| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dylan T Jones, Kanagasabai Ganeshaguru, Robert J Anderson, Trevor R Jackson, K Richard Bruckdorfer, Sylvia Y Low, Lars Palmqvist, H Grant Prentice, A Victor Hoffbrand, Atul B Mehta, R Gitendra Wickremasingh. Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis. Blood. vol 101. issue 8. 2003-06-18. PMID:12480711. |
albumin activates the akt signaling pathway and protects b-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis. |
2003-06-18 |
2023-08-12 |
human |
| Dylan T Jones, Kanagasabai Ganeshaguru, Robert J Anderson, Trevor R Jackson, K Richard Bruckdorfer, Sylvia Y Low, Lars Palmqvist, H Grant Prentice, A Victor Hoffbrand, Atul B Mehta, R Gitendra Wickremasingh. Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis. Blood. vol 101. issue 8. 2003-06-18. PMID:12480711. |
we previously showed that human plasma activated akt and potently blocked the ability of chlorambucil or gamma radiation to induce apoptosis of b-chronic lymphocytic leukemia (cll) cells. |
2003-06-18 |
2023-08-12 |
human |
| Dylan T Jones, Kanagasabai Ganeshaguru, Robert J Anderson, Trevor R Jackson, K Richard Bruckdorfer, Sylvia Y Low, Lars Palmqvist, H Grant Prentice, A Victor Hoffbrand, Atul B Mehta, R Gitendra Wickremasingh. Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis. Blood. vol 101. issue 8. 2003-06-18. PMID:12480711. |
intact plasma depleted of albumin by chromatography on cibacron blue-sepharose or plasma from a subject with analbuminemia failed either to activate akt or to protect cll cells from chlorambucil-induced apoptosis. |
2003-06-18 |
2023-08-12 |
human |
| Dylan T Jones, Kanagasabai Ganeshaguru, Robert J Anderson, Trevor R Jackson, K Richard Bruckdorfer, Sylvia Y Low, Lars Palmqvist, H Grant Prentice, A Victor Hoffbrand, Atul B Mehta, R Gitendra Wickremasingh. Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis. Blood. vol 101. issue 8. 2003-06-18. PMID:12480711. |
the data suggest that activation of akt consequent to binding of albumin by cll cells blocks chlorambucil- and radiation-induced apoptosis. |
2003-06-18 |
2023-08-12 |
human |
| David B Solit, Andrea D Basso, Adam B Olshen, Howard I Scher, Neal Rose. Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol. Cancer research. vol 63. issue 9. 2003-06-16. PMID:12727831. |
transfection of membrane-bound p110 pi3k prevented 17-aag inactivation of akt and abrogated the enhancement of taxol-induced apoptosis caused by the drug. |
2003-06-16 |
2023-08-12 |
mouse |
| Shi Dong-Yun, Deng Yu-Ru, Liu Shan-Lin, Zhang Ya-Dong, Wei Lia. Redox stress regulates cell proliferation and apoptosis of human hepatoma through Akt protein phosphorylation. FEBS letters. vol 542. issue 1-3. 2003-06-16. PMID:12729898. |
redox stress regulates cell proliferation and apoptosis of human hepatoma through akt protein phosphorylation. |
2003-06-16 |
2023-08-12 |
human |
| Shi Dong-Yun, Deng Yu-Ru, Liu Shan-Lin, Zhang Ya-Dong, Wei Lia. Redox stress regulates cell proliferation and apoptosis of human hepatoma through Akt protein phosphorylation. FEBS letters. vol 542. issue 1-3. 2003-06-16. PMID:12729898. |
our results indicate that hepatoma cell growth is ros-dependent, and fluctuation of the intracellular redox state may regulate hepatoma cell growth through akt phosphorylation and the pi3k/akt pathway, resulting in a broad array of responses from cellular proliferation to apoptosis. |
2003-06-16 |
2023-08-12 |
human |
| Christiane Knuefermann, Yang Lu, Bolin Liu, Weidong Jin, Ke Liang, Ling Wu, Mathias Schmidt, Gordon B Mills, John Mendelsohn, Zhen Fa. HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells. Oncogene. vol 22. issue 21. 2003-06-16. PMID:12761490. |
selective inhibition of pi-3k or akt activity with their respective dominant-negative expression vectors sensitized the cells to the induction of apoptosis by the chemotherapeutic agents. |
2003-06-16 |
2023-08-12 |
human |
| Alexander Arlt, Andre Gehrz, Susanne Müerköster, Jens Vorndamm, Marie-Luise Kruse, Ulrich R Fölsch, Heiner Schäfe. Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene. vol 22. issue 21. 2003-06-16. PMID:12761494. |
neither did the basal akt activity correlate with the sensitivity towards gemcitabine treatment, nor did the inhibition of pi3k/akt by ly294002 alter gemcitabine-induced apoptosis. |
2003-06-16 |
2023-08-12 |
Not clear |
| Bogdan A Stoica, Vilen A Movsesyan, Paul M Lea, Alan I Fade. Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway. Molecular and cellular neurosciences. vol 22. issue 3. 2003-05-30. PMID:12691738. |
ceramide-induced neuronal apoptosis is associated with dephosphorylation of akt, bad, fkhr, gsk-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway. |
2003-05-30 |
2023-08-12 |
Not clear |
| Marijke Kamsteeg, Thomas Rutherford, Eva Sapi, Bozena Hanczaruk, Shoreh Shahabi, Maryann Flick, David Brown, Gil Mo. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. vol 22. issue 17. 2003-05-28. PMID:12730675. |
this effect is dependent upon the activation of the caspase system, inhibiting xiap, an inhibitor of apoptosis, and disrupting flice inhibitory protein (flip) expression through the akt signal transduction pathway. |
2003-05-28 |
2023-08-12 |
Not clear |
| John G Shelton, Linda S Steelman, John T Lee, Steven L Knapp, William L Blalock, Phillip W Moye, Richard A Franklin, Steven C Pohnert, Amer M Mirza, Martin McMahon, James A McCubre. Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells. Oncogene. vol 22. issue 16. 2003-05-23. PMID:12717425. |
the individual effects of activated raf and akt on proliferation, apoptosis and autocrine growth factor synthesis were further examined with hormone-inducible constructs (delta raf-1:ar and delta akt:er*(myr(+)). |
2003-05-23 |
2023-08-12 |
Not clear |
| F Chang, J T Lee, P M Navolanic, L S Steelman, J G Shelton, W L Blalock, R A Franklin, J A McCubre. Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia. vol 17. issue 3. 2003-05-16. PMID:12646949. |
initial studies implicated both pi3k and akt in prevention of apoptosis. |
2003-05-16 |
2023-08-12 |
Not clear |
| Chunrong Yu, Mohamed Rahmani, Yun Dai, Daniel Conrad, Geoffrey Krystal, Paul Dent, Steven Gran. The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer research. vol 63. issue 8. 2003-05-16. PMID:12702569. |
inducible expression of constitutively active (myristolated) akt significantly, albeit partially, attenuated apoptosis in jurkat leukemia cells treated with either fp alone or the combination of fp and ly. |
2003-05-16 |
2023-08-12 |
human |
| Srinivasa Subramaniam, Jens Strelau, Klaus Unsicke. Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways. The Journal of biological chemistry. vol 278. issue 11. 2003-05-14. PMID:12514175. |
together, our data suggest that gdf-15 prevents apoptosis in cgn by activating akt and inhibiting endogenously active erk. |
2003-05-14 |
2023-08-12 |
Not clear |
| Olle Stål, Gizeh Pérez-Tenorio, Linda Akerberg, Birgit Olsson, Bo Nordenskjöld, Lambert Skoog, Lars Erik Rutqvis. Akt kinases in breast cancer and the results of adjuvant therapy. Breast cancer research : BCR. vol 5. issue 2. 2003-05-13. PMID:12631397. |
the serine/threonine kinase akt, or protein kinase b, has recently been a focus of interest because of its activity to inhibit apoptosis. |
2003-05-13 |
2023-08-12 |
Not clear |
| Victor M Bondar, Bridget Sweeney-Gotsch, Michael Andreeff, Gordon B Mills, David J McConke. Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Molecular cancer therapeutics. vol 1. issue 12. 2003-05-12. PMID:12481421. |
exposure of the cells to two structurally distinct inhibitors of pi3k (worthmannin and ly294002) resulted in a dose-dependent induction of apoptosis in six of seven of the cell lines that displayed constitutive akt phosphorylation but not in either of the cell lines that did not. |
2003-05-12 |
2023-08-12 |
human |
| Victor M Bondar, Bridget Sweeney-Gotsch, Michael Andreeff, Gordon B Mills, David J McConke. Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Molecular cancer therapeutics. vol 1. issue 12. 2003-05-12. PMID:12481421. |
exposure of orthotopic l3.6pl pancreatic tumors to ly294002 resulted in dose-dependent inhibition of tumor growth, and decreased peritoneal and liver metastases, effects that were associated with an inhibition of akt phosphorylation and increased terminal deoxynucleotidyl transferase-mediated nick end labeling staining characteristic of apoptosis. |
2003-05-12 |
2023-08-12 |
human |
| b' Cheng Jiang, Zaisen Wang, Howard Ganther, Junxuan L\\xc3\\xb. Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells. Molecular cancer therapeutics. vol 1. issue 12. 2003-05-12. PMID:12481429.' |
immunobiot analyses indicated that g1 arrest induced by the subapoptogenic doses of msea was associated with increased expression of p27kip1 and p21cip1, but apoptosis was accompanied by dose-dependent decreases of phosphorylation of protein kinase akt and extracellular signal-regulated kinase (erk1/2) in the absence of any phosphorylation change in p38 mitogen-activated protein kinase (p38mapk) and c-jun nh2-terminal kinase (jnk1/2). |
2003-05-12 |
2023-08-12 |
human |
| b' Cheng Jiang, Zaisen Wang, Howard Ganther, Junxuan L\\xc3\\xb. Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells. Molecular cancer therapeutics. vol 1. issue 12. 2003-05-12. PMID:12481429.' |
taken together, exposure of du145 cells to msea versus selenite induced differential patterns of cell cycle arrest and apoptosis execution as well as distinct patterns of effects on akt, erk1/2, jnk1/2, and p38mapk phosphorylation and p27kip1 and p21cip1 expression. |
2003-05-12 |
2023-08-12 |
human |