| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samuel K Kulp, Ya-Ting Yang, Chin-Chun Hung, Kuen-Feng Chen, Ju-Ping Lai, Ping-Hui Tseng, Joseph W Fowble, Patrick J Ward, Ching-Shih Che. 3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells. Cancer research. vol 64. issue 4. 2004-04-02. PMID:14973075. |
in serum-supplemented medium, celecoxib and dmc cause g(1) arrest, and at higher concentrations, they induce apoptosis with relative potency comparable with that in blocking akt activation. |
2004-04-02 |
2023-08-12 |
Not clear |
| Ann-Marie Simeone, Yu-Jiang Li, Lyle D Broemeling, Marcella M Johnson, Musaffe Tuna, Ana M Tar. Cyclooxygenase-2 is essential for HER2/neu to suppress N- (4-hydroxyphenyl)retinamide apoptotic effects in breast cancer cells. Cancer research. vol 64. issue 4. 2004-04-02. PMID:14973114. |
we show that her2/neu uses akt to induce cyclooxygenase-2 (cox-2) expression and that inhibition of akt or cox-2 increases 4-hpr-induced apoptosis and nitric oxide production. |
2004-04-02 |
2023-08-12 |
Not clear |
| Tzong-Der Way, Ming-Ching Kao, Jen-Kun Li. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. The Journal of biological chemistry. vol 279. issue 6. 2004-04-01. PMID:14602723. |
a cell survival pathway involving phosphatidylinositol 3-kinase (pi3k), and akt is known to play an important role in inhibiting apoptosis in response to her2/neu-overexpressing breast cancer cells, which prompted us to investigate whether this pathway plays a role in apigenin-induced apoptosis in her2/neu-overexpressing breast cancer cells. |
2004-04-01 |
2023-08-12 |
human |
| Tzong-Der Way, Ming-Ching Kao, Jen-Kun Li. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. The Journal of biological chemistry. vol 279. issue 6. 2004-04-01. PMID:14602723. |
therefore, we proposed that apigenin-induced cellular effects result from loss of her2/neu and her3 expression with subsequent inactivation of pi3k and akt in cells that are dependent on this pathway for cell proliferation and inhibition of apoptosis. |
2004-04-01 |
2023-08-12 |
human |
| Han C Dan, Mei Sun, Satoshi Kaneko, Richard I Feldman, Santo V Nicosia, Hong-Gang Wang, Benjamin K Tsang, Jin Q Chen. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). The Journal of biological chemistry. vol 279. issue 7. 2004-03-30. PMID:14645242. |
akt phosphorylation and stabilization of x-linked inhibitor of apoptosis protein (xiap). |
2004-03-30 |
2023-08-12 |
Not clear |
| Han C Dan, Mei Sun, Satoshi Kaneko, Richard I Feldman, Santo V Nicosia, Hong-Gang Wang, Benjamin K Tsang, Jin Q Chen. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). The Journal of biological chemistry. vol 279. issue 7. 2004-03-30. PMID:14645242. |
here, we demonstrate that akt, including akt1 and akt2, interacts with and phosphorylates x-linked inhibitor of apoptosis protein (xiap) at residue serine-87 in vitro and in vivo. |
2004-03-30 |
2023-08-12 |
Not clear |
| Han C Dan, Mei Sun, Satoshi Kaneko, Richard I Feldman, Santo V Nicosia, Hong-Gang Wang, Benjamin K Tsang, Jin Q Chen. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). The Journal of biological chemistry. vol 279. issue 7. 2004-03-30. PMID:14645242. |
conversely, a mutant that could not be phosphorylated by akt (xiap-s87a) was more rapidly degraded and showed increased cisplatin-induced apoptosis. |
2004-03-30 |
2023-08-12 |
Not clear |
| Enza Piccolo, Sara Vignati, Tania Maffucci, Pasquale F Innominato, Andrew M Riley, Barry V L Potter, Pier Paolo Pandolfi, Massimo Broggini, Stefano Iacobelli, Paolo Innocenti, Marco Falasc. Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway. Oncogene. vol 23. issue 9. 2004-03-25. PMID:14755253. |
overexpression of constitutively active akt protects skbr-3 cells from ins(1,3,4,5,6)p5-induced apoptosis. |
2004-03-25 |
2023-08-12 |
Not clear |
| Masae Haga, Alan Chen, David Gortler, Alan Dardik, Bauer E Sumpi. Shear stress and cyclic strain may suppress apoptosis in endothelial cells by different pathways. Endothelium : journal of endothelial cell research. vol 10. issue 3. 2004-03-24. PMID:13129818. |
the authors examined the effect of ss and cs on inhibition of apoptosis and phosphorylation of akt and its downstream target bad in bovine aortic ecs in vitro. |
2004-03-24 |
2023-08-12 |
cattle |
| Masae Haga, Alan Chen, David Gortler, Alan Dardik, Bauer E Sumpi. Shear stress and cyclic strain may suppress apoptosis in endothelial cells by different pathways. Endothelium : journal of endothelial cell research. vol 10. issue 3. 2004-03-24. PMID:13129818. |
these results suggest that hemodynamic forces suppress apoptosis in ecs via phosphorylation of akt and that ss and cs differentially activate the downstream phosphorylation of bad, possibly by stimulating an alternate pathway. |
2004-03-24 |
2023-08-12 |
cattle |
| Alfonso Catalano, Laura Graciotti, Luciana Rinaldi, Giorgia Raffaelli, Sabrina Rodilossi, Piergiacomo Betta, Walter Gianni, Salvatore Amoroso, Antonio Procopi. Preclinical evaluation of the nonsteroidal anti-inflammatory agent celecoxib on malignant mesothelioma chemoprevention. International journal of cancer. vol 109. issue 3. 2004-03-24. PMID:14961568. |
celecoxib, in a dose- and time-dependent manner, induced mm cell apoptosis, which involved decreased akt phosphorylation, loss of bcl-2 and survivin protein expression and caspase-3 activation. |
2004-03-24 |
2023-08-12 |
mouse |
| Alfonso Catalano, Laura Graciotti, Luciana Rinaldi, Giorgia Raffaelli, Sabrina Rodilossi, Piergiacomo Betta, Walter Gianni, Salvatore Amoroso, Antonio Procopi. Preclinical evaluation of the nonsteroidal anti-inflammatory agent celecoxib on malignant mesothelioma chemoprevention. International journal of cancer. vol 109. issue 3. 2004-03-24. PMID:14961568. |
furthermore, vascular endothelial growth factor (vegf), an mm autocrine growth factor and akt inducer, rescued celecoxib-induced apoptosis and akt dephosphorylation. |
2004-03-24 |
2023-08-12 |
mouse |
| Seo-Jin Lee, Ho Jung Yoo, Yun Soo Bae, Hwa-Jung Kim, Seung-Taek Le. TIMP-1 inhibits apoptosis in breast carcinoma cells via a pathway involving pertussis toxin-sensitive G protein and c-Src. Biochemical and biophysical research communications. vol 312. issue 4. 2004-03-18. PMID:14652000. |
these findings demonstrate that the ability of timp-1 to inhibit apoptosis in t-47d cells is mediated by the sequential activation of pertussis toxin-sensitive g protein, c-src, pi3 kinase, and akt. |
2004-03-18 |
2023-08-12 |
human |
| Shehla Pervin, Rajan Singh, William A Freije, Gautam Chaudhur. MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer. Cancer research. vol 63. issue 24. 2004-03-11. PMID:14695202. |
in this study, we investigated the possible interplay of extracellular signal-regulated kinase (erk) and akt pathways in no-induced apoptosis. |
2004-03-11 |
2023-08-12 |
human |
| Shehla Pervin, Rajan Singh, William A Freije, Gautam Chaudhur. MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer. Cancer research. vol 63. issue 24. 2004-03-11. PMID:14695202. |
the inactivation of erk1/2 preceded the dephosphorylation of akt and apoptosis. |
2004-03-11 |
2023-08-12 |
human |
| Shehla Pervin, Rajan Singh, William A Freije, Gautam Chaudhur. MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer. Cancer research. vol 63. issue 24. 2004-03-11. PMID:14695202. |
no was not able to inactivate erk1/2 or akt or to induce apoptosis in the presence of a phosphatase inhibitor, sodium orthovanadate, or antisense oligonucleotides, suggesting a cross-talk between the two pathways. |
2004-03-11 |
2023-08-12 |
human |
| Chunrong Yu, Mohamed Rahmani, Jorge Almenara, Edward A Sausville, Paul Dent, Steven Gran. Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process. Oncogene. vol 23. issue 7. 2004-03-10. PMID:14647418. |
ectopic expression of raf-1 or constitutively activated (myristolated) akt also significantly attenuated adaphostin-induced apoptosis, but protection was less than that conferred by enforced activation of mek. |
2004-03-10 |
2023-08-12 |
human |
| Chunrong Yu, Mohamed Rahmani, Jorge Almenara, Edward A Sausville, Paul Dent, Steven Gran. Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process. Oncogene. vol 23. issue 7. 2004-03-10. PMID:14647418. |
together, these findings demonstrate that the tyrphostin adaphostin induces multiple perturbations in signal transduction pathways in human leukemia cells, particularly inactivation of the cytoprotective raf-1/mek/erk and akt cascades, that culminate in mitochondrial injury, caspase activation, and apoptosis. |
2004-03-10 |
2023-08-12 |
human |
| Aviv Goldbart, Zixi Jack Cheng, Kenneth R Brittian, David Goza. Intermittent hypoxia induces time-dependent changes in the protein kinase B signaling pathway in the hippocampal CA1 region of the rat. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678760. |
protein kinase b (akt) has emerged as major signal transduction protein underlying inhibition of apoptosis and consequent increases in cell survival. |
2004-03-05 |
2023-08-12 |
rat |
| Aviv Goldbart, Zixi Jack Cheng, Kenneth R Brittian, David Goza. Intermittent hypoxia induces time-dependent changes in the protein kinase B signaling pathway in the hippocampal CA1 region of the rat. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678760. |
thus, ih induces time-dependent biphasic changes in akt survival pathways within the ca1 region that are temporally correlated with the initial increases and subsequent decreases in neuronal apoptosis. |
2004-03-05 |
2023-08-12 |
rat |