| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisabetta Ciani, Marco Virgili, Antonio Contestabil. Akt pathway mediates a cGMP-dependent survival role of nitric oxide in cerebellar granule neurones. Journal of neurochemistry. vol 81. issue 2. 2002-06-26. PMID:12064469. |
furthermore, in transfection experiments, overexpression of the akt gene significantly decreased nitric oxide deprivation-related apoptosis. |
2002-06-26 |
2023-08-12 |
Not clear |
| Sarah S Bacus, Deborah A Altomare, Ljuba Lyass, Dot Mon Chin, Michael P Farrell, Katerina Gurova, Andrei Gudkov, Joseph R Test. AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene. vol 21. issue 22. 2002-06-11. PMID:12032855. |
her-2/neu-overexpressing breast cancer cell lines were resistant to apoptosis induced by uv treatment and hypoxia, which was suppressed in the presence of the phosphatidylinositol 3-kinase inhibitors ly294002 and wortmannin, indicating a link between akt activation and stress resistance in her-2/neu-overexpressing cells. |
2002-06-11 |
2023-08-12 |
Not clear |
| Sarah S Bacus, Deborah A Altomare, Ljuba Lyass, Dot Mon Chin, Michael P Farrell, Katerina Gurova, Andrei Gudkov, Joseph R Test. AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene. vol 21. issue 22. 2002-06-11. PMID:12032855. |
these observations suggest that akt signaling augments resistance to stress-induced apoptosis in breast cancer cells overexpressing her-2/neu. |
2002-06-11 |
2023-08-12 |
Not clear |
| Imran Mohiuddin, Xiaobo Cao, Mustafa K Ozvaran, Lou Zumstein, Sunil Chada, W Roy Smyth. Phosphatase and tensin analog gene overexpression engenders cellular death in human malignant mesothelioma cells via inhibition of AKT phosphorylation. Annals of surgical oncology. vol 9. issue 3. 2002-06-04. PMID:11923140. |
a downstream target of pten is akt, a serine-threonine kinase that when activated inhibits apoptosis. |
2002-06-04 |
2023-08-12 |
human |
| Imran Mohiuddin, Xiaobo Cao, Mustafa K Ozvaran, Lou Zumstein, Sunil Chada, W Roy Smyth. Phosphatase and tensin analog gene overexpression engenders cellular death in human malignant mesothelioma cells via inhibition of AKT phosphorylation. Annals of surgical oncology. vol 9. issue 3. 2002-06-04. PMID:11923140. |
we sought to determine whether pten overexpression in mesothelioma cells would engender hypophosphorylation of akt and apoptosis. |
2002-06-04 |
2023-08-12 |
human |
| Andrew M Arsham, David R Plas, Craig B Thompson, M Celeste Simo. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. The Journal of biological chemistry. vol 277. issue 17. 2002-05-31. PMID:11859074. |
upon activation by products of phosphatidylinositol 3-kinase (pi3k), akt phosphorylates downstream targets that stimulate growth and inhibit apoptosis. |
2002-05-31 |
2023-08-12 |
Not clear |
| Graham P Pidgeon, Mustapha Kandouz, Anthony Meram, Kenneth V Hon. Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. Cancer research. vol 62. issue 9. 2002-05-31. PMID:11980674. |
the mechanisms involved were decreased phosphorylation of akt, loss of survivin and subsequent activation of caspase-3 and caspase-7 in each cell line, decreased bcl-2 and bcl-x(l) expression in du-145, and a shift in bcl-2/bax levels favoring apoptosis in pc-3 cells. |
2002-05-31 |
2023-08-12 |
Not clear |
| Chi-Hung Cheng, Chin-Ling Hsieh, Kuo-Hsiung Shu, Yen-Ling Chen, Hong-Chen Che. Effect of calcium channel antagonist diltiazem and calcium ionophore A23187 on cyclosporine A-induced apoptosis of renal tubular cells. FEBS letters. vol 516. issue 1-3. 2002-05-23. PMID:11959131. |
the rescue of cells from csa-induced apoptosis by a23187 was correlated with akt activation, bad phosphorylation, and caspase-3 inactivation. |
2002-05-23 |
2023-08-12 |
Not clear |
| Alexander Urbano, Gullu Gorgun, Francine Fos. Mechanisms of apoptosis by the tyrphostin AG957 in hematopoietic cells. Biochemical pharmacology. vol 63. issue 4. 2002-05-17. PMID:11992636. |
in this study, we explored the mechanisms of ag957-mediated growth inhibition and apoptosis in the p210(bcr-abl) negative leukemia cell lines nalm-6 and jurkat, and demonstrate that ag957-mediated apoptosis is associated with altered phosphorylation of akt and bad, which destabilizes the bcl-xl/bad complex and releases the block to apoptosis. |
2002-05-17 |
2023-08-12 |
Not clear |
| D E Carbott, L Duan, M A Davi. Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells. Apoptosis : an international journal on programmed cell death. vol 7. issue 1. 2002-05-15. PMID:11773707. |
given the reported cell survival activity of pi3 kinase signaling mostly attributed to akt kinase activation, we hypothesized that inhibition of pi3 kinase would enhance okadaic-induced apoptosis. |
2002-05-15 |
2023-08-12 |
human |
| Abdelkarim Sabri, Brenda A Wilson, Susan F Steinber. Dual actions of the Galpha(q) agonist Pasteurella multocida toxin to promote cardiomyocyte hypertrophy and enhance apoptosis susceptibility. Circulation research. vol 90. issue 8. 2002-05-14. PMID:11988485. |
surprisingly, rpmt (or novel pkc isoform activation by pma) decreases basal akt phosphorylation; rpmt prevents akt phosphorylation by egf or igf-1 and functionally augments cardiomyocyte apoptosis in response to h2o2. |
2002-05-14 |
2023-08-12 |
mouse |
| Abdelkarim Sabri, Brenda A Wilson, Susan F Steinber. Dual actions of the Galpha(q) agonist Pasteurella multocida toxin to promote cardiomyocyte hypertrophy and enhance apoptosis susceptibility. Circulation research. vol 90. issue 8. 2002-05-14. PMID:11988485. |
because inhibition of akt enhances cardiomyocyte susceptibility to apoptosis, this pathway is predicted to contribute to the transition from hypertrophy to cardiac decompensation and could be targeted for therapy in heart failure. |
2002-05-14 |
2023-08-12 |
mouse |
| Jianhua Huang, Christopher D Konto. PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. The Journal of biological chemistry. vol 277. issue 13. 2002-05-10. PMID:11784722. |
inhibition of endogenous pten in cultured endothelial cells by adenovirus-mediated overexpression of a dominant negative pten mutant (pten-c/s) enhanced vegf-mediated akt phosphorylation, and this effect correlated with decreases in caspase-3 cleavage, caspase-3 activity, and dna degradation after induction of apoptosis with tumor necrosis factor-alpha. |
2002-05-10 |
2023-08-12 |
rat |
| Keiran S M Smalley, Tim G Eise. Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects. International journal of cancer. vol 98. issue 4. 2002-05-10. PMID:11920610. |
inhibition of akt and erk activity induces apoptosis in other human cancer cell lines. |
2002-05-10 |
2023-08-12 |
human |
| Keiran S M Smalley, Tim G Eise. Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects. International journal of cancer. vol 98. issue 4. 2002-05-10. PMID:11920610. |
here it is demonstrated that inhibition of akt, or erk and akt in combination, leads to cell cycle arrest but not apoptosis in melanoma cells. |
2002-05-10 |
2023-08-12 |
human |
| Naoya Fujita, Saori Sato, Atsushi Ishida, Takashi Tsuru. Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1. The Journal of biological chemistry. vol 277. issue 12. 2002-04-29. PMID:11779851. |
geldanamycin, radicicol, and its analogues) induced akt dephosphorylation, which resulted in akt inactivation and apoptosis of the cells. |
2002-04-29 |
2023-08-12 |
Not clear |
| Lei Zhang, Bing shen Li, Wu Ma, Jeffery L Barker, Yoong H Chang, Weiqin Zhao, David R Rubino. Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing ways. Brain research. Molecular brain research. vol 98. issue 1-2. 2002-04-29. PMID:11834296. |
dehydroepiandrosterone (dhea) and its sulfated derivative (dheas) regulate apoptosis during neurogenesis by triggering the akt signaling pathway in opposing ways. |
2002-04-29 |
2023-08-12 |
rat |
| Lei Zhang, Bing shen Li, Wu Ma, Jeffery L Barker, Yoong H Chang, Weiqin Zhao, David R Rubino. Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing ways. Brain research. Molecular brain research. vol 98. issue 1-2. 2002-04-29. PMID:11834296. |
we found that dhea activated akt in neural precursor culture, in association with a decrease in apoptosis. |
2002-04-29 |
2023-08-12 |
rat |
| Lei Zhang, Bing shen Li, Wu Ma, Jeffery L Barker, Yoong H Chang, Weiqin Zhao, David R Rubino. Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing ways. Brain research. Molecular brain research. vol 98. issue 1-2. 2002-04-29. PMID:11834296. |
in contrast, dheas decreased activated akt levels and increased apoptosis. |
2002-04-29 |
2023-08-12 |
rat |
| Marina V Kisseleva, Li Cao, Philip W Majeru. Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death. The Journal of biological chemistry. vol 277. issue 8. 2002-04-24. PMID:11706019. |
one of the targets of these phosphoinositides is the serine/threonine kinase akt, which plays an important role in the control of apoptosis. |
2002-04-24 |
2023-08-12 |
Not clear |