| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guan-Hua Lai, Zichen Zhang, Alphonse E Siric. Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspases-9 and -3. Molecular cancer therapeutics. vol 2. issue 3. 2003-12-11. PMID:12657721. |
furthermore, our findings strongly suggest that increased inhibition of the antiapoptotic kinase akt activation produced by the emodin/celecoxib combination treatment plays a key role in the mechanism by which this drug combination acts to enhance cell growth suppression and apoptosis in cultured c611b chc cells and wbneu cells. |
2003-12-11 |
2023-08-12 |
rat |
| Tom Stover, Mark Keste. Liposomal delivery enhances short-chain ceramide-induced apoptosis of breast cancer cells. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12975495. |
liposomal ceramide formulations inhibited phosphorylated akt levels and stimulated caspase-3/7 activity more effectively than nonliposomal ceramide, events consistent with apoptosis. |
2003-12-10 |
2023-08-12 |
Not clear |
| Fazlul H Sarkar, Yiwei L. Soy isoflavones and cancer prevention. Cancer investigation. vol 21. issue 5. 2003-12-09. PMID:14628433. |
moreover, it has been shown that genistein inhibits the activation of nf-kappa b and akt signaling pathways, both of which are known to maintain a homeostatic balance between cell survival and apoptosis. |
2003-12-09 |
2023-08-12 |
human |
| Iwona Ciechomska, Beata Pyrzynska, Piotr Kazmierczak, Bozena Kaminsk. Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells. Oncogene. vol 22. issue 48. 2003-12-05. PMID:14576824. |
inhibition of akt kinase signalling and activation of forkhead are indispensable for upregulation of fasl expression in apoptosis of glioma cells. |
2003-12-05 |
2023-08-12 |
Not clear |
| Iwona Ciechomska, Beata Pyrzynska, Piotr Kazmierczak, Bozena Kaminsk. Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells. Oncogene. vol 22. issue 48. 2003-12-05. PMID:14576824. |
activation of akt signalling pathway is frequently found in glioma cells and may contribute to their resistance to undergo apoptosis in response to conventional therapies. |
2003-12-05 |
2023-08-12 |
Not clear |
| Iwona Ciechomska, Beata Pyrzynska, Piotr Kazmierczak, Bozena Kaminsk. Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells. Oncogene. vol 22. issue 48. 2003-12-05. PMID:14576824. |
in the present paper, we investigated an involvement of akt signalling in the regulation of fasl expression in csa-induced apoptosis. |
2003-12-05 |
2023-08-12 |
Not clear |
| Iwona Ciechomska, Beata Pyrzynska, Piotr Kazmierczak, Bozena Kaminsk. Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells. Oncogene. vol 22. issue 48. 2003-12-05. PMID:14576824. |
although treatment with ly294002, a specific inhibitor of pi3 k, decreased the phosphorylation of akt and increased fkhr translocation to the nucleus, these events were not sufficient to induce fasl expression and apoptosis of c6 glioma cells. |
2003-12-05 |
2023-08-12 |
Not clear |
| Amy L Howes, Jane F Arthur, Tong Zhang, Shigeki Miyamoto, John W Adams, Gerald W Dorn, Elizabeth A Woodcock, Joan Heller Brow. Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion. The Journal of biological chemistry. vol 278. issue 41. 2003-12-02. PMID:12900409. |
expression of a gqq209l mutant that has diminished capacity to activate phospholipase c does not decrease pip2 or akt or induce apoptosis. |
2003-12-02 |
2023-08-12 |
mouse |
| Young-Ho Kim, Jong-Wook Park, Jai-Youl Lee, Young-Joon Surh, Taeg Kyu Kwo. Bcl-2 overexpression prevents daunorubicin-induced apoptosis through inhibition of XIAP and Akt degradation. Biochemical pharmacology. vol 66. issue 9. 2003-11-21. PMID:14563488. |
bcl-2 overexpression prevents daunorubicin-induced apoptosis through inhibition of xiap and akt degradation. |
2003-11-21 |
2023-08-12 |
human |
| Young-Ho Kim, Jong-Wook Park, Jai-Youl Lee, Young-Joon Surh, Taeg Kyu Kwo. Bcl-2 overexpression prevents daunorubicin-induced apoptosis through inhibition of XIAP and Akt degradation. Biochemical pharmacology. vol 66. issue 9. 2003-11-21. PMID:14563488. |
induction of apoptosis was also accompanied by release of cytochrome c, down-regulation of x-linked inhibitor of apoptosis protein (xiap), and inactivation of akt, which was blocked by the pan-caspase inhibitor z-vad-fmk. |
2003-11-21 |
2023-08-12 |
human |
| Young-Ho Kim, Jong-Wook Park, Jai-Youl Lee, Young-Joon Surh, Taeg Kyu Kwo. Bcl-2 overexpression prevents daunorubicin-induced apoptosis through inhibition of XIAP and Akt degradation. Biochemical pharmacology. vol 66. issue 9. 2003-11-21. PMID:14563488. |
ectopic expression of bcl-2 appeared to inhibit dnr-induced apoptosis by interfering with inhibition of xiap and akt degradation. |
2003-11-21 |
2023-08-12 |
human |
| Maria Forsberg, Robert Blomgran, Maria Lerm, Eva Särndahl, Said M Sebti, Andrew Hamilton, Olle Stendahl, Limin Zhen. Differential effects of invasion by and phagocytosis of Salmonella typhimurium on apoptosis in human macrophages: potential role of Rho-GTPases and Akt. Journal of leukocyte biology. vol 74. issue 4. 2003-11-18. PMID:12960245. |
differential effects of invasion by and phagocytosis of salmonella typhimurium on apoptosis in human macrophages: potential role of rho-gtpases and akt. |
2003-11-18 |
2023-08-12 |
human |
| Maria Forsberg, Robert Blomgran, Maria Lerm, Eva Särndahl, Said M Sebti, Andrew Hamilton, Olle Stendahl, Limin Zhen. Differential effects of invasion by and phagocytosis of Salmonella typhimurium on apoptosis in human macrophages: potential role of Rho-GTPases and Akt. Journal of leukocyte biology. vol 74. issue 4. 2003-11-18. PMID:12960245. |
moreover, salmonella infection activated akt protein in a tyrosine-kinase or pi-3k-dependent manner, and a reduced expression of akt by antisense transfection rendered the cells more sensitive to apoptosis induced by opsonized salmonella. |
2003-11-18 |
2023-08-12 |
human |
| Maria Forsberg, Robert Blomgran, Maria Lerm, Eva Särndahl, Said M Sebti, Andrew Hamilton, Olle Stendahl, Limin Zhen. Differential effects of invasion by and phagocytosis of Salmonella typhimurium on apoptosis in human macrophages: potential role of Rho-GTPases and Akt. Journal of leukocyte biology. vol 74. issue 4. 2003-11-18. PMID:12960245. |
these results indicate that direct activation of cdc42 and rac1 by invasive salmonella is a prerequisite of salmonella-mediated death of u937 cells, whereas the simultaneous activation of akt by tyrosine kinase and pi-3k during receptor-mediated phagocytosis protects cells from apoptosis. |
2003-11-18 |
2023-08-12 |
human |
| David J Panka, James W Mie. Canstatin inhibits Akt activation and induces Fas-dependent apoptosis in endothelial cells. The Journal of biological chemistry. vol 278. issue 39. 2003-11-17. PMID:12876280. |
canstatin inhibits akt activation and induces fas-dependent apoptosis in endothelial cells. |
2003-11-17 |
2023-08-12 |
human |
| L A DeGraffenried, W E Friedrichs, L Fulcher, G Fernandes, J M Silva, J-M Peralba, M Hidalg. Eicosapentaenoic acid restores tamoxifen sensitivity in breast cancer cells with high Akt activity. Annals of oncology : official journal of the European Society for Medical Oncology. vol 14. issue 7. 2003-11-12. PMID:12853346. |
breast cancers with heightened akt activity are frequently associated with an aggressive disease and resistance to chemo- and hormone-therapy-induced apoptosis. |
2003-11-12 |
2023-08-12 |
Not clear |
| Jin Ho Chung, Ji Hyun Han, Eun Ju Hwang, Jin Young Seo, Kwang Hyun Cho, Kyu Han Kim, Jai Il Youn, Hee Chul Eu. Dual mechanisms of green tea extract (EGCG)-induced cell survival in human epidermal keratinocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 13. 2003-11-12. PMID:12897059. |
in conclusion, this study demonstrates that egcg promotes keratinocyte survival and inhibits the uv-induced apoptosis via two mechanisms: by phosphorylating ser112 and ser136 of bad protein through erk and akt pathways, respectively, and by increasing the bcl-2-to-bax ratio. |
2003-11-12 |
2023-08-12 |
human |
| Lijie Gong, Yiwei Li, Ana Nedeljkovic-Kurepa, Fazlul H Sarka. Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene. vol 22. issue 30. 2003-11-07. PMID:12879015. |
we found that inhibition of cell growth and induction of apoptosis by genistein are partly mediated through the downregulation of akt and nf-kappab pathways. |
2003-11-07 |
2023-08-12 |
Not clear |
| Shehla Pervin, Rajan Singh, Gautam Chaudhur. Nitric-oxide-induced Bax integration into the mitochondrial membrane commits MDA-MB-468 cells to apoptosis: essential role of Akt. Cancer research. vol 63. issue 17. 2003-11-06. PMID:14500383. |
nitric-oxide-induced bax integration into the mitochondrial membrane commits mda-mb-468 cells to apoptosis: essential role of akt. |
2003-11-06 |
2023-08-12 |
Not clear |
| Yong Liao, Mien-Chie Hun. Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis. Molecular and cellular biology. vol 23. issue 19. 2003-11-04. PMID:12972603. |
regulation of the activity of p38 mitogen-activated protein kinase by akt in cancer and adenoviral protein e1a-mediated sensitization to apoptosis. |
2003-11-04 |
2023-08-12 |
human |