| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brent D Butts, Kevin A Kwei, G Tim Bowden, Margaret M Brieh. Elevated basal reactive oxygen species and phospho-Akt in murine keratinocytes resistant to ultraviolet B-induced apoptosis. Molecular carcinogenesis. vol 37. issue 3. 2003-09-03. PMID:12884366. |
the akt kinase is a known upstream regulator of apoptosis in many cell types and has been shown to be activated by increased reactive oxygen species (ros). |
2003-09-03 |
2023-08-12 |
mouse |
| Brent D Butts, Kevin A Kwei, G Tim Bowden, Margaret M Brieh. Elevated basal reactive oxygen species and phospho-Akt in murine keratinocytes resistant to ultraviolet B-induced apoptosis. Molecular carcinogenesis. vol 37. issue 3. 2003-09-03. PMID:12884366. |
modulation of ros in 6m90 and 6r90 cells by catalase overexpression or antioxidant treatment resulted in decreased levels of akt phosphorylation and subsequent loss of resistance to uvb-induced apoptosis. |
2003-09-03 |
2023-08-12 |
mouse |
| Brent D Butts, Kevin A Kwei, G Tim Bowden, Margaret M Brieh. Elevated basal reactive oxygen species and phospho-Akt in murine keratinocytes resistant to ultraviolet B-induced apoptosis. Molecular carcinogenesis. vol 37. issue 3. 2003-09-03. PMID:12884366. |
conversely, treatment of 308 cells with hydrogen peroxide caused increases in akt phosphorylation and increased apoptosis resistance. |
2003-09-03 |
2023-08-12 |
mouse |
| Brent D Butts, Kevin A Kwei, G Tim Bowden, Margaret M Brieh. Elevated basal reactive oxygen species and phospho-Akt in murine keratinocytes resistant to ultraviolet B-induced apoptosis. Molecular carcinogenesis. vol 37. issue 3. 2003-09-03. PMID:12884366. |
these results indicate that the chronically elevated ros often observed in tumors may contribute to a malignant phenotype by keeping akt in a phosphorylated state, resulting in increased apoptosis resistance. |
2003-09-03 |
2023-08-12 |
mouse |
| B N Fahy, M Schlieman, S Virudachalam, R J Bol. AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2. British journal of cancer. vol 89. issue 2. 2003-08-29. PMID:12865934. |
the antiapoptotic effect of akt activation in pancreatic cancer cells may involve transcriptional induction of a profile of bcl-2 proteins that confer resistance to apoptosis; alteration of this balance allows sensitisation to the apoptotic effect of chemotherapy. |
2003-08-29 |
2023-08-12 |
Not clear |
| Goutam Ghosh Choudhury, Mahimainathan Lenin, Cheresa Calhaun, Jian-Hua Zhang, Hanna E Abbou. PDGF inactivates forkhead family transcription factor by activation of Akt in glomerular mesangial cells. Cellular signalling. vol 15. issue 2. 2003-08-28. PMID:12464387. |
in contrast, inhibition of pi 3 kinase and dominant negative akt increased fasl gene transcription, suggesting that suppression of pi 3 kinase/akt signalling may induce apoptosis in mesangial cells via upregulation of fasl expression. |
2003-08-28 |
2023-08-12 |
Not clear |
| Goutam Ghosh Choudhury, Mahimainathan Lenin, Cheresa Calhaun, Jian-Hua Zhang, Hanna E Abbou. PDGF inactivates forkhead family transcription factor by activation of Akt in glomerular mesangial cells. Cellular signalling. vol 15. issue 2. 2003-08-28. PMID:12464387. |
however, expression of dominant negative akt by adenovirus did not induce apoptosis in mesangial cells, suggesting that akt-independent antiapoptotic mechanisms also exist. |
2003-08-28 |
2023-08-12 |
Not clear |
| Goutam Ghosh Choudhury, Mahimainathan Lenin, Cheresa Calhaun, Jian-Hua Zhang, Hanna E Abbou. PDGF inactivates forkhead family transcription factor by activation of Akt in glomerular mesangial cells. Cellular signalling. vol 15. issue 2. 2003-08-28. PMID:12464387. |
together, our data demonstrate for the first time that pdgf inactivates forkhead domain transcription factor by akt-dependent phosphorylation and that suppression of akt signalling is not sufficient to induce apoptosis in mesangial cells. |
2003-08-28 |
2023-08-12 |
Not clear |
| Madhavi J Rane, Yong Pan, Saurabh Singh, David W Powell, Rui Wu, Timothy Cummins, Qingdan Chen, Kenneth R McLeish, Jon B Klei. Heat shock protein 27 controls apoptosis by regulating Akt activation. The Journal of biological chemistry. vol 278. issue 30. 2003-08-26. PMID:12740362. |
heat shock protein 27 controls apoptosis by regulating akt activation. |
2003-08-26 |
2023-08-12 |
Not clear |
| Madhavi J Rane, Yong Pan, Saurabh Singh, David W Powell, Rui Wu, Timothy Cummins, Qingdan Chen, Kenneth R McLeish, Jon B Klei. Heat shock protein 27 controls apoptosis by regulating Akt activation. The Journal of biological chemistry. vol 278. issue 30. 2003-08-26. PMID:12740362. |
activation of the serine-threonine kinase akt by cytokines, chemokines, and bacterial products delays constitutive neutrophil apoptosis, resulting in a prolonged inflammatory response. |
2003-08-26 |
2023-08-12 |
Not clear |
| Madhavi J Rane, Yong Pan, Saurabh Singh, David W Powell, Rui Wu, Timothy Cummins, Qingdan Chen, Kenneth R McLeish, Jon B Klei. Heat shock protein 27 controls apoptosis by regulating Akt activation. The Journal of biological chemistry. vol 278. issue 30. 2003-08-26. PMID:12740362. |
constitutive neutrophil apoptosis was accelerated by sequestration of hsp27 from akt, and this enhanced rate of apoptosis was reversed by introduction of constitutively active recombinant akt. |
2003-08-26 |
2023-08-12 |
Not clear |
| Madhavi J Rane, Yong Pan, Saurabh Singh, David W Powell, Rui Wu, Timothy Cummins, Qingdan Chen, Kenneth R McLeish, Jon B Klei. Heat shock protein 27 controls apoptosis by regulating Akt activation. The Journal of biological chemistry. vol 278. issue 30. 2003-08-26. PMID:12740362. |
our results define a new mechanism by which hsp27 regulates apoptosis, through control of akt activity. |
2003-08-26 |
2023-08-12 |
Not clear |
| Faina Kuperstein, Ephraim Yavi. Pro-apoptotic signaling in neuronal cells following iron and amyloid beta peptide neurotoxicity. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807431. |
gf, a pkc inhibitor or wortmannin, a blocker of the akt pathway enhanced abeta/fe2+-induced toxicity, while sb, a p38 mapk inhibitor, prevented cell damage and apoptosis. |
2003-08-26 |
2023-08-12 |
Not clear |
| Daniela Milani, Giorgio Zauli, Erika Rimondi, Claudio Celeghini, Sandra Marmiroli, Paola Narducci, Silvano Capitani, Paola Secchier. Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and pro-apoptotic pathways in SK-N-MC neuronal cells. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807432. |
remarkably, caspase-dependent cleavage of nf-kappab family members as well as of akt and creb proteins, but not of erk, became prominent at 24 h, a time point coincident with the peak of caspase-dependent apoptosis. |
2003-08-26 |
2023-08-12 |
Not clear |
| Ju-Hyung Woo, Young-Ho Kim, Yun-Jung Choi, Dae-Gon Kim, Kyung-Seop Lee, Jae Hoon Bae, Do Sik Min, Jong-Soo Chang, Yong-Jin Jeong, Young Han Lee, Jong-Wook Park, Taeg Kyu Kwo. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis. vol 24. issue 7. 2003-08-22. PMID:12807727. |
molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of bcl-xl and iap, the release of cytochrome c and inhibition of akt. |
2003-08-22 |
2023-08-12 |
human |
| Ju-Hyung Woo, Young-Ho Kim, Yun-Jung Choi, Dae-Gon Kim, Kyung-Seop Lee, Jae Hoon Bae, Do Sik Min, Jong-Soo Chang, Yong-Jin Jeong, Young Han Lee, Jong-Wook Park, Taeg Kyu Kwo. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis. vol 24. issue 7. 2003-08-22. PMID:12807727. |
curcumin causes dose-dependent apoptosis and dna fragmentation of caki cells, which is preceded by the sequential dephosphorylation of akt, down-regulation of the anti-apoptotic bcl-2, bcl-xl and iap proteins, release of cytochrome c and activation of caspase 3. |
2003-08-22 |
2023-08-12 |
human |
| Abdelkarim Sabri, Sasha G Alcott, Hasnae Elouardighi, Elena Pak, Claudia Derian, Patricia Andrade-Gordon, Kathleen Kinnally, Susan F Steinber. Neutrophil cathepsin G promotes detachment-induced cardiomyocyte apoptosis via a protease-activated receptor-independent mechanism. The Journal of biological chemistry. vol 278. issue 26. 2003-08-20. PMID:12707281. |
of note, prolonged incubation of cardiomyocytes with cathepsin g results in the activation of caspase-3, cleavage of fak and akt, sarcomeric disassembly, cell rounding, cell detachment from underlying matrix, and morphologic features of apoptosis. |
2003-08-20 |
2023-08-12 |
mouse |
| Haruko Shimamura, Yoshio Terada, Tomokazu Okado, Hiroyuki Tanaka, Seiji Inoshita, Sei Sasak. The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad. Journal of the American Society of Nephrology : JASN. vol 14. issue 6. 2003-08-20. PMID:12761242. |
the pi3 kinase inhibitors and dominant-negative mutant of akt increased the apoptotic signals in the presence of platelet-derived growth factor (pdgf), while the dominant-active mutant of akt prevented apoptosis induced by a serum-free medium. |
2003-08-20 |
2023-08-12 |
rat |
| Ramadevi Nimmanapalli, Erica O'Bryan, Deborah Kuhn, Hirohito Yamaguchi, Hong-Gang Wang, Kapil N Bhall. Regulation of 17-AAG-induced apoptosis: role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated down-regulation of Akt, Raf-1, and Src kinases. Blood. vol 102. issue 1. 2003-08-19. PMID:12623837. |
regulation of 17-aag-induced apoptosis: role of bcl-2, bcl-xl, and bax downstream of 17-aag-mediated down-regulation of akt, raf-1, and src kinases. |
2003-08-19 |
2023-08-12 |
human |
| Danica Ramljak, Christine M Coticchia, Tagvor G Nishanian, Motoyasu Saji, Matthew D Ringel, Suzanne D Conzen, Robert B Dickso. Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells. Experimental cell research. vol 287. issue 2. 2003-08-15. PMID:12837294. |
epidermal growth factor inhibition of c-myc-mediated apoptosis through akt and erk involves bcl-xl upregulation in mammary epithelial cells. |
2003-08-15 |
2023-08-12 |
mouse |