| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melinda E Wilson, Ying Liu, Phyllis M Wis. Estradiol enhances Akt activation in cortical explant cultures following neuronal injury. Brain research. Molecular brain research. vol 102. issue 1-2. 2003-02-11. PMID:12191493. |
these studies suggest that estradiol prevents injury-induced apoptosis and that akt activation may mediate these protective effects. |
2003-02-11 |
2023-08-12 |
rat |
| B-S Youn, K-Y Yu, J Oh, J Lee, T-H Lee, H E Broxmeye. Role of the CC chemokine receptor 9/TECK interaction in apoptosis. Apoptosis : an international journal on programmed cell death. vol 7. issue 3. 2003-02-07. PMID:11997671. |
we recently showed that activation of the cc chemokine 9 receptor (ccr9), a thymus-specific chemokine receptor, led to potent cflip(l)-independent resistance to cycloheximide-induced apoptosis and modest resistance to fas-mediated apoptosis possibly via activation of multiple signaling components involving akt and glycogen synthase kinase 3beta. |
2003-02-07 |
2023-08-12 |
Not clear |
| Daniel Martin, Marta Salinas, Naoya Fujita, Takashi Tsuruo, Antonio Cuadrad. Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B. The Journal of biological chemistry. vol 277. issue 45. 2003-02-06. PMID:12213802. |
a membrane-targeted active akt version attenuated apoptosis but not necrosis induced by h2o2 and was more resistant to dephosphorylation and proteolysis induced by apoptotic concentrations of h2o2. |
2003-02-06 |
2023-08-12 |
Not clear |
| Fredrick M Pavalko, Rita L Gerard, Suzanne M Ponik, Patricia J Gallagher, Yijun Jin, Suzanne M Norvel. Fluid shear stress inhibits TNF-alpha-induced apoptosis in osteoblasts: a role for fluid shear stress-induced activation of PI3-kinase and inhibition of caspase-3. Journal of cellular physiology. vol 194. issue 2. 2003-01-30. PMID:12494458. |
ly294002 did not, however, prevent fss-induced phosphorylation of akt suggesting that activation of akt alone is not sufficient to rescue cells from apoptosis. |
2003-01-30 |
2023-08-12 |
rat |
| Pengfei Li, Heehyoung Lee, Shaodong Guo, Terry G Unterman, Guido Jenster, Wenlong Ba. AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR. Molecular and cellular biology. vol 23. issue 1. 2003-01-28. PMID:12482965. |
recent studies suggested that the protection of cell apoptosis by akt involves phosphorylation and inhibition of fkhr and related foxo forkhead transcription factors and that androgens provide an akt-independent cell survival signal in prostate cancer cells. |
2003-01-28 |
2023-08-12 |
Not clear |
| Punita Dhawan, Amar B Singh, Darrel L Ellis, Ann Richmon. Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer research. vol 62. issue 24. 2003-01-28. PMID:12499277. |
in addition, interruption of akt activation resulted in increased apoptosis and decreased nf-kappab promoter activity. |
2003-01-28 |
2023-08-12 |
Not clear |
| Randy J Levitt, Michael Polla. Insulin-like growth factor-I antagonizes the antiproliferative effects of cyclooxygenase-2 inhibitors on BxPC-3 pancreatic cancer cells. Cancer research. vol 62. issue 24. 2003-01-28. PMID:12499282. |
the protection from celecoxib-induced apoptosis by igf-i correlated with an increase in the levels of the activated antiapoptotic protein akt. |
2003-01-28 |
2023-08-12 |
human |
| Yiwei Li, Fazlul H Sarka. Gene expression profiles of genistein-treated PC3 prostate cancer cells. The Journal of nutrition. vol 132. issue 12. 2003-01-22. PMID:12468598. |
our previous studies have shown that genistein inhibits the growth of pc3 prostate cancer cells and induces apoptosis by inhibiting nuclear factor kappab (nf-kappab) and akt signaling pathways. |
2003-01-22 |
2023-08-12 |
Not clear |
| Jeffrey P MacKeigan, Debra J Taxman, Deborah Hunter, H Shelton Earp, Lee M Graves, Jenny P-Y Tin. Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 8. issue 7. 2003-01-21. PMID:12114408. |
to confirm that inactivation of akt is significant, a constitutively active akt mutant was introduced and shown to reverse tumor cell apoptosis. |
2003-01-21 |
2023-08-12 |
Not clear |
| Yiwei Li, Fazlul H Sarka. Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 8. issue 7. 2003-01-21. PMID:12114442. |
we have previously shown that genistein induces apoptosis and inhibits the activation of nuclear factor kappab (nf-kappab) pathway, which could be mediated via akt signaling pathway, the most important survival pathway in cellular signaling. |
2003-01-21 |
2023-08-12 |
human |
| Yiwei Li, Fazlul H Sarka. Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 8. issue 7. 2003-01-21. PMID:12114442. |
in this study, we investigated whether there is any cross-talk between akt and nf-kappab during genistein-induced apoptosis in pc3 prostate cancer cells. |
2003-01-21 |
2023-08-12 |
human |
| Sunghoon Kim, Junghee Kang, Wanqin Hu, B Mark Evers, Dai H Chun. Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas. International journal of cancer. vol 103. issue 3. 2003-01-21. PMID:12471618. |
geldanamycin decreases raf-1 and akt levels and induces apoptosis in neuroblastomas. |
2003-01-21 |
2023-08-12 |
human |
| Sunghoon Kim, Junghee Kang, Wanqin Hu, B Mark Evers, Dai H Chun. Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas. International journal of cancer. vol 103. issue 3. 2003-01-21. PMID:12471618. |
the purpose of our study was to determine whether ga can alter the expression of raf-1 and akt, which have been shown to be critical for neuronal cell survival, and induce apoptosis of neuroblastoma cells. |
2003-01-21 |
2023-08-12 |
human |
| Sunghoon Kim, Junghee Kang, Wanqin Hu, B Mark Evers, Dai H Chun. Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas. International journal of cancer. vol 103. issue 3. 2003-01-21. PMID:12471618. |
ga-induced apoptosis was associated with a reduction in the level and activity of raf-1 and akt. |
2003-01-21 |
2023-08-12 |
human |
| Robert D Loberg, Eileen Vesely, Frank C Brosiu. Enhanced glycogen synthase kinase-3beta activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism. The Journal of biological chemistry. vol 277. issue 44. 2003-01-17. PMID:12200436. |
hypoxia-induced apoptosis in vascular smooth muscle cells and cos-7 cells was accompanied by a significant reduction in akt and glycogen synthase kinase-3 (gsk-3) phosphorylation resulting in increased gsk-3 activity. |
2003-01-17 |
2023-08-12 |
Not clear |
| Stacey R Vlahakis, Angelina Villasis-Keever, Timothy Gomez, Maria Vanegas, Nicholas Vlahakis, Carlos V Pay. G protein-coupled chemokine receptors induce both survival and apoptotic signaling pathways. Journal of immunology (Baltimore, Md. : 1950). vol 169. issue 10. 2003-01-14. PMID:12421931. |
in contrast, akt activation through cxcr4 by sdf1alpha interactions is necessary to confer resistance to apoptosis. |
2003-01-14 |
2023-08-12 |
Not clear |
| Susumu Rokudai, Naoya Fujita, Osamu Kitahara, Yusuke Nakamura, Takashi Tsuru. Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis. Molecular and cellular biology. vol 22. issue 24. 2003-01-13. PMID:12446787. |
because the serine/threonine kinase akt is involved in apoptosis suppression, we investigated the relationship between akt activity and drug sensitivity. |
2003-01-13 |
2023-08-12 |
Not clear |
| Susumu Rokudai, Naoya Fujita, Osamu Kitahara, Yusuke Nakamura, Takashi Tsuru. Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis. Molecular and cellular biology. vol 22. issue 24. 2003-01-13. PMID:12446787. |
we discovered that certain chemotherapeutic drugs induced apoptosis with caspase activation only when akt was inactivated after drug treatment, while inactivation of akt was not observed when tumor cells showed resistance to the drug-induced caspase activation. |
2003-01-13 |
2023-08-12 |
Not clear |
| Amy S Clark, Kip West, Samantha Streicher, Phillip A Denni. Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. Molecular cancer therapeutics. vol 1. issue 9. 2003-01-13. PMID:12479367. |
akt promoted breast cancer cell survival because a pi3k inhibitor, ly294002, or transient transfection of a dominant-negative akt mutant inhibited akt activity and increased apoptosis. |
2003-01-13 |
2023-08-12 |
Not clear |
| Amy S Clark, Kip West, Samantha Streicher, Phillip A Denni. Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. Molecular cancer therapeutics. vol 1. issue 9. 2003-01-13. PMID:12479367. |
potentiation of apoptosis by ly294002 correlated with induction of akt by doxorubicin or trastuzumab alone that occurred before the onset of apoptosis. |
2003-01-13 |
2023-08-12 |
Not clear |