| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Atsushi Saito, Purnima Narasimhan, Takeshi Hayashi, Shuzo Okuno, Michel Ferrand-Drake, Pak H Cha. Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 7. 2004-05-04. PMID:14973226. |
the akt signaling pathway contributes to regulation of apoptosis after a variety of cell death stimuli. |
2004-05-04 |
2023-08-12 |
mouse |
| Atsushi Saito, Purnima Narasimhan, Takeshi Hayashi, Shuzo Okuno, Michel Ferrand-Drake, Pak H Cha. Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 7. 2004-05-04. PMID:14973226. |
a novel proline-rich akt substrate (pras) was recently detected and found to be involved in apoptosis. |
2004-05-04 |
2023-08-12 |
mouse |
| Kiyotaka Kawauchi, Toshie Ogasawara, Masako Yasuyama, Shin ichiro Ohkaw. Involvement of Akt kinase in the action of STI571 on chronic myelogenous leukemia cells. Blood cells, molecules & diseases. vol 31. issue 1. 2004-04-30. PMID:12850478. |
primary leukemia cells from patients with cml blast crisis did not show inhibition of erk1/2 or akt kinase activity and were resistant to caspase-3-associated apoptosis after treatment with sti571. |
2004-04-30 |
2023-08-12 |
Not clear |
| Tomoka Takatani, Kyoko Takahashi, Yoriko Uozumi, Takahisa Matsuda, Takashi Ito, Stephen W Schaffer, Yasushi Fujio, Junichi Azum. Taurine prevents the ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes through Akt/caspase-9 pathway. Biochemical and biophysical research communications. vol 316. issue 2. 2004-04-27. PMID:15020243. |
activated akt kinase has been proposed as a central role in suppressing apoptosis by modulating the activities of bcl-2 family proteins and/or caspase-9. |
2004-04-27 |
2023-08-12 |
rat |
| Tomoka Takatani, Kyoko Takahashi, Yoriko Uozumi, Takahisa Matsuda, Takashi Ito, Stephen W Schaffer, Yasushi Fujio, Junichi Azum. Taurine prevents the ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes through Akt/caspase-9 pathway. Biochemical and biophysical research communications. vol 316. issue 2. 2004-04-27. PMID:15020243. |
these findings provide the first evidence that taurine inhibits ischemia-induced apoptosis in cardiac myocytes with the increase in akt activities, by inactivating caspase-9. |
2004-04-27 |
2023-08-12 |
rat |
| Zichen Zhang, Guan-Hua Lai, Alphonse E Siric. Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation. Hepatology (Baltimore, Md.). vol 39. issue 4. 2004-04-26. PMID:15057907. |
celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by akt inactivation and bax translocation. |
2004-04-26 |
2023-08-12 |
rat |
| Zichen Zhang, Guan-Hua Lai, Alphonse E Siric. Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation. Hepatology (Baltimore, Md.). vol 39. issue 4. 2004-04-26. PMID:15057907. |
in conclusion, our results indicate that celecoxib preferentially acts in vitro to induce apoptosis in chc cells through a mechanism involving akt inactivation, bax translocation, and cytochrome c release. |
2004-04-26 |
2023-08-12 |
rat |
| Ann Richmond, Guo Huang Fan, Punita Dhawan, Jinming Yan. How do chemokine/chemokine receptor activations affect tumorigenesis? Novartis Foundation symposium. vol 256. 2004-04-21. PMID:15027484. |
this never ending cycle of activation of nf-kappab, leading to enhanced production of chemokines, enhanced activation of akt and nf-kappab, and enhanced transcription of inhibitors of apoptosis and chemokines, is one that has been used to foster the growth of the tumour to the disadvantage of the host. |
2004-04-21 |
2023-08-12 |
human |
| Andrew P Mone, Peng Huang, Helene Pelicano, Carolyn M Cheney, Jennifer M Green, J Yun Tso, Amy J Johnson, Sara Jefferson, Thomas S Lin, John C Byr. Hu1D10 induces apoptosis concurrent with activation of the AKT survival pathway in human chronic lymphocytic leukemia cells. Blood. vol 103. issue 5. 2004-04-20. PMID:14630799. |
hu1d10 induces apoptosis concurrent with activation of the akt survival pathway in human chronic lymphocytic leukemia cells. |
2004-04-20 |
2023-08-12 |
human |
| Emi Arimoto-Ishida, Masahide Ohmichi, Seiji Mabuchi, Toshifumi Takahashi, Chika Ohshima, Jun Hayakawa, Akiko Kimura, Kazuhiro Takahashi, Yukihiro Nishio, Masahiro Sakata, Hirohisa Kurachi, Keiichi Tasaka, Yuji Murat. Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin. Endocrinology. vol 145. issue 4. 2004-04-16. PMID:14701673. |
the forkhead family transcription factor fkhrl1 is an inducer of apoptosis in its unphosphorylated form and was recently reported to be a substrate of akt kinase. |
2004-04-16 |
2023-08-12 |
human |
| Mitsuhiko Osaki, Satoru Kase, Keiko Adachi, Ami Takeda, Kiyoshi Hashimoto, Hisao It. Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45. Journal of cancer research and clinical oncology. vol 130. issue 1. 2004-04-15. PMID:14605879. |
on the other hand, phosphatidylinositol 3'-kinase (pi3 k) and akt mediate the survival signal and allow the cells to escape from apoptosis in various human cancers. |
2004-04-15 |
2023-08-12 |
human |
| Mitsuhiko Osaki, Satoru Kase, Keiko Adachi, Ami Takeda, Kiyoshi Hashimoto, Hisao It. Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45. Journal of cancer research and clinical oncology. vol 130. issue 1. 2004-04-15. PMID:14605879. |
thus, we postulated that ly294002, a pi3 k inhibitor, should inactivate akt, consequently inhibiting cell proliferation and increase apoptosis in the human gastric carcinoma cell line, mkn-45. |
2004-04-15 |
2023-08-12 |
human |
| Henning Schulze-Bergkamen, Dirk Brenner, Andreas Krueger, Dorothee Suess, Stefanie C Fas, Christian R Frey, Andreas Dax, Dorothea Zink, Peter Büchler, Martina Müller, Peter H Kramme. Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt. Hepatology (Baltimore, Md.). vol 39. issue 3. 2004-04-09. PMID:14999683. |
hepatocyte growth factor induces mcl-1 in primary human hepatocytes and inhibits cd95-mediated apoptosis via akt. |
2004-04-09 |
2023-08-12 |
human |
| E A Ostrakhovitch, M G Cheria. Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc. Archives of biochemistry and biophysics. vol 423. issue 2. 2004-04-09. PMID:15001399. |
these results demonstrate that copper-induced apoptosis in mcf-7 cells is p53 dependent, whereas the metal resistance in mda-mb-231 cells may be due to activation of akt in the absence of a functional p53. |
2004-04-09 |
2023-08-12 |
human |
| Hans-Guido Wendel, Elisa De Stanchina, Jordan S Fridman, Abba Malina, Sagarika Ray, Scott Kogan, Carlos Cordon-Cardo, Jerry Pelletier, Scott W Low. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature. vol 428. issue 6980. 2004-04-07. PMID:15029198. |
nevertheless, how akt disables apoptosis and its contribution to clinical drug resistance are unclear. |
2004-04-07 |
2023-08-12 |
Not clear |
| Hans-Guido Wendel, Elisa De Stanchina, Jordan S Fridman, Abba Malina, Sagarika Ray, Scott Kogan, Carlos Cordon-Cardo, Jerry Pelletier, Scott W Low. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature. vol 428. issue 6980. 2004-04-07. PMID:15029198. |
using a murine lymphoma model, we show that akt promotes tumorigenesis and drug resistance by disrupting apoptosis, and that disruption of akt signalling using the mtor inhibitor rapamycin reverses chemoresistance in lymphomas expressing akt, but not in those with other apoptotic defects. |
2004-04-07 |
2023-08-12 |
Not clear |
| Chi-Hung Cheng, Kuo-Ching Yu, Hsin-Ling Chen, Shu-Yi Chen, Chi-Hui Huang, Po-Chao Chan, Chiung-Wha Wung, Hong-Chen Che. Blockade of v-Src-stimulated tumor formation by the Src homology 3 domain of Crk-associated substrate (Cas). FEBS letters. vol 557. issue 1-3. 2004-04-06. PMID:14741371. |
attenuation of the akt pathway by the cas sh3 domain rendered v-src-transformed cells susceptible to apoptosis. |
2004-04-06 |
2023-08-12 |
mouse |
| Dong-Seok Kim, Eui-Soo Hwang, Jai-Eun Lee, Sook-Young Kim, Kyoung-Chan Par. Sphingosine-1-phosphate promotes mouse melanocyte survival via ERK and Akt activation. Cellular signalling. vol 15. issue 10. 2004-04-02. PMID:12873705. |
we next examined the regulation of the three major subfamilies of mitogen-activated protein (map) kinases and of the akt pathway by sphingosine-1-phosphate against uvb-induced apoptosis. |
2004-04-02 |
2023-08-12 |
mouse |
| Dong-Seok Kim, Eui-Soo Hwang, Jai-Eun Lee, Sook-Young Kim, Kyoung-Chan Par. Sphingosine-1-phosphate promotes mouse melanocyte survival via ERK and Akt activation. Cellular signalling. vol 15. issue 10. 2004-04-02. PMID:12873705. |
based on these results, we conclude that the activation of p38 map kinase plays an important role in uvb-induced apoptosis, and that sphingosine-1-phosphate probably exert its cytoprotective effect in mel-ab cells through erk and akt activation. |
2004-04-02 |
2023-08-12 |
mouse |
| Vita M Golubovskaya, Steven Gross, Aparna S Kaur, Richard I Wilson, Li-Hui Xu, Xi Hui Yang, William G Canc. Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Molecular cancer research : MCR. vol 1. issue 10. 2004-04-02. PMID:12939401. |
activation of caspase-3, down-regulation of fak, and src and akt activities were demonstrated in ad-fak-cd + pp2-treated colon cancer cells undergoing apoptosis. |
2004-04-02 |
2023-08-12 |
Not clear |