| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Chen, H Thakkar, F Tyan, S Gim, H Robinson, C Lee, S K Pandey, C Nwokorie, N Onwudiwe, R K Srivastav. Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer. Oncogene. vol 20. issue 42. 2001-11-01. PMID:11593415. |
akt promotes cell survival and block apoptosis. |
2001-11-01 |
2023-08-12 |
mouse |
| X Chen, H Thakkar, F Tyan, S Gim, H Robinson, C Lee, S K Pandey, C Nwokorie, N Onwudiwe, R K Srivastav. Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer. Oncogene. vol 20. issue 42. 2001-11-01. PMID:11593415. |
we have examined caspase-8 activity, bid cleavage, akt activity, mitochondrial membrane potential (deltapsi(m)) and apoptosis in prostate cancer (lncap, pc-3, pc-3m and du145) cells treated with or without trail. |
2001-11-01 |
2023-08-12 |
mouse |
| X Chen, H Thakkar, F Tyan, S Gim, H Robinson, C Lee, S K Pandey, C Nwokorie, N Onwudiwe, R K Srivastav. Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer. Oncogene. vol 20. issue 42. 2001-11-01. PMID:11593415. |
these data suggest that elevated akt activity protects lncap cells from trail-induced apoptosis, and the pi-3 kinase/akt pathway may inhibit apoptotic signals by inhibiting processing of bid. |
2001-11-01 |
2023-08-12 |
mouse |
| C M van Golen, T S Schwab, K M Ignatoski, S P Ethier, E L Feldma. PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 12. issue 7. 2001-10-25. PMID:11457734. |
insulin-like growth factor i (igf-i) protects cells from apoptosis primarily through the action of phosphatidylinositol-3 kinase and the downstream serine/threonine kinase akt. |
2001-10-25 |
2023-08-12 |
Not clear |
| C M van Golen, T S Schwab, K M Ignatoski, S P Ethier, E L Feldma. PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 12. issue 7. 2001-10-25. PMID:11457734. |
the pten gene product, a protein which dephosphorylates phosphatidylinositol lipids, prevents activation of akt and regulates several cellular functions, including cell cycle progression, cell migration, and survival from apoptosis. |
2001-10-25 |
2023-08-12 |
Not clear |
| C M van Golen, T S Schwab, K M Ignatoski, S P Ethier, E L Feldma. PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 12. issue 7. 2001-10-25. PMID:11457734. |
in this study, pten overexpression decreases igf-i-induced akt activity, enhances serum withdrawal-induced apoptosis, and decreases igf-i protection and cell growth in shep cells. |
2001-10-25 |
2023-08-12 |
Not clear |
| C M van Golen, T S Schwab, K M Ignatoski, S P Ethier, E L Feldma. PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 12. issue 7. 2001-10-25. PMID:11457734. |
the pten lipid phosphatase mutant g129e fails to inhibit igf-i-stimulated akt activity and protection from apoptosis. |
2001-10-25 |
2023-08-12 |
Not clear |
| C M van Golen, T S Schwab, K M Ignatoski, S P Ethier, E L Feldma. PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 12. issue 7. 2001-10-25. PMID:11457734. |
the c124s mutation, which abolishes both lipid and protein phosphatase activity, fails to inhibit akt activity and igf-i protection against hyperosmotic-induced apoptosis but still inhibits growth and igf-i protection against serum withdrawal-induced apoptosis. |
2001-10-25 |
2023-08-12 |
Not clear |
| D Martín, M Salinas, R López-Valdaliso, E Serrano, M Recuero, A Cuadrad. Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells. Journal of neurochemistry. vol 78. issue 5. 2001-10-25. PMID:11553674. |
we investigated the effect of the abeta-derived abeta(25-35) peptide on apoptosis and on the akt survival pathway in pc12 cells. |
2001-10-25 |
2023-08-12 |
mouse |
| N Masuyama, K Oishi, Y Mori, T Ueno, Y Takahama, Y Goto. Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis. The Journal of biological chemistry. vol 276. issue 35. 2001-10-18. PMID:11438550. |
akt inhibits the orphan nuclear receptor nur77 and t-cell apoptosis. |
2001-10-18 |
2023-08-12 |
Not clear |
| N Masuyama, K Oishi, Y Mori, T Ueno, Y Takahama, Y Goto. Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis. The Journal of biological chemistry. vol 276. issue 35. 2001-10-18. PMID:11438550. |
although some candidate akt targets have been described, the function of akt is not fully understood, particularly because of the cell type- and context-dependent apoptosis regulation. |
2001-10-18 |
2023-08-12 |
Not clear |
| N Masuyama, K Oishi, Y Mori, T Ueno, Y Takahama, Y Goto. Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis. The Journal of biological chemistry. vol 276. issue 35. 2001-10-18. PMID:11438550. |
in this study, we demonstrate that one of the mechanisms by which akt antagonizes apoptosis involves the inhibition of nur77, a transcription factor implicated in t-cell receptor-mediated apoptosis. |
2001-10-18 |
2023-08-12 |
Not clear |
| N Masuyama, K Oishi, Y Mori, T Ueno, Y Takahama, Y Goto. Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis. The Journal of biological chemistry. vol 276. issue 35. 2001-10-18. PMID:11438550. |
moreover, we found that expression of akt suppressed nur77-induced apoptosis in fibroblasts and activation-induced cell death of t-cell hybridomas. |
2001-10-18 |
2023-08-12 |
Not clear |
| N Masuyama, K Oishi, Y Mori, T Ueno, Y Takahama, Y Goto. Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis. The Journal of biological chemistry. vol 276. issue 35. 2001-10-18. PMID:11438550. |
collectively, these results may suggest that akt is a negative regulator of nur77 in t-cell apoptosis. |
2001-10-18 |
2023-08-12 |
Not clear |
| J R Nofer, B Levkau, I Wolinska, R Junker, M Fobker, A von Eckardstein, U Seedorf, G Assman. Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids. The Journal of biological chemistry. vol 276. issue 37. 2001-10-11. PMID:11432865. |
two bioactive lysosphingolipids present in hdl particles, sphingosylphosphorylcholine and lysosulfatide, fully mimicked the survival effect of hdl by blocking the mitochondrial pathway of apoptosis and potently activating akt. |
2001-10-11 |
2023-08-12 |
Not clear |
| Y Terada, S Inoshita, S Hanada, H Shimamura, M Kuwahara, W Ogawa, M Kasuga, S Sasaki, F Marum. Hyperosmolality activates Akt and regulates apoptosis in renal tubular cells. Kidney international. vol 60. issue 2. 2001-10-11. PMID:11473638. |
hyperosmolality activates akt and regulates apoptosis in renal tubular cells. |
2001-10-11 |
2023-08-12 |
rat |
| G Ghosh Choudhury, J H Zhang, N Ghosh-Choudhury, H E Abbou. Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. Biochemical and biophysical research communications. vol 286. issue 5. 2001-10-11. PMID:11527425. |
ceramide blocks pdgf-induced dna synthesis in mesangial cells via inhibition of akt kinase in the absence of apoptosis. |
2001-10-11 |
2023-08-12 |
Not clear |
| G Ghosh Choudhury, J H Zhang, N Ghosh-Choudhury, H E Abbou. Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. Biochemical and biophysical research communications. vol 286. issue 5. 2001-10-11. PMID:11527425. |
akt kinase inhibits apoptosis of cells via phosphorylation of multiple proapoptotic proteins. |
2001-10-11 |
2023-08-12 |
Not clear |
| G Ghosh Choudhury, J H Zhang, N Ghosh-Choudhury, H E Abbou. Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. Biochemical and biophysical research communications. vol 286. issue 5. 2001-10-11. PMID:11527425. |
however, inhibition of akt activity by c2 ceramide did not induce apoptosis in mesangial cells. |
2001-10-11 |
2023-08-12 |
Not clear |
| G Ghosh Choudhury, J H Zhang, N Ghosh-Choudhury, H E Abbou. Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. Biochemical and biophysical research communications. vol 286. issue 5. 2001-10-11. PMID:11527425. |
these data provide the first evidence that in mesangial cells, ceramide cross-talks with pi 3 kinase-dependent akt kinase to inhibit pdgf-induced dna synthesis without inducing apoptosis. |
2001-10-11 |
2023-08-12 |
Not clear |