| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew R Conery, Yanna Cao, E Aubrey Thompson, Courtney M Townsend, Tien C Ko, Kunxin Lu. Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis. Nature cell biology. vol 6. issue 4. 2004-05-27. PMID:15104092. |
furthermore, the ratio of smad3 to akt correlates with the sensitivity of cells to tgf-beta induced apoptosis. |
2004-05-27 |
2023-08-12 |
Not clear |
| Eric C Dietze, Michelle M Troch, Gregory R Bean, Joshua B Heffner, Michelle L Bowie, Paul Rosenberg, Brooke Ratliff, Victoria L Seewald. Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity. Oncogene. vol 23. issue 21. 2004-05-20. PMID:14990993. |
tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of akt activity. |
2004-05-20 |
2023-08-12 |
human |
| Eric C Dietze, Michelle M Troch, Gregory R Bean, Joshua B Heffner, Michelle L Bowie, Paul Rosenberg, Brooke Ratliff, Victoria L Seewald. Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity. Oncogene. vol 23. issue 21. 2004-05-20. PMID:14990993. |
at equimolar concentrations, tam and tamoxifen ethyl bromide (qtam), a membrane impermeant analog of tam, rapidly induced apoptosis in hmec-e6 cells associated with an even more rapid decrease in phosphorylation of akt at serine-473. |
2004-05-20 |
2023-08-12 |
human |
| Eric C Dietze, Michelle M Troch, Gregory R Bean, Joshua B Heffner, Michelle L Bowie, Paul Rosenberg, Brooke Ratliff, Victoria L Seewald. Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity. Oncogene. vol 23. issue 21. 2004-05-20. PMID:14990993. |
these data indicate that tam and qtam induce apoptosis in hmec-e6 cells through a plasma membrane-activated akt-signaling pathway that results in (1) decreased akt phosphorylation at ser-473, (2) mitochondrial membrane depolarization, and (3) activated caspase-9 and -3. |
2004-05-20 |
2023-08-12 |
human |
| Momoko Yamada, Yoshiko Banno, Yoh Takuwa, Masahiro Koda, Akira Hara, Yoshinori Nozaw. Overexpression of phospholipase D prevents actinomycin D-induced apoptosis through potentiation of phosphoinositide 3-kinase signalling pathways in Chinese-hamster ovary cells. The Biochemical journal. vol 378. issue Pt 2. 2004-05-19. PMID:14640974. |
however, in the early phase of apoptosis, actd induced an increase in pld activity and activation of key factors in the cell-survival signalling pathways, such as pi3k (phosphoinositide 3-kinase), akt, p70s6k (p70 s6 kinase) and erk (extracellular-signal-regulated kinase). |
2004-05-19 |
2023-08-12 |
Not clear |
| Stephan Kiessling, Gerhard Muller-Newen, Sandra N Leeb, Martin Hausmann, Heiko C Rath, Jorn Strater, Tanja Spottl, Klaus Schlottmann, Johannes Grossmann, F A Montero-Julian, Jurgen Scholmerich, Tilo Andus, Armin Buschauer, Peter C Heinrich, Gerhard Rogle. Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells. The Journal of biological chemistry. vol 279. issue 11. 2004-05-19. PMID:14701802. |
however, il-11 stimulation resulted in a dose-dependent tyrosine phosphorylation of akt, a decreased activation of caspase-9, and a reduced induction of apoptosis in cultured cec. |
2004-05-19 |
2023-08-12 |
human |
| C Robin Hiley, William R For. Cannabinoid pharmacology in the cardiovascular system: potential protective mechanisms through lipid signalling. Biological reviews of the Cambridge Philosophical Society. vol 79. issue 1. 2004-05-19. PMID:15005177. |
stimulation of cb1 receptors also modulates the activity of k+ and ca2+ channels and of protein kinase pathways including protein kinase b (akt) which might mediate effects on apoptosis. |
2004-05-19 |
2023-08-12 |
human |
| Lulu Farhana, Marcia I Dawson, Ying Huang, Yuxiang Zhang, Arun K Rishi, Kaladhar B Reddy, Robert S Freeman, Joseph A Fontan. Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities. Oncogene. vol 23. issue 10. 2004-05-13. PMID:14981538. |
apoptosis signaling by the novel compound 3-cl-ahpc involves increased egfr proteolysis and accompanying decreased phosphatidylinositol 3-kinase and akt kinase activities. |
2004-05-13 |
2023-08-12 |
Not clear |
| Lulu Farhana, Marcia I Dawson, Ying Huang, Yuxiang Zhang, Arun K Rishi, Kaladhar B Reddy, Robert S Freeman, Joseph A Fontan. Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities. Oncogene. vol 23. issue 10. 2004-05-13. PMID:14981538. |
the threonine and serine protein kinase akt plays a major role in inhibiting apoptosis in a number of malignant cell types including prostate and breast carcinoma. |
2004-05-13 |
2023-08-12 |
Not clear |
| Lulu Farhana, Marcia I Dawson, Ying Huang, Yuxiang Zhang, Arun K Rishi, Kaladhar B Reddy, Robert S Freeman, Joseph A Fontan. Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities. Oncogene. vol 23. issue 10. 2004-05-13. PMID:14981538. |
we now report that the novel compound 4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid (3-cl-ahpc), induces apoptosis in breast and prostate carcinoma cells and inhibits akt activity in these cells. |
2004-05-13 |
2023-08-12 |
Not clear |
| Lulu Farhana, Marcia I Dawson, Ying Huang, Yuxiang Zhang, Arun K Rishi, Kaladhar B Reddy, Robert S Freeman, Joseph A Fontan. Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities. Oncogene. vol 23. issue 10. 2004-05-13. PMID:14981538. |
overexpression of a constitutively activated akt inhibits 3-cl-ahpc-mediated apoptosis. |
2004-05-13 |
2023-08-12 |
Not clear |
| Lulu Farhana, Marcia I Dawson, Ying Huang, Yuxiang Zhang, Arun K Rishi, Kaladhar B Reddy, Robert S Freeman, Joseph A Fontan. Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities. Oncogene. vol 23. issue 10. 2004-05-13. PMID:14981538. |
overexpression of egfr results in increased akt activity and inhibition of 3-cl-ahpc-mediated decrease in akt activation, akt activity and 3-cl-ahpc-mediated apoptosis. |
2004-05-13 |
2023-08-12 |
Not clear |
| Kohji Fukunaga, Takayuki Kawan. Akt is a molecular target for signal transduction therapy in brain ischemic insult. Journal of pharmacological sciences. vol 92. issue 4. 2004-05-11. PMID:12939516. |
our findings lead to the conclusion that akt activity is a potential target for neuroprotective drugs in brain ischemic insult and other episodes of excitotoxic neuronal apoptosis such as seizure and huntington's and parkinson's diseases. |
2004-05-11 |
2023-08-12 |
Not clear |
| Paul W Rhyne, Jason D Scull, Lynn M Stiles, Dominic P Eisinge. Analysis of apoptotic cells using Beadlyte suspension arrays. BioTechniques. vol 35. issue 3. 2004-05-11. PMID:14513568. |
we found that phosphorylated akt levels dropped dramatically with 2 h or more of anisomycin treatment, whereas active caspase-3 levels rose sharply with 2 h of treatment, signifying the onset of apoptosis. |
2004-05-11 |
2023-08-12 |
Not clear |
| Ami Takeda, Mitsuhiko Osaki, Keiko Adachi, Soichiro Honjo, Hisao It. Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines. Pancreas. vol 28. issue 3. 2004-05-10. PMID:15084985. |
: phosphatidylinositol 3'-kinase (pi3k) and akt mediate survival signals and allow the cells to escape apoptosis in various human cancers. |
2004-05-10 |
2023-08-12 |
human |
| Ami Takeda, Mitsuhiko Osaki, Keiko Adachi, Soichiro Honjo, Hisao It. Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines. Pancreas. vol 28. issue 3. 2004-05-10. PMID:15084985. |
ly294002 (50 micromol/l) caused a decrease in phosphorylated akt and inhibition of cell proliferation in a time-dependent manner, but there was no obvious induction of apoptosis. |
2004-05-10 |
2023-08-12 |
human |
| Mitra Esfandiarei, Honglin Luo, Bobby Yanagawa, Agripina Suarez, Darya Dabiri, Jianchang Zhang, Bruce M McManu. Protein kinase B/Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent. Journal of virology. vol 78. issue 8. 2004-05-06. PMID:15047842. |
in the present study, we investigated the role of protein kinase b (pkb) (also known as akt), a general downstream mediator of survival signals through the pi3k cascade, in regulating cvb3 replication and virus-induced apoptosis in a well-established hela cell model. |
2004-05-06 |
2023-08-12 |
Not clear |
| Yves Pommier, Olivier Sordet, Smitha Antony, Richard L Hayward, Kurt W Koh. Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene. vol 23. issue 16. 2004-05-06. PMID:15077155. |
this review will focus on programmed cell death (apoptosis) and on survival pathways (bcl-2, apaf-1, akt, nf-kappab) involved in multidrug resistance. |
2004-05-06 |
2023-08-12 |
Not clear |
| Veronique Gagnon, Marie-Eve St-Germain, Sophie Parent, Eric Asseli. Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1. International journal of oncology. vol 23. issue 3. 2004-05-04. PMID:12888921. |
akt phosphorylation decreased and apoptosis was strongly increased in mutated pten human endometrial cancer cells in the presence of pi 3-k inhibitor (wortmannin) which was accompanied by a down-regulation of ciap-1 protein. |
2004-05-04 |
2023-08-12 |
human |
| Veronique Gagnon, Marie-Eve St-Germain, Sophie Parent, Eric Asseli. Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1. International journal of oncology. vol 23. issue 3. 2004-05-04. PMID:12888921. |
these results suggest a pivotal role of akt in the regulation of endometrial cancer cell survival through the up-regulation of a specific inhibitor of apoptosis protein. |
2004-05-04 |
2023-08-12 |
human |