| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nathan Majewski, Veronique Nogueira, R Brooks Robey, Nissim Ha. Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Molecular and cellular biology. vol 24. issue 2. 2004-02-18. PMID:14701745. |
glucose deprivation, which impaired the ability of akt to maintain mitochondrion-hexokinase association, prevented akt from inhibiting bid-mediated apoptosis. |
2004-02-18 |
2023-08-12 |
Not clear |
| Nathan Majewski, Veronique Nogueira, R Brooks Robey, Nissim Ha. Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Molecular and cellular biology. vol 24. issue 2. 2004-02-18. PMID:14701745. |
these results suggest that akt inhibits bid-mediated apoptosis downstream of bid cleavage via promotion of mitochondrial hexokinase association and antagonism of tbid-mediated bax and bak activation at the mitochondria. |
2004-02-18 |
2023-08-12 |
Not clear |
| Shozo Nishida, Shohei Yoshioka, Saori Kinoshita-Kimoto, Michiyo Kotani, Masanobu Tsubaki, Yoshiki Fujii, Takanori T Tomura, Kiyohiro Irimajir. Pretreatment with PKC inhibitor triggers TNF-alpha induced apoptosis in TNF-alpha-resistant B16 melanoma BL6 cells. Life sciences. vol 74. issue 6. 2004-02-11. PMID:14654170. |
after the inhibition of protein kinase b (akt) by ly294002 or p38 mitogen-activated protein kinase (p38mapk) by sb203580, the addition of tnf-alpha did not cause apoptosis. |
2004-02-11 |
2023-08-12 |
Not clear |
| Carsten Skurk, Henrike Maatz, Hyo-Soo Kim, Jiang Yang, Md Ruhul Abid, William C Aird, Kenneth Wals. The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. The Journal of biological chemistry. vol 279. issue 2. 2004-02-10. PMID:14551207. |
these data suggest that foxo3a is a downstream target of akt in endothelial cells that can promote apoptosis via flip down-regulation and activation of the extrinsic apoptotic pathway. |
2004-02-10 |
2023-08-12 |
human |
| Kenji Takeuchi, Fumiaki It. Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway. The Journal of biological chemistry. vol 279. issue 2. 2004-02-10. PMID:14570904. |
the protective effect of hgf/sf against the adr-induced apoptosis was abolished in the presence of either ly294002, an inhibitor of phosphatidylinositol-3'-oh kinase (pi3-k) or 1l-6-hydroxymethyl-chiro-inositol 2-(r)-2-o-methyl-3-o-octadecylcarbonate, an inhibitor of akt, thus implicating the activation of pi3-k-akt signaling in the antiapoptotic action of hgf/sf. |
2004-02-10 |
2023-08-12 |
human |
| T Sugatani, U M Alvarez, K A Hrusk. Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors. Journal of cellular biochemistry. vol 90. issue 1. 2004-02-09. PMID:12938156. |
activin a alone failed to activate akt, bad, and mtor by immunoblotting, and it also failed to prevent apoptosis in osteoclast precursors. |
2004-02-09 |
2023-08-12 |
mouse |
| Ke Liang, Weidong Jin, Christiane Knuefermann, Mathias Schmidt, Gordon B Mills, K Kian Ang, Luka Milas, Zhen Fa. Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy. Molecular cancer therapeutics. vol 2. issue 4. 2004-02-06. PMID:12700279. |
to determine a causal relationship between the activity of akt and radioresistance in human breast cancer cells, mcf7 cells, transfected with constitutively active h-ras (radg12v) or constitutively active akt, were chosen for analysis of the cell clonogenic survival fraction and induction of apoptosis after ionizing radiation. |
2004-02-06 |
2023-08-12 |
human |
| Manuela Campiglio, Alberta Locatelli, Clelia Olgiati, Nicola Normanno, Giulia Somenzi, Lucia Viganò, Marzia Fumagalli, Sylvie Ménard, Luca Giann. Inhibition of proliferation and induction of apoptosis in breast cancer cells by the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 ('Iressa') is independent of EGFR expression level. Journal of cellular physiology. vol 198. issue 2. 2004-02-06. PMID:14603528. |
we analyzed the ability of zd1839 to induce apoptosis and/or inhibition of proliferation in breast carcinoma cell lines, as well any association between this ability and the downregulation activity of mapk and akt, two recently proposed markers of zd1839 activity. |
2004-02-06 |
2023-08-12 |
human |
| Manuela Campiglio, Alberta Locatelli, Clelia Olgiati, Nicola Normanno, Giulia Somenzi, Lucia Viganò, Marzia Fumagalli, Sylvie Ménard, Luca Giann. Inhibition of proliferation and induction of apoptosis in breast cancer cells by the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 ('Iressa') is independent of EGFR expression level. Journal of cellular physiology. vol 198. issue 2. 2004-02-06. PMID:14603528. |
our data suggest that the antitumor activity of zd1839 is due to a cytostatic effect, and involves apoptosis induction in a subset of sensitive cells only, and that neither mapk nor akt is a reliable marker of zd1839 activity. |
2004-02-06 |
2023-08-12 |
human |
| Sreenivasa R Chinni, Samir A Alhasan, Asha S Multani, Sen Pathak, Fazlul H Sarka. Pleotropic effects of genistein on MCF-7 breast cancer cells. International journal of molecular medicine. vol 12. issue 1. 2004-02-04. PMID:12792805. |
from these results, we conclude that genistein-induced inhibition of cell division is partly mediated by decreased telomere length, reduced mitosis and inhibition of akt activation, leading to induction of apoptosis. |
2004-02-04 |
2023-08-12 |
Not clear |
| Keiji Shimada, Mitsutoshi Nakamura, Eiwa Ishida, Munehiro Kishi, Syuchi Matsuyoshi, Noboru Konish. The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells. Molecular carcinogenesis. vol 39. issue 1. 2004-02-03. PMID:14694442. |
a selective inhibitor of akt phosphorylation, ly294002, accelerated formation of the death-inducing signaling complex (disc) not only by flip reduction but also by enhancement of recruitment of the fadd to fas, thereby sensitizing pc3 cells to apoptosis similar to the case with 2-me stimulation. |
2004-02-03 |
2023-08-12 |
human |
| Keiji Shimada, Mitsutoshi Nakamura, Eiwa Ishida, Munehiro Kishi, Syuchi Matsuyoshi, Noboru Konish. The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells. Molecular carcinogenesis. vol 39. issue 1. 2004-02-03. PMID:14694442. |
moreover, we found that inhibition of 2-me-induced extracellular signal-regulated kinase (erk) activation by the upstream kinase inhibitor pd98059 significantly enhanced 2-me-mediated suppression of akt activation, resulting in much greater sensitization to apoptosis. |
2004-02-03 |
2023-08-12 |
human |
| Keiji Shimada, Mitsutoshi Nakamura, Eiwa Ishida, Munehiro Kishi, Syuchi Matsuyoshi, Noboru Konish. The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells. Molecular carcinogenesis. vol 39. issue 1. 2004-02-03. PMID:14694442. |
taken together, the present findings indicate that 2-me suppresses nf-kappab/flip signaling and enhances disc formation through inhibition of akt, and that pc3 cells thereby are being sensitized to fas-mediated apoptosis and by a process closely associated with erk. |
2004-02-03 |
2023-08-12 |
human |
| Seiji Mabuchi, Masahide Ohmichi, Akiko Kimura, Yukihiro Nishio, Emi Arimoto-Ishida, Namiko Yada-Hashimoto, Keiichi Tasaka, Yuji Murat. Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines. Endocrinology. vol 145. issue 1. 2004-01-23. PMID:14500571. |
akt and apoptosis signal-regulating kinase 1 (ask1) were physically associated, and e2 induced the phosphorylation of ask1 at serine-83, which is a consensus akt phosphorylation site. |
2004-01-23 |
2023-08-12 |
human |
| M Ozaki, S Haga, H Q Zhang, K Irani, S Suzuk. Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1. Cell death and differentiation. vol 10. issue 5. 2004-01-22. PMID:12728249. |
in contrast, pleiotropic protein kinase akt protects against apoptosis. |
2004-01-22 |
2023-08-12 |
Not clear |
| M Ozaki, S Haga, H Q Zhang, K Irani, S Suzuk. Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1. Cell death and differentiation. vol 10. issue 5. 2004-01-22. PMID:12728249. |
in a model of oxidative stress and apoptosis induced by hypoxia/reoxygenation (h/r) in primary hepatocytes, activation of the pi3-k akt axis by the prosurvival hepatocyte growth factor (hgf) inhibited h/r-stimulated rac1 activation and intracellular ros production, and suppressed apoptosis. |
2004-01-22 |
2023-08-12 |
Not clear |
| Hiroaki Murata, Yoshito Ihara, Hajime Nakamura, Junji Yodoi, Koji Sumikawa, Takahito Kond. Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt. The Journal of biological chemistry. vol 278. issue 50. 2004-01-15. PMID:14522978. |
here we demonstrated that overexpression of grx protected cells from hydrogen peroxide (h2o2)-induced apoptosis by regulating the redox state of akt. |
2004-01-15 |
2023-08-12 |
Not clear |
| Hiroaki Murata, Yoshito Ihara, Hajime Nakamura, Junji Yodoi, Koji Sumikawa, Takahito Kond. Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt. The Journal of biological chemistry. vol 278. issue 50. 2004-01-15. PMID:14522978. |
akt was transiently phosphorylated, dephosphorylated, and then degraded in cardiac h9c2 cells undergoing h2o2-induced apoptosis. |
2004-01-15 |
2023-08-12 |
Not clear |
| Hiroaki Murata, Yoshito Ihara, Hajime Nakamura, Junji Yodoi, Koji Sumikawa, Takahito Kond. Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt. The Journal of biological chemistry. vol 278. issue 50. 2004-01-15. PMID:14522978. |
overexpression of grx protected akt from h2o2-induced oxidation and suppressed recruitment of protein phosphatase 2a to akt, resulting in a sustained phosphorylation of akt and inhibition of apoptosis. |
2004-01-15 |
2023-08-12 |
Not clear |
| Hiroaki Murata, Yoshito Ihara, Hajime Nakamura, Junji Yodoi, Koji Sumikawa, Takahito Kond. Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt. The Journal of biological chemistry. vol 278. issue 50. 2004-01-15. PMID:14522978. |
thus, grx plays an important role in protecting cells from apoptosis by regulating the redox state of akt. |
2004-01-15 |
2023-08-12 |
Not clear |