| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danica Ramljak, Christine M Coticchia, Tagvor G Nishanian, Motoyasu Saji, Matthew D Ringel, Suzanne D Conzen, Robert B Dickso. Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells. Experimental cell research. vol 287. issue 2. 2003-08-15. PMID:12837294. |
blockade of egfr kinase activity and the pi3-k/akt and mek/erk pathways with pharmacological inhibitors resulted in a significant induction of cellular apoptosis, paralleled by a downregulation of both akt and erk1/2 proteins. |
2003-08-15 |
2023-08-12 |
mouse |
| Danica Ramljak, Christine M Coticchia, Tagvor G Nishanian, Motoyasu Saji, Matthew D Ringel, Suzanne D Conzen, Robert B Dickso. Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells. Experimental cell research. vol 287. issue 2. 2003-08-15. PMID:12837294. |
consistent with a survival-promoting role of akt, we observed that constitutively activated akt (myr-akt) inhibited apoptosis of pro-apoptotic, c-myc-overexpressing cells following the inhibition of egfr tyrosine kinase activity. |
2003-08-15 |
2023-08-12 |
mouse |
| Chih-Cheng Yang, Ho-Pi Lin, Chang-Shi Chen, Ya-Ting Yang, Ping-Hui Tseng, Vivek M Rangnekar, Ching-Shih Che. Bcl-xL mediates a survival mechanism independent of the phosphoinositide 3-kinase/Akt pathway in prostate cancer cells. The Journal of biological chemistry. vol 278. issue 28. 2003-08-14. PMID:12738789. |
whereas both cell lines are equally susceptible to ly294002-mediated akt dephosphorylation, only lncap cells default to apoptosis, as evidenced by dna fragmentation and cytochrome c release. |
2003-08-14 |
2023-08-12 |
Not clear |
| Jeong-Ok Hah, Kyung-Ah Lee, Yun Jung Choi, Won-Duck Kim, Jong-Wook Park, Taeg Kyu Kwo. Inactive caspase 3 activates Akt in human leukemia cells susceptible or resistant to apoptosis induced by phorbol ester. International journal of oncology. vol 22. issue 5. 2003-08-11. PMID:12684678. |
inactive caspase 3 activates akt in human leukemia cells susceptible or resistant to apoptosis induced by phorbol ester. |
2003-08-11 |
2023-08-12 |
human |
| Jeong-Ok Hah, Kyung-Ah Lee, Yun Jung Choi, Won-Duck Kim, Jong-Wook Park, Taeg Kyu Kwo. Inactive caspase 3 activates Akt in human leukemia cells susceptible or resistant to apoptosis induced by phorbol ester. International journal of oncology. vol 22. issue 5. 2003-08-11. PMID:12684678. |
r-u937 cells exhibited less cytochrome c release and sustained phosphorylation level of akt during pma-induced apoptosis. |
2003-08-11 |
2023-08-12 |
human |
| Saya Nakagomi, Yasuhiro Suzuki, Kazuhiko Namikawa, Sumiko Kiryu-Seo, Hiroshi Kiyam. Expression of the activating transcription factor 3 prevents c-Jun N-terminal kinase-induced neuronal death by promoting heat shock protein 27 expression and Akt activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832543. |
overexpression of atf3 by adenovirus inhibits the mitogen-activated kinase kinase kinase 1 (mekk1)-c-jun n-terminal kinase (jnk)-induced apoptosis and induces neurite elongation via akt activation in pc12 cells and superior nerve ganglion neurons. |
2003-08-05 |
2023-08-12 |
Not clear |
| Saya Nakagomi, Yasuhiro Suzuki, Kazuhiko Namikawa, Sumiko Kiryu-Seo, Hiroshi Kiyam. Expression of the activating transcription factor 3 prevents c-Jun N-terminal kinase-induced neuronal death by promoting heat shock protein 27 expression and Akt activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832543. |
hsp27 expression significantly inhibits jnk-induced apoptosis as well as akt activation in pc12 cells and superior cervical ganglion neurons. |
2003-08-05 |
2023-08-12 |
Not clear |
| Saya Nakagomi, Yasuhiro Suzuki, Kazuhiko Namikawa, Sumiko Kiryu-Seo, Hiroshi Kiyam. Expression of the activating transcription factor 3 prevents c-Jun N-terminal kinase-induced neuronal death by promoting heat shock protein 27 expression and Akt activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832543. |
we conclude that the combination of atf3 and c-jun induces the anti-apoptotic factor hsp27, which directly or indirectly activates akt, and thereby possibly inhibits apoptosis and induces nerve elongation. |
2003-08-05 |
2023-08-12 |
Not clear |
| Yosuke Osawa, Masahito Nagaki, Yoshiko Banno, David A Brenner, Yoshinori Nozawa, Hisataka Moriwaki, Shigeru Nakashim. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 8. 2003-07-31. PMID:12682234. |
expression of the nf-kappa b target gene x-ray-inducible immediate early response factor-1 short enhances tnf-alpha-induced hepatocyte apoptosis by inhibiting akt activation. |
2003-07-31 |
2023-08-12 |
human |
| William Tatton, David Chen, Ruth Chalmers-Redman, Larry Wheeler, Ralph Nixon, Nadine Tatto. Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation. Survey of ophthalmology. vol 48 Suppl 1. 2003-07-24. PMID:12852432. |
activation of alpha-2 adrenergic receptors reduces neuronal apoptosis, in part through a protein kinase b (akt)-dependent signaling pathway. |
2003-07-24 |
2023-08-12 |
Not clear |
| Alessandra Trencia, Anna Perfetti, Angela Cassese, Giovanni Vigliotta, Claudia Miele, Francesco Oriente, Stefania Santopietro, Ferdinando Giacco, Gerolama Condorelli, Pietro Formisano, Francesco Beguino. Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action. Molecular and cellular biology. vol 23. issue 13. 2003-07-22. PMID:12808093. |
in the u373mg glioma cells, blocking akt also reduced ped/pea-15 levels and induced sensitivity to tumor necrosis factor-related apoptosis-inducing ligand apoptosis. |
2003-07-22 |
2023-08-12 |
Not clear |
| Sang-Oh Yoon, Chang-Hyun Yun, An-Sik Chun. Dose effect of oxidative stress on signal transduction in aging. Mechanisms of ageing and development. vol 123. issue 12. 2003-07-21. PMID:12470897. |
antioxidants such as selenium block apoptosis induced by ros through blocking apoptotic signal ask1 and stimulating survival signal akt activity. |
2003-07-21 |
2023-08-12 |
Not clear |
| Sang-Oh Yoon, Chang-Hyun Yun, An-Sik Chun. Dose effect of oxidative stress on signal transduction in aging. Mechanisms of ageing and development. vol 123. issue 12. 2003-07-21. PMID:12470897. |
old hepatocytes are more susceptible to ros-induced apoptosis than young hepatocytes, which is associated with low expression of erk and akt kinases. |
2003-07-21 |
2023-08-12 |
Not clear |
| Lisa A Madge, Jie-Hui Li, Jaehyuk Choi, Jordan S Pobe. Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis. The Journal of biological chemistry. vol 278. issue 23. 2003-07-18. PMID:12663669. |
inhibition of phosphatidylinositol 3-kinase (pi3k) by ly294002, but not inhibition of akt by dominant-negative mutation, also sensitizes ec to cytokine-initiated apoptosis. |
2003-07-18 |
2023-08-12 |
human |
| Zhongjian Jiang, Yun Zhang, Xiao Qian Chen, Philip Yeung Lam, Hui Yang, Qunyuan Xu, Albert Cheung Hoi Y. Apoptosis and activation of Erkl/2 and Akt in astrocytes postischemia. Neurochemical research. vol 28. issue 6. 2003-07-08. PMID:12718435. |
apoptosis and activation of erkl/2 and akt in astrocytes postischemia. |
2003-07-08 |
2023-08-12 |
Not clear |
| Zhongjian Jiang, Yun Zhang, Xiao Qian Chen, Philip Yeung Lam, Hui Yang, Qunyuan Xu, Albert Cheung Hoi Y. Apoptosis and activation of Erkl/2 and Akt in astrocytes postischemia. Neurochemical research. vol 28. issue 6. 2003-07-08. PMID:12718435. |
we also measured the changes of phosphorylated erk1/2 (p-erk1/2) and phosphorylated akt (p-akt) in order to determine whether these two pathways play a role in apoptosis. |
2003-07-08 |
2023-08-12 |
Not clear |
| Fazlul H Sarkar, Yiwei L. Mechanisms of cancer chemoprevention by soy isoflavone genistein. Cancer metastasis reviews. vol 21. issue 3-4. 2003-07-07. PMID:12549765. |
it has been found that genistein inhibits the activation of the nuclear transcription factor, nf-kappab and akt signaling pathway, both of which are known to maintain a balance between cell survival and programmed cell death (apoptosis). |
2003-07-07 |
2023-08-12 |
Not clear |
| Marty W Mayo, Chadrick E Denlinger, Robert M Broad, Fan Yeung, Eugene T Reilly, Yang Shi, David R Jone. Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway. The Journal of biological chemistry. vol 278. issue 21. 2003-07-07. PMID:12649266. |
ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of nf-kappa b through the akt pathway. |
2003-07-07 |
2023-08-12 |
Not clear |
| Maria Chiara Deregibus, Stefano Buttiglieri, Simona Russo, Benedetta Bussolati, Giovanni Camuss. CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis. The Journal of biological chemistry. vol 278. issue 20. 2003-06-25. PMID:12637493. |
moreover, apoptosis of hmec was associated with an impairment of akt phosphorylation, which was restored by stimulation with scd154. |
2003-06-25 |
2023-08-12 |
human |
| R Chihab, M I Pörn-Ares, M Alvarado-Kristensson, T Andersso. Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kinase. Cellular and molecular life sciences : CMLS. vol 60. issue 4. 2003-06-25. PMID:12785724. |
neither akt activity nor change in basal activity of c-jun n-terminal kinases was detected during apoptosis or after adding spp. |
2003-06-25 |
2023-08-12 |
human |