cells. The Journal of biological chemistry. vol 276. issue 23. 2001-07-12. PMID:11278645. |
whereas the repression of the transcriptional activity of the ar by pten is likely to involve the down-regulation of akt, androgens protected prostate cancer cells from pten-induced apoptosis without an effect on akt activity, demonstrating a differential involvement of akt in the interaction between pten and the ar. |
2001-07-12 |
2023-08-12 |
Not clear |
| M Cuello, S A Ettenberg, A S Clark, M M Keane, R H Posner, M M Nau, P A Dennis, S Lipkowit. Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. Cancer research. vol 61. issue 12. 2001-07-12. PMID:11406568. |
down-regulation of akt kinase activity by a phosphatidylinositol 3'-kinase inhibitor (ly294002) also resulted in enhancement of trail-mediated apoptosis. |
2001-07-12 |
2023-08-12 |
Not clear |