| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisabetta Ciani, Sandra Guidi, Renata Bartesaghi, Antonio Contestabil. Nitric oxide regulates cGMP-dependent cAMP-responsive element binding protein phosphorylation and Bcl-2 expression in cerebellar neurons: implication for a survival role of nitric oxide. Journal of neurochemistry. vol 82. issue 5. 2002-10-18. PMID:12358775. |
we have recently demonstrated that long-lasting exposure to an neuronal nitric oxide synthase (nnos) inhibitor down-regulated serine/threonine kinase (akt) survival pathway and caused apoptosis in cerebellar granule cell cultures. |
2002-10-18 |
2023-08-12 |
Not clear |
| Xi-Lin Niu, Kevin G Peters, Christopher D Konto. Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism. The Journal of biological chemistry. vol 277. issue 35. 2002-10-17. PMID:12082108. |
enhanced akt activation correlated with significant inhibition of staurosporine-induced apoptosis. |
2002-10-17 |
2023-08-12 |
Not clear |
| Andrea H Bild, Francisco J Mendoza, Erika M Gibson, Mei Huang, Jacylyn Villanueva, Timothy P Garrington, Richard Jove, Gary L Johnson, Spencer B Gibso. MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage. Oncogene. vol 21. issue 43. 2002-10-10. PMID:12242663. |
herein, we investigate the role of death receptor activation and the ability of akt/pkb (akt) to inhibit cell death in mekk1-induced apoptosis. |
2002-10-10 |
2023-08-12 |
Not clear |
| Andrea H Bild, Francisco J Mendoza, Erika M Gibson, Mei Huang, Jacylyn Villanueva, Timothy P Garrington, Richard Jove, Gary L Johnson, Spencer B Gibso. MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage. Oncogene. vol 21. issue 43. 2002-10-10. PMID:12242663. |
mekk1-induced apoptosis is amplified by blocking pi-3 kinase activation and overexpression of akt blocked both mekk1-induced apoptosis and caspase activation. |
2002-10-10 |
2023-08-12 |
Not clear |
| Andrea H Bild, Francisco J Mendoza, Erika M Gibson, Mei Huang, Jacylyn Villanueva, Timothy P Garrington, Richard Jove, Gary L Johnson, Spencer B Gibso. MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage. Oncogene. vol 21. issue 43. 2002-10-10. PMID:12242663. |
akt did not, however, block mekk1-induced jnk activation, showing that regulation of the jnk pathway by mekk1 is independent of its role in regulation of apoptosis. |
2002-10-10 |
2023-08-12 |
Not clear |
| Andrea H Bild, Francisco J Mendoza, Erika M Gibson, Mei Huang, Jacylyn Villanueva, Timothy P Garrington, Richard Jove, Gary L Johnson, Spencer B Gibso. MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage. Oncogene. vol 21. issue 43. 2002-10-10. PMID:12242663. |
thus, mekk1-induced apoptosis requires trail death receptor activation and is blocked by akt through inhibition of mekk1 cleavage. |
2002-10-10 |
2023-08-12 |
Not clear |
| b' Zaisen Wang, Cheng Jiang, Junxuan L\\xc3\\xb. Induction of caspase-mediated apoptosis and cell-cycle G1 arrest by selenium metabolite methylselenol. Molecular carcinogenesis. vol 34. issue 3. 2002-09-24. PMID:12112305.' |
exposure of du145 cells to methylselenol so generated in the sub-micromolar range led to caspase-mediated cleavage of poly(adp-ribose) polymerase, nucleosomal dna fragmentation, and morphologic apoptosis and resulted in a profile of biochemical effects similar to that of methylseleninic acid (msea) exposure as exemplified by the inhibition of phosphorylation of protein kinase akt and extracellularly regulated kinases 1/2. |
2002-09-24 |
2023-08-12 |
human |
| Zeng-qiang Yuan, Richard I Feldman, Mei Sun, Nancy E Olashaw, Domenico Coppola, Gene E Sussman, Sue A Shelley, Santo V Nicosia, Jin Q Chen. Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells. The Journal of biological chemistry. vol 277. issue 33. 2002-09-20. PMID:12048203. |
furthermore, phosphatidylinositol 3-kinase inhibitor or dominant negative akt2 significantly enhances uv- and tnf alpha-induced apoptosis, whereas expression of constitutively active akt2 inhibits programmed cell death in response to uv and tnfalpha -induced apoptosis by inhibition of stress kinases and provide the first evidence that akt inhibits stress kinase jnk through activation of the nf kappa b pathway. |
2002-09-20 |
2023-08-12 |
human |
| Wenle Xia, Robert J Mullin, Barry R Keith, Lei-Hua Liu, Hong Ma, David W Rusnak, Gary Owens, Krystal J Alligood, Neil L Specto. Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene. vol 21. issue 41. 2002-09-19. PMID:12214266. |
complete inhibition of activated akt in erbb2 overexpressing cells correlated with a 23-fold increase in apoptosis compared with vehicle controls. |
2002-09-19 |
2023-08-12 |
human |
| Yun-Jung Choi, Jong-Wook Park, Ju-Hyung Woo, Young-Ho Kim, Sang-Han Lee, Jin-Man Lee, Taeg Kyu Kwo. Failure to activate caspase 3 in phorbol ester-resistant leukemia cells is associated with resistance to apoptotic cell death. Cancer letters. vol 182. issue 2. 2002-09-17. PMID:12048164. |
activation of akt occurs to a greater extent in the r-u937 cells than the u937 cells and thus might be related to protection from ro-31-8220-induced apoptosis. |
2002-09-17 |
2023-08-12 |
human |
| Cynthia R L Webster, Paul Usechak, M Sawkat Anwe. cAMP inhibits bile acid-induced apoptosis by blocking caspase activation and cytochrome c release. American journal of physiology. Gastrointestinal and liver physiology. vol 283. issue 3. 2002-09-17. PMID:12181189. |
these results suggest that gcdc-induced apoptosis in cultured rat hepatocytes proceeds through a caspase-dependent intracellular stress pathway and that the survival effect of camp is mediated in part by pi3k-dependent akt activation at the level of the mitochondria. |
2002-09-17 |
2023-08-12 |
rat |
| Manabu Kawada, Tohru Masuda, Masaaki Ishizuka, Tomio Takeuch. 15-Deoxyspergualin inhibits Akt kinase activation and phosphatidylcholine synthesis. The Journal of biological chemistry. vol 277. issue 31. 2002-09-16. PMID:12021268. |
these results demonstrate that dsg inhibits tumor cell growth through the inhibition of protein synthesis and induction of apoptosis, which is caused by the down-regulation of akt kinase and p70s6k. |
2002-09-16 |
2023-08-12 |
mouse |
| Mohammed Akbar, Hee-Yong Ki. Protective effects of docosahexaenoic acid in staurosporine-induced apoptosis: involvement of phosphatidylinositol-3 kinase pathway. Journal of neurochemistry. vol 82. issue 3. 2002-08-30. PMID:12153489. |
when cells were enriched with dha in serine-free medium, the ps increase diminished and the dha effect on caspase-3 activation as well as akt phosphorylation in st-induced apoptosis was no longer apparent, suggesting that dha's role in accumulating membrane ps is an important component for the observed protection. |
2002-08-30 |
2023-08-12 |
Not clear |
| Sang-Youel Park, Dai-Wu Seo. Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis. Biochemical and biophysical research communications. vol 295. issue 2. 2002-08-29. PMID:12150980. |
regulation of akt by egf-r inhibitors, a possible mechanism of egf-r inhibitor-enhanced trail-induced apoptosis. |
2002-08-29 |
2023-08-12 |
Not clear |
| Vassiliki Poulaki, Constantine S Mitsiades, Vassiliki Kotoula, Sophia Tseleni-Balafouta, Avi Ashkenazi, Demetrios A Koutras, Nicholas Mitsiade. Regulation of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in thyroid carcinoma cells. The American journal of pathology. vol 161. issue 2. 2002-08-28. PMID:12163389. |
igf-1 activated akt; up-regulated the caspase inhibitors flip, ciap-2, xiap, and survivin; and attenuated apo2l/trail-induced apoptosis. |
2002-08-28 |
2023-08-12 |
Not clear |
| Bin Tian, Khashayar Lessan, Judy Kahm, Jill Kleidon, Craig Henk. beta 1 integrin regulates fibroblast viability during collagen matrix contraction through a phosphatidylinositol 3-kinase/Akt/protein kinase B signaling pathway. The Journal of biological chemistry. vol 277. issue 27. 2002-08-27. PMID:11986332. |
we show that akt phosphorylation decreased during collagen contraction and that this decrease correlated precisely with the onset of fibroblast apoptosis. |
2002-08-27 |
2023-08-12 |
Not clear |
| Bin Tian, Khashayar Lessan, Judy Kahm, Jill Kleidon, Craig Henk. beta 1 integrin regulates fibroblast viability during collagen matrix contraction through a phosphatidylinositol 3-kinase/Akt/protein kinase B signaling pathway. The Journal of biological chemistry. vol 277. issue 27. 2002-08-27. PMID:11986332. |
fibroblasts transfected with constitutively active pi3k displayed increased akt phosphorylation and were protected from anoikis and collagen gel contraction-induced apoptosis. |
2002-08-27 |
2023-08-12 |
Not clear |
| Doris Polgar, Susanne Gfatter, Maria Uhl, Fekadu Kassie, Christina Leisser, Georg Krupitza, Michael Grusc. Potential mechanisms of benzamide riboside mediated cell death. Current medicinal chemistry. vol 9. issue 7. 2002-08-23. PMID:11966440. |
it is shown here, however, that also survival-relevant genes such as cdc25a, akt, bcl-2 and transferrin receptor become repressed by br, whereas the expression level of the apoptosis enforcing gene c-myc persists. |
2002-08-23 |
2023-08-12 |
Not clear |
| Bhumsoo Kim, Eva L Feldma. Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. The Journal of biological chemistry. vol 277. issue 30. 2002-08-22. PMID:12011046. |
treatment of the cells with zvad, a general caspase inhibitor, blocks the mannitol-induced fak and akt degradation as well as cell detachment and apoptosis. |
2002-08-22 |
2023-08-12 |
human |
| Bhumsoo Kim, Eva L Feldma. Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. The Journal of biological chemistry. vol 277. issue 30. 2002-08-22. PMID:12011046. |
these results suggest that one of the pathways of mannitol-mediated apoptosis is through the degradation of fak and akt and that igf-i protects the cells from apoptosis by blocking the activation of caspases, which may be responsible for the loss of fak and akt. |
2002-08-22 |
2023-08-12 |
human |