| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Young E Whang, Xiu-Juan Yuan, Yuanbo Liu, Samarpan Majumder, Terrence D Lewi. Regulation of sensitivity to TRAIL by the PTEN tumor suppressor. Vitamins and hormones. vol 67. 2004-07-07. PMID:15110188. |
growth factors such as epidermal growth factor or insulin-like growth factor-1 also inhibit trail-induced apoptosis through the akt pathway. |
2004-07-07 |
2023-08-12 |
human |
| Huifang M Zhang, Jaladanki N Rao, Xin Guo, Lan Liu, Tongtong Zou, Douglas J Turner, Jian-Ying Wan. Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion. The Journal of biological chemistry. vol 279. issue 21. 2004-06-30. PMID:15024023. |
akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion. |
2004-06-30 |
2023-08-12 |
Not clear |
| Huifang M Zhang, Jaladanki N Rao, Xin Guo, Lan Liu, Tongtong Zou, Douglas J Turner, Jian-Ying Wan. Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion. The Journal of biological chemistry. vol 279. issue 21. 2004-06-30. PMID:15024023. |
the current studies test the hypothesis that polyamines are involved in the control of akt activity in normal intestinal epithelial cells (iec-6 line) and that activated akt mediates suppression of apoptosis following polyamine depletion. |
2004-06-30 |
2023-08-12 |
Not clear |
| Huifang M Zhang, Jaladanki N Rao, Xin Guo, Lan Liu, Tongtong Zou, Douglas J Turner, Jian-Ying Wan. Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion. The Journal of biological chemistry. vol 279. issue 21. 2004-06-30. PMID:15024023. |
this activated akt was associated with both decreased levels of active caspase-3 and increased resistance to tumor necrosis factor-alpha/cycloheximide-induced apoptosis. |
2004-06-30 |
2023-08-12 |
Not clear |
| Huifang M Zhang, Jaladanki N Rao, Xin Guo, Lan Liu, Tongtong Zou, Douglas J Turner, Jian-Ying Wan. Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion. The Journal of biological chemistry. vol 279. issue 21. 2004-06-30. PMID:15024023. |
inactivation of akt by either treatment with ly294002 or ectopic expression of a dominant negative akt mutant (dnmakt) not only enhanced the caspase-3 activation in polyamine-deficient cells but also prevented the increased resistance to tumor necrosis factor-alpha/cycloheximide-induced apoptosis. |
2004-06-30 |
2023-08-12 |
Not clear |
| Huifang M Zhang, Jaladanki N Rao, Xin Guo, Lan Liu, Tongtong Zou, Douglas J Turner, Jian-Ying Wan. Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion. The Journal of biological chemistry. vol 279. issue 21. 2004-06-30. PMID:15024023. |
these results indicate that polyamine depletion induces the akt activation mediating suppression of apoptosis via inhibition of caspase-3 in normal intestinal epithelial cells. |
2004-06-30 |
2023-08-12 |
Not clear |
| Kun Jiang, Jiazhi Sun, Jin Cheng, Julie Y Djeu, Sheng Wei, Saïd Sebt. Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis. Molecular and cellular biology. vol 24. issue 12. 2004-06-30. PMID:15169915. |
ectopic expression of rhob, but not the close relative rhoa, inhibits ras, pi3k, and akt induction of transformation, migration, and invasion and induces apoptosis and anoikis. |
2004-06-30 |
2023-08-12 |
mouse |
| Kiyoshi Hirai, Takeshi Hayashi, Pak H Chan, Jianying Zeng, Guo-Yuan Yang, Vladimir J Basus, Thomas L James, Lawrence Lit. PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis. Brain research. Molecular brain research. vol 124. issue 1. 2004-06-28. PMID:15093685. |
acute hypoxia can deplete atp and induce mitochondrial release of cytochrome c (cyt c) to initiate or enhance apoptosis, a process delayed or overcome with sufficient atp and phosphorylation (activation) of survival factors such as akt (also known as protein kinase b). |
2004-06-28 |
2023-08-12 |
rat |
| Kiyoshi Hirai, Takeshi Hayashi, Pak H Chan, Jianying Zeng, Guo-Yuan Yang, Vladimir J Basus, Thomas L James, Lawrence Lit. PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis. Brain research. Molecular brain research. vol 124. issue 1. 2004-06-28. PMID:15093685. |
we used an ex vivo brain slice model to investigate associations between levels of phosphorylated akt (phospho-akt) and the extent of intrinsic pathway apoptosis. |
2004-06-28 |
2023-08-12 |
rat |
| Jee-Yin Ahn, Yuanxin Hu, Todd G Kroll, Paulette Allard, Keqiang Y. PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 18. 2004-06-22. PMID:15118108. |
pike-a is amplified in human cancers and prevents apoptosis by up-regulating akt. |
2004-06-22 |
2023-08-12 |
human |
| Jee-Yin Ahn, Yuanxin Hu, Todd G Kroll, Paulette Allard, Keqiang Y. PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 18. 2004-06-22. PMID:15118108. |
here, we show that pike-a is amplified in a variety of human cancers and that amplified pike-a directly stimulates akt and inhibits apoptosis compared to cells with normal pike-a copy number. |
2004-06-22 |
2023-08-12 |
human |
| Jee-Yin Ahn, Yuanxin Hu, Todd G Kroll, Paulette Allard, Keqiang Y. PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 18. 2004-06-22. PMID:15118108. |
overexpression of pike-a wild-type but not dominant-negative mutant stimulates akt activity and prevents apoptosis. |
2004-06-22 |
2023-08-12 |
human |
| Jee-Yin Ahn, Yuanxin Hu, Todd G Kroll, Paulette Allard, Keqiang Y. PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 18. 2004-06-22. PMID:15118108. |
moreover, knockdown of pike-a diminishes akt activity and increases apoptosis. |
2004-06-22 |
2023-08-12 |
human |
| Jee-Yin Ahn, Yuanxin Hu, Todd G Kroll, Paulette Allard, Keqiang Y. PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 18. 2004-06-22. PMID:15118108. |
our findings suggest that pike-a amplification contributes to cancer cell survival and progression by inhibiting apoptosis through up-regulating akt. |
2004-06-22 |
2023-08-12 |
human |
| S Sianna Castillo, John Brognard, Pavel A Petukhov, Chunyu Zhang, Junji Tsurutani, Courtney A Granville, Min Li, Michael Jung, Kip A West, Joell G Gills, Alan P Kozikowski, Phillip A Denni. Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues. Cancer research. vol 64. issue 8. 2004-06-10. PMID:15087394. |
importantly, pias increased apoptosis 20-30-fold in cancer cell lines with high levels of endogenous akt activity but only 4-5-fold in cancer cell lines with low levels of akt activity. |
2004-06-10 |
2023-08-12 |
Not clear |
| Hui-Chiu Chang, Chin Hsu, Hseng-Kuang Hsu, Rei-Cheng Yan. Functional role of caspases in sphingosine-induced apoptosis in human hepatoma cells. IUBMB life. vol 55. issue 7. 2004-06-02. PMID:14584591. |
in addition, enforced expression of constitutively activated akt kinase which is known to inhibit apoptosis induced by sphingosine, potently suppressed activation of procaspases-7 and -8. |
2004-06-02 |
2023-08-12 |
human |
| Jennifer K Ness, Russell C Scaduto, Teresa L Woo. IGF-I prevents glutamate-mediated bax translocation and cytochrome C release in O4+ oligodendrocyte progenitors. Glia. vol 46. issue 2. 2004-05-28. PMID:15042585. |
we also demonstrated that igf-i had the unique ability to sustain activation of akt in the pro-ol and provide long-term protection of these cells from glutamate-mediated apoptosis. |
2004-05-28 |
2023-08-12 |
Not clear |
| Diviya Sinha, Saswati Bannergee, John H Schwartz, Wilfred Lieberthal, Jerrold S Levin. Inhibition of ligand-independent ERK1/2 activity in kidney proximal tubular cells deprived of soluble survival factors up-regulates Akt and prevents apoptosis. The Journal of biological chemistry. vol 279. issue 12. 2004-05-27. PMID:14701865. |
inhibition of ligand-independent erk1/2 activity in kidney proximal tubular cells deprived of soluble survival factors up-regulates akt and prevents apoptosis. |
2004-05-27 |
2023-08-12 |
mouse |
| Andrew R Conery, Yanna Cao, E Aubrey Thompson, Courtney M Townsend, Tien C Ko, Kunxin Lu. Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis. Nature cell biology. vol 6. issue 4. 2004-05-27. PMID:15104092. |
akt interacts directly with smad3 to regulate the sensitivity to tgf-beta induced apoptosis. |
2004-05-27 |
2023-08-12 |
Not clear |
| Andrew R Conery, Yanna Cao, E Aubrey Thompson, Courtney M Townsend, Tien C Ko, Kunxin Lu. Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis. Nature cell biology. vol 6. issue 4. 2004-05-27. PMID:15104092. |
here we report that the sensitivity to tgf-beta induced apoptosis is regulated by crosstalk between the akt/pkb serine/threonine kinase and smad3 through a mechanism that is independent of akt kinase activity. |
2004-05-27 |
2023-08-12 |
Not clear |