| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tanya M Gottlieb, Juan Fernando Martinez Leal, Rony Seger, Yoichi Taya, Moshe Ore. Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene. vol 21. issue 8. 2002-03-08. PMID:11850850. |
taken together, our findings suggest that depending on the balance of signals, p53-dependent downregulation of akt may promote an irreversible commitment to apoptotic cell death, whereas effective recruitment of akt by appropriate survival signals may lead to activation of mdm2, inactivation of p53, and eventually inhibition of p53-dependent apoptosis. |
2002-03-08 |
2023-08-12 |
Not clear |
| Jung-hsin Hsu, Yijiang Shi, Liping Hu, Myrna Fisher, Thomas F Franke, Alan Lichtenstei. Role of the AKT kinase in expansion of multiple myeloma clones: effects on cytokine-dependent proliferative and survival responses. Oncogene. vol 21. issue 9. 2002-03-07. PMID:11857082. |
in addition, although the level of akt activation can regulate sensitivity to dexamethasone-induced apoptosis, additional cytokine-induced akt-independent pathways can mediate il-6 protection against dexamethasone. |
2002-03-07 |
2023-08-12 |
Not clear |
| Donatella Del Bufalo, Valeriana Di Castro, Annamaria Biroccio, Marco Varmi, Debora Salani, Laura Rosanò, Daniela Trisciuoglio, Francesca Spinella, Anna Bagnat. Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation. Molecular pharmacology. vol 61. issue 3. 2002-03-05. PMID:11854432. |
endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for akt activation. |
2002-03-05 |
2023-08-12 |
Not clear |
| Donatella Del Bufalo, Valeriana Di Castro, Annamaria Biroccio, Marco Varmi, Debora Salani, Laura Rosanò, Daniela Trisciuoglio, Francesca Spinella, Anna Bagnat. Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation. Molecular pharmacology. vol 61. issue 3. 2002-03-05. PMID:11854432. |
these results establish a novel role for et-1 in determining protection of ovarian carcinoma cells against paclitaxel-induced apoptosis through bcl-2-dependent and pi3-k-mediated akt pathways and suggest that et-1 and et(a)r could represent important targets for anticancer therapy. |
2002-03-05 |
2023-08-12 |
Not clear |
| T Maehama, G S Taylor, J E Dixo. PTEN and myotubularin: novel phosphoinositide phosphatases. Annual review of biochemistry. vol 70. 2002-02-27. PMID:11395408. |
mutations that impair pten function result in a marked increase in cellular levels of pip3 and constitutive activation of akt survival signaling pathways, leading to inhibition of apoptosis, hyperplasia, and tumor formation. |
2002-02-27 |
2023-08-12 |
human |
| Hee-Sae Park, Mi-Sung Kim, Sung-Ho Huh, Jihyun Park, Jongkyeong Chung, Sang Sun Kang, Eui-Ju Cho. Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. The Journal of biological chemistry. vol 277. issue 4. 2002-02-25. PMID:11707464. |
finally, activated akt inhibited sek1-mediated apoptosis, and this effect of akt was prevented by overexpression of sek(s78a). |
2002-02-25 |
2023-08-12 |
Not clear |
| Klemen Strle, Jian Hua Zhou, Suzanne R Broussard, Homer D Venters, Rodney W Johnson, Gregory G Freund, Robert Dantzer, Keith W Kelle. IL-10 promotes survival of microglia without activating Akt. Journal of neuroimmunology. vol 122. issue 1-2. 2002-02-21. PMID:11777539. |
in contrast to il-10, igf-i increases enzymatic activity of pi 3-kinase and causes phosphorylation on serine(473) of akt but does not prevent microglial apoptosis. |
2002-02-21 |
2023-08-12 |
Not clear |
| J Wu, H Suzuki, Y W Zhou, W Liu, M Yoshihara, M Kato, A A Akhand, A Hayakawa, K Takeuchi, K Hossain, M Kurosawa, I Nakashim. Cepharanthine activates caspases and induces apoptosis in Jurkat and K562 human leukemia cell lines. Journal of cellular biochemistry. vol 82. issue 2. 2002-02-15. PMID:11527146. |
when used in combination with a nontoxic concentration of herbimycin a, lower concentrations (2-5 microm) of cep induced obvious apoptosis in k562 cells with rapid degradation or decrease in the amount of bcr-abl and akt proteins. |
2002-02-15 |
2023-08-12 |
human |
| Xiu-Juan Yuan, Young E Whan. PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. Oncogene. vol 21. issue 2. 2002-02-15. PMID:11803475. |
adenovirus-mediated expression of pten completely suppressed constitutive akt activation in lncap prostate cancer cells and enhanced apoptosis induced by a broad range of apoptotic stimuli. |
2002-02-15 |
2023-08-12 |
human |
| Jiayuh Lin, Xiaohong Jin, Kori Rothman, Huey-Jen Lin, Huaijing Tang, William Burk. Modulation of signal transducer and activator of transcription 3 activities by p53 tumor suppressor in breast cancer cells. Cancer research. vol 62. issue 2. 2002-02-15. PMID:11809683. |
interestingly, the p53-dependent apoptosis occurred in the presence of high levels of phosphorylated akt and erk1/2. |
2002-02-15 |
2023-08-12 |
human |
| Erika M Gibson, Elizabeth S Henson, Neil Haney, Jacylyn Villanueva, Spencer B Gibso. Epidermal growth factor protects epithelial-derived cells from tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by inhibiting cytochrome c release. Cancer research. vol 62. issue 2. 2002-02-15. PMID:11809700. |
expression of activated akt was sufficient to block trail-induced apoptosis, and kinase-inactive akt expression blocked egf-protective response. |
2002-02-15 |
2023-08-12 |
mouse |
| Erika M Gibson, Elizabeth S Henson, Neil Haney, Jacylyn Villanueva, Spencer B Gibso. Epidermal growth factor protects epithelial-derived cells from tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by inhibiting cytochrome c release. Cancer research. vol 62. issue 2. 2002-02-15. PMID:11809700. |
these findings indicate that egf receptor activation provides a survival response against trail-induced apoptosis by inhibiting mitochondrial cytochrome c release that is mediated by akt activation in epithelial-derived cells. |
2002-02-15 |
2023-08-12 |
mouse |
| Hemant K Roy, Bola F Olusola, Dahn L Clemens, William J Karolski, Anne Ratashak, Henry T Lynch, Thomas C Smyr. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis. vol 23. issue 1. 2002-02-14. PMID:11756242. |
the early inhibition of apoptosis during sporadic colon carcinogenesis may be related, at least partly, to the overexpression of akt. |
2002-02-14 |
2023-08-12 |
human |
| Wei-Ping Lee, Yong Wen, Brian Varnum, Mien-Chie Hun. Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene. vol 21. issue 3. 2002-02-14. PMID:11821945. |
akt is required for axl-gas6 signaling to protect cells from e1a-mediated apoptosis. |
2002-02-14 |
2023-08-12 |
Not clear |
| Wei-Ping Lee, Yong Wen, Brian Varnum, Mien-Chie Hun. Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene. vol 21. issue 3. 2002-02-14. PMID:11821945. |
to determine how the axl-gas6 interaction prevents e1a-mediated apoptosis, we analysed the expression of anti-apoptotic molecules and found that the activated form of akt was suppressed in the e1a transfectant ip 1-e1a and that gas6 was able to activate akt in ip 1-e1a cells reexpressing axl (ip 1-e1a-axl). |
2002-02-14 |
2023-08-12 |
Not clear |
| Wei-Ping Lee, Yong Wen, Brian Varnum, Mien-Chie Hun. Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene. vol 21. issue 3. 2002-02-14. PMID:11821945. |
to determine whether activated akt is required to prevent e1a-mediated apoptosis, ip 1-e1a-axl cells were treated with the phosphatidylinositol-3'-oh kinase inhibitor wortmannin or transfected with a dominant negative akt mutant. |
2002-02-14 |
2023-08-12 |
Not clear |
| Wei-Ping Lee, Yong Wen, Brian Varnum, Mien-Chie Hun. Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene. vol 21. issue 3. 2002-02-14. PMID:11821945. |
thus, we conclude that activated akt is required for axl-gas6 signaling to prevent e1a-mediated apoptosis induced by serum deprivation. |
2002-02-14 |
2023-08-12 |
Not clear |
| Alexey L Glazyrin, Sreenivasa Chinni, Samir Alhasan, Volkan N Adsay, Vainutis K Vaitkevicius, Fazlul H Sarka. Molecular mechanism(s) of actinomycin-D induced sensitization of pancreatic cancer cells to CD95 mediated apoptosis. International journal of oncology. vol 20. issue 1. 2002-02-13. PMID:11743665. |
actd at a dose that is known to sensitize pancreatic cancer cells to cd95 mediated apoptosis abrogated the dna binding activity of nf-kappab but did not affect expression of phosphorylated akt. |
2002-02-13 |
2023-08-12 |
Not clear |
| Alexey L Glazyrin, Sreenivasa Chinni, Samir Alhasan, Volkan N Adsay, Vainutis K Vaitkevicius, Fazlul H Sarka. Molecular mechanism(s) of actinomycin-D induced sensitization of pancreatic cancer cells to CD95 mediated apoptosis. International journal of oncology. vol 20. issue 1. 2002-02-13. PMID:11743665. |
over-expression of phosphorylated akt in pancreatic cancer cells is controlled by effective apoptotic signaling from cd95 receptors, but do not protect tumor cells from cd95 induced apoptosis. |
2002-02-13 |
2023-08-12 |
Not clear |
| Alexey L Glazyrin, Sreenivasa Chinni, Samir Alhasan, Volkan N Adsay, Vainutis K Vaitkevicius, Fazlul H Sarka. Molecular mechanism(s) of actinomycin-D induced sensitization of pancreatic cancer cells to CD95 mediated apoptosis. International journal of oncology. vol 20. issue 1. 2002-02-13. PMID:11743665. |
thus, our results indicate that modulation of nf-kappab activity rather then akt may provide a useful tool to sensitize pancreatic cancer cells to cd95 mediated apoptosis. |
2002-02-13 |
2023-08-12 |
Not clear |