| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Devin S Gary, Mark P Mattso. PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. Neuromolecular medicine. vol 2. issue 3. 2003-05-09. PMID:12622404. |
pten regulates akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. |
2003-05-09 |
2023-08-12 |
mouse |
| Devin S Gary, Mark P Mattso. PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. Neuromolecular medicine. vol 2. issue 3. 2003-05-09. PMID:12622404. |
the tumor suppressor phosphatase pten can promote apoptosis of mitotic cells by inhibiting activation of the cell survival kinase akt. |
2003-05-09 |
2023-08-12 |
mouse |
| Jennifer K Ness, Nina E Mitchell, Teresa L Woo. IGF-I and NT-3 signaling pathways in developing oligodendrocytes: differential regulation and activation of receptors and the downstream effector Akt. Developmental neuroscience. vol 24. issue 5. 2003-05-08. PMID:12666655. |
in contrast, even submaximal igf-i concentrations maintain long-term akt activation and prevent glutamate-mediated apoptosis in pro-ols. |
2003-05-08 |
2023-08-12 |
Not clear |
| John W Davis, Andrew D Burdick, Fredine T Lauer, Scott W Burchie. The aryl hydrocarbon receptor antagonist, 3'methoxy-4'nitroflavone, attenuates 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of growth factor signaling and apoptosis in the MCF-10A cell line. Toxicology and applied pharmacology. vol 188. issue 1. 2003-05-07. PMID:12668121. |
in addition, mnf attenuated tcdd's ability to inhibit apoptosis and to activate akt and erk1,2, two egfr-dependent signaling molecules. |
2003-05-07 |
2023-08-12 |
human |
| John W Davis, Andrew D Burdick, Fredine T Lauer, Scott W Burchie. The aryl hydrocarbon receptor antagonist, 3'methoxy-4'nitroflavone, attenuates 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of growth factor signaling and apoptosis in the MCF-10A cell line. Toxicology and applied pharmacology. vol 188. issue 1. 2003-05-07. PMID:12668121. |
mnf's effects on tcdd action in the mcf-10a cell line occurred at concentrations ranging from 1 nm for akt phosphorylation and tgfalpha expression to 100 nm for inhibition of apoptosis. |
2003-05-07 |
2023-08-12 |
human |
| Hadassah Sade, Apurva Sari. IL-7 inhibits dexamethasone-induced apoptosis via Akt/PKB in mature, peripheral T cells. European journal of immunology. vol 33. issue 4. 2003-05-07. PMID:12672057. |
the anti-apoptotic role of akt suggested by these experiments was tested by overexpression of constitutively active akt, which blocked dexamethasone-induced apoptosis and elevated iap-2 but not bcl-x(l) levels in a mature t cell line. |
2003-05-07 |
2023-08-12 |
mouse |
| Hadassah Sade, Apurva Sari. IL-7 inhibits dexamethasone-induced apoptosis via Akt/PKB in mature, peripheral T cells. European journal of immunology. vol 33. issue 4. 2003-05-07. PMID:12672057. |
thus, il-7 regulates iap-2 expression and inhibits dexamethasone-induced apoptosis by activating akt via pi3k-dependent signaling, but regulates bcl-x(l)expression via a pi3k-independent pathway in mature t cells. |
2003-05-07 |
2023-08-12 |
mouse |
| Yiwei Li, Xingli Li, Fazlul H Sarka. Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis. The Journal of nutrition. vol 133. issue 4. 2003-04-30. PMID:12672912. |
studies from our laboratory and others have shown that indole-3-carbinol (i3c) and its in vivo dimeric product, 3,3'-diindolylmethane (dim), inhibit the growth of pc3 prostate cancer cells and induce apoptosis by inhibiting nuclear factor (nf)-kappab and akt pathways. |
2003-04-30 |
2023-08-12 |
human |
| Geoffrey W Krystal, Geoffrey Sulanke, Julie Lit. Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy. Molecular cancer therapeutics. vol 1. issue 11. 2003-04-15. PMID:12481412. |
expression of ca akt by itself also induced resistance to etoposide-mediated apoptosis. |
2003-04-15 |
2023-08-12 |
Not clear |
| Junichi Asakuma, Makoto Sumitomo, Takako Asano, Tomohiko Asano, Masamichi Hayakaw. Selective Akt inactivation and tumor necrosis actor-related apoptosis-inducing ligand sensitization of renal cancer cells by low concentrations of paclitaxel. Cancer research. vol 63. issue 6. 2003-04-11. PMID:12649200. |
in the present study, we investigated the role of akt in the apoptosis resistance to trail and chemotherapeutic agents-induced trail sensitization in human renal cell carcinoma cells. |
2003-04-11 |
2023-08-12 |
human |
| Junichi Asakuma, Makoto Sumitomo, Takako Asano, Tomohiko Asano, Masamichi Hayakaw. Selective Akt inactivation and tumor necrosis actor-related apoptosis-inducing ligand sensitization of renal cancer cells by low concentrations of paclitaxel. Cancer research. vol 63. issue 6. 2003-04-11. PMID:12649200. |
apoptosis assays and western blot analyses revealed that apoptosis resistance to trail correlates well with the level of akt phosphorylation at ser 473 rather than protein expression levels of trail receptors, dr4 and dr5. |
2003-04-11 |
2023-08-12 |
human |
| Junichi Asakuma, Makoto Sumitomo, Takako Asano, Tomohiko Asano, Masamichi Hayakaw. Selective Akt inactivation and tumor necrosis actor-related apoptosis-inducing ligand sensitization of renal cancer cells by low concentrations of paclitaxel. Cancer research. vol 63. issue 6. 2003-04-11. PMID:12649200. |
the apoptosis sensitivity to trail in trail-resistant skrc-49 and trail-sensitive caki-1 cells was altered by modulation of akt activity, which increased the protein expression of cellular fadd-like il-1beta-converting enzyme-like inhibitory protein (cflip). |
2003-04-11 |
2023-08-12 |
human |
| Junichi Asakuma, Makoto Sumitomo, Takako Asano, Tomohiko Asano, Masamichi Hayakaw. Selective Akt inactivation and tumor necrosis actor-related apoptosis-inducing ligand sensitization of renal cancer cells by low concentrations of paclitaxel. Cancer research. vol 63. issue 6. 2003-04-11. PMID:12649200. |
paclitaxel (5 and 100 nm) and cisplatin (10 microm) but not etoposide (1 and 10 microm) promoted trail-induced apoptosis in skrc-49 cells, which was not mediated by increased trail receptor expression but by chemotherapeutic agents-induced akt inactivation through ceramide formation derived from sphingomyelin hydrolysis. |
2003-04-11 |
2023-08-12 |
human |
| Simona Cicconi, Natascia Ventura, Donatella Pastore, Paolo Bonini, Paolo Di Nardo, Renato Lauro, Lionel N J L Marlie. Characterization of apoptosis signal transduction pathways in HL-5 cardiomyocytes exposed to ischemia/reperfusion oxidative stress model. Journal of cellular physiology. vol 195. issue 1. 2003-04-02. PMID:12599206. |
we investigated the effects of serum/glucose depletion combined or not to ros exposure on akt and map kinases activation to address the role of each event with respect to apoptosis. |
2003-04-02 |
2023-08-12 |
Not clear |
| Yun-Jung Choi, Jong-Wook Park, Seong-Il Suh, Kyo Cheol Mun, Jae Hoon Bae, Dae-Kyu Song, Sang-Pyo Kim, Taeg Kyu Kwo. Arsenic trioxide-induced apoptosis in U937 cells involve generation of reactive oxygen species and inhibition of Akt. International journal of oncology. vol 21. issue 3. 2003-03-24. PMID:12168106. |
arsenic trioxide-induced apoptosis in u937 cells involve generation of reactive oxygen species and inhibition of akt. |
2003-03-24 |
2023-08-12 |
Not clear |
| Yun-Jung Choi, Jong-Wook Park, Seong-Il Suh, Kyo Cheol Mun, Jae Hoon Bae, Dae-Kyu Song, Sang-Pyo Kim, Taeg Kyu Kwo. Arsenic trioxide-induced apoptosis in U937 cells involve generation of reactive oxygen species and inhibition of Akt. International journal of oncology. vol 21. issue 3. 2003-03-24. PMID:12168106. |
this activation of apoptosis is accompanied by release of cytochrome c, down-regulation of ciap1, and inactivation of akt. |
2003-03-24 |
2023-08-12 |
Not clear |
| Yun-Jung Choi, Jong-Wook Park, Seong-Il Suh, Kyo Cheol Mun, Jae Hoon Bae, Dae-Kyu Song, Sang-Pyo Kim, Taeg Kyu Kwo. Arsenic trioxide-induced apoptosis in U937 cells involve generation of reactive oxygen species and inhibition of Akt. International journal of oncology. vol 21. issue 3. 2003-03-24. PMID:12168106. |
bcl-2 overexpression attenuates arsenic trioxide-induced apoptosis in u937 cells by inhibition of caspase 3 activity, but not inhibition of akt. |
2003-03-24 |
2023-08-12 |
Not clear |
| Subham Basu, Nicholas F Totty, Meredith S Irwin, Marius Sudol, Julian Downwar. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Molecular cell. vol 11. issue 1. 2003-03-18. PMID:12535517. |
akt phosphorylates the yes-associated protein, yap, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. |
2003-03-18 |
2023-08-12 |
Not clear |
| Subham Basu, Nicholas F Totty, Meredith S Irwin, Marius Sudol, Julian Downwar. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Molecular cell. vol 11. issue 1. 2003-03-18. PMID:12535517. |
yap overexpression increases, while yap depletion decreases, p73-mediated apoptosis following dna damage, in an akt inhibitable manner. |
2003-03-18 |
2023-08-12 |
Not clear |
| Kuntebommanahalli N Thimmaiah, John Easton, Shile Huang, Karen A Veverka, Glen S Germain, Franklin C Harwood, Peter J Houghto. Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways. Cancer research. vol 63. issue 2. 2003-03-13. PMID:12543789. |
to determine the role of the pi3k-akt pathway in rescuing cells from apoptosis caused by rapamycin, cells expressing dominant-negative akt were tested. |
2003-03-13 |
2023-08-12 |
human |